diazooxonorleucine has been researched along with glutamine in 121 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (42.98) | 18.7374 |
| 1990's | 25 (20.66) | 18.2507 |
| 2000's | 10 (8.26) | 29.6817 |
| 2010's | 22 (18.18) | 24.3611 |
| 2020's | 12 (9.92) | 2.80 |
| Authors | Studies |
|---|---|
| Cooney, DA; Homan, ER; Jayaram, HN; Milman, HA; Rosenbluth, RJ | 1 |
| Cooney, DA; Geran, RI; Homan, ER; Jayaram, HN; Milman, HA; Pittillo, R; Rosenbluth, RJ; Ryan, J | 1 |
| Truitt, CD; Zalkin, H | 1 |
| Meister, A; Novogrodsky, A; Tate, SS | 1 |
| Seegmiller, JE; Willis, RC | 1 |
| Kane, JF; Moyed, HS; Patel, N | 1 |
| Freikopf, A; Kulka, RG | 1 |
| Clark, VM; Curthoys, NP; Shapiro, RA | 1 |
| Ekblom, P; Lash, JW; Lehtonen, E; Nordling, S; Saxén, L | 1 |
| Goldstein, L | 2 |
| Rando, RR | 1 |
| Greene, RM; Kochhar, DM | 1 |
| Aydelotte, MB; Kochhar, DM | 1 |
| Kon, C; Sanders, MM | 1 |
| Larsen, MC; Schuster, SM | 1 |
| Komi, N; Okada, A; Takehara, H; Yoshioka, K | 1 |
| Elford, BC; Pinches, RA | 1 |
| Hundal, HS; Mackenzie, B; Rennie, MJ; Robertson, E; Taylor, PM | 1 |
| Mehlhaff, PM; Schuster, SM | 1 |
| Battaglioli, G; Martin, DL | 1 |
| Ahmed, A; Low, SY; Pogson, CI; Rennie, MJ; Taylor, PM | 1 |
| da Fonseca-Wollheim, F | 1 |
| Azoulay, M; Frappier, F; Vilmont, M | 1 |
| Clark, CC; Iozzo, RV; Richards, CF | 1 |
| Hundal, HS; Mackenzie, B; Rennie, MJ; Taylor, PM | 1 |
| Richter, K; Wolf, G | 1 |
| Christopherson, RI; Lyons, SD; Sant, ME | 1 |
| Durschlag, RP; Smith, RJ | 1 |
| Bigner, DD; Campbell, GL; Dranoff, G; Elion, GB; Friedman, HS | 1 |
| Aronson, AI; Strauch, MA; Zalkin, H | 1 |
| Clark, CC; Iozzo, RV | 1 |
| Huber, KR; Roberts, J; Rosenfeld, H | 1 |
| Borowski, E; Chmara, H; Milewski, S | 1 |
| Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
| Matsuno, T; Miwa, N; Mizuno, S | 1 |
| Kaufman, ER | 1 |
| Edidin, M; Frye, LD | 1 |
| Brenchley, JE; Magasanik, B; Prival, MJ | 1 |
| Zalkin, H | 1 |
| Bresnick, E; Lyman, K; Mayfield, ED | 1 |
| Hwang, LH; Zalkin, H | 1 |
| Wyngaarden, JB | 1 |
| Johnstone, RM; Trachewsky, D | 1 |
| Carter, SK; Cooney, DA; Livingston, RB; Venditti, JM | 1 |
| Gaumond, C; Handschumacher, RE | 1 |
| Hartman, SC; McGrath, TF | 1 |
| Hartman, SC; Stochaj, EM | 1 |
| Hartman, SC; Lee, BH | 1 |
| Gan, JC; Trujillo, JL | 1 |
| Koshland, DE; Levitzki, A | 1 |
| Koshland, DE; Levitzki, A; Stallcup, WB | 1 |
| Ellis, DB; Sommar, KM | 1 |
| Chu, SY; Henderson, JF | 1 |
| Neal, AL; Smulson, ME | 1 |
| Jiao, RS; Jin, ZK; Liu, CJ; Lu, ZM; Ni, LY; Zhang, XC | 1 |
| Aharony, D; Dobson, P | 1 |
| Arakawa, M; Ardalan, B; Cooney, DA; Jayaram, H; Villacorte, D | 1 |
| Goldstein, G; Guskey, LE | 1 |
| DeMoss, JA; Henkin, J; Keesey, J; Paukert, JL | 1 |
| Garber, BB; Gots, JS; Jochimsen, BU | 1 |
| Bower, SG; Hermodson, MA; Switzer, RL; Vollmer, SJ; Zalkin, H | 1 |
| Roberts, J; Rosenfeld, H | 1 |
| Edelson, DR; Galbraith, DB; Wolf, BL | 1 |
| Carter, J | 1 |
| Alvarez Gonzalez, ML; Bourguignon, JP; Franchimont, P; Gerard, A; Purnelle, G | 1 |
| Crane, AM; Deibler, GE; Driscoll, BF; Law, MJ | 1 |
| Mason, RM; Sweeney, C | 1 |
| Souba, WW | 1 |
| Cinatl, J; Doerr, HW; Kabickova, H; Kornhuber, B; Vogel, JU | 1 |
| Chang, EB; Madonna, MB; Musch, MW; Thisted, R; Wischmeyer, PE | 1 |
| Bertino, JR; Gritsman, H; Li, WW; Tong, WP; Waltham, MC | 1 |
| Greenman, J; Hassan, IJ; Millar, MR; Stark, RM; Suleiman, MS | 1 |
| Murphy, C; Newsholme, P | 2 |
| Huang, Q; Lau, SS; Monks, TJ | 1 |
| Lacount, MW; Lebioda, L; Lewinski, K; Ortlund, E | 1 |
| Haynes, TE; Li, H; Meininger, CJ; Wu, G | 1 |
| Badet, B; Brown, MF; Hill, AJ; Lynas, JF; Martin, SL; McDowell, A; Walker, B | 1 |
| Chittur, SV; Davisson, VJ; Klem, TJ; Shafer, CM | 1 |
| Curi, R; Doi, SQ; Freitas, JJ; Lagranha, C; Newsholme, P; Palanch, AC; Pithon-Curi, TC; Schumacher, RI | 1 |
| Dieterich, W; Schuppan, D | 1 |
| COGGIN, JH; MARTIN, WR | 1 |
| Brasse-Lagnel, C; Fairand, A; Husson, A; Lavoinne, A | 1 |
| Dong, YX; Kondo, H; Nikawa, J; Sueda, S | 1 |
| Banerjee, M; Ghosh, S; Maity, P; Roy, S | 1 |
| Albrecht, J; Beresewicz, A; Freśko, I; Hilgier, W; Klemenska, E; Oja, SS; Saransaari, P; Zielińska, M | 1 |
| Huysentruyt, LC; Seyfried, TN; Shelton, LM | 1 |
| Albrecht, J; Bringmann, A; Karl, A; Krügel, K; Obara-Michlewska, M; Pannicke, T; Reichenbach, A; Wiedemann, P; Wurm, A | 1 |
| Chen, K; Deussen, ZA; Liu, JL; Siswick, MY; Tastan, ÖY; Zhang, J | 1 |
| Archer, SL; Fang, YH; Parikh, K; Piao, L; Ryan, JJ; Toth, PT | 1 |
| Chong, QY; Low, BC; Sivaraman, J; Thangavelu, K | 1 |
| Freeman, KW; Mary-Sinclair, MN; Olsen, RR; Yin, Z | 1 |
| Alt, J; Baxter, VK; Griffin, DE; Mathey, RW; Potter, MC; Rojas, C; Slusher, BS | 1 |
| Anand, SK; Beer, DG; Carskadon, SL; Chakravarthi, BV; Chen, G; Chinnaiyan, AM; Giordano, TJ; Goswami, MT; Palanisamy, N; Pathi, SS; Thomas, DG; Varambally, S | 1 |
| Akkaya, M; Gordon, EB; Hamilton, SE; Hart, GT; Kim, AS; Lee, CF; Lo, YC; Miller, LH; Pena, M; Pierce, SK; Powell, JD; Qi, CF; Tran, TM; Waisberg, M; Yazew, T | 1 |
| Andrade-Oliveira, V; Bowman, CE; Brandacher, G; Cheng, CH; Furtmüller, GJ; Lee, CF; Lo, YC; Oh, B; Powell, JD; Slusher, BS; Thomas, AG; Wolfgang, MJ | 1 |
| Crunkhorn, S | 1 |
| Baxter, VK; Griffin, DE; Manivannan, S; Schultz, KL; Slusher, BS | 1 |
| Adams, R; Alt, J; Elgogary, A; Englert, J; Ferraris, D; Jančařík, A; Le, A; Majer, P; Monincová, L; Nedelcovych, M; Pate, K; Powell, J; Rais, R; Rojas, C; Slusher, BS; Tan, J; Tenora, L | 1 |
| Baxter, VK; Braxton, AM; Glowinski, R; Griffin, DE; Potter, MC; Slusher, BS | 1 |
| Brentnall, TA; Chen, R; Jung, L; Lai, LA; Pan, S; Pillarisetty, VG; Riddell, J; Sullivan, Y; Wang, L; Wong, M | 1 |
| Erez, A; Hassanov, T; Karunker, I; Kolodkin-Gal, I; Steinberg, N | 1 |
| Lemberg, KM; Rais, R; Slusher, BS; Vornov, JJ | 1 |
| Hammoud, DA; Maric, D; Miller, LH; Munasinghe, JP; Pierce, SK; Powell, JD; Prchalova, E; Riggle, BA; Schreiber-Stainthorp, W; Sinharay, S; Slusher, BS | 1 |
| Beggs, HS; Chan-Li, Y; Collins, SL; Doerschuk, CM; Horton, MR; Powell, JD; Vigeland, CL | 1 |
| Morinobu, A; Nishimura, K; Okano, T; Saegusa, J; Sendo, S; Ueda, Y; Yamada, H | 1 |
| Arismendi-Morillo, G; Augur, ZM; Bronson, RT; Chinopoulos, C; Domin, MA; Greenwood, B; Hill, C; Kiebish, MA; Kondakci, G; Li, M; Mukherjee, P; Narain, NR; Seyfried, TN | 1 |
| Allen, SJ; Alt, J; Eberhart, CG; Hanaford, AR; Kaur, H; Orr, BA; Poore, B; Price, A; Raabe, EH; Rubens, JA; Slusher, BS; Wang, SZ | 1 |
| Dueñas-Gonzalez, A; Schcolnik-Cabrera, A | 1 |
| Chung, L; Ding, D; Elisseeff, JH; Feeley, M; Hillel, AT; Lina, I; Motz, KM; Murphy, MK; Tsai, HW | 1 |
| Alt, J; Eberhart, CG; Maxwell, MJ; Pham, K; Raabe, EH; Rais, R; Slusher, BS; Sweeney, H | 1 |
| Sun, L; Xin, Y; Yang, X; Yu, W; Yuan, S; Zhang, Q | 1 |
| Choi, YK; Jin, J; Kim, JG; Kim, MJ; Lee, S; Park, HY; Park, KG | 1 |
| Gao, RD; Hin, N; Lam, J; Pal, A; Prchalová, E; Rais, R; Slusher, BS; Tsukamoto, T | 1 |
| Berber, E; Miller, L; Rouse, BT; Sumbria, D | 1 |
| Estok, TM; Wild, R; Yokoyama, Y | 1 |
| He, QQ; Huang, J; Li, T; Liang, Y; Lu, P; Ou, W; Tang, K; Wu, W; Xie, M; Yang, M; Yu, H; Zhang, Y; Zhou, J; Zuo, Y | 1 |
| Aguilar, JMH; Alt, J; Arwood, ML; Dash, RP; Lam, J; Lemberg, KM; Leone, RD; Majer, P; Pal, A; Pandey, R; Peters, DE; Powell, JD; Rais, R; Seiwert, T; Slusher, BS; Tallon, C; Tenora, L; Thomas, AG; Wu, Y; Zhao, L | 1 |
| Bader, JE; Chi, C; Fisher, EL; Hathaway, ES; Karijolich, J; Landis, MD; Madden, MZ; Muka, JE; Needle, GA; O'Neil, RT; Patterson, AR; Philip, M; Rathmell, JC; Reinfeld, BI; Wolf, MM; Ye, X | 1 |
| Alt, J; Gori, S; Lam, J; Majer, P; Mettu, VS; Novotná, K; Paule, J; Prchalová, E; Rais, R; Slusher, BS; Šnajdr, I; Tenora, L; Tsukamoto, T; Veeravalli, V; Wu, Y | 1 |
8 review(s) available for diazooxonorleucine and glutamine
| Article | Year |
|---|---|
Regulation of renal glutamine deamination.
Topics: Acidosis; Ammonia; Animals; Biological Transport; Chronic Disease; Dactinomycin; Deamination; Diazooxonorleucine; Enzyme Inhibitors; Glutamate Synthase; Glutaminase; Glutamine; Humans; Kidney; Mitochondria; Phosphates | 1975 |
Inducible transport systems in the regulation of parasite growth in malaria-infected red blood cells.
Topics: Animals; Biological Transport, Active; Diazooxonorleucine; Erythrocytes; Glutamine; Humans; Malaria, Falciparum; Plasmodium falciparum; Surface Properties | 1992 |
Anthranilate synthetase.
Topics: Anthranilate Synthase; Binding Sites; Cyclohexanecarboxylic Acids; Diazooxonorleucine; Escherichia coli; Glutamine; Isoenzymes; Kinetics; Macromolecular Substances; Magnesium; Molecular Biology; Multienzyme Complexes; Neurospora crassa; ortho-Aminobenzoates; Pentosephosphates; Pentosyltransferases; Protein Binding; Salmonella typhimurium; Species Specificity; Tryptophan; Vinyl Compounds | 1973 |
Glutamine phosphoribosylpyrophosphate amidotransferase.
Topics: Animals; Azaserine; Binding Sites; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Diazooxonorleucine; Glutamine; Iron; Kinetics; Leucine; Liver; Magnesium; Molecular Weight; Multienzyme Complexes; Mutation; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Protein Binding; Protein Conformation; Ribonucleotides; Sulfhydryl Compounds | 1972 |
Glutamine antagonists in chemotherapy.
Topics: Adult; Aminobutyrates; Animals; Asparaginase; Azaserine; Azo Compounds; Child; Diazooxonorleucine; Drug Combinations; Drug Interactions; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Hydroxylysine; Leukemia; Leukemia L1210; Liver; Methionine Sulfoximine; Mice; Neoplasms; Rats; RNA, Transfer | 1970 |
Glutamine and cancer.
Topics: Antimetabolites, Antineoplastic; Cell Division; Diazooxonorleucine; Glutamine; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lymphocytes; Muscles; Neoplasms; Parenteral Nutrition, Total; Randomized Controlled Trials as Topic | 1993 |
We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of
Topics: Animals; Antimetabolites, Antineoplastic; Diazooxonorleucine; Glutamine; Humans; Molecular Structure; Nausea; Neoplasms; Prodrugs; Vomiting | 2018 |
Targeting GLS1 to cancer therapy through glutamine metabolism.
Topics: Apoptosis; Benzophenanthridines; Cell Proliferation; Diazooxonorleucine; Disease Progression; Drug Resistance, Neoplasm; Genes, myc; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasm Proteins; Neoplasms; NF-kappa B; Oxidation-Reduction; Phosphates; Prognosis; Retinoblastoma Protein; Sulfides; Thiadiazoles | 2021 |
113 other study(ies) available for diazooxonorleucine and glutamine
| Article | Year |
|---|---|
DON, CONV and DONV-II. Inhibition of L-'asparagine synthetase in vivo.
Topics: Amino Acids; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Azo Compounds; Cells, Cultured; Diazooxonorleucine; DNA; Formates; Glutamine; Levulinic Acids; Ligases; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pancreas | 1976 |
DON, CONV and DONV-III. Pharmacologic and toxicologic studies.
Topics: Amino Acids; Animals; Asparagine; Azo Compounds; Candida; Cells, Cultured; Diazooxonorleucine; Erythrocytes; Escherichia coli; gamma-Glutamyltransferase; Glutamine; In Vitro Techniques; Levulinic Acids; Mice; Mice, Inbred Strains; Protein Binding | 1976 |
Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase.
Topics: Alkylation; Amino Acids; Ammonia; Carbon-Nitrogen Ligases; Diazooxonorleucine; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Hydrogen-Ion Concentration; Iodoacetamide; Kinetics; Ligases; Pentanoic Acids; Protein Binding | 1977 |
Uptake and utilization of L-glutamine by human lymphoid cells; relationship to gamma-glutamyl transpeptidase activity.
Topics: Amino Acids; Biological Transport, Active; Cell Line; Diazooxonorleucine; gamma-Glutamyltransferase; Glutamates; Glutamine; Humans; Kinetics; Lymphocytes | 1977 |
The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast.
Topics: Azaserine; Azo Compounds; Cell Line; Diazooxonorleucine; gamma-Glutamyltransferase; Glutaminase; Glutamine; Rotenone | 1977 |
Properties of xanthosine 5'-monophosphate-amidotransferase from Escherichia coli.
Topics: Adenosine; Adenosine Triphosphate; Chloromercuribenzoates; Diazooxonorleucine; Diphosphates; Dithionitrobenzoic Acid; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Kinetics; Ligases; Magnesium; Pyruvates; Sulfhydryl Compounds; Tromethamine | 1977 |
Specificity of the glutamine-binding site involved in the reguation of glutamine-synthetase activity in hepatoma tissue-culture cells.
Topics: Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Diazooxonorleucine; Enzyme Induction; Glutamate-Ammonia Ligase; Glutamine; Kinetics; Liver Neoplasms; Methionine; Neoplasms, Experimental; Sulfones | 1975 |
Inactivation of rat renal phosphate-dependent glutaminase with 6-diazo-5-oxo-L-norleucine. Evidence for interaction at the glutamine binding site.
Topics: Animals; Azo Compounds; Binding Sites; Diazooxonorleucine; Glutaminase; Glutamine; Kidney; Kinetics; Phosphates; Protein Binding; Rats | 1979 |
Inhibition of morphogenetic cell interactions by 6-diazo-5-oxo-norleucine (DON).
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Azo Compounds; Cell Communication; Cell Differentiation; Diazooxonorleucine; Embryonic Induction; Glucosamine; Glutamine; Guanosine; Kidney Tubules; Mice; Morphogenesis; Organ Culture Techniques | 1979 |
On the mechanism of action of antibiotics which act as irreversible enzyme inhibitors.
Topics: Alanine; Anti-Bacterial Agents; Asparagine; Azaserine; Azo Compounds; Carbamates; Catalysis; Cell Wall; Cephalosporins; Cycloserine; Diazooxonorleucine; Enzyme Inhibitors; Glutamine; Models, Chemical; Models, Molecular; Penicillins; Purines; Pyridoxal Phosphate; Pyrimidines; Racemases and Epimerases; Serine | 1975 |
Limb development in mouse embryos: protection against teratogenic effects of 6-diazo-5-ox-L-norleucine (DON) in vivo and in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Cartilage Diseases; Cleft Lip; Diazooxonorleucine; Extremities; Female; Glucosamine; Glutamine; Glycosaminoglycans; Mice; Organ Culture Techniques; Pregnancy; Purines; Teratogens | 1975 |
Influence of 6-diazo-5-oxo-L-norleucine (DON), a glutamine analogue, on cartilaginous differentiation in mouse limb buds in vitro.
Topics: Animals; Azo Compounds; Cartilage; Cell Differentiation; Diazooxonorleucine; Dose-Response Relationship, Drug; Embryo, Mammalian; Extremities; Glutamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphogenesis; Organ Culture Techniques | 1975 |
Glutamine transport by mitochondria isolated from normal and acidotic rats.
Topics: Acidosis; Adaptation, Physiological; Amino Acids; Animals; Biological Transport; Depression, Chemical; Diazooxonorleucine; Enzyme Inhibitors; Glutamine; Kidney; Kinetics; Male; Membranes; Mitochondria; Rats | 1975 |
Glutamine and glutamate metabolism in normal and heat shock conditions in Drosophila Kc cells: conditions supporting glutamine synthesis maximize heat shock polypeptide expression.
Topics: Amino Acids; Aminooxyacetic Acid; Ammonia; Animals; Carbon Dioxide; Cells, Cultured; Diazooxonorleucine; Dogs; Drosophila; Glutamates; Glutamic Acid; Glutamine; Heat-Shock Proteins; Lactates; Pyruvates; Salts; Solutions; Transaminases | 1992 |
The topology of the glutamine and ATP binding sites of human asparagine synthetase.
Topics: Adenosine Triphosphate; Affinity Labels; Antibodies, Monoclonal; Aspartate-Ammonia Ligase; Azides; Cloning, Molecular; Diazooxonorleucine; Enzyme-Linked Immunosorbent Assay; Glutamine; Humans; Kinetics; Recombinant Proteins; Saccharomyces cerevisiae; Ultraviolet Rays | 1992 |
Glutamine antagonist with diet deficient in glutamine and aspartate reduce tumor growth.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Division; Diazooxonorleucine; Diet; Glutamine; Male; Rats; Rats, Inbred Strains; Sarcoma, Yoshida | 1992 |
Transport and membrane binding of the glutamine analogue 6-diazo-5-oxo-L-norleucine (DON) in Xenopus laevis oocytes.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Diazooxonorleucine; Female; Glutamine; Kinetics; Oocytes; Xenopus laevis | 1992 |
Bovine pancreatic asparagine synthetase explored with substrate analogs and specific monoclonal antibodies.
Topics: Ammonia; Animals; Antibodies, Monoclonal; Aspartate-Ammonia Ligase; Binding Sites; Cattle; Chromatography, Gel; Diazooxonorleucine; Dose-Response Relationship, Drug; Epitopes; Glutamine; Macromolecular Substances; Molecular Structure; Pancreas; Protein Binding | 1991 |
GABA synthesis in brain slices is dependent on glutamine produced in astrocytes.
Topics: 4-Aminobutyrate Transaminase; Animals; Astrocytes; Brain; Cyclohexanecarboxylic Acids; Diazooxonorleucine; gamma-Aminobutyric Acid; Glutaminase; Glutamine; Kinetics; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Substrate-specificity of glutamine transporters in membrane vesicles from rat liver and skeletal muscle investigated using amino acid analogues.
Topics: Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Animals; Azaserine; Biological Transport; Carrier Proteins; Cell Membrane; Diazooxonorleucine; Female; Glutamine; Kinetics; Lithium; Liver; Muscles; Rats; Rats, Inbred Strains; Sarcolemma; Sodium | 1991 |
Deamidation of glutamine by increased plasma gamma-glutamyltransferase is a source of rapid ammonia formation in blood and plasma specimens.
Topics: Ammonia; Borates; Chromatography, Gel; Diazooxonorleucine; False Positive Reactions; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Humans; Maleates; Serine; Specimen Handling | 1990 |
Metabolism of glutamine in erythrocytes infected with the human malaria parasite: Plasmodium falciparum.
Topics: Animals; Antimetabolites; Cells, Cultured; Diazooxonorleucine; Erythrocytes; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Isoxazoles; Plasmodium falciparum | 1990 |
Post-translational alterations in newly synthesized cartilage proteoglycans induced by the glutamine analogue 6-diazo-5-oxo-L-norleucine. Time course of inhibition and recovery.
Topics: Aggrecans; Animals; Cartilage; Cells, Cultured; Chick Embryo; Chondroitin Sulfate Proteoglycans; Chromatography, Gel; Diazooxonorleucine; Extracellular Matrix Proteins; Glucosamine; Glutamine; Glycoproteins; Kinetics; Lectins, C-Type; Protein Processing, Post-Translational; Proteoglycans; Sulfur Radioisotopes; Uridine Diphosphate N-Acetylglucosamine | 1991 |
Uptake of glutamine in Xenopus oocytes: inhibition by 6-diazo-5-oxo-L-norleucine and harmaline.
Topics: Animals; Biological Transport; Diazooxonorleucine; Female; Glutamine; Harmaline; Kinetics; Oocytes; Xenopus | 1990 |
High-affinity glutamine uptake of the rat hippocampus during postnatal development: a quantitative autoradiographic study.
Topics: Aging; Amino Acids, Diamino; Animals; Diazooxonorleucine; Glutamine; Hippocampus; Male; Rats; Rats, Inbred Strains | 1990 |
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet | 1990 |
Regulation of glutamine production by skeletal muscle cells in culture.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1985 |
Influence of glutamine on the growth of human glioma and medulloblastoma in culture.
Topics: 2-Aminoadipic Acid; Cells, Cultured; Diazooxonorleucine; Dose-Response Relationship, Drug; Glioma; Glutamate-Ammonia Ligase; Glutamine; Humans; Hydroxylysine; Medulloblastoma | 1985 |
Characterization of the glutamyl-tRNA(Gln)-to-glutaminyl-tRNA(Gln) amidotransferase reaction of Bacillus subtilis.
Topics: Ammonia; Asparagine; Bacillus subtilis; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamine; Hot Temperature; Methionine Sulfoximine; Mutation; Nitrogenous Group Transferases; RNA, Transfer, Amino Acyl; RNA, Transfer, Gln; Transferases | 1988 |
Modulation of heparan sulfate biosynthesis. Effects of 6-diazo-5-oxo-L-norleucine and low glutamine on the synthesis of heparan sulfate proteoglycan by human colon carcinoma cells.
Topics: Azo Compounds; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chondroitin Sulfate Proteoglycans; Colonic Neoplasms; Diazooxonorleucine; Electrophoresis, Polyacrylamide Gel; Glucosamine; Glutamine; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Hexosamines; Microscopy, Electron; Oligosaccharides; Protein Biosynthesis; Proteoglycans; Sulfates | 1987 |
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured | 1988 |
Anticapsin: an active site directed inhibitor of glucosamine-6-phosphate synthetase from Candida albicans.
Topics: Alanine; Candida albicans; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Mathematics; Sulfhydryl Reagents; Transaminases | 1986 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Production of tumor growth-inhibiting protein by the neonatal mouse brain: dependence on intracellular glutamine metabolism.
Topics: Animals; Brain; Cycloheximide; Cytarabine; Dactinomycin; Diazooxonorleucine; DNA Replication; Glutamine; Growth Inhibitors; Mice; Nerve Tissue Proteins; Protein Biosynthesis; Transcription, Genetic | 1987 |
Isolation and characterization of a mutant Chinese hamster cell line resistant to the glutamine analog 6-diazo-5-oxo-L-norleucine.
Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cell Line; Cricetinae; Cricetulus; Diazooxonorleucine; Drug Resistance; Glutamine; Ligases; Nucleosides; Phenotype; Ribonucleotides | 1985 |
The rapid intermixing of cell surface antigens after formation of mouse-human heterokaryons.
Topics: Adenosine Triphosphate; Animals; Antigens; Cell Line; Cell Membrane; Chloramphenicol; Culture Techniques; Cycloheximide; Cytoplasm; Depression, Chemical; Diazooxonorleucine; Dinitrophenols; Fluorescent Antibody Technique; Fluorides; Glutamine; Goats; Humans; Hybridization, Genetic; Immune Sera; Mice; Mosaicism; Parainfluenza Virus 1, Human; Protein Biosynthesis; Puromycin; Rabbits; Staining and Labeling; Temperature | 1970 |
Regulation of the synthesis of enzymes responsible for glutamate formation in Klebsiella aerogenes.
Topics: Amino Acid Oxidoreductases; Ammonia; Bacteriophages; Diazooxonorleucine; Enterobacter; Enzyme Repression; Galactosidases; Genotype; Glucose; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Histidine; Histidine Ammonia-Lyase; Ketoglutaric Acids; Mutation; Phenotype; Species Specificity; Transaminases | 1973 |
Incorporation of bicarbonate-14 C into pyrimidines and into ribonucleic acid of the Novikoff ascites tumor cell.
Topics: Ammonia; Animals; Aspartic Acid; Bicarbonates; Carcinoma, Hepatocellular; Chromatography, Ion Exchange; Diazooxonorleucine; Glutamine; In Vitro Techniques; Liver Neoplasms; Neoplasms, Experimental; Orotic Acid; Pyrimidines; Rats; RNA, Neoplasm; Uracil Nucleotides | 1967 |
Multiple forms of anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium.
Topics: Binding Sites; Carbon Isotopes; Centrifugation, Density Gradient; Cyclohexanecarboxylic Acids; Diazooxonorleucine; Electrophoresis, Disc; Glutamine; Lipase; Molecular Weight; ortho-Aminobenzoates; Pancreas; Pentosephosphates; Phosphoric Acids; Salmonella typhimurium; Solubility; Sulfhydryl Compounds; Transaminases; Transferases; Trypsin; Vibration | 1971 |
Utilization of ammonium ions for purine precursor synthesis in soluble extracts of Ehrlich ascites cells.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Line; Cell-Free System; Deoxyribonucleotides; Diazooxonorleucine; Formates; Glucose; Glutamine; Glycine; Hydrogen-Ion Concentration; Mice; NADP; Neoplasms, Experimental; Nucleic Acids; Nucleotides; Protein Biosynthesis; Purines; Pyrimidines; Quaternary Ammonium Compounds; Ribonucleotides; Serine; Sodium | 1969 |
Modification of L-asparaginase by subunit cross-linking with dimethylsuberimidate.
Topics: Alanine; Asparaginase; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Detergents; Diazooxonorleucine; Dicarboxylic Acids; Electrophoresis; Escherichia coli; Glutamine; Imides; Kinetics; Lysine; Macromolecular Substances; Nitriles; Protein Binding; Sulfuric Acids | 1972 |
Glutaminase A of escherichia coli. Reactions with the substrate analogue, 6-diazo-5-oxonorleucine.
Topics: Alkylation; Amidohydrolases; Anti-Bacterial Agents; Azo Compounds; Benzoates; Binding Sites; Carbon Radioisotopes; Catalysis; Chemical Phenomena; Chemistry; Diazomethane; Diazooxonorleucine; Escherichia coli; Esters; Glutamates; Glutamine; Hydrolysis; Isoelectric Focusing; Kinetics; Methanol; Tritium; Water | 1973 |
Glutaminase A of Escherichia coli. Subunit structure and cooperative behavior.
Topics: Amidohydrolases; Binding Sites; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Diazooxonorleucine; Electrophoresis, Disc; Enzyme Activation; Escherichia coli; Glutamine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Models, Chemical; Molecular Weight; Oxidation-Reduction; Protein Binding; Protein Conformation; Protons; Radiation Effects; Sodium Dodecyl Sulfate | 1973 |
Preferential utilization of glutamine for amination of xanthosine 5'-phosphate to guanosine 5'-phosphate by purified enzymes from Escherichia coli.
Topics: Ammonia; Binding Sites; Chromatography, DEAE-Cellulose; Chromatography, Gel; Diazooxonorleucine; Escherichia coli; Glutamine; Guanine Nucleotides; Ligases; Molecular Weight; Protein Binding; Ribonucleotides; Xanthines | 1974 |
Glycoprotein biosynthesis. VI. Regulation of uridine diphosphate N-acetyl-D-glucosamine metabolism in bovine thyroid gland slices.
Topics: Acetates; Animals; Carbon Isotopes; Cattle; Diazooxonorleucine; Feedback; Fructose; Fructosephosphates; Glucosamine; Glutamine; Glycoproteins; In Vitro Techniques; Puromycin; Thyroglobulin; Thyroid Gland; Transaminases; Uridine Diphosphate Sugars | 1973 |
Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Ammonium Sulfate; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Cytosine Nucleotides; Diazooxonorleucine; Escherichia coli; Glutamine; Hydrogen-Ion Concentration; Iodoacetates; Isotope Labeling; Kinetics; Ligases; Methylation; Models, Biological; Models, Structural; Oxygen Isotopes; Protein Binding; Tritium; Uracil Nucleotides | 1971 |
Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase.
Topics: Adenosine Triphosphate; Ammonia; Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Diazooxonorleucine; Electrophoresis; Escherichia coli; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Magnesium; Models, Biological; Models, Structural; Molecular Weight; Nitro Compounds; Protein Binding; Protein Conformation; Uracil Nucleotides; Urea | 1971 |
Biosynthesis of respiratory tract mucins. II. Control of hexosamine metabolism by L-glutamine: D-fructose 6-phosphate aminotransferase.
Topics: Allosteric Regulation; Ammonium Sulfate; Animals; Cattle; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, Gel; Diazooxonorleucine; Fructosephosphates; Glucosamine; Glutamine; Hexosamines; Hydrogen-Ion Concentration; Kinetics; Mathematics; Molecular Weight; Mucins; Mucous Membrane; Nucleoside Diphosphate Sugars; Trachea; Transaminases; Uracil Nucleotides | 1972 |
Inhibition of the phosphoribosyl-formylglycineamidine synthetase of Ehrlich ascites tumor cells by glutamine analogues.
Topics: Animals; Azaserine; Carcinoma, Ehrlich Tumor; Diazooxonorleucine; Glutamine; Glycine; Kinetics; Ligases; Osmolar Concentration; Parabens; Pentosephosphates; Protein Binding | 1972 |
Comparative effects of glutamine analogues on protein metabolism of 6C3H-ED and Ehrlich ascites carcinoma.
Topics: Amides; Animals; Azaserine; Azides; Carcinoma, Ehrlich Tumor; Diazooxonorleucine; Glutamine; Hydroxamic Acids; In Vitro Techniques; Isoleucine; Lymphoma, Non-Hodgkin; Methionine; Methionine Sulfoximine; Neoplasm Proteins; Sarcoma, Experimental; Valine | 1965 |
The route of incorporation of nitrogen atom into rifamycin during its biosynthesis.
Topics: Ammonium Sulfate; Diazooxonorleucine; Fermentation; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Nitrogen; Nocardia; Rifamycins | 1984 |
Discriminative effect of gamma-glutamyl transpeptidase inhibitors on metabolism of leukotriene C4 in peritoneal cells.
Topics: Aniline Compounds; Animals; Ascitic Fluid; Azaserine; Boric Acids; Calcimycin; Cattle; Diazooxonorleucine; gamma-Glutamyltransferase; Glutamates; Glutamine; Kidney; Kinetics; Rats; Serine; SRS-A | 1984 |
Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo.
Topics: Adenocarcinoma; Animals; Azaserine; Colonic Neoplasms; Diazooxonorleucine; Glutamine; Intestine, Small; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Neoplasms, Experimental; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1982 |
Poliovirus and vesicular stomatitis virus replication in the presence of 6-diazo-5-oxo-L-norleucine or 2-deoxy-D-glucose.
Topics: Animals; Azo Compounds; Cell Line; Chlorocebus aethiops; Deoxy Sugars; Deoxyglucose; Diazooxonorleucine; Glutamine; Humans; Kinetics; Nucleotides; Poliovirus; RNA; RNA, Viral; Tunicamycin; Uridine; Vesicular stomatitis Indiana virus; Viral Plaque Assay; Virus Replication | 1984 |
Anthranilate synthase of Neurospora crassa: reaction and labeling with glutamine analogs.
Topics: Anthranilate Synthase; Azaserine; Diazooxonorleucine; Glutamine; Kinetics; Magnesium; Neurospora; Neurospora crassa | 1982 |
Glutamine and related analogs regulate guanosine monophosphate reductase in Salmonella typhimurium.
Topics: Azo Compounds; Bacterial Proteins; Diazooxonorleucine; Enzyme Induction; Glutamine; GMP Reductase; Guanosine; Guanosine Monophosphate; Methionine Sulfoximine; NADH, NADPH Oxidoreductases; Salmonella typhimurium | 1980 |
The glutamine-utilizing site of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase.
Topics: Amidophosphoribosyltransferase; Amino Acid Sequence; Bacillus subtilis; Binding Sites; Diazooxonorleucine; Glutamine; Pentosyltransferases | 1983 |
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature | 1981 |
Developmental arrest of mouse tooth germs in vitro by 6-diazo-5-oxonorleucine (DON).
Topics: Ameloblasts; Animals; Azo Compounds; Cell Differentiation; Culture Techniques; Diazooxonorleucine; Glutamine; Incisor; Mice; Mice, Inbred C57BL; Molar; Morphogenesis; Odontoblasts; Odontogenesis | 1981 |
Detection of antigens on mouse giant trophoblast cells after incubation with an inhibitor of glycoprotein synthesis.
Topics: Animals; Azo Compounds; Blastocyst; Diazooxonorleucine; Female; Glucosamine; Glutamine; Histocompatibility Antigens; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pregnancy; Trophoblasts | 1981 |
Endogenous glutamate involvement in pulsatile secretion of gonadotropin-releasing hormone: evidence from effect of glutamine and developmental changes.
Topics: Aging; Animals; Diazooxonorleucine; Glutamates; Glutamic Acid; Glutamine; Gonadotropin-Releasing Hormone; Male; Pulsatile Flow; Rats; Rats, Wistar; Veratridine | 1995 |
Damage to neurons in culture following medium change: role of glutamine and extracellular generation of glutamate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cell Division; Cell Survival; Cells, Cultured; Culture Media; Diazooxonorleucine; Dopamine; Embryo, Mammalian; Glutamates; Glutamine; Kinetics; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1993 |
The relationship between proteoglycan synthesis in Swarm chondrocytes and pathways of cellular energy and UDP-sugar metabolism.
Topics: Aggrecans; Alanine; Anaerobiosis; Animals; Azides; Cartilage; Chondroitin Sulfate Proteoglycans; Diazooxonorleucine; Energy Metabolism; Extracellular Matrix Proteins; Glutamine; Iodoacetates; Iodoacetic Acid; Lactates; Lectins, C-Type; Proteoglycans; Rats; Sodium Azide; Tumor Cells, Cultured; Uridine Diphosphate Sugars | 1994 |
Antiviral effects of 6-diazo-5-oxo-L-norleucin on replication of herpes simplex virus type 1.
Topics: Animals; Antiviral Agents; Cell Division; Cell Survival; Chlorocebus aethiops; Diazooxonorleucine; Glutamine; HeLa Cells; Herpesvirus 1, Human; Humans; Vero Cells; Viral Envelope Proteins; Virus Replication | 1997 |
Glutamine protects intestinal epithelial cells: role of inducible HSP70.
Topics: Animals; Cell Line; Diazooxonorleucine; Glutamine; Hot Temperature; HSP70 Heat-Shock Proteins; Intestinal Mucosa; Oxidants; Rats; RNA, Messenger | 1997 |
gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists.
Topics: Azaserine; Diazooxonorleucine; Enzyme Inhibitors; gamma-Glutamyl Hydrolase; Glutamine; Humans; Isoxazoles; Kinetics; Methotrexate; Sarcoma; Substrate Specificity; Tumor Cells, Cultured | 1997 |
Amino acid utilisation and deamination of glutamine and asparagine by Helicobacter pylori.
Topics: Amino Acids; Ammonia; Asparaginase; Asparagine; Culture Media; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Helicobacter pylori | 1997 |
Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production.
Topics: Animals; Arginine; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Urea | 1998 |
Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and
Topics: Animals; Cell Line; Cells, Cultured; Coculture Techniques; Diazooxonorleucine; Enzyme Inhibitors; Extracellular Space; Glutaminase; Glutamine; Humans; Interleukin-8; Islets of Langerhans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Tumor Necrosis Factor-alpha | 1999 |
Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine.
Topics: Animals; Aspartic Acid; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Culture Media; Cytidine; Cytidine Triphosphate; Diazooxonorleucine; DNA Damage; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Glutamine; Isoxazoles; Ketoglutaric Acids; Kidney Tubules, Proximal; RNA, Messenger; Salts; Swine; Transcription Factor CHOP; Transcription Factors; Uridine | 1999 |
Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.
Topics: Amidohydrolases; Aminolevulinic Acid; Asparagine; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Diazooxonorleucine; Electrons; Enzyme Inhibitors; Glutamic Acid; Glutamine; Pseudomonas; Threonine; Tyrosine | 2000 |
Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase.
Topics: Alanine; Ammonia; Animals; Antimetabolites, Antineoplastic; Aorta; Asparagine; Aspartic Acid; Azaserine; Carbon Dioxide; Cattle; Cells, Cultured; Diazooxonorleucine; Endothelium, Vascular; Enzymes; Glutamic Acid; Glutamine; Humans; Microcirculation; Ornithine; Ornithine-Oxo-Acid Transaminase; Umbilical Veins; Venules | 2000 |
Inhibition of Escherichia coli glucosamine synthetase by novel electrophilic analogues of glutamine--comparison with 6-diazo-5-oxo-norleucine.
Topics: Antimetabolites, Antineoplastic; Diazooxonorleucine; Enzyme Inhibitors; Escherichia coli; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Kinetics; Static Electricity; Structure-Activity Relationship; Sulfides | 2000 |
Mechanism for acivicin inactivation of triad glutamine amidotransferases.
Topics: Amino Acid Sequence; Aminohydrolases; Anthranilate Synthase; Azaserine; Binding, Competitive; Carbon-Nitrogen Ligases; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Diazooxonorleucine; Enzyme Inhibitors; Escherichia coli; Glutamine; Isoxazoles; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Nitrogenous Group Transferases; Ribonucleotides; Saccharomyces cerevisiae; Static Electricity; Stereoisomerism; Substrate Specificity | 2001 |
Glutamine delays spontaneous apoptosis in neutrophils.
Topics: Animals; Apoptosis; Cells, Cultured; Chromatin; Diazooxonorleucine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamine; Humans; Male; Membrane Potentials; Mitochondria; Neutrophils; Phagocytosis; Phosphatidylserines; Rats; Rats, Wistar | 2003 |
A molecular warhead and its target: tissue transglutaminase and Celiac Sprue.
Topics: Celiac Disease; Diazooxonorleucine; Glutamine; Glutens; GTP-Binding Proteins; Humans; Peptides; Protein Glutamine gamma Glutamyltransferase 2; Transglutaminases | 2003 |
6-DIAZO-5-OXO-L-NORLEUCINE INHIBITION OF ESCHERICHIA COLI.
Topics: Antimetabolites; Cell Membrane; Cell Physiological Phenomena; Diazooxonorleucine; Drug Resistance; Drug Resistance, Microbial; Electrons; Escherichia coli; Glucosamine; Glutamine; Leucine; Microscopy; Microscopy, Electron; Pharmacology; Research | 1965 |
Glutamine stimulates argininosuccinate synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells.
Topics: Argininosuccinate Synthase; Blotting, Northern; Blotting, Western; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cell Nucleus; Cytosol; Diazooxonorleucine; DNA, Complementary; Dose-Response Relationship, Drug; Fructosephosphates; Glucosamine; Glutamine; Glycosylation; Humans; Models, Biological; Precipitin Tests; Promoter Regions, Genetic; Protein Transport; RNA, Messenger; Sp1 Transcription Factor; Time Factors; Transcription, Genetic | 2003 |
Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae.
Topics: Chromosome Mapping; Chromosomes, Fungal; Diazooxonorleucine; DNA Primers; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Kinetics; Mutation; Plasmids; Pyridoxine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2004 |
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Time Factors; Vascular Endothelial Growth Factor A | 2004 |
Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis.
Topics: Ammonia; Animals; Arginine; Butyrates; Chromatography, High Pressure Liquid; Corpus Striatum; Cyclic GMP; Diazooxonorleucine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemical Techniques; Glutamine; In Vitro Techniques; Isobutyrates; Male; Microdialysis; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2009 |
Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Glucose; Body Weight; Brain Neoplasms; Caloric Restriction; Cell Growth Processes; Cell Line, Tumor; Cerebrum; Diazooxonorleucine; Drug Delivery Systems; Female; Glucose; Glutamine; Male; Mice; Neoplasm Metastasis | 2010 |
Synergistic action of hypoosmolarity and glutamine in inducing acute swelling of retinal glial (Müller) cells.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Arachidonic Acid; Cell Size; Diazooxonorleucine; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Glutamine; Hydrogen Peroxide; In Vitro Techniques; Membrane Potential, Mitochondrial; Neuroglia; Osmosis; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Xanthines | 2011 |
Glutamine analogs promote cytoophidium assembly in human and Drosophila cells.
Topics: Animals; Apoptosis; Azaserine; Carbon-Nitrogen Ligases; Cell Compartmentation; Cell Cycle; Diazooxonorleucine; Drosophila melanogaster; Enzyme Inhibitors; Female; Glutamine; HeLa Cells; Humans; Intracellular Space; Male; Oogenesis; RNA Interference | 2011 |
Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Carrier Proteins; Diazooxonorleucine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucose; Glutamine; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Models, Biological; Oxidation-Reduction; Proto-Oncogene Proteins c-myc; Rats | 2013 |
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Diazooxonorleucine; Glutaminase; Glutamine; Humans; Kidney; Kinetics; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Substrate Specificity | 2014 |
Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism.
Topics: Aniline Compounds; Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Drug Synergism; Glutamine; Humans; Mice; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Sarcoma, Ewing; Sulfonamides; Xenograft Model Antitumor Assays | 2015 |
Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine.
Topics: Alphavirus Infections; Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Diazooxonorleucine; Disease Models, Animal; Encephalitis, Viral; Enzyme-Linked Immunosorbent Assay; Glutamine; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; Sindbis Virus | 2015 |
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Topics: Adenocarcinoma; Aged; Amidophosphoribosyltransferase; Aneuploidy; Animals; Biomarkers, Tumor; Carboxy-Lyases; Cell Line, Tumor; Cell Proliferation; Chickens; Diazooxonorleucine; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Peptide Synthases; Prognosis; Purines | 2015 |
Targeting glutamine metabolism rescues mice from late-stage cerebral malaria.
Topics: Animals; Antimalarials; Blood-Brain Barrier; Diazooxonorleucine; Glutamine; Malaria, Cerebral; Malaria, Falciparum; Mice | 2015 |
Preventing Allograft Rejection by Targeting Immune Metabolism.
Topics: Allografts; Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Diazooxonorleucine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glutamine; Glycolysis; Graft Rejection; Heart Transplantation; Metformin; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; T-Lymphocytes, Regulatory | 2015 |
Infectious disease: Glutamine analogue reverses cerebral malaria.
Topics: Animals; Antimalarials; Diazooxonorleucine; Glutamine; Malaria, Cerebral; Malaria, Falciparum | 2015 |
Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis.
Topics: Alphavirus; Alphavirus Infections; Animals; Cells, Cultured; Central Nervous System; Cytokines; Diazooxonorleucine; Encephalitis; Encephalitis, Viral; Encephalomyelitis; Female; Glutamine; Lymphocytes; Mice; Mice, Inbred C57BL; Paralysis; Sindbis Virus; Virus Replication | 2016 |
Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Diazooxonorleucine; Female; Glioblastoma; Glutamine; Haplorhini; Humans; Mice; Mice, Nude; Prodrugs | 2016 |
Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis.
Topics: Alphavirus Infections; Animals; Antiviral Agents; Diazooxonorleucine; Encephalomyelitis; Glutamine; Humans; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Sindbis Virus | 2017 |
Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Diazooxonorleucine; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Glutamine; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Pancreatic Neoplasms; Proteomics | 2017 |
Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine.
Topics: Aminooxyacetic Acid; Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Biofilms; Carbon; Diazooxonorleucine; Gene Expression Regulation, Bacterial; Glutamic Acid; Glutamine; Mutant Proteins; Nitrogen; Repressor Proteins | 2018 |
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.
Topics: Adult; Animals; Antimalarials; Biomarkers; Blood-Brain Barrier; Brain; Brain Edema; Child; Diazooxonorleucine; Disease Models, Animal; Disease Progression; Female; Glutamine; Humans; Magnetic Resonance Imaging; Malaria, Cerebral; Malaria, Falciparum; Mice; Mice, Inbred C57BL; Plasmodium falciparum | 2018 |
Inhibition of glutamine metabolism accelerates resolution of acute lung injury.
Topics: Acute Lung Injury; Amphiregulin; Animals; Anti-Inflammatory Agents; Antimetabolites; Cytokines; Diazooxonorleucine; Disease Models, Animal; Glutamine; Inflammation Mediators; Lipopolysaccharides; Lung; Macrophages; Mice, Inbred C57BL; Neutrophil Infiltration; Pneumonia; Time Factors | 2019 |
Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.
Topics: Animals; Arthritis; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Dendritic Cells; Diazooxonorleucine; Female; Glutamine; Immunosuppression Therapy; Macrophages; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Sirolimus; Th17 Cells; TOR Serine-Threonine Kinases | 2019 |
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma.
Topics: Animals; Body Weight; Brain; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Diet, Ketogenic; Disease Models, Animal; Female; Fermentation; Glioblastoma; Glucose; Glutamine; Humans; Immunohistochemistry; Ketone Bodies; Ketones; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation | 2019 |
Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Diazooxonorleucine; Female; Glutamine; Humans; Metabolome; Mice; Mice, Nude; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Rhabdoid Tumor; Teratoma; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Mouse Model for Efficient Simultaneous Targeting of Glycolysis, Glutaminolysis, and De Novo Synthesis of Fatty Acids in Colon Cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Diazooxonorleucine; Drug Screening Assays, Antitumor; Fatty Acid Synthase, Type I; Fatty Acids; Female; Glutaminase; Glutamine; Glycolysis; Hexokinase; Indazoles; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Orlistat; Smegmamorpha | 2021 |
Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis.
Topics: Animals; Bleomycin; Collagen; Diazooxonorleucine; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression; Glutamine; Iatrogenic Disease; Injections, Intraperitoneal; Laryngostenosis; Mice; Mucous Membrane; Prospective Studies; Trachea; Tracheal Stenosis | 2021 |
Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis.
Topics: Animals; Apoptosis; Caproates; Cell Line, Tumor; Cerebellar Neoplasms; Diazooxonorleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamine; Humans; Medulloblastoma; Mice; Mice, Nude | 2021 |
Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Diazooxonorleucine; Glutamine; Glycolysis; Immunohistochemistry; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mitochondria; Muscle, Smooth, Vascular; Neointima; Oxidative Phosphorylation; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine | 2021 |
Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.
Topics: Diazooxonorleucine; Drug Design; Drug Stability; Glutamine; Molecular Structure; Prodrugs | 2021 |
Modulating glutamine metabolism to control viral immuno-inflammatory lesions.
Topics: Animals; Diazooxonorleucine; Glutamine; Keratitis, Herpetic; Latent Infection; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes; Trigeminal Ganglion; Virus Activation; Virus Latency | 2021 |
Sirpiglenastat (DRP-104) Induces Antitumor Efficacy through Direct, Broad Antagonism of Glutamine Metabolism and Stimulation of the Innate and Adaptive Immune Systems.
Topics: Amino Acids, Essential; Cell Line, Tumor; Diazooxonorleucine; Glutamine; Humans; Immune System; Neoplasms; Prodrugs; Tumor Microenvironment | 2022 |
Hypoxia-triggered O-GlcNAcylation in the brain drives the glutamate-glutamine cycle and reduces sensitivity to sevoflurane in mice.
Topics: Acetylglucosamine; Anesthetics, General; Animals; Brain; Diazooxonorleucine; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hypoxia; Mice; Oxygen; Sevoflurane | 2022 |
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Topics: CD8-Positive T-Lymphocytes; Diazooxonorleucine; Enzyme Inhibitors; Glutamine; Humans; Neoplasms; Prodrugs | 2022 |
Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.
Topics: Animals; CD8-Positive T-Lymphocytes; Diazooxonorleucine; Glutamine; Mice; Neoplasms | 2023 |
Discovery of
Topics: Diazooxonorleucine; Esters; Glutamine; Humans; Neoplasms; Prodrugs | 2023 |