diazepam has been researched along with tolbutamide in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| El-Denshary, ES; Ismail, NA; Montague, W | 1 |
| Denbeigh, P; Dolman, L; Sellers, EM; Thiessen, JJ | 1 |
| Aronoff, GR; Bergstrom, RF; Enas, GG; Farid, NA; Lemberger, L; Wolen, RL | 1 |
| Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y | 1 |
| Flessa, HC; Sigell, LT | 1 |
| Bradbury, A; Houston, JB; Worboys, PD | 1 |
| Cheron, G; Cresteil, T; Gueret, G; Sonnier, M; Treluyer, JM | 1 |
| Ishihara, K; Kamei, H; Kitada, M; Kushida, H; Ohmori, S; Wakui, Y; Yanagisawa, T; Yuzurihara, M | 1 |
| Ebara, M; Fukuda, H; Motoji, N; Okuyama, M; Saisho, H; Shigematsu, A; Shimizu, R; Sugiura, N; Watayo, T; Yoshikawa, M | 1 |
| Doshi, U; Li, AP; Peng, CC; Prakash, C | 1 |
2 review(s) available for diazepam and tolbutamide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats.
Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin | 1985 |
27 other study(ies) available for diazepam and tolbutamide
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effects of tetracycline and diazepam on insulin secretion and adenylyl cyclase activity of isolated rat islets of Langerhans.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Diazepam; Dose-Response Relationship, Drug; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Tetracycline; Tolbutamide | 1977 |
Plasma protein binding of diazepam and tolbutamide in chronic alcoholics.
Topics: Alcoholism; Blood Proteins; Chemical and Drug Induced Liver Injury; Chronic Disease; Diazepam; Female; Humans; Male; Protein Binding; Serum Albumin; Tolbutamide | 1976 |
Fluoxetine: clinical pharmacology and physiologic disposition.
Topics: Administration, Oral; Adult; Age Factors; Aged; Animals; Antidepressive Agents; Blood Platelets; Blood Proteins; Carbon Radioisotopes; Chlorothiazide; Diazepam; Fasting; Fluoxetine; Half-Life; Humans; Intestinal Absorption; Kinetics; Propylamines; Rats; Renal Dialysis; Serotonin; Tolbutamide | 1985 |
Drug interactions with anticoagulants.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Coagulation; Blood Coagulation Tests; Cardiac Glycosides; Chlordiazepoxide; Chlorothiazide; Contraceptives, Oral; Diazepam; Dogs; Drug Antagonism; Epinephrine; Ethchlorvynol; Glucagon; Haloperidol; Humans; Methylphenidate; Phenethylamines; Phenylbutazone; Phenytoin; Quinolines; Salicylates; Steroids; Substance-Related Disorders; Tetanus Toxoid; Tolbutamide; Xanthines | 1970 |
Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.
Topics: Animals; Caffeine; Diazepam; In Vitro Techniques; Liver; Male; Ondansetron; Pharmacokinetics; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide | 1997 |
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.
Topics: Adult; Aging; Child, Preschool; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Female; Fetus; Gestational Age; Humans; Hydroxylation; Infant; Infant, Newborn; Microsomes, Liver; RNA; Tolbutamide | 1997 |
Interaction of drugs and Chinese herbs: pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Hypoglycemic Agents; Injections, Intravenous; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2000 |
Increased metabolizing activities of the tricarboxylic acid cycle and decreased drug metabolism in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Chromatography, Thin Layer; Citric Acid Cycle; Diazepam; Fibrosis; Humans; Liver; Liver Neoplasms; Mitochondria; Radiation-Protective Agents; Succinic Acid; Tolbutamide; Tumor Cells, Cultured | 2002 |
A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds.
Topics: Adult; Biological Assay; Biotransformation; Cells, Cultured; Cryopreservation; Diazepam; Female; Hepatocytes; Humans; Kinetics; Linear Models; Male; Middle Aged; Models, Biological; Pharmaceutical Preparations; Reproducibility of Results; Tolbutamide; Young Adult | 2016 |