diazepam has been researched along with pk 11195 in 108 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (21.30) | 18.7374 |
| 1990's | 49 (45.37) | 18.2507 |
| 2000's | 23 (21.30) | 29.6817 |
| 2010's | 12 (11.11) | 24.3611 |
| 2020's | 1 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Bertolasi, V; Borea, PA; Campiani, G; Dalpiaz, A; Fiorini, I; Greco, G; Manzoni, C; Mennini, T; Nacci, V; Novellino, E | 1 |
| Anzini, M; Basile, AS; Bruni, G; Cappelli, A; Giorgi, G; Langer, T; Romeo, MR; Vomero, S | 1 |
| Blatt, NB; Boitano, A; Dineen, TA; Ellman, JA; Emal, CD; Glick, GD; Leonetti, F; Opipari, AW; Roush, WR | 1 |
| Cleary, J; Glick, GD; Johnson, KM; Opipari, AW | 1 |
| Goodman, MM; Miller, AH; Voll, RJ; Wang, E; Yu, W | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Ittner, LM; Kassiou, M; Scarf, AM | 1 |
| Anzini, M; Biggio, G; Bini, G; Cappelli, A; Concas, A; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Giuliani, G; Makovec, F; Paolino, M; Porcu, P; Stasi, LP; Valenti, S; Vomero, S | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Baba, S; Fukaya, T; Ishiyama, T; Masumoto, S | 1 |
| Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Baglini, E; Barresi, E; Robello, M; Salerno, S; Settimo, FD; Taliani, S | 1 |
| Chang, CL; Cheng, JT; Lin, SS; Tsai, YC | 1 |
| Järvinen, A; Männistö, PT; Rägo, L | 1 |
| Brodie, MJ; Larkin, JG; Scobie, G; Thompson, GG | 1 |
| Järvinen, A; Männistö, PT; Paakkari, I | 1 |
| Hernández, J | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Elgoyhen, AB; Kazanietz, MG | 1 |
| De Luca, C; Massotti, M; Mele, L | 1 |
| Calandra, RS; Calvo, DJ; Medina, JH; Ritta, MN | 1 |
| Hernández, J; Pérez, D; Ruiz, F | 1 |
| Adler-Graschinsky, E; Elgoyhen, B | 1 |
| Bachy, A; Cordeau, LR; Croizat, BP; Gros, F; Keane, PE; Larcher, JC; Le Marquer, FJ; Vayssiere, JL | 1 |
| Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC | 1 |
| Gavish, M; Weizman, R | 1 |
| Albertson, TE; Joy, RM | 1 |
| Krsiak, M; Sulcová, A | 1 |
| Calandra, RS; Ritta, MN | 1 |
| Han, XQ; Tang, SB; Zhang, HY | 1 |
| Marangos, PJ; Patel, J; Post, RM; Weiss, SR | 1 |
| Fares, F; Gavish, M | 1 |
| Belin, C; Carriot, T; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 2 |
| Bryere, P; Naquet, R; Valin, A | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Bender, AS; Hertz, L | 1 |
| Lenfant, M; Zavala, F | 1 |
| Gavish, M; Golomb, M; Granek, M; Karp, L; Tanne, Z; Tyano, S; Weizman, R | 1 |
| Albertson, TE; Walby, WF | 1 |
| File, SE | 1 |
| Benavides, J; Dubroeucq, MC; Flamier, A; Guérémy, C; Imbault, F; Le Fur, G; Perrier, ML; Renault, C; Uzan, A; Vaucher, N | 1 |
| Benavides, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Renault, C; Rufat, P; Uzan, A | 1 |
| Benavides, J; Dubroeucq, MC; Flamier, A; Guérémy, C; Le Fur, G; Perrier, ML; Renault, C; Uzan, A; Vaucher, N | 1 |
| Ekström, P; Grossmann, E; Meissl, H; Yáñez, J | 1 |
| Hashimoto, Y; Iwasaki, S; Nakajima, O | 1 |
| Camarasa, J; Camins, A; Diez-Fernandez, C; Escubedo, E; Pujadas, E | 1 |
| Camarasa, J; Camins, A; Diez-Fernandez, C; Escubedo, E | 1 |
| Bruce, JH; Jorgensen, SL; Neary, JT; Norenberg, MD; Oracion, AM | 1 |
| Farber, JL; Gilfor, E; Hoek, JB; Pastorino, JG; Simbula, G | 1 |
| Giusti, L; Lucacchini, A; Martini, C; Trincavelli, L | 1 |
| Alenfall, J; Batra, S | 1 |
| Lichtensteiger, W; Ramseier, H; Schlumpf, M | 1 |
| Lichtensteiger, W; Parmar, R; Schlumpf, M | 1 |
| Ben-Haim, SA; Edoute, Y; Gavish, M; Giris, J; Hayam, G; Katz, Y; Lochner, A; Weizman, A | 1 |
| Pericić, D; Pivac, N | 1 |
| Code, WE; Hertz, L; Zhao, Z | 1 |
| Kwan, YW; Ngan, MP; Yiu, MK | 1 |
| Neu, JM; Niles, LP; Tenn, CC | 1 |
| Leeuwin, RS; Van Wilgenburg, H; Zeegers, A | 2 |
| Kulkarni, SK; Reddy, DS | 1 |
| Holtman, PH; Jing, X; Sloan, JW; Wala, EP | 1 |
| Lin, WC | 1 |
| Bessler, H; Caspi, B; Gavish, M; Rehavi, M; Weizman, A | 1 |
| Jing, X; Sloan, JW; Wala, EP | 3 |
| Butterworth, RF; Rao, VL | 1 |
| Caldiroli, E; Cattaneo, S; Cosentino, M; Di Grazia, L; Frigo, G; Lecchini, S; Marino, F | 1 |
| Conway, EL | 1 |
| Holtman, JR; Jing, X; Milliken, B; Sloan, JW; Wala, E | 1 |
| Beery, E; Brenner, S; Gavish, M; Landau, M; Landau, O; Nordenberg, J; Wasseman, L; Weizman, A; Zoref-Shani, E | 1 |
| Blanc, F; Butterworth, RF; Fabbro-Peray, P; Lavoie, J; Layrargues, GP; Mousseau, DD; Perney, P | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Honma, Y; Matsuzaki, T; Namiki, A; Tsujiguchi, N; Yamakage, M | 1 |
| Fraser, R; Kenyon, CJ; Thomson, I | 1 |
| Chaki, S; Nagamine, M; Nakazato, A; Ogawa, S; Okubo, T; Okuyama, S; Suzuki, Y; Tomisawa, K; Yoshikawa, R | 1 |
| Fornai, F; Gesi, M; Lenzi, P; Natale, G; Paparelli, A; Pellegrini, A; Riva, A; Soldani, P | 1 |
| Bono, F; Herbert, JM; Lamarche, I; Le Fur, G; Prabonnaud, V | 1 |
| Beinlich, A; Kaufmann, M; Kuhl, H; Strohmeier, R | 1 |
| Flemström, G; Säfsten, B | 1 |
| Holtman, JR; Jing, X; Sloan, JW; Wala, EP | 2 |
| Noma, T; Sugimoto, Y; Yamada, J | 1 |
| Chugun, A; Futamura, K; Hara, Y; Kobayashi, H; Kondo, H; Nishino, T; Ooshiro, S; Temma, K | 1 |
| Cattaneo, S; Cosentino, M; Di Grazia, L; Fietta, AM; Frigo, G; Lecchini, S; Marino, F; Rasini, E | 1 |
| Lazzarini, R; Malucelli, BE; Palermo-Neto, J | 1 |
| Abella, C; Hernandez, J; Vargas, ML | 1 |
| Fuentes, T; Galindo, A; García Estañ, J; Hernández, J; Vargas, ML | 1 |
| Kleinrok, Z; Rajtar, G; Zółkowska, D | 1 |
| Kawaguchi, M; Kujirai, M; Sawaki, K | 1 |
| Bidmon, HJ; Foster, N; Görg, B; Häussinger, D; Höngen, A; Reinehr, R; Schliess, F | 1 |
| da Silva, FR; de Oliveira Massoco, C; de Sá-Rocha, LC; Lazzarini, R; Morgulis, MS; Palermo-Neto, J | 1 |
| Bae, YC; Choi, HS; Jung, JS; Kang, SK; Kim, YK; Lee, DH; Lee, RH; Park, HY; Ryu, JM; Suh, KT | 1 |
| Breton, JD; Keller, AF; Poisbeau, P; Schlichter, R | 1 |
| Camins, A; Canudas, AM; Folch, J; Jiménez, A; Jordà, EG; Pallàs, M; Sureda, FX; Verdaguer, E | 1 |
| Castellano, S; Florio, C; Rizzetto, E; Stefancich, G; Vadori, M | 1 |
| Lopes, DV; Mendonça-Silva, DL; Noël, F; Thibaut, JP | 1 |
| Ha, JH; Kim, DH; Lee, IK; Lee, JT | 1 |
| Dagli, ML; Ferraz-de-Paula, V; Martinez-Arguelles, DB; Palermo-Neto, J; Papadopoulos, V; Pinheiro, ML; Quinteiro-Filho, WM; Ribeiro, A; Rone, MB; Sakai, M | 1 |
| Fan, Y; Li, L; Liu, X; Liu, Y; Meng, R; Tao, L; Wei, M; Wu, C | 1 |
| Bouyer, G; Cueff, A; Egée, S; Gallagher, PG; Glogowska, E; Kmiecik, J; Maksimova, Y; Thomas, SL | 1 |
| Deeva, OA; Gudasheva, TA; Mokrov, GV; Seredenin, SB; Yarkov, SA; Yarkova, MA | 1 |
| Graeber, E; Korkhov, VM | 1 |
2 review(s) available for diazepam and pk 11195
| Article | Year |
|---|---|
The translocator protein (18 kDa): central nervous system disease and drug design.
Topics: Acetamides; Apoptosis; Central Nervous System; Central Nervous System Diseases; Drug Design; Humans; Indoleacetic Acids; Indoles; Mitochondrial Membranes; Neurodegenerative Diseases; Phenyl Ethers; Pyrazoles; Pyrimidines; Receptors, GABA | 2009 |
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.
Topics: Amides; Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Humans; Ketones | 2021 |
106 other study(ies) available for diazepam and pk 11195
| Article | Year |
|---|---|
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Topics: Animals; Brain; Computer Simulation; Crystallization; Male; Mitochondria; Models, Molecular; Molecular Conformation; Pyrroles; Rats; Receptors, GABA-A; Structure-Activity Relationship; Thiazepines; X-Ray Diffraction | 1995 |
Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cerebral Cortex; Drug Design; Flunitrazepam; Imidazoles; Isoquinolines; Models, Molecular; Protein Conformation; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Structure activity studies of a novel cytotoxic benzodiazepine.
Topics: Animals; Arthritis; Benzodiazepines; Cell Death; Lupus Vulgaris; Structure-Activity Relationship | 2003 |
Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Cell Proliferation; GABA-A Receptor Antagonists; Humans; Hydrolysis; Isoquinolines; Kinetics; Ligands; Mitochondria; Proton-Translocating ATPases; Structure-Activity Relationship | 2007 |
Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Topics: Animals; Binding, Competitive; Fluorine Radioisotopes; Isoquinolines; Kidney; Ligands; Mitochondrial Membranes; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Rats; Receptors, GABA-A | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold.
Topics: Animals; Anti-Anxiety Agents; Carrier Proteins; Cerebral Cortex; Crystallography, X-Ray; Humans; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Mononeuropathies; Pyrazoles; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Structure-Activity Relationship | 2011 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
Identification of a novel benzoxazolone derivative as a selective, orally active 18 kDa translocator protein (TSPO) ligand.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Avoidance Learning; Benzoxazoles; Carrier Proteins; Cell Line, Tumor; Conflict, Psychological; Humans; Ligands; Male; Mice; Molecular Structure; Motor Activity; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship | 2013 |
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship; Temozolomide; Urea | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Effect of premedication on the changes of neuropeptide Y (NPY) in anesthesia.
Topics: Animals; Diazepam; Female; Isoquinolines; Male; Meperidine; Neuropeptide Y; Preanesthetic Medication; Rats; Rats, Wistar; Sympathetic Nervous System | 1992 |
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.
Topics: Animals; Benzodiazepinones; Carbolines; Clonazepam; Cold Temperature; Diazepam; Flumazenil; Hypothalamo-Hypophyseal System; Isoquinolines; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1992 |
Central and peripheral benzodiazepine receptors in rat brain and platelets: effects of treatment with diazepam and clobazam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Blood Platelets; Brain; Clobazam; Diazepam; Drug Tolerance; Flunitrazepam; Injections, Intraperitoneal; Isoquinolines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Brain Stem; Carbolines; Clonazepam; Diazepam; Duodenum; Hypothalamus; Isoquinolines; Male; Muscle, Smooth; Pituitary Gland, Anterior; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone | 1991 |
The negative inotropic effect of diazepam in rat right ventricular strips.
Topics: Animals; Depression, Chemical; Diazepam; Electric Stimulation; Female; Flumazenil; Heart Ventricles; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Clonazepam; Convulsants; Diazepam; Estradiol; Estrogens; Female; Flumazenil; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Uterine Contraction | 1990 |
Involvement of the "peripheral" benzodiazepine receptor type (omega 3) in the tolerance to the electroencephalographic effects of benzodiazepines in rats: comparison of diazepam and clonazepam.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; Drug Tolerance; Electroencephalography; Isoquinolines; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Peripheral-type benzodiazepine receptors are highly concentrated in mitochondrial membranes of rat testicular interstitial cells.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Diazepam; Flunitrazepam; Intracellular Membranes; Isoquinolines; Kinetics; Leydig Cells; Male; Mitochondria; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
The effect of diazepam on ventricular automaticity induced by a local injury. Evidence of involvement of "peripheral type" benzodiazepine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diazepam; Diltiazem; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Ventricles; Isoquinolines; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ventricular Function | 1989 |
Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Colforsin; Cyclic AMP; Diazepam; Female; Flumazenil; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinolines; Mice; Mitochondria; Neuroblastoma; Oxygen Consumption; Receptors, GABA-A | 1989 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma; Isoquinolines; Mice; Neuroblastoma; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 1989 |
Chronic diazepam treatment induces an increase in peripheral benzodiazepine binding sites.
Topics: Animals; Cerebral Cortex; Chromatography, Gel; Diazepam; Heart; Isoquinolines; Kinetics; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Isoquinolines; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Urethane | 1989 |
A peripheral antagonist of benzodiazepine receptors (PK 11195) did not reverse behavioural effects of diazepam in mice.
Topics: Aggression; Agonistic Behavior; Animals; Diazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Mice; Receptors, GABA-A | 1989 |
Testicular interstitial cells as targets for peripheral benzodiazepines.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; In Vitro Techniques; Isoquinolines; Leydig Cells; Male; Rats; Rats, Inbred Strains; Testosterone | 1989 |
[Effects of diazepam on the action potential and contractility of the rabbit papillary muscle].
Topics: Animals; Diazepam; Female; Guinea Pigs; Isoquinolines; Male; Myocardial Contraction; Papillary Muscles; Rabbits; Receptors, GABA-A; Species Specificity | 1987 |
Differential mediation of the anticonvulsant effects of carbamazepine and diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Carbamazepine; Diazepam; Drug Interactions; Isoquinolines; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Solubilization of peripheral benzodiazepine-binding sites from rat kidney.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Chlordiazepoxide; Clonazepam; Diazepam; Digitonin; Flumazenil; Flurazepam; Guanidine; Guanidines; Hot Temperature; Isoquinolines; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Time Factors; Urea | 1985 |
Pharmacology of peripheral type benzodiazepine receptors in the heart.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Electric Stimulation; Guinea Pigs; Heart; Heart Ventricles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Receptors, GABA-A; Ventricular Function | 1985 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Isoquinolines; Papio; Receptors, GABA-A; Seizures | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Dissimilarities between benzodiazepine-binding sites and adenosine uptake sites in astrocytes and neurons in primary cultures.
Topics: Adenosine; Animals; Astrocytes; Benzodiazepines; Binding Sites; Cells, Cultured; Diazepam; Flumazenil; Isoquinolines; Neurons; Pyrazoles; Receptors, GABA-A | 1987 |
Peripheral benzodiazepines enhance the respiratory burst of macrophage-like P388D1 cells stimulated by arachidonic acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzodiazepinones; Cell Line; Clonazepam; Diazepam; Isoquinolines; Kinetics; Macrophages; Receptors, GABA-A; Superoxides | 1987 |
Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
Topics: Adult; Anxiety; Blood Platelets; Cell Membrane; Diazepam; Female; Humans; Isoquinolines; Kinetics; Male; Psychiatric Status Rating Scales; Receptors, GABA-A; Substance Withdrawal Syndrome | 1987 |
Effects of the benzodiazepine antagonists RO 15-1788, CGS-8216 and PK-11195 on amygdaloid kindled seizures and the anticonvulsant efficacy of diazepam.
Topics: Amygdala; Animals; Diazepam; Flumazenil; Isoquinolines; Kindling, Neurologic; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Electrophysiological and pharmacological characterization of peripheral benzodiazepine receptors in a guinea pig heart preparation.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine | 1984 |
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies.
Topics: Adrenal Glands; Animals; Benzodiazepinones; Blood Platelets; Brain; Clonazepam; Diazepam; In Vitro Techniques; Isoquinolines; Kidney; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1983 |
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies.
Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Diazepam; Isoquinolines; Kidney; Kinetics; Male; Mice; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; Dipyridamole; Isoquinolines; Ligands; Male; Membranes; Myocardium; Rats; Receptors, Cell Surface; Receptors, GABA-A; Thermodynamics | 1983 |
Benzodiazepines influence melatonin secretion of the pineal organ of the trout in vitro.
Topics: 5-Methoxytryptamine; Animals; Benzodiazepines; Calcium; Clonazepam; Culture Media; Dark Adaptation; Diazepam; Flumazenil; Hydroxyindoleacetic Acid; In Vitro Techniques; Indoles; Isoquinolines; Light; Magnesium; Melatonin; Oncorhynchus mykiss; Pineal Gland | 1994 |
Possible involvement of peripheral-type benzodiazepine receptors in erythroid differentiation of human leukemia cell line, K562.
Topics: Cell Differentiation; Cell Line; Diazepam; Erythroid Precursor Cells; GABA Modulators; Hemin; Humans; Isoquinolines; Leukemia, Experimental; Protoporphyrins; Receptors, GABA-A | 1995 |
A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands.
Topics: Animals; Benzodiazepinones; Calcium; Cell Division; Cells, Cultured; Cricetinae; Cricetulus; Diazepam; DNA; Dose-Response Relationship, Drug; Isoquinolines | 1995 |
Cell surface expression of heat shock proteins in dog neutrophils induced by mitochondrial benzodiazepine receptor ligands.
Topics: Animals; Benzodiazepinones; Cell Membrane; Diazepam; Dogs; Heat-Shock Proteins; In Vitro Techniques; Isoquinolines; Ligands; Mitochondria; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Receptors, GABA-A | 1995 |
Inhibition of growth factor-induced DNA synthesis in astrocytes by ligands of peripheral-type benzodiazepine receptors.
Topics: Animals; Animals, Newborn; Astrocytes; Benzodiazepinones; Convulsants; Diazepam; DNA; Fibroblast Growth Factor 2; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GTP-Binding Proteins; Humans; Isoquinolines; Ligands; Mitosis; Peripheral Nervous System; Rats; Receptor Protein-Tyrosine Kinases; Receptors, GABA-A; Thymidine | 1995 |
Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Diazepam; Drug Synergism; Intracellular Membranes; Isoquinolines; Ligands; Liver; Male; Membrane Potentials; Mitochondria, Liver; Permeability; Protoporphyrins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Rotenone | 1994 |
Characterization of peripheral-type benzodiazepine binding sites from rat and pig pancreas.
Topics: Animals; Benzodiazepinones; Binding Sites; Binding, Competitive; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Isoquinolines; Male; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Swine | 1994 |
Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Benzodiazepinones; Binding, Competitive; Diazepam; Flunitrazepam; Isoquinolines; Male; Mesoporphyrins; Microsomes; Mitochondria; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Receptors, GABA-A | 1994 |
In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression.
Topics: Animals; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Female; Flumazenil; Immunity, Cellular; In Vitro Techniques; Interleukin-1; Interleukin-2; Isoquinolines; Lymphocyte Activation; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Neuroimmunomodulation; Receptors, GABA-A; T-Lymphocytes | 1993 |
Prenatal diazepam induced persisting downregulation of peripheral (omega 3) benzodiazepine receptors on rat splenic macrophages.
Topics: Animals; B-Lymphocytes; Binding Sites; Cell Membrane; Diazepam; Down-Regulation; Female; Isoquinolines; Macrophages; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Spleen; T-Lymphocytes; Tritium | 1993 |
Ro 5-4864 and PK 11195, but not diazepam, depress cardiac function in an isolated working rat heart model.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Heart; Hemodynamics; In Vitro Techniques; Isoquinolines; Male; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
Effects of benzodiazepines on potassium-induced increase in free cytosolic calcium concentration in astrocytes: interactions with nifedipine and the peripheral-type benzodiazepine antagonist PK 11195.
Topics: Animals; Anti-Anxiety Agents; Astrocytes; Calcium; Calcium Channel Blockers; Cytosol; Diazepam; Drug Interactions; Isoquinolines; Membrane Potentials; Mice; Mice, Inbred Strains; Midazolam; Nifedipine; Potassium | 1996 |
Hormonal modulation of benzodiazepines' actions on rat isolated uterus.
Topics: Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Estrogens; Female; Isoquinolines; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Uterine Contraction; Uterus | 1996 |
PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzodiazepines; Benzodiazepinones; Colforsin; Corpus Striatum; Diazepam; Drug Interactions; Flumazenil; GABA-A Receptor Antagonists; Guanosine Triphosphate; Indoles; Isoquinolines; Kinetics; Male; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Virulence Factors, Bordetella | 1996 |
PK 11195 antagonizes the positive inotropic response of the isolated rat heart to diazepam but not the negative inotropic response.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Female; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Rats; Rats, Wistar; Stimulation, Chemical | 1996 |
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Behavior, Animal; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mitochondria; Motor Activity; Pain Measurement; Picrotoxin; Progesterone; Receptors, GABA-A; RNA; Stress, Psychological; Triazolam | 1996 |
Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Flumazenil; GABA-A Receptor Antagonists; Injections, Spinal; Isoquinolines; Rats; Rats, Sprague-Dawley; Tremor | 1996 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Significant inhibition of spontaneous IgA secretion by selective peripheral-type benzodiazepine receptor ligands.
Topics: Anti-Anxiety Agents; Antibody-Producing Cells; B-Lymphocytes; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Isoquinolines; Lymphocyte Activation | 1997 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Characterization of binding sites for the omega3 receptor ligands [3H]PK11195 and [3H]RO5-4864 in human brain.
Topics: Allosteric Regulation; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Clonazepam; Convulsants; Detergents; Diazepam; Dithiothreitol; Female; Histidine; Humans; Isoquinolines; Ligands; Male; Occipital Lobe; Receptors, GABA-A; Sulfhydryl Reagents; Tritium | 1997 |
Modulation of intracellular calcium in human neutrophils by peripheral benzodiazepine receptor ligands.
Topics: Anti-Anxiety Agents; Benzodiazepinones; Calcium; Clonazepam; Cytosol; Diazepam; Drug Antagonism; GABA Modulators; Humans; Isoquinolines; Neutrophils; Receptors, GABA-A | 1998 |
Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine.
Topics: Animals; Brain; Cerebral Ventricles; Diazepam; Injections, Intraventricular; Isoquinolines; Kinetics; Learning Disabilities; Male; Maze Learning; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Time Factors | 1998 |
Diazepam-treated female rats: flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Female; Flumazenil; GABA Modulators; Hippocampus; Isoquinolines; Microinjections; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.
Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Cell Cycle; Cell Differentiation; Cell Division; Clonazepam; Diazepam; GABA Agents; gamma-Glutamyltransferase; Isoquinolines; Melanoma, Experimental; Mice; Nucleotides; Phenotype; Tumor Cells, Cultured | 1998 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Oxazepam; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Inhibitory effects of diazepam and midazolam on Ca2+ and K+ channels in canine tracheal smooth muscle cells.
Topics: Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Calcium Channels; Diazepam; Dogs; Electrophysiology; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Midazolam; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Trachea | 1999 |
Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study.
Topics: Animals; Benzodiazepines; Cardiac Output; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Perfusion; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 1998 |
Stimulation of aldosterone secretion by benzodiazepines in bovine adrenocortical cells.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Anti-Anxiety Agents; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cattle; Cells, Cultured; Cholesterol; Cholesterol, HDL; Desoxycorticosterone; Diazepam; Hypolipidemic Agents; Isoquinolines; Potassium; Zona Glomerulosa | 1999 |
Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.
Topics: Acetamides; Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Buspirone; Cell Membrane; Diazepam; Exploratory Behavior; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Hexobarbital; Isoquinolines; Male; Mice; Mice, Inbred ICR; Mitochondria; Motor Activity; Phenyl Ethers | 1999 |
Central and peripheral benzodiazepine ligands prevent mitochondrial damage induced by noise exposure in the rat myocardium: an ultrastructural study.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; GABA Modulators; Isoquinolines; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Mitochondria, Heart; Myocardium; Noise; Rats; Rats, Wistar; Time Factors | 1999 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Electrodes, Implanted; Electroencephalography; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra; Weight Gain | 1999 |
Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities.
Topics: Apoptosis; Benzodiazepinones; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Isoquinolines; Jurkat Cells; Kinetics; Ligands; Receptors, GABA-A; Transfection; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
Specific binding of benzodiazepines to human breast cancer cell lines.
Topics: Benzodiazepinones; Breast Neoplasms; Cell Division; Convulsants; Diazepam; Dose-Response Relationship, Drug; Humans; Isoquinolines; Receptors, GABA-A; Tumor Cells, Cultured | 1999 |
Effects of gamma-aminobutyric acid and peripheral benzodiazepine ligands on duodenal bicarbonate secretion.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzodiazepines; Bicarbonates; Bicuculline; Diazepam; Duodenum; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Intestinal Mucosa; Isoquinolines; Ligands; Male; Muscimol; Rats; Rats, Inbred Lew | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra | 1999 |
Involvement of adrenaline in diazepam-induced hyperglycemia in mice.
Topics: Adrenergic beta-Antagonists; alpha-Methyltyrosine; Animals; Blood Glucose; Diazepam; Epinephrine; Hyperglycemia; Idazoxan; Insulin; Isoquinolines; Male; Metoprolol; Mice; Propanolamines | 2000 |
The effect of PK 11 195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Female; GABA-A Receptor Antagonists; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 2000 |
Negative inotropic effect of diazepam in isolated guinea pig heart.
Topics: Adjuvants, Anesthesia; Animals; Anti-Arrhythmia Agents; Calcium Channels; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Patch-Clamp Techniques; Verapamil | 2001 |
Diazepam stimulates migration and phagocytosis of human neutrophils: possible contribution of peripheral-type benzodiazepine receptors and intracellular calcium.
Topics: Calcium; Calcium Channel Blockers; Cells, Cultured; Chemotaxis, Leukocyte; Diazepam; Flow Cytometry; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Isoquinolines; Neutrophils; Phagocytosis; Receptors, GABA-A; Verapamil | 2001 |
Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone.
Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepinones; Capillary Permeability; Carrageenan; Corticosterone; Diazepam; GABA-A Receptor Agonists; Inflammation; Irritants; Isoquinolines; Male; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Flumazenil; Hypothalamus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Pituitary Gland; Rats; Rats, Sprague-Dawley; Rolipram; Sulfonamides | 2001 |
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Topics: Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Milrinone; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Blood Platelets; Calcium Signaling; Clonazepam; Diazepam; Drug Interactions; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, GABA-A; Respiratory Burst; Thrombin | 2002 |
Inhibitory effect of diazepam on muscarinic receptor-stimulated inositol 1,4,5-trisphosphate production in rat parotid acinar cells.
Topics: Animals; Anticonvulsants; Calcium; Carbachol; Chlorides; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Parotid Gland; Phenylephrine; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Time Factors | 2002 |
Benzodiazepine-induced protein tyrosine nitration in rat astrocytes.
Topics: Animals; Astrocytes; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Diazepam; Diazepam Binding Inhibitor; Isoquinolines; Nitrates; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2003 |
Effects of acute and long-term diazepam administrations on neutrophil activity: a flow cytometric study.
Topics: Animals; Benzodiazepinones; Carrageenan; Chromatography, High Pressure Liquid; Corticosterone; Diazepam; Drug Tolerance; Edema; Flow Cytometry; GABA Modulators; GABA-A Receptor Agonists; Isoquinolines; Lipopolysaccharides; Male; Neutrophil Infiltration; Neutrophils; Phagocytosis; Rats; Rats, Wistar; Respiratory Burst; Tetradecanoylphorbol Acetate | 2003 |
Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells.
Topics: Anti-Anxiety Agents; Benzodiazepinones; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Convulsants; Diazepam; Humans; Isoquinolines; Jurkat Cells; Ligands; Mesoderm; Receptors, GABA-A; Stem Cells | 2004 |
Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Age Factors; Animals; Diazepam; Enzyme Inhibitors; Finasteride; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Steroids | 2004 |
Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Benzodiazepinones; Cell Survival; Cells, Cultured; Cerebellum; Colchicine; Diazepam; Isoquinolines; Ligands; Mitochondria; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors | 2005 |
5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors.
Topics: Adrenal Cortex; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Central Nervous System; Cerebral Cortex; Diazepam; Hypnotics and Sedatives; Imidazoles; Isoquinolines; Peripheral Nervous System; Rats; Receptors, GABA-A | 2006 |
Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Clonazepam; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Schistosoma mansoni; Synaptosomes; Temperature; Time Factors; Tritium; Zolpidem | 2007 |
Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apigenin; Cell Line, Tumor; Cell Survival; Diazepam; Drug Screening Assays, Antitumor; Fatty Acid Synthases; Fatty Acid Synthesis Inhibitors; Flavonoids; Flavonols; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypnotics and Sedatives; Isoquinolines; Lovastatin; Vascular Endothelial Growth Factor A | 2008 |
Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Ehrlich Tumor; Cell Proliferation; Diazepam; Drug Administration Schedule; Isoquinolines; Isotope Labeling; Male; Mice; Molecular Sequence Data; Receptors, GABA; Sequence Analysis, DNA | 2010 |
Suppressive effect of diazepam on IFN-gamma production by human T cells.
Topics: Adult; Benzodiazepinones; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Central Nervous System; Depression, Chemical; Diazepam; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Hypnotics and Sedatives; Indicators and Reagents; Interferon-gamma; Isoquinolines; Male; Microglia; Neutrophils; Peripheral Nervous System; Receptors, GABA-A; T-Lymphocytes; Young Adult | 2010 |
Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum.
Topics: Antimalarials; Benzodiazepinones; Diazepam; Erythrocytes; Humans; In Vitro Techniques; Ion Channel Gating; Isoquinolines; Ligands; Malaria, Falciparum; Plasmodium falciparum; Receptors, GABA-A; RNA, Messenger; Up-Regulation; Voltage-Dependent Anion Channels | 2011 |
Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides.
Topics: Amides; Animals; Anti-Anxiety Agents; Anxiety; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Design; Gene Expression; Isoquinolines; Ligands; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Protein Binding; Pyrazines; Receptors, GABA; Structure-Activity Relationship | 2015 |
Characterisation of the ligand binding sites in the translocator protein TSPO using the chimeric bacterial-mammalian constructs.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Cattle; Cloning, Molecular; Diazepam; Drug Discovery; Humans; Isoquinolines; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, GABA; Recombinant Fusion Proteins; Rhodobacter sphaeroides | 2019 |