diazoxide has been researched along with glyburide in 274 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (9.49) | 18.7374 |
| 1990's | 83 (30.29) | 18.2507 |
| 2000's | 115 (41.97) | 29.6817 |
| 2010's | 47 (17.15) | 24.3611 |
| 2020's | 3 (1.09) | 2.80 |
| Authors | Studies |
|---|---|
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonoi, T; Gonzalez, G; Inagaki, N; Inazawa, J; Namba, N; Seino, S | 1 |
| Andres, H; Bray, K; Manley, PW; Quast, U | 1 |
| Higashiguchi, O; Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Matsuzawa, Y; Yamada, M | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Carroll, WA; Coghlan, MJ; Gopalakrishnan, M | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bouider, N; Boyer, M; Faury, G; Fhayli, W; Florence, X; Ghandour, Z; Harrouche, K; Khelili, S; Lebrun, P; Pirotte, B | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Söderberg, M | 1 |
| Alric, R; Lignon, F; Loubatières, A; Manteghetti, M; Puech, R | 1 |
| Andersson, SE | 1 |
| Avallone, A; Florio, T; Grimaldi, M; Landolfi, E; Meucci, O; Schettini, G; Scorziello, A; Ventra, C | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Chathadi, KV; Hopfer, U; Jiang, B; Thévenod, F | 1 |
| Isom, GE; Patel, MN; Yim, GK | 1 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Briggs, JP; Brosius, FC; Furspan, PB; Lorenz, JN; Schnermann, J | 1 |
| Cameron, JS; Ciampolillo, F; Tung, DE | 1 |
| Ben-Ari, Y | 1 |
| Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Ashcroft, SJ; Niki, I | 2 |
| Löser, S; Panten, U; Rietze, I; Schwanstecher, M | 1 |
| Cavero, I; Mondot, S; Montier, F; Pratz, J | 1 |
| Seemayer, TA; Vlahos, WD; Yale, JF | 1 |
| Atwater, I; Kukuljan, M; Li, MY | 1 |
| Krnjević, K | 1 |
| Bray, KM; Brown, BS; Duty, S; Edwards, G; Kay, PB; Longmore, J; McHarg, AD; Newgreen, DT; Southerton, JS; Weston, AH | 1 |
| Ohno-Shosaku, T; Rorsman, P; Trube, G | 1 |
| Lenzen, S; Männer, K; Panten, U; Trube, G; Zünkler, BJ | 1 |
| Baskin, EP; Garcia, ML; Heaney, LA; Kaczorowski, GJ; Stein, RB; Wallace, AA; Winquist, RJ | 1 |
| Cook, NS; Quast, U | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Faivre, JF; Findlay, I | 1 |
| Falke, LC; Gee, WM; Gillis, KD; Hammoud, A; McDaniel, ML; Misler, S | 1 |
| Ashford, ML; Carrington, CA; Hales, CN; Kozlowski, RZ; Sturgess, NC | 1 |
| Garrino, MG; Henquin, JC; Meissner, HP; Nenquin, M; Schmeer, W | 1 |
| Hellman, B; Sehlin, J; Täljedal, IB | 2 |
| Gylfe, E; Hellman, B | 1 |
| Loubatières, A; Loubatières-Mariani, MM | 1 |
| Danielsson, A | 1 |
| Loubatiéres, A; Mariani, MM | 1 |
| Portenhauser, R; Schäfer, G; Trolp, R | 1 |
| Howell, SL; Montague, W | 1 |
| Butter, R; Fiedler, H; Hahn, HJ; Henkel, M; Ziegler, B; Ziegler, M | 1 |
| Edwards, JC; Howell, SL; Montague, W | 1 |
| Idahl, LA | 1 |
| Hellman, B; Lernmark, A; Sehlin, J; Täljedal, IB | 1 |
| Danielsson, A; Hellman, B; Idahl, LA | 1 |
| Hellman, B; Sehlin, J; Täljedal, I | 1 |
| Halban, PA; Meda, P; Michaels, RL; Orci, L; Sheridan, JD | 1 |
| Abrahams, Z; Sutter, MC | 1 |
| Dubinsky, WP; Mayorga-Wark, O; Schultz, SG | 1 |
| Angel, I; Eon, MT; Langer, SZ; Lorrain, J; Oblin, A | 1 |
| Dan, K; Fujita, T; Hirose, H; Ito, K; Kanda, N; Kato, R; Maruyama, H; Saruta, T; Seto, Y | 1 |
| Lenzen, S; Tiedge, M | 1 |
| Alarcón, S; Hernandez, J; Laorden, ML | 1 |
| Ichihara, K; Nakai, T | 1 |
| Ballanyi, K; Richter, DW; Trapp, S | 1 |
| Reeves, WB; Shah, SV | 1 |
| Aupetit-Faisant, B; Cailmail, S; Kirstetter, P; Komeichi, H; Lebrec, D; Moreau, R; Yang, S | 1 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Alkadhi, KA; Salgado, D; Shek, EW | 1 |
| Baró, I; Berthon, B; Escande, D; Hongre, AS | 1 |
| Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P | 1 |
| Furspan, PB; Webb, RC | 1 |
| Chai, S; Kolias, TJ; Webb, RC | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Amoroso, S; Bernardi, H; De Weille, JR; Epelbaum, J; Fosset, M; Lazdunski, M; Mourre, C; Slama, A | 1 |
| Arita, M; Kiyosue, T; Nakamura, S; Sato, T; Wu, B | 1 |
| Dan, K; Fujita, H; Fujita, T; Kato, R; Seto, Y | 1 |
| Gäbel, J; Lebrun, P; Malaisse, WJ; Pirotte, B; Rorsman, P; Valverde, I; Van Poelje, PD; Villanueva-Peñacarrillo, ML; Viñambres, C | 1 |
| Bijlstra, PJ; Lutterman, JA; Russel, FG; Smits, P; Thien, T | 1 |
| Ballanyi, K; Brockhaus, J; Doutheil, J | 1 |
| Kitano, I; Matsunaga, T; Mori, N | 1 |
| Abdel-Wahab, YH; Barnett, CR; Flatt, PR; O'Harte, FP | 1 |
| Chang, HY; Chen, CR; Chen, CW; Hsiue, TR | 1 |
| Adler-Graschinsky, E; Feleder, EC | 1 |
| Akiyoshi, M; Fujitani, S; Ikenoue, T; Kondo, N; Maki, T; Okazaki, K | 1 |
| Nakai, T | 1 |
| Leung, CK; Ye, GL; Yung, WH | 1 |
| Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR | 1 |
| Daher, A; Diamond, T; Howes, LG; Lykos, D; Morris, R; Sundaresan, P | 3 |
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonzalez, G; Kunjilwar, K; Panten, U; Schwanstecher, M | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| Daut, J; Langheinrich, U | 1 |
| Boulpaep, EL; Mauerer, UR; Segal, AS | 1 |
| Aubin, R; Lajeunesse, D; Lapointe, JY; Moreau, R | 1 |
| Bouskela, E; Conde, CM; Cyrino, FZ; Garcia, AA | 1 |
| Cregan, M; Miller, R; Strickler, L; Suttles, J; Wondergem, R | 1 |
| Kikuchi, M; Niki, I; Oka, Y; Sakurada, M; Tsukuda, K | 1 |
| Ashcroft, FM; Ashcroft, SJ; Coles, B; Niki, I | 1 |
| Haller, M; Langohr, K; Mironov, SL; Richter, DW | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Richardson, PJ | 1 |
| Aguilar-Bryan, L; Bryan, J; Dörschner, H; Gross, I; Schwanstecher, C; Schwanstecher, M; Sieverding, C | 1 |
| Mahmoudian, M; Mirkhani, H | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Araki, E; Kaneko, K; Kishikawa, H; Motoshima, H; Motoyoshi, S; Sakai, K; Shichiri, M; Shirakami, A; Shirotani, T; Yoshizato, K | 1 |
| Chagneau, C; De Gottardi, A; Fléjou, JF; Fouassier, L; Housset, C; Lahaye, P; Lebrec, D; Moreau, R; Reichen, J; Rona, JP; Tazi, KA | 1 |
| Fang, ZY; Fontaine, J | 1 |
| Brioni, JD; Sullivan, JP; Zhu, DX | 1 |
| Anello, M; Henquin, JC; Sato, Y | 1 |
| Hu, H; Johns, DC; Liu, Y; Marbán, E; O'Rourke, B; Sato, T; Seharaseyon, J | 1 |
| Abban, G; Akar, F; Buharalioğlu, CK; Heinemann, A; Holzer, P; Uydeş-Doğan, BS; Van de Voorde, J | 1 |
| Moustaid-Moussa, N; Shi, H; Wilkison, WO; Zemel, MB | 1 |
| Baertschi, AJ; Baron, A; Monnier, D; Roatti, A; van Bever, L | 1 |
| Gonoi, T; Inagaki, N; Ishida, H; Seino, S; Seino, Y; Sunaga, Y; Yamada, Y | 1 |
| Foldes, FF; Matkó, I; Nagashima, H; Oe, K; Sántha, E; Sperlágh, B; Vizi, ES | 1 |
| Bakhtiarian, A; Djahanguiri, B; Rahgozar, M; Toroudi, HP | 1 |
| Nadal, A; Quesada, I; Soria, B | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Dallaporta, M; Orsini, JC; Perrin, J | 1 |
| Galiñanes, M; Ghosh, S; Standen, NB | 1 |
| Brioni, JD; Gopalakrishnan, M; Molinari, EJ; Monteggia, LM; Roch, JM; Scott, VE; Shieh, CC; Sullivan, JP; Whiteaker, KL | 1 |
| Firth, TA; Mawe, GM; Nelson, MT | 1 |
| Antoine, MH; Lebrun, P; Malaisse, WJ; Nguyen, QA; Picton, S | 1 |
| Mohan, RM; Paterson, DJ | 1 |
| Antoine, MH; Arkhammar, P; Hansen, JB; Lebrun, P; Nguyen, QA; Pirotte, B | 1 |
| Chi, X; Hellermann, G; Price, JM; Sutton, ET | 1 |
| Asai, M; Iwasaki, Y; Morishita, M; Mutsuga, N; Nomura, A; Oiso, Y; Saito, H; Yamamori, E; Yoshida, M | 1 |
| Ovide-Bordeaux, S; Veksler, V; Ventura-Clapier, R | 1 |
| Cohen, MV; Critz, SD; Downey, JM; Heusch, G; Liu, GS; Nakano, A; Pain, T; Yang, XM; Yue, Y | 1 |
| Almond, SC; Paterson, DJ | 1 |
| Bolli, R; Takano, H; Tang, XL | 1 |
| Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS | 1 |
| Cone, J; Liu, Y; Wang, S | 1 |
| Elmi, A; Idahl, LA; Sehlin, J | 2 |
| Liu, Y; Marbán, E; O'Rourke, B; Ren, G; Seharaseyon, J | 1 |
| Debska, G; Elger, CE; Kicińska, A; Kunz, WS; May, R; Szewczyk, A | 1 |
| García de Boto, MJ; Hidalgo, A; Martínez, C; Sánchez, M | 1 |
| Akaike, T; Cho, C; Goto, M; Kobayashi, K; Maruyama, A; Miyazaki, J; Park, K; Takei, R | 1 |
| Li, RA; Marbán, E; Miki, T; Nakaya, H; Ogura, T; Ohmoto-Sekine, Y; Sakamoto, N; Seino, S; Suzuki, M; Tamagawa, M; Uemura, H | 1 |
| Liu, Y; O'Rourke, B | 1 |
| Abood, ME; Goforth, PB; Kinard, TA; Satin, LS; Tao, Q; Teague, J | 1 |
| Bakhtiarian, A; Djahanguiri, B; Pazokitoroudi, H; Rahgozar, M | 1 |
| Asano, Y; Fujita, N; Itabashi, N; Muto, S; Ohta, T; Okada, K; Saito, T | 1 |
| Baxter, GF; Lawrence, CL; Maddock, HL; Mocanu, MM; Standen, NB; Yellon, DM | 1 |
| Bae, YH; Kim, SW; Park, KH | 1 |
| Haller, M; Mironov, SL; Richter, DW | 1 |
| Bajgar, R; Garlid, KD; Kowaltowski, AJ; Paucek, P; Seetharaman, S | 1 |
| Bielfeld-Ackermann, A; Konstas, AA; Korbmacher, C | 1 |
| Antoine, MH; Barnes, PD; Becker, B; Cosgrove, KE; Dunne, MJ; Lebrun, P; Nguyen, QA; Pirotte, B; Rigo, B | 1 |
| Genda, S; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Nozawa, Y; Shimamoto, K; Tanno, M; Tsuchida, A | 1 |
| Campbell, WB; Chen, YF; Gross, GJ; Li, PL; Zhang, DX; Zou, AP | 1 |
| Aketa, S; Kamada, Y; Nakagawa, I; Nakase, H; Sakaki, T; Yamashita, M | 1 |
| LaFranchi, S; Lester, LB; Mougey, A; Shen, S; Shyng, SL; Taschenberger, G | 1 |
| Abbink, EJ; Lutterman, JA; Pickkers, P; Russel, FG; Smits, P; Tack, CJ; van Rosendaal, AJ | 1 |
| Abbink, EJ; Jansen van Rosendaal, A; Lutterman, JA; Pickkers, P; Russel, FG; Smits, P; Tack, CJ | 1 |
| De Proft, R; Dejonghe, S; Gorus, F; Ling, Z; Pipeleers, D; Schuit, F; Winnock, F | 1 |
| Driedzic, WR; MacCormack, TJ | 1 |
| Englert, H; Kilbinger, H; Krause, A; Mang, CF; Wirth, K | 1 |
| Ashcroft, FM; Ashfield, R; Bondo Hansen, J; Dabrowski, M; Egebjerg, J; Lebrun, P; Pirotte, B; Wahl, P | 1 |
| del Valle, HF; Lascano, EC; Negroni, JA | 1 |
| Giblin, JP; Quinn, K; Tinker, A | 1 |
| Houston, RJ; Legtenberg, RJ; Oeseburg, B; Rongen, GA; Smits, P | 1 |
| Almeida, JP; Loss, ES; Von Ledebur, EI; Wassermann, GF | 1 |
| Debska, G; Elger, CE; Kicinska, A; Kunz, WS; May, R; Skalska, J; Szewczyk, A | 1 |
| Cartier, EA; Shen, S; Shyng, SL | 1 |
| Farouque, HM; Meredith, IT | 1 |
| Das, M; Halestrap, AP; Parker, JE | 1 |
| Auclair, J; Bouskela, E; Félétou, M; Levens, N; Néliat, G; Ravel, D | 1 |
| Amiel, SA; Bingham, E; Hopkins, D; Macdonald, IA; Pernet, A; Reid, H | 1 |
| Akaike, A; Honda, Y; Kashii, S; Yamauchi, T; Yasuyoshi, H; Zhang, S | 1 |
| Hogan, Q; Kwok, WM; McCallum, B; Sapunar, D; Sarantopoulos, C | 1 |
| Chan, KW; Logothetis, DE; Zhang, H | 1 |
| Nakagawa, I; Nakase, H; Noriyama, Y; Ogawa, Y; Sakaki, T; Yamashita, M | 1 |
| Cohen, MV; Downey, JM; Garlid, KD; Grover, GJ; Krieg, T; Oldenburg, O; Yang, XM | 1 |
| Chen, M; Dong, Y; Simard, JM | 1 |
| Busija, DW; Grover, G; Lacza, Z; Miller, AW; Snipes, JA; Szabó, C | 1 |
| Busija, DW; Horiguchi, T; Kis, B; Nagy, K; Rajapakse, NC; Snipes, JA | 1 |
| Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA | 1 |
| Jiang, K; Shui, Q; Xia, Z; Zhao, Z | 1 |
| Kawano, T; Kitahata, H; Kuroda, Y; Nakaya, Y; Oshita, S; Takahashi, A; Tomiyama, Y; Tsutsumi, Y | 1 |
| Ahmadi, S; Djahanguiri, B; Jafari, MR; Zarrindast, MR | 1 |
| Djahanguiri, B; Jafari, MR; Shafaghi, B; Zarrindast, MR | 1 |
| Beresewicz, A; Duda, M; Maczewski, M | 1 |
| Miki, T; Miura, T | 1 |
| Broadhead, MW; Kharbanda, RK; MacAllister, RJ; Peters, MJ | 1 |
| Cook, MA; Karmazyn, M; Rajapurohitam, V; Xia, Y | 1 |
| Hambrock, A; Kayar, T; Osswald, H; Stumpp, D | 1 |
| Bøtker, HE; Kristiansen, SB; Nielsen, TT; Nielsen-Kudsk, JE | 1 |
| Andrade, AA; Assreuy, J; Bonjardim, CA; Cassali, GD; Cunha, FQ; Lara, GG; Passaglio, KT; Pompermayer, K; Silveira, KD; Souza, DG; Teixeira, MM; Vieira, MA | 1 |
| Avshalumov, MV; Chen, BT; Koós, T; Rice, ME; Tepper, JM | 1 |
| Bari, F; Busija, DW; Domoki, F; Grover, G; Katakam, P; Kis, B; Rajapakse, NC | 1 |
| Cameron, JS; Chen, J; Wilson, I; Zhu, JX | 1 |
| Akaike, T; Park, KH | 1 |
| Fowler, A; Galiñanes, M; Hassouna, A; Loubani, M; Matata, BM; Standen, NB | 1 |
| Acevedo, JJ; Darszon, A; de la Vega-Beltrán, JL; Felix, R; Mendoza-Lujambio, I; Treviño, CL | 1 |
| Kwon, G; Liu, H; Marshall, CA; McDaniel, ML; Pappan, KL; Remedi, MS | 1 |
| Conte Camerino, D; Desai, RR; George, AL; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Amanpour, S; Beheshtian, A; Dehpour, AR; Demehri, S; Ghazinezami, B; Kiumehr, S; Mohagheghi, MA; Nezami, BG; Rabbani, S; Rahimpour, S; Salmasi, AH | 1 |
| Almoznino-Sarafian, D; Alon, I; Berman, S; Cohen, N; Efrati, S; Gorelik, O; Shteinshnaider, M; Weissgarten, J | 1 |
| Kaku, K; Katsura, M; Matsuda, M; Ohkuma, S; Shigeto, M | 1 |
| Cheng, KS; Li, CL; Lin, MW; Ting, WH; Wu, AZ; Wu, SN | 1 |
| Cunha, FQ; Gomes, AS; Lima, LM; Ribeiro, RA; Santos, CL; Souza, MH | 1 |
| Aishima, M; Ito, Y; Naito, S; Nakano, T; Seki, N; Sueishi, K; Teramoto, N; Tomoda, T; Yonemitsu, Y; Yunoki, T | 1 |
| Ebrahimi, M; Khalilzadeh, A; Zarrindast, MR | 1 |
| Mohajeri, S; Zarrindast, MR | 1 |
| Sung, RJ; Wu, AZ; Wu, SN | 1 |
| Comelli, M; Mavelli, I; Metelli, G | 1 |
| Coetzee, WA; Ghiu, I; Gutstein, DE; Hendricks-Munoz, KD; Kontogeorgis, A; Malester, B; Tong, X; Xu, J | 1 |
| Bednarczyk, P; Choma, K; Dolowy, K; Jarmuszkiewicz, W; Kicinska, A; Koszela-Piotrowska, I; Swida, A; Szewczyk, A | 1 |
| Khalilzadeh, A; Sattari-Naeini, M; Zarrindast, MR | 1 |
| El-Ani, D; Mashiach, Y; Shainberg, A; Zimlichman, R | 1 |
| Ishida, H; Kimoto, K; Kizaki, T; Miyazawa, N; Nakano, N; Ohno, H; Sakurai, T; Suzuki, K; Takahashi, K; Takahashi, M | 1 |
| de Olinda, TM; Lemos, TL; Machado, LL; Rao, VS; Santos, FA | 1 |
| Bazargan, M; Chitsaz, M; Faghihi, M | 1 |
| Brito, GA; Gadelha, GG; Garcia, JA; Lima, SJ; Medeiros, JV; Ribeiro, RA; Santos, AA; Soares, PM; Souza, MH | 1 |
| Buck, LT; Cooray, M; Pamenter, ME; Shin, DS | 1 |
| Anvari, M; Khalilzadeh, A; Khalilzadeh, O; Sahebgharani, M; Zarrindast, MR | 1 |
| Camara, AK; Eells, JT; Heinen, A; Henry, MM; Riess, ML; Stowe, DF | 1 |
| Mozaffari, MS; Schaffer, SW | 1 |
| Dehpour, AR; Fakhimi, A; Ghasemi, M; Niaki, SE; Shafaroodi, H; Shakiba, B | 1 |
| Chua, S; Gutierrez-Juarez, R; Jo, YH; Su, Y | 1 |
| Guerra, MJ; Joglar, B; Labandeira-Garcia, JL; Parga, JA; Rodriguez-Pallares, J | 1 |
| Campos, MG; Jiménez-Estrada, M; Oropeza, M; Reyes-Chilpa, R; Torres-Sosa, C | 1 |
| Efimov, IR; Fedorov, VV; Flagg, TP; Glukhov, AV; Nichols, CG | 1 |
| Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR | 1 |
| Bakhtiarian, A; Djahanguiri, B; Katebi, M; Soleimani, M; Toroudi, HP; Zarch, AV | 1 |
| Andrade, F; Huerta, M; Montoya-Pérez, R; Ortiz, M; Saavedra-Molina, A; Sánchez-Pastor, E; Trujillo, X | 1 |
| Garg, GR; Halder, S; Khanna, N; Malhotra, RS; Mehta, AK; Sharma, KK | 1 |
| Bertini, S; Gianelli, P; Menozzi, A; Passeri, B; Poli, E; Pozzoli, C | 1 |
| Akopova, OV; Bouryi, VA; Mankovskaya, IN; Nosar, VI; Sagach, VF | 1 |
| Carroll, JL; Donnelly, DF; Kim, D; Kim, I; Papreck, JR | 1 |
| Du, X; Wang, C; Zhang, H | 1 |
| Coetzee, WA; Patel, JC; Rice, ME; Witkovsky, P | 1 |
| Bahler, CK; Chang, M; Chowdhury, UR; Fautsch, MP; Hann, CR; Resch, ZT; Romero, MF | 1 |
| Boucai, L; Bursheh, S; Esterson, YB; Gutierrez-Juarez, R; Hawkins, M; Kehlenbrink, S; Kishore, P; Koppaka, S; Li, W; Mehta, D; Muzumdar, R; Schiwek, A; Schwartz, GJ; Su, Y; Zhang, K | 1 |
| Ducza, E; Falkay, G; Gáspár, R; Lovász, N | 1 |
| Vadziuk, OB | 1 |
| Mishra, S; Nguyen, KH; Nguyen, QT; Nyomba, BL; Pham, HD; Pham, TH; Ta, TN | 1 |
| Afify, EA; Khedr, MM; Nasser, SA; Omar, AG | 1 |
| Ajami, M; Azad, N; Davoodi, SH; Farahini, H; Habibey, R; Pazoki-Toroudi, H; Soleimani, M; Tavakkoli-Hosseini, M | 1 |
| Assa, S; Dehpour, AR; Elmi, A; Emami, H; Nezami, BG; Ostovaneh, MR; Talab, SS | 1 |
| Gerzanich, V; Ivanov, A; Kwon, MS; Simard, JM; Woo, SK | 1 |
| Babes, A; Engel, MA; Filipovic, M; Fischer, MJ; Flonta, ML; Reeh, PW | 1 |
| Blust, R; Hectors, TL; Martens, GA; Pereira-Fernandes, A; Vanparys, C | 1 |
| Araki, Y; Kawamura, G; Kitamura, T; Mori, Y; Sato, K; Sato, R; Yamada, Y | 1 |
| Behmoaras, J; Buján, J; Escoubet, B; Jacob, MP; Lacolley, P; Lannoy, M; Pezet, M; Sloboda, N; Slove, S | 1 |
| Aragão, KS; Barbosa, AL; Carvalho, NS; Costa, NR; Damasceno, SR; Medeiros, JV; Nicolau, LA; Silva, RO; Soares, PM; Souza, MH | 1 |
| Li, CY; Pi, MS; Ru, Q; Tian, X; Wu, RH; Wu, YX | 1 |
| Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Görbe, A; Kupai, K; Pálóczi, J; Puskás, LG; Zvara, A | 1 |
| Giovani de Oliveira Nascimento, C; Giusti-Paiva, A; Pereira de Ávila, MA | 1 |
| Drain, P; Luppi, P | 1 |
| Honda, M; Inoue, K; Martin, DT; Oikawa, R; Saito, M; Sejima, T; Shimizu, S; Shimizu, T; Tanaka, K; Tomita, S; Tsounapi, P | 1 |
| Bu, HM; Ma, HJ; Sun, H; Wang, ML; Yang, CY; Zhang, Y | 1 |
| Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H | 1 |
| Chen, Y; Fan, Z; Huang, L; Lin, W; Tan, W; Wen, T; Yin, C | 1 |
| Hoshmandi, E; Karbalaei, N; Noorafshan, A | 1 |
| Adachi, T; Fujisawa, S; Hongoh, M; Ohba, T; Ono, K; Shimbo, T | 1 |
| Karbalaei, N; Nadimi, E; Noorafshan, A; Safayee, S | 1 |
| Chen, M; Feng, J; Lan, J; Li, J; Liang, W; Song, M; Zhang, W; Zheng, D | 1 |
| Du, X; Jiang, H; Jiao, Q; Shi, L; Zhang, Z | 1 |
| Kandasamy, B; Shyng, SL | 1 |
| Dehpour, AR; Foroutan, A; Ghaffari, SH; Haddadi, NS; Momeny, M; Norouzi-Javidan, A; Ostadhadi, S; Zarrinrad, G | 1 |
| Bayles, J; Fisher, SJ; Reno, CM; Skinner, A | 1 |
| Dantzler, HA; Kline, DD; Martinez, D; Matott, MP | 1 |
| Aleksic, S; Bhansali, S; Carey, M; Hawkins, M; Huffman, DM; Kehlenbrink, S; Koppaka, S; Lontchi-Yimagou, E; Maginley, SR; Mitchell, W; Reda, S; Zhang, K | 1 |
| Akopova, O; Kolchinskaya, L; Mankovska, I; Nosar, V; Sagach, V | 1 |
| Albuquerque, AC; Bezerra Palácio, P; Brito Lucas, AM; Facundo, HT; Nunes Varela, AL; Oliveira Cunha, PL; Ponte Viana, YI; Varlla de Lacerda Alexandre, J | 1 |
3 review(s) available for diazoxide and glyburide
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Urinary Incontinence | 2001 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Humans; Ion Channel Gating; Myocardial Reperfusion Injury; Nicorandil; Pinacidil; Potassium Channel Blockers; Potassium Channels; Randomized Controlled Trials as Topic; Vasodilator Agents | 2003 |
7 trial(s) available for diazoxide and glyburide
| Article | Year |
|---|---|
Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans.
Topics: Adult; Analysis of Variance; Blood Pressure; Diazoxide; Forearm; Glyburide; Humans; Hypoglycemic Agents; Injections, Intra-Arterial; Male; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Reference Values; Regional Blood Flow; Sulfonylurea Compounds; Vasodilation; Vasodilator Agents | 1996 |
Comparative effects of glibenclamide and metformin on ambulatory blood pressure and cardiovascular reactivity in NIDDM.
Topics: Acetylcholine; Adult; Aged; Angiotensin II; Blood Glucose; Blood Pressure; Cholesterol; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Double-Blind Method; Female; Forearm; Glyburide; Heart Rate; Hemodynamics; Humans; Hypoglycemic Agents; Infusions, Intra-Arterial; Lipoproteins; Male; Metformin; Middle Aged; Nitroprusside; Norepinephrine; Regional Blood Flow; Vascular Resistance | 1997 |
Acute effects of oral glibenclamide on blood pressure and forearm vascular resistance in diabetics.
Topics: Adenosine Triphosphate; Adult; Aged; Blood Glucose; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Double-Blind Method; Forearm; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Norepinephrine; Potassium Channels; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Acute effects of oral glibenclamide on blood pressure and forearm vascular resistance in diabetics.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Double-Blind Method; Forearm; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Norepinephrine; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.
Topics: Acetylcholine; Adult; Aged; Blood Flow Velocity; Blood Pressure; Body Mass Index; Body Weight; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Dipyridamole; Double-Blind Method; Female; Forearm; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Vasodilation | 2002 |
The effects of KATP channel modulators on counterregulatory responses and cognitive function during acute controlled hypoglycaemia in healthy men: a pilot study.
Topics: Adenosine Triphosphate; Adult; Blood Glucose; Cognition; Diabetes Mellitus; Diazoxide; Glucose Clamp Technique; Glyburide; Hormones; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Pilot Projects; Potassium Channels; Vasodilator Agents | 2003 |
Activation of K(ATP) channels suppresses glucose production in humans.
Topics: Adult; Animals; Blood Glucose; Blood-Brain Barrier; Calcium Channel Blockers; Diazoxide; Double-Blind Method; Enzyme Induction; Female; Gluconeogenesis; Glucose Clamp Technique; Glucose-6-Phosphatase; Glyburide; Humans; Hypothalamus; Injections, Intraventricular; Insulin; Ion Channel Gating; Liver; Male; Phosphorylation; Potassium Channels; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor | 2011 |
264 other study(ies) available for diazoxide and glyburide
| Article | Year |
|---|---|
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Cricetinae; Diazoxide; Humans; Islets of Langerhans; KATP Channels; Mice; Molecular Sequence Data; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Rubidium; Sulfonylurea Compounds; Sulfonylurea Receptors | 1995 |
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.
Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents | 1993 |
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Mice; Molecular Sequence Data; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release.
Topics: Animals; Benzene Derivatives; Cells, Cultured; Diazoxide; Drug Design; Elastin; Insulin; Insulin Antagonists; Potassium Channels; Rats, Wistar; Thiourea; Vasodilator Agents | 2015 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Glucose inhibiton of the permeation of chloromercuribenzene-p-sulphonic acid in the plasma membrane of pancreatic beta-cells.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Cell Membrane; Cell Membrane Permeability; Depression, Chemical; Diazoxide; Epinephrine; Female; Glucose; Glyburide; Heptoses; Islets of Langerhans; Mannose; Mice; Organometallic Compounds; Time Factors | 1975 |
[Non-saturable cooperative binding of tolbutamide to rat endocrine pancreas. Criteria of specificity].
Topics: Animals; Diazoxide; Drug Interactions; Glipizide; Glucose; Glyburide; Islets of Langerhans; Kinetics; Rats; Tolbutamide | 1976 |
Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Diazoxide; Glyburide; Hypotension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium Channels; Rabbits; Uvea; Vasodilation | 1992 |
Dopamine and somatostatin inhibition of prolactin secretion from MMQ pituitary cells: role of adenosine triphosphate-sensitive potassium channels.
Topics: Adenosine Triphosphate; Calcium; Cell Line; Diazoxide; Dopamine; Glyburide; Pituitary Gland; Potassium; Potassium Channels; Prolactin; Somatostatin | 1992 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
ATP-sensitive K+ conductance in pancreatic zymogen granules: block by glyburide and activation by diazoxide.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Cations, Monovalent; Cell Membrane; Cytoplasmic Granules; Diazoxide; Enzyme Precursors; Glyburide; Hydrogen-Ion Concentration; Male; Pancreas; Potassium; Rats; Rats, Sprague-Dawley | 1992 |
Potentiation of cyanide neurotoxicity by blockade of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Drug Synergism; Glyburide; Hippocampus; Kinetics; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Potassium Channels; Sodium Cyanide; Valine | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K+ channels in the rabbit.
Topics: Adenosine Triphosphate; Animals; Arterioles; Deoxyglucose; Diazoxide; Glyburide; In Vitro Techniques; Perfusion; Potassium Channels; Rabbits; Vasoconstriction; Verapamil | 1992 |
Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cells, Cultured; Diazoxide; Glyburide; Ion Channel Gating; Male; Potassium; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1992 |
Modulation of ATP sensitive K+ channels: a novel strategy to reduce the deleterious effects of anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Galanin; Glutamates; Glutamic Acid; Glyburide; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Membrane Potentials; Peptides; Potassium Channels; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Effects of cromakalim, RP49356, diazoxide, glibenclamide and galanin in rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Picolines; Portal Vein; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Colforsin; Diazoxide; Glyburide; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Phosphorylation; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Proteins; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Tetradecanoylphorbol Acetate | 1991 |
Phosphate and thiophosphate group donating adenine and guanine nucleotides inhibit glibenclamide binding to membranes from pancreatic islets.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Binding, Competitive; Calcium; Diazoxide; Glyburide; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Islets of Langerhans; Kinetics; Magnesium; Membranes; Mice; Microsomes; Organothiophosphates; Phosphates; Phosphorylation; Tritium | 1991 |
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Drug Interactions; Glucose; Glyburide; Infusions, Intravenous; Insulin; Male; Membrane Potentials; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Renin | 1991 |
Diabetes prevention in BB rats by inhibition of endogenous insulin secretion.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus; Diazoxide; Glucose Tolerance Test; Glyburide; Insulin; Insulin Antagonists; Pancreas; Rats; Rats, Brattleboro | 1991 |
Characterization of potassium channels in pancreatic beta cells from ob/ob mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Electric Conductivity; Glucose; Glyburide; In Vitro Techniques; Ion Channel Gating; Islets of Langerhans; Membrane Potentials; Mice; Mice, Obese; Potassium Channels | 1990 |
Adenosine triphosphate-sensitive potassium channels in anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neurons; Potassium Channels; Tolbutamide | 1990 |
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Diazoxide; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Minoxidil; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1990 |
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Glucose; Glyburide; Ion Channels; Islets of Langerhans; Mice; Potassium; Tolbutamide | 1986 |
Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Benzamides; Diazoxide; Glipizide; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Ion Channels; Islets of Langerhans; Mice; Mice, Inbred Strains; Potassium; Sulfonylurea Compounds; Tolbutamide | 1988 |
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Antihypertensive Agents; Benzopyrans; Charybdotoxin; Cromakalim; Diazoxide; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation | 1989 |
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.
Topics: Angiotensin II; Animals; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Glyburide; Heart Rate; In Vitro Techniques; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rubidium; Vasoconstriction | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Heart; In Vitro Techniques; Male; Potassium Channels; Rats; Rats, Inbred Strains; Tolbutamide | 1989 |
Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Electric Conductivity; Glucose; Glyburide; Islets of Langerhans; Kinetics; Mathematics; Membrane Potentials; Models, Biological; Potassium Channels; Rats; Tolbutamide | 1989 |
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Diazoxide; Electrophysiology; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Nucleotides; Potassium Channels; Rats; Sulfonylurea Compounds; Tolbutamide | 1988 |
Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide.
Topics: Animals; Benzamides; Calcium; Diazoxide; Female; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Mice, Inbred Strains; Rubidium | 1985 |
The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.
Topics: Animals; Antimycin A; Carbon Isotopes; Chlorpromazine; Diazoxide; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Mice; Serum Albumin; Sulfur Isotopes; Tolbutamide | 1973 |
Role of glucose as a regulator and precursor of amino acids in the pancreatic beta-cells.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoradiography; Carbon Radioisotopes; Chromatography, Thin Layer; Diazoxide; Epinephrine; Female; Glucose; Glutamates; Glyburide; In Vitro Techniques; Islets of Langerhans; Methods; Mice; Tritium | 1974 |
In vitro secretion of insulin after glucose, sulphonylureas, adrenergic and cholinergic substances studied by isolated perfused rat pancreas.
Topics: Acetylcholine; Animals; Atropine; Diazoxide; Epinephrine; Glucagon; Glucose; Glyburide; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Isoproterenol; Ketoses; Norepinephrine; Pancreas; Parasympathomimetics; Perfusion; Phenoxybenzamine; Practolol; Propranolol; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1974 |
Effects of nutritional state and of administration of glucose, glibenclamide or diazoxide on the storage of amylase in mouse pancreas.
Topics: Amylases; Animals; Carbachol; Cholecystokinin; Diazoxide; Dinitrophenols; Female; Glucose; Glyburide; Insulin; Mice; Nutritional Physiological Phenomena; Organ Size; Pancreas; Parotid Gland; Starvation | 1974 |
[Recent pharmacologic aspects of sulfamides modifying insulin secretion (hypoglycemic and hyperglycemic sulfamides)].
Topics: Animals; Catecholamines; Diazoxide; Dogs; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Pancreas; Pancreatectomy; Phenoxybenzamine; Propranolol; Rats; Tolbutamide | 1973 |
Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide. II. Interaction with energy conservation and ion transport.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Citric Acid Cycle; Cytochromes; Diazoxide; Drug Antagonism; Electron Transport; Glutamates; Glyburide; Hydroxybutyrates; Ketoglutaric Acids; Male; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen Consumption; Polarography; Pyruvates; Rats; Succinates; Uncoupling Agents | 1971 |
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical; Diazoxide; Epinephrine; Glucose; Glyburide; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Leucine; Male; Mice; Monosaccharides; Obesity; Oxidation-Reduction; Pyruvates; Stimulation, Chemical; Succinates | 1971 |
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol | 1973 |
[Islands of Langerhans in vitro. VII. Comparative studies on insulin secretion stimulation by various substrates in the rat].
Topics: Animals; Arginine; Bucladesine; Caffeine; Calcium; Diazoxide; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Radioimmunoassay; Rats; Time Factors; Xylitol | 1973 |
Regulation of adenylate cyclase and cyclic-AMP dependent protein kinase activities in A2-cell rich guinea-pig islets of Langerhans.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Arginine; Bucladesine; Cyclic AMP; Diazoxide; Epinephrine; Fluorides; Glucagon; Glyburide; Guinea Pigs; Islets of Langerhans; Leucine; Male; Microbial Collagenase; Phosphorus Radioisotopes; Protein Kinases; Radioimmunoassay; Streptozocin; Theophylline | 1974 |
Glucose-6-phosphate content in mammalian pancreatic beta-cells. Effects of various stimulators and inhibitors of insulin release.
Topics: Animals; Bucladesine; Cells, Cultured; Diazoxide; Epinephrine; Female; Glucosephosphates; Glyburide; In Vitro Techniques; Islets of Langerhans; Mice; Mice, Obese | 1971 |
Transport and storage of 5-hydroxytryptamine in pancreatic -cells.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Gel; Diazoxide; Glucose; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Obesity; Osmolar Concentration; Pargyline; Protein Binding; Reserpine; Serotonin | 1972 |
Levels of -ketoglutarate and glutamate in stimulated pancreatic -cells.
Topics: Animals; Carbutamide; Chemical Phenomena; Chemistry; Depression, Chemical; Diazoxide; Female; Fluorometry; Glucose; Glutamate Dehydrogenase; Glutamates; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Ischemia; Islets of Langerhans; Ketoglutaric Acids; Liver; Mice; Obesity; Protein Conformation; Stimulation, Chemical | 1970 |
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia; Islets of Langerhans; Leucine; Mice; Obesity; Pancreas; Pyruvates; Sodium; Stereoisomerism; Succinates; Time Factors | 1971 |
In vivo modulation of gap junctions and dye coupling between B-cells of the intact pancreatic islet.
Topics: Animals; Blood Glucose; Cell Communication; Cytoplasmic Granules; Diazoxide; Freeze Fracturing; Glyburide; Insulin; Intercellular Junctions; Islets of Langerhans; Male; Rats | 1983 |
Effects of K+ channel openers on the vascular actions of human gamma globulin.
Topics: Animals; Diazoxide; gamma-Globulins; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Reconstitution of a KATP channel from basolateral membranes of Necturus enterocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Intestine, Small; Membranes; Necturus; Potassium Channels; Tolbutamide | 1995 |
Inhibition of insulin release induced by galanin in the dog is not exclusively mediated by activation of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Diazoxide; Dioxanes; Dogs; Female; Galanin; Ganglia, Sympathetic; Glyburide; Idazoxan; Insulin; Insulin Secretion; Male; Norepinephrine; Pancreas; Peptides; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha; Sensitivity and Specificity | 1993 |
Effects of D-phenylalanine-derivative hypoglycemic agent A-4166 on pancreatic alpha- and beta-cells: comparative study with glibenclamide.
Topics: Analysis of Variance; Animals; Cyclohexanes; Diazoxide; Drug Interactions; Glucagon; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Perfusion; Phenylalanine; Rats; Rats, Wistar | 1995 |
Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats.
Topics: Animals; Base Sequence; Diazoxide; DNA Primers; Fasting; Gene Expression Regulation, Enzymologic; Glucokinase; Glucose; Glucose Transporter Type 2; Glyburide; Islets of Langerhans; Liver; Male; Molecular Sequence Data; Monosaccharide Transport Proteins; Rats; Rats, Wistar; RNA, Messenger | 1995 |
Diazoxide blocks the morphine induced lengthening of action potential duration on guinea-pig papillary muscle.
Topics: Action Potentials; Animals; Diazoxide; Electric Stimulation; Electrophysiology; Glyburide; Guinea Pigs; Heart; In Vitro Techniques; Morphine; Papillary Muscles | 1995 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorometry; Fura-2; Glyburide; In Vitro Techniques; Lactates; Lactic Acid; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Ischemia; Norepinephrine; Ouabain; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1994 |
Spontaneous activation of KATP current in rat dorsal vagal neurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diffusion; Female; Glyburide; Male; Membrane Potentials; Neurons; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium Compounds; Tolbutamide; Vagus Nerve | 1994 |
Activation of potassium channels contributes to hypoxic injury in proximal tubules.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Diazoxide; DNA Damage; Dose-Response Relationship, Drug; Glyburide; Hypoxia; Ischemia; Kidney Diseases; Kidney Tubules, Proximal; Potassium; Potassium Channels; Rats; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Effects of glibenclamide on systemic and splanchnic haemodynamics in conscious rats.
Topics: Animals; Corticosterone; Diazoxide; Glyburide; Hemodynamics; Injections, Intraventricular; Male; Nicardipine; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Vasoconstriction | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Effects of ATP-sensitive K(+)-channel activators on transmitter release parameters at the frog neuromuscular junction.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; In Vitro Techniques; Membrane Potentials; Motor Endplate; Muscles; Neuromuscular Junction; Neurotransmitter Agents; Parasympatholytics; Potassium Channels; Pyrroles; Rana pipiens | 1993 |
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Topics: Adenosine Triphosphate; Blood Proteins; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Electrophysiology; Glyburide; Humans; Sulfonylurea Compounds; Tolbutamide | 1994 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagonoma; Glyburide; Insulinoma; Kinetics; Membrane Potentials; Mice; Pancreatic Neoplasms; Potassium Channels; Tolbutamide; Tritium; Tumor Cells, Cultured | 1993 |
Decreased ATP sensitivity of a K+ channel and enhanced vascular smooth muscle relaxation in genetically hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Arteries; Cerebrovascular Disorders; Diazoxide; Female; Glyburide; Male; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Tail; Vasodilation | 1993 |
Characterization and solubilization of the sulphonylurea receptor in rat brain.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Animals; ATP-Binding Cassette Transporters; Benzamides; Binding, Competitive; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Diazoxide; Glyburide; Guanine Nucleotides; Hypoglycemic Agents; In Vitro Techniques; Membranes; Microsomes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1993 |
Potassium channel antagonists and vascular reactivity in stroke-prone spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Amifampridine; Animals; Apamin; Barium; Cardiovascular System; Carotid Arteries; Cell Membrane; Cerebrovascular Disorders; Diazoxide; Female; Glyburide; Hypertension; Male; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Risk Factors; Tetraethylammonium; Tetraethylammonium Compounds; Vasoconstriction; Vasodilation | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; Calcium; Cells, Cultured; Diazoxide; Female; Glipizide; Glyburide; Growth Hormone; Hypoglycemic Agents; Kinetics; Membrane Potentials; Oligomycins; Pituitary Gland, Anterior; Potassium Channels; Rats; Receptors, Drug; Sulfonylurea Compounds | 1993 |
Cibenzoline inhibits diazoxide- and 2,4-dinitrophenol-activated ATP-sensitive K+ channels in guinea-pig ventricular cells.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Diazoxide; Dinitrophenols; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Imidazoles; In Vitro Techniques; Membrane Potentials; Potassium Channels | 1993 |
Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion.
Topics: Animals; Blood Glucose; Cricetinae; Cyclohexanes; Diazoxide; Drug Interactions; Glyburide; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mesocricetus; Nateglinide; Pancreas; Perfusion; Phenylalanine; Vasodilator Agents | 1995 |
The riddle of formycin A insulinotropic action.
Topics: Adenosine; Animals; Calcium; Diabetes Mellitus, Type 2; Diazoxide; Female; Formycins; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Ribonucleotides; Tubercidin; Verapamil; Xanthines | 1996 |
Membrane potentials and microenvironment of rat dorsal vagal cells in vitro during energy depletion.
Topics: Animals; Brain Stem; Cell Hypoxia; Diazoxide; Electric Stimulation; Glucose; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Neuroglia; Neurons; Oxygen Consumption; Potassium; Rats; Synaptic Transmission; Tolbutamide; Vagus Nerve | 1996 |
Role of ATP-sensitive K+ channels in anoxia-sensitive negative potential of endolymph.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Basal Ganglia; Cell Hypoxia; Cochlea; Diazoxide; Diuretics; Electrolytes; Endolymph; Furosemide; Glyburide; Guinea Pigs; Hypoglycemic Agents; Microelectrodes; Potassium Channel Blockers; Potassium Channels; Scala Tympani; Sodium-Potassium-Exchanging ATPase | 1995 |
Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture.
Topics: Ascorbic Acid; Aspirin; Cell Line; Diazoxide; Enzyme Inhibitors; Glucose; Glyburide; Glycosylation; Guanidines; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Stimulation, Chemical; Time Factors | 1997 |
Role of KATP channels on modulating diaphragmatic microvascular flow during hemorrhagic hypotension.
Topics: Adenosine Triphosphate; Animals; Diaphragm; Diazoxide; Glyburide; Hemorrhage; Hypotension; Laser-Doppler Flowmetry; Male; Microcirculation; Nitroprusside; Potassium Channels; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1997 |
Endothelium-mediated and N omega-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed.
Topics: Adrenergic alpha-Agonists; Animals; Benzopyrans; Cromakalim; Diazoxide; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1997 |
Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166).
Topics: Animals; Binding, Competitive; Blood Glucose; Calcium; Cell Line; Cyclohexanes; Diazoxide; Diuretics; Dogs; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Rats; Rats, Wistar; Sodium Chloride Symporter Inhibitors; Stimulation, Chemical | 1997 |
Effects of diazoxide on KCl- and norepinephrine-induced contraction in isolated rat aorta.
Topics: Animals; Aorta, Thoracic; Diazoxide; Glyburide; In Vitro Techniques; Male; Norepinephrine; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Tetraethylammonium Compounds; Vasoconstriction; Vasodilator Agents | 1994 |
Pre-synaptic effect of the ATP-sensitive potassium channel opener diazoxide on rat substantia nigra pars reticulata neurons.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; gamma-Aminobutyric Acid; Glyburide; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channels; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
Association and stoichiometry of K(ATP) channel subunits.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; COS Cells; Diazoxide; Glyburide; Glycosylation; Histidine; Ion Channel Gating; Molecular Weight; Mutagenesis; Patch-Clamp Techniques; Photochemistry; Potassium Channels; Recombinant Fusion Proteins; Sulfonylurea Compounds | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation.
Topics: Adenosine Triphosphate; Animals; Barbiturates; Capillaries; Chromans; Coronary Circulation; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; Gramicidin; Guanidines; Guinea Pigs; In Vitro Techniques; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Osmolar Concentration; Pinacidil; Potassium; Potassium Channels; Pyrrolidines; Sodium Chloride; Vasodilator Agents | 1997 |
Properties of an inwardly rectifying ATP-sensitive K+ channel in the basolateral membrane of renal proximal tubule.
Topics: Adenosine Triphosphate; Ambystoma; Animals; Barium; Biological Transport; Cations; Cells, Cultured; Cytidine Triphosphate; Diazoxide; Diuretics; Electric Conductivity; Glyburide; Guanosine Triphosphate; Hypoglycemic Agents; Inosine Triphosphate; Ion Channel Gating; Kidney Tubules, Proximal; Kinetics; Microvilli; Patch-Clamp Techniques; Potassium Channels; Sodium Chloride Symporter Inhibitors; Sodium-Potassium-Exchanging ATPase; Thallium; Thymine Nucleotides; Uridine Triphosphate | 1998 |
Pharmacological and biochemical evidence for the regulation of osteocalcin secretion by potassium channels in human osteoblast-like MG-63 cells.
Topics: Adenosine Triphosphate; Antihypertensive Agents; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Diazoxide; Dose-Response Relationship, Drug; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Osteoblasts; Osteocalcin; Osteosarcoma; Potassium Channels; Tumor Cells, Cultured | 1997 |
Microvascular permeability with sulfonylureas in normal and diabetic hamsters.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capillary Permeability; Cricetinae; Dextrans; Diabetes Mellitus, Experimental; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescein-5-isothiocyanate; Gliclazide; Glyburide; Histamine; Hypoglycemic Agents; Insulin; Macromolecular Substances; Male; Mesocricetus; Nifedipine; Potassium Channels; Reperfusion Injury; Streptozocin; Sulfonylurea Compounds | 1997 |
Membrane potassium channels and human bladder tumor cells: II. Growth properties.
Topics: Cell Division; Cell Membrane; Diazoxide; Glyburide; Growth Inhibitors; Humans; Potassium Channel Blockers; Potassium Channels; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1998 |
Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Calcium; Cell Line; Cyclohexanes; Diazoxide; Epinephrine; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Somatostatin; Stereoisomerism; Sulfonylurea Receptors; Tolbutamide | 1998 |
Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Diazoxide; Enzyme Inhibitors; Glyburide; Islets of Langerhans; Kinetics; Membrane Proteins; Phosphoproteins; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Protein Kinases; Receptors, Drug; Sulfonylurea Receptors | 1997 |
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburide; Hypoglycemic Agents; Hypoxia; Hypoxia, Brain; Ion Channel Gating; Medulla Oblongata; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Potassium Channels; Respiration; Tolbutamide; Vasodilator Agents | 1998 |
Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diuretics; Electric Stimulation; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Neostriatum; Parasympathetic Nervous System; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride Symporter Inhibitors; Tolbutamide | 1998 |
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Cricetinae; Diazoxide; Glyburide; Guanidines; Humans; Mutation; Peptide Fragments; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Pyridines; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors | 1998 |
Effect of diazoxide, an ATP-dependent potassium-channel opener, on isolated aortae of normal and diabetic rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diazoxide; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Rats | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose.
Topics: Adenoma; Calcium Channel Blockers; Corticotropin-Releasing Hormone; Diazoxide; Gene Expression; Glucokinase; Glucose; Glucose Transporter Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Monosaccharide Transport Proteins; Nifedipine; Pituitary Neoplasms; Potassium Chloride; Transfection; Tumor Cells, Cultured | 1998 |
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis.
Topics: Adenosine Triphosphate; Animals; Aorta; Bosentan; Cromakalim; Diazoxide; Endothelin-1; Endothelium, Vascular; Glyburide; Liver Cirrhosis, Experimental; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides; Tolbutamide | 1999 |
Vasodilative properties of BPDZ 79, a new potassium channel opener, in isolated aorta.
Topics: Animals; Aorta, Thoracic; Diazoxide; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Potassium Channels; Rats; Rats, Wistar; Thiadiazines; Vasodilation; Vasodilator Agents | 1997 |
ATP-sensitive potassium channels regulate in vivo dopamine release in rat striatum.
Topics: Adenosine Triphosphate; Animals; Consciousness; Cromakalim; Dextroamphetamine; Diazoxide; Dopamine; Dopamine Uptake Inhibitors; Glyburide; Hypoglycemic Agents; Injections, Subcutaneous; Male; Microdialysis; Movement; Neostriatum; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Exocytosis; Female; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Mice; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1999 |
Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels.
Topics: Animals; Cells, Cultured; Decanoic Acids; Diazoxide; Diuretics; Electrophysiology; Flavoproteins; Glyburide; Humans; Hydroxy Acids; Membrane Potentials; Mice; Mitochondria, Heart; Myocardium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sarcolemma; Sodium Chloride Symporter Inhibitors; Subcellular Fractions | 1999 |
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.
Topics: Animals; Arteries; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Agents; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Neutrophils; Peroxidase; Rats; Regional Blood Flow; Stomach; Stomach Diseases; Vasodilation; Vasodilator Agents | 1999 |
Role of the sulfonylurea receptor in regulating human adipocyte metabolism.
Topics: Adipocytes; Adipose Tissue; ATP-Binding Cassette Transporters; Calcium; Diazoxide; Dose-Response Relationship, Drug; Fatty Acid Synthases; Glyburide; Glycerolphosphate Dehydrogenase; Humans; Lipid Metabolism; Lipolysis; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 1999 |
A novel K(ATP) current in cultured neonatal rat atrial appendage cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Atrial Appendage; Cells, Cultured; Cromakalim; Diazoxide; Electric Conductivity; Glyburide; Hypotonic Solutions; Physical Stimulation; Potassium Channels; Protein Isoforms; Rats | 1999 |
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Chromans; COS Cells; Diazoxide; Electrophysiology; Glyburide; Membrane Potentials; Pinacidil; Pioglitazone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Recombinant Fusion Proteins; Rubidium Radioisotopes; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Transfection; Troglitazone | 1999 |
Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Clonidine; Cromakalim; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Atria; Humans; Hydroxy Acids; In Vitro Techniques; Male; Muscarinic Agonists; Norepinephrine; Oxotremorine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stimulation, Chemical; Sympathetic Nervous System | 1999 |
Potassium channel modulators and indomethacin-induced gastric ulceration in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Enalapril; Gastric Mucosa; Glyburide; Hydralazine; Indomethacin; Male; Peptic Ulcer; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans.
Topics: Animals; Boron Compounds; Calcium; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Inbred Strains; Potassium Channels; Receptors, Drug; Signal Transduction; Tolbutamide | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Male; Nerve Tissue Proteins; Neurons; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Solitary Nucleus; Tolbutamide | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Heart; Humans; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Ischemia; Pinacidil; Potassium Channel Blockers; Potassium Channels; Random Allocation; Sarcolemma; Sulfonamides; Thiourea | 2000 |
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.
Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Cations; Cell Line; Deoxyglucose; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Fluorescence; Gene Expression; Glipizide; Glyburide; Humans; Membrane Potentials; Oligomycins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Receptors, Drug; Recombinant Fusion Proteins; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolazamide; Tolbutamide; Tritium | 2000 |
Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Enzyme Activation; Female; Gallbladder; Glyburide; Guinea Pigs; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoric Monoester Hydrolases; Pinacidil; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2000 |
Metabolic, cationic and secretory response to D-glucose in depolarized and Ca(2+)-deprived rat islets exposed to diazoxide.
Topics: Animals; Calcium; Cell Polarity; Cells, Cultured; Cytosol; Diazoxide; Dose-Response Relationship, Drug; Extracellular Matrix; Glucose; Glyburide; Hexoses; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Potassium; Rats | 2000 |
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glyburide; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; Male; Nitric Oxide; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Stellate Ganglion; Sympathetic Nervous System; Tolbutamide | 2000 |
A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Blood Glucose; Cell Line; Diazoxide; Dose-Response Relationship, Drug; Fluorescent Dyes; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isometric Contraction; Kinetics; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Rats; Rubidium | 2000 |
Potassium channel openers prevent beta-amyloid toxicity in bovine vascular endothelial cells.
Topics: Amyloid beta-Peptides; Animals; Benzimidazoles; Brain; Cattle; Cells, Cultured; Diazoxide; Endothelium, Vascular; Glyburide; Potassium Channels; Tetraethylammonium | 2000 |
Antidiabetic sulfonylurea enhances secretagogue-induced adrenocorticotropin secretion and proopiomelanocortin gene expression in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Cell Line; Clone Cells; Colforsin; Diazoxide; Diuretics; Gene Expression; Glyburide; Hypoglycemic Agents; Plasmids; Pro-Opiomelanocortin; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride Symporter Inhibitors; Stimulation, Chemical; Sulfonylurea Compounds | 2000 |
Do modulators of the mitochondrial K(ATP) channel change the function of mitochondria in situ?
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Creatine Kinase; Diazoxide; Glyburide; Hypoglycemic Agents; KATP Channels; Male; Mitochondria; Oxygen Consumption; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar | 2000 |
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Decanoic Acids; Diazoxide; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Genistein; Glyburide; Hemodynamics; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rabbits | 2000 |
Sulphonylurea-sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro.
Topics: Acetylcholine; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Glyburide; Guinea Pigs; Heart Conduction System; Heart Rate; Ion Transport; Male; Muscle Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium; Potassium Channels; Signal Transduction; Sulfonylurea Compounds; Tolbutamide; Vagus Nerve | 2000 |
Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Glyburide; Heart; Hemodynamics; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Pilot Projects; Potassium Channel Blockers; Potassium Channels; Rabbits; Vasodilator Agents | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Ion Channel Gating; Kinetics; Male; Mammals; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolbutamide | 2000 |
Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Diazoxide; Glyburide; Heart; Hemodynamics; Hypoglycemic Agents; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Protein Kinase C; Rabbits | 2001 |
Relationships between the Na(+)/K(+) pump and ATP and ADP content in mouse pancreatic islets: effects of meglitinide and glibenclamide.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzamides; Diazoxide; Dose-Response Relationship, Drug; Female; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Islets of Langerhans; Mice; Mice, Obese; Oxidation-Reduction; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase | 2000 |
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Glyburide; Guanidines; Heart Ventricles; Humans; KATP Channels; Membrane Proteins; Mitochondria, Heart; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rabbits; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Vasodilator Agents | 2001 |
Potassium channel openers depolarize hippocampal mitochondria.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzoates; Cytochrome c Group; Decanoic Acids; Diazoxide; Glyburide; Hippocampus; Hydroxy Acids; Intracellular Membranes; Lipid Bilayers; Membrane Potentials; Mitochondria; Mitochondrial Swelling; Potassium Channels; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Valinomycin | 2001 |
Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta.
Topics: Animals; Aorta; Colforsin; Cyclic AMP; Diazoxide; Diethylstilbestrol; Dose-Response Relationship, Drug; Eflornithine; Glyburide; In Vitro Techniques; Indoles; Male; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Potassium Channels; Rats; Rats, Wistar; Spermine; Tamoxifen; Tetraethylammonium; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
Enhanced effect of sulfonylurea (SU) in copolymer comprising a sugar moiety and SU derivative as double ligands on insulin secretion from MIN6 cells.
Topics: Adenosine Triphosphate; Animals; Carbohydrates; Cell Adhesion; Cell Culture Techniques; Cell Division; Cell Line; Diazoxide; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Lactose; Ligands; Maltose; Mice; Microscopy, Phase-Contrast; Models, Chemical; Polymers; Polystyrenes; Potassium Channel Blockers; Sulfonylurea Compounds; Time Factors; Vasodilator Agents | 2000 |
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Aorta; Blood Pressure; Blotting, Northern; Diazoxide; Dose-Response Relationship, Drug; Electrophysiology; Genetic Vectors; Genotype; Glyburide; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Transfection; Vasoconstriction; Vasodilator Agents; Ventricular Function | 2001 |
Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?
Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcium; Cell Respiration; Decanoic Acids; Diazoxide; Energy Metabolism; Flavoproteins; Fluorescent Dyes; Glyburide; Heart Ventricles; Hydroxy Acids; Ion Channel Gating; Ischemic Preconditioning, Myocardial; Membrane Potentials; Mitochondria, Heart; Myocardium; Oxygen; Potassium Channel Blockers; Potassium Channels; Rats; Reactive Oxygen Species; Recovery of Function; Research Design; Vasodilator Agents | 2001 |
Chloride channels regulate HIT cell volume but cannot fully account for swelling-induced insulin secretion.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Size; Chloride Channels; Clone Cells; Cricetinae; Diazoxide; Furosemide; Gadolinium; Glucose; Glyburide; Homeostasis; Hypotonic Solutions; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Molecular Sequence Data; Niflumic Acid; Sodium-Potassium-Chloride Symporters; Tetraethylammonium | 2001 |
Diazoxide, a K(ATP) opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Ethanol; Glyburide; Indomethacin; Male; Polyamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Wound Healing | 2001 |
A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.
Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Butyrates; Calcium; Calcium Channel Blockers; Cell Line; Cell Membrane; Cyclohexanes; Diabetes Mellitus, Type 2; Diazoxide; Drug Synergism; Extracellular Space; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Membrane Potentials; Mice; Mice, Transgenic; Microelectrodes; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2001 |
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.
Topics: Animals; Diazoxide; Glyburide; Guanosine Triphosphate; Heart; Heart Ventricles; Hemodynamics; Hypoglycemic Agents; In Vitro Techniques; Intracellular Membranes; Ischemic Preconditioning, Myocardial; Male; Membrane Potentials; Membrane Proteins; Mitochondria, Heart; Myocardial Infarction; Myocardial Ischemia; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Ventricular Function | 2001 |
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Glyburide; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnetic Resonance Spectroscopy; Materials Testing; Molecular Structure; Pancreatic Neoplasms; Povidone; Sulfonylurea Compounds; Tolbutamide; Tumor Cells, Cultured | 2001 |
Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Anti-Bacterial Agents; Antihypertensive Agents; Diazoxide; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glyburide; Hypoglossal Nerve; Hypoglycemic Agents; Hypoxia; Kainic Acid; Macrolides; Mice; Mitochondrial Swelling; N-Methylaspartate; Optics and Photonics; Organ Culture Techniques; Ouabain; Potassium Channels; Respiratory Center; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 2001 |
Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Boron Compounds; Brain; Cromakalim; Decanoic Acids; Diazoxide; Fluorescent Dyes; Glyburide; Guanosine Triphosphate; Hydroxy Acids; Kinetics; Ligands; Liver; Membrane Proteins; Mitochondria; Mitochondria, Liver; Models, Biological; Myocardium; Oxygen Consumption; Potassium Channels; Proteolipids; Rats; Time Factors; Vasodilator Agents | 2001 |
Modulation of beta-cell ouabain-sensitive 86Rb+ influx (Na+/K+ pump) by D-glucose, glibenclamide or diazoxide.
Topics: Animals; Diazoxide; Enzyme Inhibitors; Female; Glucose; Glyburide; Hypoglycemic Agents; Islets of Langerhans; Mice; Mice, Obese; Ouabain; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase | 2001 |
Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.
Topics: Animals; ATP-Binding Cassette Transporters; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Diuretics; Epithelial Sodium Channels; Glyburide; Hypoglycemic Agents; Oocytes; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Sodium Chloride Symporter Inhibitors; Sulfonylurea Receptors; Time Factors; Tolbutamide; Vasodilator Agents; Xenopus laevis | 2001 |
Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Radioisotopes; Diazoxide; Dose-Response Relationship, Drug; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lipids; Muscle, Smooth, Vascular; Potassium Channels; Quinolones; Rats; Rats, Wistar; Rubidium Radioisotopes; Time Factors; Vasoconstriction | 2001 |
Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Ion Channel Gating; Ischemic Preconditioning; Male; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Potassium Channels; Rabbits; Vasodilator Agents | 2001 |
Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cattle; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Ethylmaleimide; Glyburide; Guanosine Triphosphate; Hydroxy Acids; Ion Channel Gating; Lipid Bilayers; Membrane Potentials; Mitochondria, Heart; Myocardium; Potassium; Potassium Channels; Subcellular Fractions; Sulfhydryl Reagents; Superoxides; Xanthine; Xanthine Oxidase | 2001 |
ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Convulsants; Diazoxide; Excitatory Postsynaptic Potentials; Gerbillinae; Glyburide; Hippocampus; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Nitro Compounds; Organ Culture Techniques; Potassium Channel Blockers; Potassium Channels; Propionates; Vasodilator Agents | 2002 |
Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.
Topics: Amino Acid Motifs; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Base Sequence; Blotting, Western; COS Cells; Cricetinae; Diazoxide; DNA, Complementary; Endoplasmic Reticulum; Glyburide; Humans; Hyperinsulinism; Hypoglycemic Agents; Immunoblotting; Luminescent Measurements; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Plasmids; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Structure, Tertiary; Protein Transport; Receptors, Drug; Rubidium; Signal Transduction; Sulfonylurea Receptors; Time Factors; Transfection | 2002 |
Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes.
Topics: Acarbose; Acetylcholine; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Dipyridamole; Double-Blind Method; Female; Forearm; Glyburide; Humans; Hypoglycemic Agents; Ischemia; Male; Middle Aged; Plethysmography; Potassium Channel Blockers; Vasodilator Agents | 2002 |
Correlation between GABA release from rat islet beta-cells and their metabolic state.
Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil | 2002 |
Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart.
Topics: Aerobiosis; Animals; ATP-Binding Cassette Transporters; Decanoic Acids; Diazoxide; Fishes; Flounder; Glyburide; Heart; Hydroxy Acids; Hypoxia; In Vitro Techniques; KATP Channels; Myocardial Contraction; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Species Specificity | 2002 |
Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.
Topics: Acetylcholine; Animals; Atrial Function; Cromakalim; Diazoxide; Female; Glyburide; Guinea Pigs; Heart Atria; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Myocardial Contraction; Neuromuscular Junction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Thiourea | 2002 |
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.
Topics: Adenosine Triphosphate; Animals; Benzothiadiazines; Binding Sites; Cell Line; Cell Membrane; Diazoxide; Electric Conductivity; Gene Expression; Glyburide; Hypoglycemic Agents; Ion Channel Gating; Mice; Mutagenesis; Oocytes; Potassium Channels, Inwardly Rectifying; Rats; Recombinant Fusion Proteins; Transfection; Tritium; Xenopus laevis | 2002 |
Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels.
Topics: Action Potentials; Analysis of Variance; Animals; Decanoic Acids; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Hydroxy Acids; Insulin; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Stunning; Potassium Channel Blockers; Potassium Channels; Sarcolemma; Sheep; Time Factors | 2002 |
The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Biotinylation; Cell Line; Cell Membrane; Cricetinae; Diazoxide; Fluorescent Antibody Technique; Glyburide; Humans; Kidney; Macromolecular Substances; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Structure, Tertiary; Protein Transport; Receptors, Drug; Sequence Deletion; Structure-Activity Relationship; Sulfonylurea Receptors; Tolbutamide | 2002 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; Pinacidil; Potassium Channels; Rats; Rats, Wistar | 2002 |
Rapid effect of testosterone on rat Sertoli cell membrane potential. Relationship with K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Seminiferous Tubules; Sertoli Cells; Testosterone | 2002 |
Opening of potassium channels modulates mitochondrial function in rat skeletal muscle.
Topics: Animals; Anti-Arrhythmia Agents; Cell Line; Cell Respiration; Diazoxide; Glutamic Acid; Glyburide; Malates; Membrane Potentials; Mitochondria, Muscle; Muscle, Skeletal; Myoblasts; Nicorandil; Oxidation-Reduction; Oxygen; Potassium Channels; Rats | 2002 |
Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Blotting, Western; COS Cells; Cricetinae; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Immunoblotting; Luminescent Measurements; Magnesium; Mice; Mutation; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Time Factors; Transfection; Vasodilator Agents | 2003 |
Inhibition of vascular ATP-sensitive K+ channels does not affect reactive hyperemia in human forearm.
Topics: Adenosine Triphosphate; Adult; Blood Vessels; Diazoxide; Female; Forearm; Glyburide; Humans; Hyperemia; Male; Potassium Channel Blockers; Potassium Channels; Regional Blood Flow; Vasodilation | 2003 |
Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Diuretics; Glyburide; Hypoglycemic Agents; Light; Magnesium; Male; Mitochondria; Mitochondrial Swelling; Myocardium; Phosphates; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Scattering, Radiation; Sodium Chloride Symporter Inhibitors | 2003 |
Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cricetinae; Cromakalim; Diazoxide; Drug Interactions; Gliclazide; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Ion Channel Gating; Male; Potassium Channels; Rats; Rats, Wistar; Species Specificity; Sulfonylurea Compounds; Vasodilation; Vasodilator Agents | 2003 |
Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection.
Topics: Animals; Bradykinin; Cell Culture Techniques; Cell Survival; Cytoprotection; Decanoic Acids; Diazoxide; Glutamic Acid; Glyburide; Hydroxy Acids; Membrane Potentials; Membrane Proteins; Mitochondria; Molsidomine; Neurons; Neuroprotective Agents; Nitroprusside; Potassium Channels; Rats; Rats, Wistar; Retina | 2003 |
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.
Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic Acids; Diazoxide; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Glyburide; KATP Channels; Male; Neurons, Afferent; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley | 2003 |
N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Diazoxide; Glyburide; Ion Channel Gating; Mutagenesis, Site-Directed; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Xenopus | 2003 |
Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Diazoxide; Excitatory Postsynaptic Potentials; Gerbillinae; Glutamic Acid; Glyburide; Hippocampus; In Vitro Techniques; Neurotoxins; Nitro Compounds; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Propionates | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Liposomes; Mitochondria, Heart; Myocardial Infarction; Myocardial Ischemia; Potassium Channels; Pyridines; Rabbits; Rats; Reactive Oxygen Species; Vasodilator Agents | 2003 |
Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain.
Topics: Adenosine Triphosphate; Animals; Antibodies; Astrocytes; ATP-Binding Cassette Transporters; Binding, Competitive; Brain; Brain Injuries; Cell Size; Cells, Cultured; Diazoxide; Gliosis; Glyburide; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sodium Azide; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Trypsin | 2003 |
Heart mitochondria contain functional ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Diazoxide; Glyburide; Membrane Potentials; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria, Heart; Nitrogen Mustard Compounds; Potassium Channels; Potassium Channels, Inwardly Rectifying; Proteomics; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents | 2003 |
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Glucose; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Mitochondria; Neurons; Neuroprotective Agents; Nicorandil; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxides; Time Factors | 2003 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; Glomerular Filtration Rate; Glyburide; Kidney; Kidney Function Tests; Male; Organ Culture Techniques; Potassium Channels; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2003 |
Electro-acupuncture preconditioning abrogates the elevation of c-Fos and c-Jun expression in neonatal hypoxic-ischemic rat brains induced by glibenclamide, an ATP-sensitive potassium channel blocker.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Western; Brain; Diazoxide; Disease Models, Animal; Electroacupuncture; Female; Glyburide; Hypoxia-Ischemia, Brain; Male; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels.
Topics: Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Electrophysiology; Glyburide; Humans; Molecular Biology; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propofol; Rats; Receptors, Drug; Sulfonylurea Receptors; Thiamylal; Vasodilator Agents | 2004 |
Influence of central administration ATP-dependent K+ channel on morphine state-dependent memory of passive avoidance.
Topics: Animals; ATP-Binding Cassette Transporters; Avoidance Learning; Diazoxide; Glyburide; Injections, Intraventricular; KATP Channels; Male; Memory; Mice; Morphine; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Narcotics; Parasympathetic Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Scopolamine | 2004 |
Influence of potassium channel modulators on morphine state-dependent memory of passive avoidance.
Topics: Adenosine Triphosphate; Animals; Atropine; Avoidance Learning; Diazoxide; Glyburide; Male; Memory; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Potassium Channel Blockers; Potassium Channels | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radicals; Glyburide; Guinea Pigs; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Nitric Oxide; Perfusion; Potassium Channel Blockers; Potassium Channels | 2004 |
KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo.
Topics: Acetylcholine; Adenosine Triphosphate; Adult; Diazoxide; Endothelial Cells; Endothelium, Vascular; Female; Forearm; Glyburide; Humans; Ion Transport; Ischemic Preconditioning; Male; Nitroglycerin; Potassium; Potassium Channel Blockers; Potassium Channels; Second Messenger Systems; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2004 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegaly; Cell Size; Cells, Cultured; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypertrophy; Mitochondria; Myocardium; Myocytes, Cardiac; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Rats | 2004 |
Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Chromans; Cromakalim; Diazoxide; Glyburide; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Oocytes; Potassium Channels, Inwardly Rectifying; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Transfection; Xenopus | 2004 |
Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.
Topics: Alanine; Amino Acids; Animals; Diazoxide; Drug Interactions; Glutamic Acid; Glyburide; Glycogen; Lactic Acid; Male; Myocardial Ischemia; Myocardium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar | 2005 |
The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.
Topics: Adenosine Triphosphate; Animals; Cytokines; Diazoxide; Disease Models, Animal; Glyburide; Interleukin-10; Kidney; Male; Neutrophils; NF-kappa B; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2005 |
Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cromakalim; Diazoxide; Dopamine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Glutathione Peroxidase; Glyburide; Guinea Pigs; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; Isoquinolines; Membrane Potentials; Mesencephalon; Neurons; Organoplatinum Compounds; Patch-Clamp Techniques; Potassium Channels; Tetrodotoxin; Thiomalates; Time Factors; Vasodilator Agents | 2005 |
Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Animals, Newborn; Benzopyrans; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; Hydroxy Acids; Imidazoles; Membrane Potentials; Mitochondria; Organometallic Compounds; Potassium Channel Blockers; Potassium Channels; Reactive Oxygen Species; Swine; Time Factors | 2005 |
Cardioprotective effects of K ATP channel activation during hypoxia in goldfish Carassius auratus.
Topics: Acclimatization; Action Potentials; Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Glyburide; Goldfish; Hypoxia; Mitochondria; Models, Biological; Myocardium; NG-Nitroarginine Methyl Ester; Penicillamine; Potassium Channels; Sarcolemma | 2005 |
Probing of specific binding of synthetic sulfonylurea with the insulinoma cell line MIN6.
Topics: Calcium; Diazoxide; Glyburide; Hypoglycemic Agents; Insulinoma; Microscopy, Confocal; Pancreatic Neoplasms; Potassium Channels; Sulfonylurea Compounds; Tumor Cells, Cultured | 2005 |
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Topics: Adenosine; Adrenergic alpha-Agonists; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diazoxide; Enzyme Activation; Glyburide; Heart Atria; Humans; Hypoglycemic Agents; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Membrane Potentials; Metformin; Mitochondria, Heart; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Potassium Channels; Protein Kinase C; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2006 |
KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium; Diazoxide; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Membrane Potentials; Mice; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Messenger; Sperm Capacitation; Spermatogenesis; Spermatozoa; Sulfonylurea Receptors; Time Factors; Tolbutamide | 2006 |
Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.
Topics: Animals; Blotting, Western; Calcium; Cell Cycle; Cell Division; Cell Proliferation; Cells, Cultured; Cytosol; Diazoxide; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Glucose; Glyburide; Islets of Langerhans; Male; Nifedipine; Potassium; Potassium Channels; Protein Kinases; Rats; Rats, Sprague-Dawley; S Phase; Sirolimus; Thymidine; TOR Serine-Threonine Kinases | 2006 |
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; ATP-Binding Cassette Transporters; Biophysics; Cromakalim; Diazoxide; DNA Primers; Dose-Response Relationship, Drug; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; KATP Channels; Kinetics; Male; Models, Statistical; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscles; Patch-Clamp Techniques; Phenotype; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Tolbutamide | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
ATP-sensitive potassium channels mediate the anti-ischemic properties of ischemic and pharmacologic preconditioning in rat random-pattern skin flap.
Topics: Adenosine; Adenosine Triphosphate; Animals; Dermatologic Surgical Procedures; Diazoxide; Glyburide; Hypoglycemic Agents; Ischemia; Ischemic Preconditioning; Male; Morphine; Narcotics; Potassium Channels; Random Allocation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Skin; Surgical Flaps; Tissue Survival; Vasodilator Agents | 2006 |
Total cellular calcium and magnesium content of cultured human peripheral blood mononuclear cells following exposure to antidiabetic drugs.
Topics: Adult; Calcium; Cells, Cultured; Diazoxide; Glyburide; Humans; Hypoglycemic Agents; Leukocytes; Magnesium; Metformin; Middle Aged; Potassium Channels; Rosiglitazone; Thiazolidinediones | 2006 |
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.
Topics: Animals; Calcium; Calcium Isotopes; Cell Line, Tumor; Cell Survival; Dantrolene; Diazoxide; Dose-Response Relationship, Drug; Extracellular Fluid; Glucose; Glyburide; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; L-Lactate Dehydrogenase; Male; Mice; Potassium Channels; Sodium Channels; Tetrodotoxin; Tolbutamide; Verapamil | 2006 |
Changes in membrane cholesterol of pituitary tumor (GH3) cells regulate the activity of large-conductance Ca2+-activated K+ channels.
Topics: Action Potentials; Animals; Apamin; beta-Cyclodextrins; Caffeic Acids; Calcium; Cholesterol; Cilostazol; Dexamethasone; Diazoxide; Glyburide; Indoles; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Membrane Lipids; Phenylethyl Alcohol; Pituitary Neoplasms; Rats; Tetrazoles; Tumor Cells, Cultured | 2006 |
LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Escherichia coli; Glyburide; Hypoglycemic Agents; Indomethacin; Injections, Intravenous; Leukocyte Count; Lipopolysaccharides; Male; Peroxidase; Potassium Channels, Inwardly Rectifying; Protective Agents; Rats; Rats, Wistar; Stomach Diseases | 2006 |
Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.
Topics: ATP-Binding Cassette Transporters; Carbachol; Diazoxide; Dihydropyridines; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gliclazide; Glyburide; Humans; Immunochemistry; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Urinary Bladder | 2006 |
Influence of ATP-sensitive potassium channels on lithium state-dependent memory of passive avoidance in mice.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Diazoxide; Electroshock; Glyburide; KATP Channels; Lithium Chloride; Male; Memory; Mice; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying | 2006 |
Influence of ATP-dependent K+ channels on nicotine-induced inhibition of withdrawal in morphine-dependent mice.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Behavior, Animal; Diarrhea; Diazoxide; Dose-Response Relationship, Drug; Ganglionic Stimulants; Glyburide; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Potassium Channels, Inwardly Rectifying; Substance Withdrawal Syndrome | 2006 |
Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes.
Topics: Animals; Blotting, Western; Calcium; Diazoxide; Dinitrophenols; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Direct; Gene Expression; Glyburide; Heart Ventricles; KATP Channels; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug.
Topics: Adenosine Triphosphate; Animals; ATPase Inhibitory Protein; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cardiotonic Agents; Cell Line; Cell Respiration; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hydrogen-Ion Concentration; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myoblasts, Cardiac; Potassium Channel Blockers; Potassium Channels; Proteins; Proton-Translocating ATPases; Rats; Time Factors; Uncoupling Agents | 2007 |
Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Coronary Circulation; Diazoxide; Electrocardiography; Endothelin-1; Endothelium, Vascular; Ergonovine; Exocytosis; Gene Expression Regulation; Genes, Synthetic; Glyburide; KATP Channels; Mice; Mice, Transgenic; Point Mutation; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pressure; Rats; Rats, Sprague-Dawley; Tolbutamide; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
ATP-sensitive potassium channel in mitochondria of the eukaryotic microorganism Acanthamoeba castellanii.
Topics: Acanthamoeba castellanii; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cell Respiration; Diazoxide; Electrophysiology; Glyburide; Membrane Potential, Mitochondrial; Mitochondria; Potassium; Potassium Channels | 2007 |
Involvement of glucose and ATP-sensitive potassium (K+) channels on morphine-induced conditioned place preference.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Diazoxide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Glucose; Glyburide; Injections, Intraperitoneal; Injections, Subcutaneous; KATP Channels; Locomotion; Male; Mice; Morphine; Potassium Channel Blockers; Reward; Spatial Behavior | 2007 |
Adenosine and TNF-alpha exert similar inotropic effect on heart cultures, suggesting a cardioprotective mechanism against hypoxia.
Topics: Adenosine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cell Hypoxia; Cell Line; Deoxyglucose; Diazoxide; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Glyburide; Heart; Isoproterenol; Myocardial Contraction; Myocytes, Cardiac; Neuroprotective Agents; Rats; Rubidium Radioisotopes; Sarcoplasmic Reticulum; Tumor Necrosis Factor-alpha | 2007 |
Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes.
Topics: Adipocytes, Brown; Adipocytes, White; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Proliferation; Diazoxide; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Gliclazide; Glyburide; Hypoglycemic Agents; Mice; Phosphorylation; PPAR gamma; Signal Transduction; Sulfonylurea Compounds | 2007 |
Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.
Topics: Animals; Arginine; Capsaicin; Diazoxide; Dose-Response Relationship, Drug; Ethanol; Glyburide; Indomethacin; Inositol; KATP Channels; Male; Mice; Misoprostol; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Prostaglandins; Stomach Ulcer | 2008 |
Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of K(ATP) channels.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Diazoxide; Drug Administration Schedule; Glyburide; Heart Rate; In Vitro Techniques; KATP Channels; Magnesium Compounds; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Ventricular Function, Left; Ventricular Pressure | 2008 |
Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Topics: Animals; Arginine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Diazoxide; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Glutathione; Glyburide; Guanylate Cyclase; Hemoglobins; KATP Channels; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peptic Ulcer Hemorrhage; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Stomach Ulcer; Sulfones | 2008 |
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.
Topics: Adenosine Triphosphate; Animals; Calcium; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypoxia; KATP Channels; Mitochondria, Heart; Patch-Clamp Techniques; Potassium Channel Blockers; Receptors, N-Methyl-D-Aspartate; Turtles | 2008 |
Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Diazoxide; Drug Tolerance; Glyburide; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Mice; Morphine; Narcotics; Nociceptors; Potassium Channels; Vasodilator Agents | 2008 |
KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.
Topics: Animals; Decanoic Acids; Diazoxide; Electron Transport Complex I; Electron Transport Complex II; Glyburide; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; Mitochondria, Heart; Mitochondrial Proton-Translocating ATPases; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels | 2008 |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
Topics: Animals; Cardiotonic Agents; Cyclosporine; Diazoxide; Disease Models, Animal; Glyburide; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypertension; In Vitro Techniques; Indoles; Lithium Chloride; Male; Maleimides; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Ventricular Function, Left; Ventricular Pressure | 2008 |
Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Diazoxide; Dose-Response Relationship, Drug; Electroencephalography; Glyburide; Injections, Intraperitoneal; KATP Channels; Male; Mice; Mice, Inbred Strains; Mouth Breathing; Nasal Obstruction; Pentylenetetrazole; Seizures | 2008 |
Oleic acid directly regulates POMC neuron excitability in the hypothalamus.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; ATP-Binding Cassette Transporters; Biophysics; Diazoxide; Dietary Fats; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Glyburide; Green Fluorescent Proteins; Hypoglycemic Agents; Hypothalamus; In Vitro Techniques; Mice; Mice, Transgenic; Models, Biological; Neural Inhibition; Neurons; Oleic Acid; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pro-Opiomelanocortin; Receptors, Drug; Sulfonylurea Receptors | 2009 |
The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antihypertensive Agents; Benzimidazoles; Carbocyanines; Cell Count; Cells, Cultured; Decanoic Acids; Diazoxide; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Ethidium; Glyburide; Hydroxy Acids; Membrane Potential, Mitochondrial; Mesencephalon; Neurons; Oxidopamine; Potassium Channel Blockers; Potassium Channels; Rats; Reactive Oxygen Species; Rhodamines; Time Factors; Tritium; Tyrosine 3-Monooxygenase | 2009 |
Sesquiterpenoids from antidiabetic Psacalium decompositum block ATP sensitive potassium channels.
Topics: Animals; Aorta; Asteraceae; Diazoxide; Glyburide; Hypoglycemic Agents; KATP Channels; Male; Phenylephrine; Plant Extracts; Plant Roots; Plants, Medicinal; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Rhizome; Sesquiterpenes; Vasoconstrictor Agents; Vasodilator Agents | 2009 |
Differential K(ATP) channel pharmacology in intact mouse heart.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Diazoxide; Glyburide; Heart; In Vitro Techniques; KATP Channels; Mice; Mice, Knockout; Microscopy; Myocardium; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents | 2010 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; KATP Channels; Kidney; Kidney Diseases; LLC-PK1 Cells; Necrosis; Potassium Channel Blockers; Propofol; Protective Agents; Reperfusion Injury; Swine; Time Factors | 2009 |
Neuroprotective effects of diazoxide and its antagonism by glibenclamide in pyramidal neurons of rat hippocampus subjected to ischemia-reperfusion-induced injury.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Cell Death; Diazoxide; Diuretics; Gene Expression; Genes, bcl-2; Glyburide; Hippocampus; Hypoglycemic Agents; KATP Channels; Male; Microscopy, Electron; Mitochondria; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Reperfusion Injury | 2009 |
Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.
Topics: Animals; Chickens; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; In Vitro Techniques; Mitochondria, Muscle; Muscle, Skeletal; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels | 2010 |
Interaction of morphine and potassium channel openers on experimental models of pain in mice.
Topics: Animals; Calcium Channel Agonists; Cromakalim; Diazoxide; Drug Interactions; Drug Therapy, Combination; Female; Glyburide; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Minoxidil; Morphine; Naloxone; Pain; Pain Measurement; Potassium Channels | 2011 |
Diazoxide attenuates indomethacin-induced small intestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Glyburide; Indomethacin; Intestine, Small; Ion Channel Gating; KATP Channels; Lipid Peroxidation; Male; Peroxidase; Potassium Channel Blockers; Rats; Rats, Wistar | 2011 |
Influence of ATP-dependent K(+)-channel opener on K(+)-cycle and oxygen consumption in rat liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Glyburide; KATP Channels; Mitochondria, Liver; Oxygen Consumption; Potassium; Potassium Channel Blockers; Rats; Rats, Wistar | 2010 |
Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Calcium; Carotid Body; Cell Hypoxia; Cells, Cultured; Chemoreceptor Cells; Cyanides; Diazoxide; Glucose; Glyburide; Hypoglycemic Agents; Ion Channel Gating; KATP Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Sweetening Agents; Vasodilator Agents | 2011 |
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Nociceptors; Pain; Physical Stimulation; Pinacidil; Rats; Rats, Sprague-Dawley; Temperature | 2011 |
Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels.
Topics: Analysis of Variance; Animals; ATP-Binding Cassette Transporters; Biophysics; Corpus Striatum; Diazoxide; Dopamine; Dopamine Agonists; Electric Stimulation; Electrochemistry; Glyburide; Guinea Pigs; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Mecamylamine; Neurons; Nicotinic Antagonists; Potassium Channels, Inwardly Rectifying; Presynaptic Terminals; Quinpirole; Receptors, Drug; Sulfonylurea Receptors; Thiomalates; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.
Topics: Aged; Aged, 80 and over; Animals; Cells, Cultured; Diazoxide; Female; Glyburide; Guanidines; Humans; Immunohistochemistry; Intraocular Pressure; KATP Channels; Male; Middle Aged; Nicorandil; Organ Culture Techniques; Patch-Clamp Techniques; Pyridines; Rats; Rats, Inbred BN; Reverse Transcriptase Polymerase Chain Reaction; Tonometry, Ocular; Trabecular Meshwork; Vasodilator Agents | 2011 |
[Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].
Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Diazoxide; Female; Gene Expression Regulation; Glyburide; KATP Channels; Myometrium; Oxytocin; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pregnancy; Protein Isoforms; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tocolytic Agents; Uterine Contraction | 2011 |
[Effects of diazoxide on the mitochondrial membrane potential and ROS generation in rat uterus cells].
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Glyburide; Humans; Hypoglycemic Agents; Kinetics; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Muscle Cells; Potassium Channels; Rats; Reactive Oxygen Species; Uterus; Vasodilator Agents | 2012 |
Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.
Topics: Animals; Antihypertensive Agents; Aporphines; ATP-Binding Cassette Transporters; Cell Line; Cyclic AMP-Dependent Protein Kinases; Diazoxide; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Mice; Nelumbo; Nimodipine; Plant Extracts; Potassium; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Receptors, Drug; Sulfonylurea Receptors; Vietnam | 2012 |
The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chemical and Drug Induced Liver Injury; Diazoxide; Disease Models, Animal; Glyburide; Inflammation; KATP Channels; Liver; Male; Malondialdehyde; Morphine; Oxidative Stress; Pain; Pain Measurement; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley | 2013 |
Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Catalase; Cell Nucleus; Diazoxide; DNA Fragmentation; Glyburide; KATP Channels; Lipid Peroxidation; Male; Malondialdehyde; Muscle, Skeletal; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2012 |
Na(+)-H+ exchange inhibition attenuates ischemic injury in rat random pattern skin flap: the role of mitochondrial ATP-sensitive potassium channels.
Topics: Amiloride; Animals; Dermatologic Surgical Procedures; Diazoxide; Glyburide; Ion Channel Gating; Ischemia; KATP Channels; Male; Mitochondria; Postoperative Complications; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Surgical Flaps; Tissue Survival | 2013 |
The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Membrane; Chlorocebus aethiops; COS Cells; Diazoxide; Fluorescence Resonance Energy Transfer; Glyburide; Glycosylation; HEK293 Cells; Humans; Immunoprecipitation; Mice; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Multimerization; Rats; Receptors, Drug; Recombinant Proteins; Spinal Cord Injuries; Sulfonylurea Receptors; TRPM Cation Channels | 2013 |
The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel.
Topics: Acetanilides; Animals; Calcium; Calcium Channels; Cells, Cultured; Cysteine; Diazoxide; Ganglia, Spinal; Glyburide; HEK293 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Purines; Recombinant Proteins; Sensory Receptor Cells; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2013 |
Evaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.
Topics: Benzhydryl Compounds; Cell Line; Diazoxide; Exenatide; Glyburide; Humans; Hydrocarbons, Fluorinated; Insulin; Insulin Secretion; Insulin-Secreting Cells; Peptides; Phenols; Phthalic Acids; Sulfonamides; Venoms | 2013 |
Glucose use in fasted rats under sevoflurane anesthesia and propofol anesthesia.
Topics: Adiponectin; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Diazoxide; Energy Intake; Fasting; Glucose; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Methyl Ethers; Propofol; Rats; Rats, Wistar; Sevoflurane; Tumor Necrosis Factor-alpha | 2013 |
Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Diazoxide; Elastic Tissue; Elastin; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pinacidil; Potassium Channels; Rats; Rats, Inbred BN; Vasodilator Agents | 2013 |
The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats.
Topics: Alendronate; Analysis of Variance; Animals; Cystathionine gamma-Lyase; Diagnosis, Computer-Assisted; Diazoxide; Female; Gastric Mucosa; Glutathione; Glyburide; Hydrogen Sulfide; Indicators and Reagents; Interleukin-1beta; KATP Channels; Malondialdehyde; Organothiophosphorus Compounds; Peroxidase; Rats; Rats, Wistar; Stomach Diseases; Tumor Necrosis Factor-alpha | 2013 |
Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma.
Topics: 4-Aminopyridine; Animals; Apoptosis; Calcium; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Diazoxide; G1 Phase Cell Cycle Checkpoints; Glioma; Glyburide; Humans; KATP Channels; Mice; Mice, Nude; Peptides; Phloretin; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Scorpion Venoms; Tetraethylammonium; Xenograft Model Antitumor Assays | 2014 |
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cholesterol, Dietary; Cromakalim; Decanoic Acids; Diazoxide; Diet, High-Fat; Glyburide; Hydroxy Acids; In Vitro Techniques; KATP Channels; Lactic Acid; Male; Myocardial Infarction; Oxidative Stress; Potassium Channel Blockers; Rats; Rats, Wistar | 2014 |
The peripheral antinociceptive effect induced by the heme oxygenase/carbon monoxide pathway is associated with ATP-sensitive K+ channels.
Topics: Analgesics; Animals; Biliverdine; Carbon Monoxide; Carrageenan; Diazoxide; Drug Interactions; Ferrous Compounds; Glyburide; Heme Oxygenase (Decyclizing); Hemin; KATP Channels; Male; Metalloporphyrins; Naloxone; Nociception; Peripheral Nervous System; Potassium Channel Blockers; Protoporphyrins; Rats; Rats, Wistar; Signal Transduction | 2014 |
Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
Topics: Adaptation, Physiological; Animals; Apoptosis; Autocrine Communication; C-Peptide; Cell Line, Tumor; Diazoxide; Disease Models, Animal; Glucose; Glyburide; Hydrogen Peroxide; Hypoglycemic Agents; Insulin-Secreting Cells; Insulinoma; Oxidative Stress; Pancreatic Neoplasms; Potassium Chloride; Rats; Reactive Oxygen Species | 2014 |
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Apoptosis; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; KATP Channels; Male; Malondialdehyde; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Potassium Channel Blockers; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2014 |
K(ATP) channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat.
Topics: Animals; Atmospheric Pressure; Atractyloside; Cardiotonic Agents; Cyclosporine; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypoxia; Male; Microscopy, Electron, Transmission; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2015 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Electroshock; Glyburide; Male; Mice; Pentylenetetrazole; Potassium Channel Blockers; Reaction Time; Seizures; Triamterene | 2016 |
Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes.
Topics: Acetylcysteine; Action Potentials; Animals; Calcium Channels, L-Type; Diazoxide; Diterpenes, Kaurane; Flavoproteins; Fluorescence; Glyburide; Guinea Pigs; Heart Ventricles; Ion Channel Gating; KATP Channels; Mitochondria; Myocytes, Cardiac; Oxidation-Reduction; Pinacidil; Reactive Oxygen Species; Sarcolemma; Time Factors | 2016 |
Impaired glucose-stimulated insulin secretion and reduced β-cell mass in pancreatic islets of hyperthyroid rats.
Topics: Animals; Calcium Channels, L-Type; Diazoxide; Glucose; Glucose Tolerance Test; Glyburide; Hyperthyroidism; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Thyroid Hormones; Thyroxine | 2016 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats | 2016 |
Induction of oxidative stress, suppression of glucose-induced insulin release, ATP production, glucokinase activity, and histomorphometric changes in pancreatic islets of hypothyroid rat.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antioxidants; Calcium Channels, L-Type; Diazoxide; Glucokinase; Glucose; Glyburide; Hexokinase; Hypothyroidism; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Lipid Peroxidation; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Thyroid Hormones | 2016 |
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation; Glucose; Glyburide; Hydroxy Acids; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Necrosis; Oxidative Stress; Pinacidil; Potassium Channels; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sulfonamides; Toll-Like Receptor 4 | 2017 |
Acute action of rotenone on excitability of catecholaminergic neurons in rostral ventrolateral medulla.
Topics: Animals; Catecholamines; Central Nervous System Agents; Diazoxide; Free Radical Scavengers; Glyburide; KATP Channels; Medulla Oblongata; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats, Wistar; Reactive Oxygen Species; Rotenone; Synaptic Transmission; Tissue Culture Techniques; Tyrosine 3-Monooxygenase; Ubiquinone | 2017 |
Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; Congenital Hyperinsulinism; COS Cells; Diabetes Mellitus; Diazoxide; Gene Expression Regulation; Genetic Predisposition to Disease; Glyburide; Humans; Infant, Newborn; Mutation; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Sulfonylurea Receptors; Workflow | 2018 |
Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice.
Topics: Animals; Antimalarials; Behavior, Animal; Chloroquine; Diazoxide; Glyburide; Injections, Intradermal; KATP Channels; Male; Mice; Minoxidil; Pruritus; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 2018 |
Hydrogen peroxide inhibits neurons in the paraventricular nucleus of the hypothalamus via potassium channel activation.
Topics: Animals; Barium Compounds; Chlorides; Diazoxide; Glyburide; Hydrogen Peroxide; Hypoglycemic Agents; Male; Neurons; Paraventricular Hypothalamic Nucleus; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2019 |
Central K
Topics: Adult; Animals; Blood Glucose; Diazoxide; Drug Interactions; Female; Gene Expression Regulation; Glucose; Glucose Clamp Technique; Glyburide; Humans; Hypoglycemic Agents; KATP Channels; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Young Adult | 2020 |
Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Energy Metabolism; Female; Glyburide; Hydroxy Acids; Ion Transport; KATP Channels; Magnesium; Mitochondria, Liver; Oxygen Consumption; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Reactive Oxygen Species | 2020 |
Pharmacological and molecular docking studies reveal that glibenclamide competitively inhibits diazoxide-induced mitochondrial ATP-sensitive potassium channel activation and pharmacological preconditioning.
Topics: Animals; Diazoxide; Glyburide; KATP Channels; Molecular Docking Simulation; Rats | 2021 |