Compounds > dibromobimane
Page last updated: 2024-09-03

dibromobimane and verapamil

dibromobimane has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(dibromobimane)		Trials
(dibromobimane)		Recent Studies (post-2010)
(dibromobimane)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
280517,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomydibromobimane (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clarke, DM; Loo, TW3

Other Studies

3 other study(ies) available for dibromobimane and verapamil

ArticleYear
Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate.
    The Journal of biological chemistry, 1997, Dec-19, Volume: 272, Issue:51

    Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Colchicine; Cysteine; Enzyme Inhibitors; Humans; Mutagenesis, Site-Directed; Sulfhydryl Compounds; Verapamil; Vinblastine

1997
Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Calcium Channel Blockers; Colchicine; Cross-Linking Reagents; Cysteine; Humans; Immunoblotting; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Verapamil; Vinblastine

2000
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
    The Journal of biological chemistry, 2002, Nov-15, Volume: 277, Issue:46

    Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cell Line; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Models, Chemical; Multidrug Resistance-Associated Proteins; Mutation; Protein Binding; Protein Structure, Tertiary; Rhodamines; Transfection; Verapamil

2002