diazooxonorleucine has been researched along with glutaminase in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (42.50) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 5 (12.50) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cooney, DA; Homan, ER; Jayaram, HN; Milman, HA; Rosenbluth, RJ | 1 |
| Truitt, CD; Zalkin, H | 1 |
| Seegmiller, JE; Willis, RC | 1 |
| Kane, JF; Moyed, HS; Patel, N | 1 |
| Clark, VM; Curthoys, NP; Shapiro, RA | 2 |
| Ericsson, L; Holcenberg, JS; Roberts, J | 1 |
| Goldstein, L | 1 |
| Hanazawa, A; Kaneko, T; Mizuno, N | 1 |
| Battaglioli, G; Martin, DL | 1 |
| da Fonseca-Wollheim, F | 1 |
| Azoulay, M; Frappier, F; Vilmont, M | 1 |
| Bradford, HF; Foley, P; Ward, HK | 1 |
| Durschlag, RP; Smith, RJ | 1 |
| Mott, J; Sherman, AD | 1 |
| Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
| Carter, SK; Cooney, DA; Livingston, RB; Venditti, JM | 1 |
| Hartman, SC | 1 |
| Dolowy, WC; Holcenberg, JS; Roberts, J | 1 |
| Curthoys, NP; Morehouse, RF; Shapiro, RA | 1 |
| Curthoys, NP; Morehouse, RF | 1 |
| Conti, F; Minelli, A | 1 |
| Greenman, J; Hassan, IJ; Millar, MR; Stark, RM; Suleiman, MS | 1 |
| Murphy, C; Newsholme, P | 2 |
| Dong, YX; Kondo, H; Nikawa, J; Sueda, S | 1 |
| Banerjee, M; Ghosh, S; Maity, P; Roy, S | 1 |
| Eigenbrodt, E; Hütter, E; Jansen-Dürr, P; Lener, B; Mazurek, S; Unterluggauer, H; Zwerschke, W | 1 |
| Doi, Y; Liang, J; Mizuno, T; Suzumura, A; Takeuchi, H; Yawata, I | 1 |
| Doi, Y; Harada, Y; Hua, L; Kawanokuchi, J; Liang, J; Mizuno, T; Noda, M; Shijie, J; Sonobe, Y; Suzumura, A; Takeuchi, H; Yasuoka, S; Yawata, I; Zhou, Y | 1 |
| Hoffman, EM; Miller, KE | 1 |
| Hyzinski-García, MC; Keller, RW; Mongin, AA; Vincent, MY | 1 |
| Chong, QY; Low, BC; Sivaraman, J; Thangavelu, K | 1 |
| Cao, BB; Huang, Y; Jiang, YY; Peng, YP; Qiu, YH | 1 |
| Cervantes-Madrid, D; Dueñas-González, A | 1 |
| Alt, J; Brandacher, G; Chao, W; Dash, RP; Furtmüller, G; Gadiano, AJ; Garrett, C; Hadas, E; Jančařík, A; Kelschenbach, J; Kim, BH; Majer, P; Nedelcovych, MT; Oh, B; Prchalová, E; Rais, R; Slusher, BS; Tenora, L; Volsky, DJ; Zimmermann, SC | 1 |
| Alt, J; Coomer, W; Hasegawa, Y; Kamiya, A; Majer, P; Moreno-Megui, A; Nedelcovych, MT; Perez, G; Prchalova, E; Rais, R; Rojas, C; Saito, A; Slusher, BS; Tenora, L; Thomas, AG; Vohra, V; Wu, Y; Zhu, X | 1 |
| Dueñas-Gonzalez, A; Schcolnik-Cabrera, A | 1 |
| Sun, L; Xin, Y; Yang, X; Yu, W; Yuan, S; Zhang, Q | 1 |
| Hoque, M; Khan, AU; Khan, MI; Suhail, M; Tabrez, S; Zughaibi, TA | 1 |
3 review(s) available for diazooxonorleucine and glutaminase
| Article | Year |
|---|---|
Regulation of renal glutamine deamination.
Topics: Acidosis; Ammonia; Animals; Biological Transport; Chronic Disease; Dactinomycin; Deamination; Diazooxonorleucine; Enzyme Inhibitors; Glutamate Synthase; Glutaminase; Glutamine; Humans; Kidney; Mitochondria; Phosphates | 1975 |
Glutamine antagonists in chemotherapy.
Topics: Adult; Aminobutyrates; Animals; Asparaginase; Azaserine; Azo Compounds; Child; Diazooxonorleucine; Drug Combinations; Drug Interactions; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Hydroxylysine; Leukemia; Leukemia L1210; Liver; Methionine Sulfoximine; Mice; Neoplasms; Rats; RNA, Transfer | 1970 |
Targeting GLS1 to cancer therapy through glutamine metabolism.
Topics: Apoptosis; Benzophenanthridines; Cell Proliferation; Diazooxonorleucine; Disease Progression; Drug Resistance, Neoplasm; Genes, myc; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasm Proteins; Neoplasms; NF-kappa B; Oxidation-Reduction; Phosphates; Prognosis; Retinoblastoma Protein; Sulfides; Thiadiazoles | 2021 |
37 other study(ies) available for diazooxonorleucine and glutaminase
| Article | Year |
|---|---|
Don, conv and donv--I. Inhibition of L-asparagine synthetase in vitro.
Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Azo Compounds; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutaminase; In Vitro Techniques; Ligases; Male; Mice; Mice, Inbred Strains; Pancreas; Time Factors; Transaminases | 1976 |
Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase.
Topics: Alkylation; Amino Acids; Ammonia; Carbon-Nitrogen Ligases; Diazooxonorleucine; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Hydrogen-Ion Concentration; Iodoacetamide; Kinetics; Ligases; Pentanoic Acids; Protein Binding | 1977 |
The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast.
Topics: Azaserine; Azo Compounds; Cell Line; Diazooxonorleucine; gamma-Glutamyltransferase; Glutaminase; Glutamine; Rotenone | 1977 |
Properties of xanthosine 5'-monophosphate-amidotransferase from Escherichia coli.
Topics: Adenosine; Adenosine Triphosphate; Chloromercuribenzoates; Diazooxonorleucine; Diphosphates; Dithionitrobenzoic Acid; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Kinetics; Ligases; Magnesium; Pyruvates; Sulfhydryl Compounds; Tromethamine | 1977 |
Inactivation of rat renal phosphate-dependent glutaminase with 6-diazo-5-oxo-L-norleucine. Evidence for interaction at the glutamine binding site.
Topics: Animals; Azo Compounds; Binding Sites; Diazooxonorleucine; Glutaminase; Glutamine; Kidney; Kinetics; Phosphates; Protein Binding; Rats | 1979 |
Amino acid sequence of the diazooxonorleucine binding site of Acinetobacter and Pseudomonas 7A glutaminase--asparaginase enzymes.
Topics: Acinetobacter; Amino Acid Sequence; Amino Acids; Asparaginase; Azo Compounds; Binding Sites; Diazooxonorleucine; Glutaminase; Protein Binding; Pseudomonas; Species Specificity | 1978 |
Enhancement of glutaminase-like immunoreactivity in rat brain by an irreversible inhibitor of the enzyme.
Topics: Animals; Brain; Cerebral Ventricles; Diazooxonorleucine; Glutaminase; Injections, Intraventricular; Neurons; Rats; Rats, Inbred Strains | 1992 |
GABA synthesis in brain slices is dependent on glutamine produced in astrocytes.
Topics: 4-Aminobutyrate Transaminase; Animals; Astrocytes; Brain; Cyclohexanecarboxylic Acids; Diazooxonorleucine; gamma-Aminobutyric Acid; Glutaminase; Glutamine; Kinetics; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Deamidation of glutamine by increased plasma gamma-glutamyltransferase is a source of rapid ammonia formation in blood and plasma specimens.
Topics: Ammonia; Borates; Chromatography, Gel; Diazooxonorleucine; False Positive Reactions; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Humans; Maleates; Serine; Specimen Handling | 1990 |
Metabolism of glutamine in erythrocytes infected with the human malaria parasite: Plasmodium falciparum.
Topics: Animals; Antimetabolites; Cells, Cultured; Diazooxonorleucine; Erythrocytes; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Isoxazoles; Plasmodium falciparum | 1990 |
Glutaminase inhibition and the release of neurotransmitter glutamate from synaptosomes.
Topics: Ammonium Chloride; Animals; Azo Compounds; Cerebral Cortex; Diazooxonorleucine; Enzyme Inhibitors; Female; Glutamates; Glutamic Acid; Glutaminase; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Regulation of glutamine production by skeletal muscle cells in culture.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1985 |
Effects of glutaminase inhibition on release of endogenous glutamic acid.
Topics: 2-Chloroadenosine; Adenosine; Amygdala; Animals; Aspartic Acid; Diazooxonorleucine; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutaminase; Glycine; Haloperidol; In Vitro Techniques; Rats; Serotonin; Synaptosomes | 1986 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Glutaminase of Escherichia coli. I. Purification and general catalytic properties.
Topics: Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Copper; Diazooxonorleucine; Edetic Acid; Electrophoresis; Escherichia coli; Ethylmaleimide; Glutamates; Glutaminase; Hydrogen Peroxide; Hydroxamic Acids; Hydroxylamines; Iodoacetates; Isoflurophate; Kinetics; Lead; Mercury; Molecular Weight; Phenanthrolines; Silver | 1968 |
Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity.
Topics: Alcaligenes; Amino Acids; Antineoplastic Agents; Asparaginase; Bacteria; Carbohydrates; Cell-Free System; Crystallization; Culture Media; Diazooxonorleucine; Disulfides; Glutaminase; Hydrogen-Ion Concentration; Isoelectric Focusing; Kinetics; Macromolecular Substances; Phospholipids; Soil Microbiology; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Temperature | 1972 |
Comparison of the hydrolysis and the covalent binding of 6-diazo-5-oxo-L-[6-14C]norleucine by rat renal phosphate-dependent glutaminase.
Topics: Animals; Azo Compounds; Chromatography, Thin Layer; Diazooxonorleucine; Glutamates; Glutamic Acid; Glutaminase; Hydrolysis; Kidney; Phosphates; Rats; Time Factors; Trypsin | 1982 |
Inhibition by glutamate of phosphate-dependent glutaminase of rat kidney.
Topics: Animals; Diazooxonorleucine; Enzyme Activation; Glutamates; Glutamic Acid; Glutaminase; In Vitro Techniques; Intracellular Membranes; Kidney; Kinetics; Levulinic Acids; Male; Mitochondria; Phosphates; Rats; Rats, Inbred Strains | 1982 |
Properties of rat renal phosphate-dependent glutaminase coupled to Sepharose. Evidence that dimerization is essential for activation.
Topics: Animals; Diazooxonorleucine; Enzyme Activation; Glutaminase; Kidney; Macromolecular Substances; Male; Methylamines; Phosphates; Polysaccharides; Rats; Sepharose | 1981 |
Glutamate immunoreactivity in rat cerebral cortex is reversibly abolished by 6-diazo-5-oxo-L-norleucine (DON), an inhibitor of phosphate-activated glutaminase.
Topics: Animals; Cell Survival; Cerebral Cortex; Diazooxonorleucine; Female; Glutamates; Glutamic Acid; Glutaminase; Immunohistochemistry; Male; Microinjections; Neurons; Parietal Lobe; Phosphates; Rats; Rats, Sprague-Dawley | 1994 |
Amino acid utilisation and deamination of glutamine and asparagine by Helicobacter pylori.
Topics: Amino Acids; Ammonia; Asparaginase; Asparagine; Culture Media; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Helicobacter pylori | 1997 |
Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production.
Topics: Animals; Arginine; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Urea | 1998 |
Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and
Topics: Animals; Cell Line; Cells, Cultured; Coculture Techniques; Diazooxonorleucine; Enzyme Inhibitors; Extracellular Space; Glutaminase; Glutamine; Humans; Interleukin-8; Islets of Langerhans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Tumor Necrosis Factor-alpha | 1999 |
Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae.
Topics: Chromosome Mapping; Chromosomes, Fungal; Diazooxonorleucine; DNA Primers; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Kinetics; Mutation; Plasmids; Pyridoxine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2004 |
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Time Factors; Vascular Endothelial Growth Factor A | 2004 |
Premature senescence of human endothelial cells induced by inhibition of glutaminase.
Topics: Adenosine Triphosphate; Cell Proliferation; Cells, Cultured; Cellular Senescence; Diazooxonorleucine; Endothelial Cells; Energy Metabolism; Enzyme Inhibitors; Glucose; Glutaminase; Glycolysis; Humans; Lactic Acid; Phenotype; Time Factors | 2008 |
Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors.
Topics: Animals; Antibiotics, Antineoplastic; Carbenoxolone; Cell Death; Cytokines; Diazooxonorleucine; Dizocilpine Maleate; Gap Junctions; Glutamic Acid; Glutaminase; Indicators and Reagents; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Neurons; Neuroprotective Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2008 |
Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice.
Topics: Animals; Carbenoxolone; Cell Death; Diazooxonorleucine; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Gap Junctions; Glutamic Acid; Glutaminase; Mice; Mice, Inbred C57BL; Microglia; Neurons; Spinal Cord | 2009 |
Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat.
Topics: Analgesics; Animals; Carrageenan; Diazooxonorleucine; Edema; Glutamic Acid; Glutaminase; Inflammation; Nerve Endings; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2010 |
A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells.
Topics: Animals; Astrocytes; Diazooxonorleucine; Enzyme Assays; Glutamate-Ammonia Ligase; Glutaminase; Methionine Sulfoximine; Neuroglia; Rats; Rats, Sprague-Dawley | 2011 |
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Diazooxonorleucine; Glutaminase; Glutamine; Humans; Kidney; Kinetics; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Substrate Specificity | 2014 |
Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways.
Topics: Animals; Aspartic Acid; Axons; Cerebellar Nuclei; Diazooxonorleucine; Enzyme Inhibitors; Female; Glutamic Acid; Glutaminase; Hypothalamic Area, Lateral; Hypothalamus; Immunity; Injections; Killer Cells, Natural; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; T-Lymphocytes; Thalamus | 2015 |
Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.
Topics: Animals; Apoptosis; Cell Survival; Diazooxonorleucine; Drug Synergism; Fatty Acid Synthases; Fatty Acids; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glycolysis; Hexokinase; Humans; Indazoles; Lactones; Metabolic Networks and Pathways; Mice; Neoplasms; Orlistat | 2015 |
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
Topics: Aminocaproates; Animals; Azo Compounds; Blood; Brain; Diazooxonorleucine; Drug Stability; Female; Glutamic Acid; Glutaminase; HIV Infections; Humans; Male; Mice, Inbred C57BL; Neurocognitive Disorders; Nootropic Agents; Prodrugs; Swine; Viral Load | 2017 |
JHU-083 selectively blocks glutaminase activity in brain CD11b
Topics: Animals; Behavior, Animal; CD11b Antigen; Depression; Diazooxonorleucine; Disease Models, Animal; Glutaminase; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Prodrugs; Signal Transduction; Stress, Psychological | 2019 |
Mouse Model for Efficient Simultaneous Targeting of Glycolysis, Glutaminolysis, and De Novo Synthesis of Fatty Acids in Colon Cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Diazooxonorleucine; Drug Screening Assays, Antitumor; Fatty Acid Synthase, Type I; Fatty Acids; Female; Glutaminase; Glutamine; Glycolysis; Hexokinase; Indazoles; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Orlistat; Smegmamorpha | 2021 |
Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression.
Topics: Diazooxonorleucine; Early Detection of Cancer; Glutaminase; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Neoplastic Processes | 2022 |