Compounds > diazoxide

diazoxide and 7-chloro-3-isopropylamino-4h-1,2,4-benzothiadiazine 1,1-dioxide

diazoxide has been researched along with 7-chloro-3-isopropylamino-4h-1,2,4-benzothiadiazine 1,1-dioxide in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (66.67)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Antoine, MH; Becker, B; Boverie, S; Dabrowski, M; de Tullio, P; Hansen, JB; Lebrun, P; Ouedraogo, R; Pirotte, B; Sebille, S; Somers, F; Wahl, P1
Arkhammar, PO; Bondo Hansen, J; Jacobsen, P; Nielsen, FE; Wahl, P; Worsaae, A1
Antoine, MH; Becker, B; Boverie, S; Counerotte, S; de Tullio, P; Lebrun, P; Ouedraogo, R; Pirotte, B; Sebille, S; Somers, F1
Antoine, MH; Becker, B; Boverie, S; Counerotte, S; de Tullio, P; Francotte, P; Lebrun, P; Nguyen, QA; Pirotte, B; Sebille, S1
Baroni, M; Carosati, E; Cianchetta, G; Fremming, T; Hansen, JB; Mannhold, R; Wahl, P; Zamora, I1
Antoine, MH; Becker, B; de Tullio, P; Florence, X; Lebrun, P; Michaux, C; Pirotte, B; Sebille, S; Wouters, J1
de Tullio, P; Florence, X; Fraikin, P; Hansen, JB; Lebrun, P; Nguyen, QA; Pirotte, B; Somers, F; Wahl, P1
Boverie, S; de Tullio, P; Lebrun, P; Michaux, C; Pirotte, B1
Boverie, S; de Tullio, P; Florence, X; Goffin, E; Lebrun, P; Pirotte, B; Somers, F1
Antoine, MH; Arkhammar, P; Hansen, JB; Lebrun, P; Nguyen, QA; Pirotte, B1
Antoine, MH; Becker, B; Boverie, S; de Tullio, P; Lebrun, P; Pirotte, B; Sebille, S; Somers, F1
Chiap, P; de Tullio, P; Francotte, P; Frédérich, M; Gillotin, F; Lebrun, P; Pirotte, B; Van Heugen, JC1

Other Studies

12 other study(ies) available for diazoxide and 7-chloro-3-isopropylamino-4h-1,2,4-benzothiadiazine 1,1-dioxide

ArticleYear
Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
    Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15

    Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Isomerism; Molecular Conformation; Muscle Relaxation; Muscle, Smooth, Vascular; Oocytes; Organ Specificity; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Xenopus laevis

2003
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.
    Bioorganic & medicinal chemistry letters, 2004, Dec-06, Volume: 14, Issue:23

    Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzamides; Benzothiadiazines; Diazoxide; Islets of Langerhans; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Receptors, Drug; Sulfonylurea Receptors; Thiadiazines

2004
Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents

2005
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
    Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

    Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Cyclic S-Oxides; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Muscle Contraction; Muscle, Smooth, Vascular; Organ Specificity; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship

2005
Virtual screening for novel openers of pancreatic K(ATP) channels.
    Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9

    Topics: ATP-Binding Cassette Transporters; Cell Line; Databases, Factual; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Membrane Potentials; Models, Molecular; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quantitative Structure-Activity Relationship; Receptors, Drug; Sulfonylurea Receptors

2007
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
    Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10

    Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Diazoxide; Drug Evaluation, Preclinical; Insulin-Secreting Cells; Molecular Structure; Pinacidil; Potassium Channels; Quantum Theory; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Temperature; Time Factors

2008
Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
    Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1

    Topics: Adenosine Triphosphate; Animals; Benzothiadiazines; Cell Line; Chlorine; Cyclic S-Oxides; Diazoxide; Drug Evaluation, Preclinical; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Structure; Muscle, Smooth, Vascular; Potassium Channels; Rats; Stereoisomerism

2010
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Hydrogen Bonding; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; KATP Channels; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Uterus

2011
1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.
    Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8

    Topics: Animals; Benzothiadiazines; Diazoxide; Insulin-Secreting Cells; KATP Channels; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Structure-Activity Relationship; Thiadiazines

2013
A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release.
    Diabetologia, 2000, Volume: 43, Issue:6

    Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Blood Glucose; Cell Line; Diazoxide; Dose-Response Relationship, Drug; Fluorescent Dyes; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isometric Contraction; Kinetics; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Rats; Rubidium

2000
Effect on insulin release of compounds structurally related to the potassium-channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-d
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:7

    Topics: Animals; Benzothiadiazines; Diazoxide; Female; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Potassium Channel Blockers; Rats; Rats, Wistar

2001
Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium chan
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:2

    Topics: Animals; ATP-Binding Cassette Transporters; Benzothiadiazines; Chromatography, High Pressure Liquid; Cyclic S-Oxides; Diazoxide; Humans; Ion Channel Gating; Isomerism; KATP Channels; Magnetic Resonance Spectroscopy; Male; Membrane Transport Modulators; Metabolic Detoxication, Phase I; Microsomes, Liver; Phenobarbital; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Drug; Solid Phase Extraction; Sulfonylurea Receptors; Tandem Mass Spectrometry

2010