diazepam has been researched along with picrotoxin in 241 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 135 (56.02) | 18.7374 |
| 1990's | 55 (22.82) | 18.2507 |
| 2000's | 36 (14.94) | 29.6817 |
| 2010's | 12 (4.98) | 24.3611 |
| 2020's | 3 (1.24) | 2.80 |
| Authors | Studies |
|---|---|
| Haefely, W; Polc, P | 1 |
| Javid, MJ; Stone, WE | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS | 1 |
| Guidotti, A; Kurosawa, A; Naik, SR | 1 |
| Georgiev, VP; Markovska, VL; Petkova, BP | 1 |
| Costa, E; Guidotti, A; Mao, CC | 1 |
| Costa, E; Suria, A | 1 |
| Pletscher, A; Saner, A | 1 |
| Risley, EA; Williams, M | 1 |
| Barnes, CD; Polzin, RL | 1 |
| Chéramy, A; Glowinski, J; Leviel, V; Nieoullon, A | 1 |
| Anhut, H; Hertting, G; Steinhauer, HB | 1 |
| Fukuda, H | 1 |
| Simon, P; Soubrie, P | 1 |
| Aliev, MN; Kryzhanovskiĭ, GN | 1 |
| Bolme, P; Fuxe, K | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Georgiev, V | 1 |
| Jobert, A; Soubrié, P; Thiébot, MH | 1 |
| Euvrard, C; Glowinski, J; Herbet, A; Javoy, F | 1 |
| Horton, RW; Meldrum, BS; Sawaya, MC; Stephenson, JD | 1 |
| Boissier, JR; Simon, P; Soubrié, P | 1 |
| Georgiev, V; Markovska, V | 1 |
| Georgiev, VP; Markovska, VL | 1 |
| Barnes, CD; Polzin, R | 1 |
| Golovko, AI; Sofronov, GA | 2 |
| Lin, WC; Watanabe, K; Yano, S | 2 |
| Barnard, EA; Darlison, MG; Harvey, RJ; Zaman, SH | 1 |
| Harro, J; Lang, A; Soosaar, A; Vasar, E | 1 |
| Allan, AM; Draski, LJ; Mayes, GG | 1 |
| Agmo, A; Fernández, H | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Araki, Y; Gomita, Y; Ichimaru, Y; Moriyama, M | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Baur, R; Malherbe, P; Möhler, H; Sigel, E; Trube, G | 1 |
| Kang, T; Xiao-Hong, D; Xin-Quan, J | 1 |
| Albertson, TE; Joy, RM | 1 |
| Kim, KH; Takeuchi, H | 1 |
| Mehta, AK; Ticku, MK | 2 |
| Godlevskiĭ, LS; Makul'kin, RF; Mazarati, AM; Shandra, AA | 1 |
| Dragunow, M | 1 |
| Hong, SP; Kim, SB; Kim, WS; Lee, SI; Lee, SK; Lim, DY; Suh, J; Yoo, HJ | 1 |
| Holtzman, SG | 1 |
| Baker, K; Clifford, DB; Covey, DF; Yang, J; Zorumski, CF | 1 |
| Fukuda, H; Matsumoto, K; Ono, H; Yamazaki, J | 1 |
| Hernández, J; Pérez, D; Ruiz, F | 1 |
| Fillenz, M; Pei, Q; Zetterström, T | 1 |
| Baur, R; Malherbe, P; Möhler, H; Sigel, E | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Acquas, E; Carboni, E; Di Chiara, G; Leone, P | 1 |
| Cooper, SJ; Estall, LB | 1 |
| Fukuda, H; Ishikawa, M; Miyazaki, H | 1 |
| Li, DX; Shen, GS; Wang, Y | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiĭ, VG | 1 |
| Iasnetsov, VS; Novikov, VE | 1 |
| Handley, SL; Heaton, JC; Rea, PJ; Singh, L | 1 |
| Gross, RA; Macdonald, RL; Weddle, MG | 1 |
| Chou, LS; Lin, MT; Liu, HJ; Yang, CP | 1 |
| McGarrick, JD; Stone, TW; Thexton, AJ | 1 |
| Bender, AS; Hertz, L | 1 |
| Lakić, N; Manev, H; Pericić, D | 2 |
| Dichter, MA; Snodgrass, SR; White, WF | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Humphrey, SJ; McCall, RB | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Dewhurst, DG | 1 |
| Biggio, G; Corda, MG | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Ayhan, IH; Palaoglu, O | 1 |
| Buzsáki, G | 1 |
| Furui, T; Go, VL; Kanawati, IS; Yaksh, TL | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Arbilla, S; Langer, SZ; Lista, A | 1 |
| Asami, T; Koizumi, Y; Naruse, T | 1 |
| Cook, JA; Guzman, F; Hagen, TJ; Shannon, HE | 1 |
| Fehér, O; Toldi, J | 1 |
| Conte, B; Furio, M; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Kawabata, Y; Kontani, H; Koshiura, R | 1 |
| Cupello, A; Hyden, H; Palm, A | 1 |
| Goddard, GV; Morimoto, K | 1 |
| Mann, MD | 1 |
| Xu, NS; Zhang, JR; Zheng, WA | 1 |
| Longo, VG; Sagratella, S | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Kazandjian, A; Spyraki, C; Varonos, D | 1 |
| Borenstein, P; Pointis, D | 1 |
| Huang, CJ; Xiang, JZ | 1 |
| Gallo, V; Guidotti, A; Vaccarino, F; Wise, BC | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Barrada, O; Oftedal, SI | 1 |
| Barnes, CD; Stratten, WP | 1 |
| Chusid, JG; Kopeloff, LM | 1 |
| Frank, GB; Jhamandas, K | 1 |
| Izquierdo, I | 1 |
| Barnes, CD; Moolenaar, GM | 1 |
| Yoshino, T | 1 |
| Kádár, T; Penke, B; Pesti, A; Telegdy, G | 1 |
| File, SE | 3 |
| Langwiński, R; Matla, J | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Andreev, BV; Ignatov, IuD | 1 |
| Goldstein, JM; Knobloch, LC; Malick, JB | 1 |
| Miyamoto, M; Nagawa, Y; Saji, Y; Shintani, M | 1 |
| Barker, JL; Segal, M | 1 |
| Handley, SL; Mithani, S | 1 |
| Engel, JA; Liljequist, S | 1 |
| Classen, K; Göthert, M; Schlicker, E | 1 |
| Fujimoto, M; Okabayashi, T | 1 |
| Davis, WC; Ticku, MK | 6 |
| Olsen, RW | 1 |
| Massotti, M; Sagratella, S | 1 |
| Fukuda, H; Matsumoto, K | 1 |
| Buldakova, SL; Glushankov, PG; Saakian, SA; Skrebitskiĭ, VG | 1 |
| Janiszewski, W; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Casida, JE; Gammon, D | 1 |
| Ashton, D | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| Di Chiara, G; Diana, M; Imperato, A; Nicoletti, F; Scapagnini, U | 1 |
| Jog, MV; Kulkarni, SK | 1 |
| Gold, R; Lemme, P; Mende, T; Morgenstern, R; Oelssner, W | 1 |
| Lupandin, IuV | 1 |
| Wee, EL; Zimmerman, EF | 1 |
| Collinge, J; Pycock, CJ; Taberner, PV | 1 |
| Ramanjaneyulu, R; Ticku, MK | 1 |
| Acs, Z; Makara, GB; Stark, E | 1 |
| Carter, RB; Leander, JD | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Broadhurst, PL; Shephard, RA | 1 |
| Fibiger, HC; Pinel, JP; Treit, D | 1 |
| Artaud, F; Bourgoin, S; Cesselin, F; Glowinski, J; Hamon, M | 1 |
| Schwarz, M; Sontag, KH; Turski, L | 1 |
| Collinge, J; Pycock, C | 1 |
| Casida, JE; Gammon, DW; Lawrence, LJ | 1 |
| Davis, RE | 1 |
| Aliev, MN; Kryzhanovsky, GN | 1 |
| Blair, S; Gavin, M | 1 |
| Fukuda, H; Ishikawa, M; Kudo, Y | 1 |
| Gallager, DW; Mallorga, P; Tallman, JF | 1 |
| Forchetti, CM; Meek, JL | 1 |
| Bourn, WM; Reigel, CE | 1 |
| Iwasaki, T; Nakagawa, Y | 1 |
| Ali, BH; Banna, NR; Bashir, AK; Tanira, MO | 1 |
| Angelides, KJ; Duffy, S; Fraser, DD; Kettenmann, H; MacVicar, BA; Perez-Velazquez, JL | 1 |
| Cannizzaro, C; Cannizzaro, E; Cannizzaro, G; Gagliano, M; Mineo, A; Sabatino, M | 1 |
| Parkman, HP; Stapelfeldt, WH; Szurszewski, JH | 1 |
| Hashimoto, T; Obata, K; Stork, O | 1 |
| Blackmore, PF; Bleasdale, JE; Im, WB | 1 |
| Ho, IK; Ito, Y | 1 |
| Korpi, ER; Seeburg, PH | 1 |
| Amabeoku, GJ; Chikuni, O | 1 |
| Abbott, FV; Franklin, KB | 1 |
| Drummer, HL; Hasan, ZA; Tubbs, T; Woolley, DE; Zimmer, L | 1 |
| Ishima, T; Iwasaki, T; Kimura, K; Nakagawa, Y | 1 |
| Pericić, D; Pivac, N | 1 |
| al-Hader, AF; Hasan, MM; Hasan, ZA; Takrouri, MS | 1 |
| Krůsek, J; Vanĕcek, J; Zemková, H | 1 |
| Chang, YF; Gao, XM | 1 |
| Macdonald, RL; Saxena, NC | 1 |
| Pruett, SB; Wu, WJ | 1 |
| Fukura, H; Igarashi, M; Komiya, Y | 1 |
| Amato, F; Biggio, G; Deserra, T; Motzo, C; Murgia, A; Sanna, E | 1 |
| Matsumoto, K; Nguyen, MD; Nguyen, TN; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Chu, TF; Lin, MT | 1 |
| Kulkarni, SK; Reddy, DS | 1 |
| Dalvi, A; Rodgers, RJ | 2 |
| Cannizzaro, C; Cannizzaro, E; Gagliano, M; Mangiapane, N | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Lin, WC | 1 |
| Belachew, S; Coucke, P; Goffin, F; Lefebvre, PP; Malgrange, B; Moonen, G; Rigo, JM; Van de Water, TR; Xhauflaire, G | 1 |
| Golovko, AI; Kliuntina, TV; Kurganova, TA; Sofronov, GA | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Jayakumar, AR; Jayakumar, R; Paul, V; Puviarasan, K; Sujatha, R | 1 |
| Racine, RJ; Trepel, C | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Qian, H; Ripps, H | 1 |
| Anic, T; Aralica, G; Dodig, G; Duplancie, B; Jelovac, N; Marovic, A; Mise, S; Perovic, D; Petek, M; Pigac, B; Prkacin, I; Rucman, R; Sebecic, B; Seiwerth, S; Sikiric, P; Slobodnjak, Z; Stancic-Rokotov, D; Turkovic, B; Ziger, T; Zoricic, I | 1 |
| Bijak, M; Chojnacka-Wójcik, E; Czuczwar, SJ; Kroczka, B; Kłodzińska, A; Pilc, A; Swiader, M | 1 |
| Jayakumar, AR; Paul, V | 1 |
| Saxena, NC | 1 |
| Albach, CA; Berlese, DB; Bittencourt, SR; Bonacorso, HG; Maixner, AE; Mello, CF; Queiroz, CM; Rubin, MA | 1 |
| Paul, V; Rajasekaran, K; Subramanian, EH | 1 |
| Baufreton, J; Bioulac, B; Dovero, S; Dufy, B; Garret, M; Taupignon, A | 1 |
| Jayakumar, AR; Vanaja, P | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Nemmani, KV; Ramarao, P | 1 |
| Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Bernardi, MM; Spinosa, Hde S; Stilck, SR | 1 |
| Andjelković, DS; Bokonjić, DR; Obradović, DI; Savić, MM; Stojilković, MP; Ugresić, ND | 1 |
| Dillon, GH; Huang, RQ | 1 |
| Cannizzaro, C; Cannizzaro, E; Gagliano, M; Martire, M; Mineo, A; Provenzano, G; Steardo, L | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Paul, V | 1 |
| Epstein, OI; Molodavkin, GM; Sergeeva, SA; Voronina, TA | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| Carrer, HF; Isoardi, NA; Martijena, ID; Molina, VA | 1 |
| Feigenspan, A; Weiler, R | 1 |
| Ekambaram, P; Paul, V | 1 |
| Buznego, MT; Pérez-Saad, H | 1 |
| Chéramy, A; Glowinski, J; Nieoullon, A | 1 |
| Liu, QS; Poo, MM; Pu, L | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Chang, SM; Ha, JH; Lee, JT; Lee, MG | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 2 |
| Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT | 1 |
| Mustafa, AA; Salih, MA | 1 |
| Camilo Flório, J; Palermo-Neto, J; Rodrigues-Costa, EC; Stankevicius, D | 1 |
| Furukawa, K; Kita, A | 1 |
| Baratti, CM; Blake, MG; Boccia, MM | 1 |
| Bailabar, T; Bum, EN; Hiana, IR; Moto, FC; Nkainsa, LA; Rakotonirina, A; Rakotonirina, SV; Seke Etet, PF; Seyni, P; Taiwe, GS | 1 |
| Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A | 1 |
| Araki, H; Kawasaki, H; Ochi, R; Suemaru, K | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G | 1 |
| Adio, O; Fageyinbo, S; Sowemimo, AA | 1 |
| Arnold, LA; Chen, Q; Cook, JM; Emala, CW; Ionescu-Zanetti, C; Johnson, J; Smith, S; Wang, ZJ; Yim, PD; Yuan, N | 1 |
| Carro-Juárez, M; García-Orduña, F; Rodríguez-Landa, JF; Rodríguez-Peña, Mde L; Rovirosa-Hernández, Mde J | 1 |
| Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA | 1 |
| Belcher, SF; Morton, TR | 1 |
| Andreatini, R; Baretta, IP; Chioca, LR; Ferreira, J; Ferro, MM; Losso, EM; Oliveira, SM; Silva, CR | 1 |
| Bisson, JF; Scheepens, A; Skinner, M | 1 |
| Ago, Y; Hasebe, S; Hashimoto, H; Hiramatsu, N; Matsuda, T; Mori, K; Onaka, Y; Takuma, K; Watabe, Y | 1 |
| Baldisserotto, B; Bandeira, G; Bianchini, AE; Brusque, ICM; da Cunha, JA; Garlet, QI; Heinzmann, BM; Salbego, J | 1 |
| Aricescu, AR; Desai, R; Karia, D; Kotecha, A; Laverty, D; Malinauskas, T; Masiulis, S; Miller, KW; Pardon, E; Serna Martin, I; Steyaert, J; Uchański, T; Zivanov, J | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD | 1 |
| Barker, S; Costa, ACS; Faber, J; Pinheiro, DJLL; Scorza, CA; Scott-McKean, JJ; Stasko, MR; Victorino, DB | 1 |
4 review(s) available for diazepam and picrotoxin
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Appetite; Appetite Depressants; Benzodiazepines; Benzodiazepinones; Carbolines; Chlordiazepoxide; Chlorides; Choice Behavior; Diazepam; Drinking Behavior; Feeding Behavior; Flumazenil; Food Deprivation; Food Preferences; gamma-Aminobutyric Acid; Ion Channels; Midazolam; Picrotoxin; Punishment; Pyrazoles; Receptors, GABA-A; Satiation; Sodium Chloride; Species Specificity | 1985 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptic Membranes | 1981 |
Tutu toxicity: three case reports of Coriaria arborea ingestion, review of literature and recommendations for management.
Topics: Adult; Anticonvulsants; Diazepam; Epilepsy, Tonic-Clonic; Female; Fruit; Humans; Male; Nausea; Picrotoxin; Plant Poisoning; Plants, Toxic; Sesquiterpenes; Tachycardia; Young Adult | 2013 |
237 other study(ies) available for diazepam and picrotoxin
| Article | Year |
|---|---|
Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Cats; Diazepam; Drug Interactions; Evoked Potentials; Flunitrazepam; Glutamate Decarboxylase; Medulla Oblongata; Neural Inhibition; Phenobarbital; Picrotoxin; Propionates; Semicarbazides; Synapses; Synaptic Transmission | 1976 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Harmaline; Male; Mice; Oxotremorine; Pentobarbital; Pentylenetetrazole; Picrotoxin; Tremor | 1976 |
Possible role of gamma aminobutyric acid (GABA) in the regulation of cAMP system in rat anterior pituitary.
Topics: Aminobutyrates; Animals; Baclofen; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Hypothalamus; Isoniazid; Isoxazoles; Male; Nipecotic Acids; Pargyline; Picrotoxin; Pituitary Gland, Anterior; Protein Kinases; Rats; Reserpine | 1977 |
Apomorphine stereotypies and transmitter mechanisms in the striatum. I. Changes in the apomorphine stereotypies caused by drugs acting on the GABA-ergic, dopaminergic and cholinergic transmission.
Topics: Aminooxyacetic Acid; Animals; Apomorphine; Behavior; Corpus Striatum; Diazepam; Ditiocarb; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Humans; Levodopa; Male; Methyltyrosines; Mice; Parasympathetic Nervous System; Picrotoxin; Semicarbazides; Stereotyped Behavior; Synaptic Transmission | 1978 |
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoniazid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Strychnine | 1975 |
Evidence for GABA involvement in the action of diazepam on presynaptic nerve terminals in bullfrog sympathetic ganglia.
Topics: Action Potentials; Aminobutyrates; Animals; Anura; Cyclic AMP; Cyclic GMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Ganglionic Blockers; Glutamates; Glycine; In Vitro Techniques; Nerve Endings; Picrotoxin; Rana catesbeiana | 1975 |
Effect of diazepam on cerebral 5-hydroxytryptamine synthesis.
Topics: 5-Hydroxytryptophan; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Reserpine; Serotonin | 1979 |
Enhancement of the binding of 3H-diazepam to rat brain membranes in vitro by SQ 20009, A novel anxiolytic, gamma-aminobutyric acid (GABA) and muscimol.
Topics: Animals; Bicuculline; Brain; Diazepam; Etazolate; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Muscimol; Nicotinic Acids; Oxazoles; Picrotoxin; Rats; Stimulation, Chemical | 1979 |
Effect of diazepam on GABAergic cuneate neurons.
Topics: Animals; Bicuculline; Cats; Diazepam; gamma-Aminobutyric Acid; Glutamates; Medulla Oblongata; Neurons; Picrotoxin | 1979 |
Symmetric bilateral changes in dopamine release from the caudate nuclei of the cat induced by unilateral nigral application of glycine and GABA-related compounds.
Topics: Animals; Cats; Caudate Nucleus; Diazepam; Dominance, Cerebral; Dopamine; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Muscimol; Neural Pathways; Picrotoxin; Potassium; Strychnine; Substantia Nigra; Tyrosine | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione | 1979 |
[Effects of diazepam and baclofen on the anemic decerebrate rigidity in rats (author's transl)].
Topics: Aminooxyacetic Acid; Animals; Baclofen; Brain; Decerebrate State; Depression, Chemical; Diazepam; Disulfiram; In Vitro Techniques; Male; Methyltyrosines; Muscle Rigidity; Picrotoxin; Pyridoxine; Rats; Semicarbazides | 1979 |
Comparative study of the antagonism of bemegride and picrotoxin on behavioural depressant effects of diazepam in rats and mice.
Topics: Amnesia; Animals; Behavior, Animal; Bemegride; Diazepam; Humans; Male; Mice; Motor Activity; Motor Skills; Picrotoxin; Rats; Seizures; Strychnine | 1978 |
[Pathogenesis of stereotyped behavior].
Topics: Animals; Behavior; Caudate Nucleus; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Haloperidol; Humans; Lithium; Penicillins; Picrotoxin; Rats; Schizophrenia; Stereotyped Behavior; Syndrome; Tetanus Toxin | 1979 |
Possible involvement of GABA mechanisms in central cardiovascular and respiratory control. Studies on the interaction between diazepam, picrotoxin and clonidine.
Topics: Aminobutyrates; Animals; Blood Pressure; Clonidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Male; Picrotoxin; Rats; Respiration | 1977 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Aminobutyric Acid; Imidazoles; Male; Mice; Papaverine; Picrotoxin; Seizures; Theophylline; Time Factors | 1978 |
Picrotoxin-diazepam interaction in a behavioural schedule of differential reinforcement of low rates.
Topics: Animals; Conditioning, Operant; Diazepam; Male; Picrotoxin; Rats; Reinforcement Schedule; Strychnine | 1978 |
Involvement of the dopamine nigrostriatal system in the picrotoxin effect on striatal acetylcholine levels.
Topics: Acetylcholine; Animals; Cholinergic Fibers; Corpus Striatum; Diazepam; Dopamine; Hippocampus; Limbic System; Male; Picrotoxin; Rats; Substantia Nigra | 1977 |
Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Chickens; Diazepam; gamma-Aminobutyric Acid; Phenobarbital; Picrotoxin | 1976 |
Antagonism of diazepam against central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism.
Topics: Aminobutyrates; Animals; Atropine; Benztropine; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Motor Activity; Parasympatholytics; Picrotoxin; Scopolamine; Semicarbazides; Strychnine; Trihexyphenidyl | 1976 |
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold.
Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizures; Theophylline | 1976 |
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline.
Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Receptors, Dopamine; Seizures; Theophylline | 1976 |
The effect of diazepam and picrotoxin on brainstem evoked dorsal root potentials.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Diazepam; Drug Interactions; Electric Stimulation; Evoked Potentials; Picrotoxin; Reticular Formation | 1976 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Tritium | 1992 |
Involvement of central GABAA receptor complex in controlling the basal gastric secretory activity in pylorus-ligated rats.
Topics: Analysis of Variance; Anesthesia; Animals; Bicuculline; Diazepam; Gastric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAA receptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Endrin; Heptachlor Epoxide; Insecticides; Lymnaea; Picrotoxin; Receptors, GABA-A; RNA; Transcription, Genetic | 1992 |
Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol.
Topics: Aggression; Animals; Behavior, Animal; Ceruletide; Dextroamphetamine; Diazepam; Electroshock; Haloperidol; Male; Mice; Motor Activity; Picrotoxin; Receptors, Cholecystokinin; Seizures | 1992 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Muscimol; Pentobarbital; Phenobarbital; Phenotype; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Selection, Genetic | 1991 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
Effects of anxiolytic drugs on escape behavior induced by dorsal central gray stimulation in rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Avoidance Learning; Bicuculline; Brain Mapping; Bromazepam; Chlordiazepoxide; Diazepam; Electric Stimulation; Escape Reaction; GABA Antagonists; Male; Meprobamate; Pentobarbital; Periaqueductal Gray; Picrotoxin; Rats; Rats, Inbred Strains; Sensory Thresholds | 1991 |
Involvement of the GABAA/benzodiazepine chloride ionophore receptor complex in the 5,7-DHT Induced anticonflict effect.
Topics: 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Bicuculline; Diazepam; Drinking Behavior; Electroshock; Flumazenil; Hippocampus; Injections, Intraventricular; Limbic System; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1991 |
The effect of subunit composition of rat brain GABAA receptors on channel function.
Topics: Animals; Benzodiazepines; Binding Sites; Brain; Carbolines; Dactinomycin; Diazepam; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Channels; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Xenopus | 1990 |
Pentobarbital selectively blocks supraspinal morphine analgesia. Evidence for GABAA receptor involvement.
Topics: Analgesia; Animals; Diazepam; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord | 1990 |
Interactions of GABAA antagonists with deltamethrin, diazepam, pentobarbital, and SKF100330A in the rat dentate gyrus.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Female; GABA Antagonists; Hippocampus; Insecticides; Male; Membrane Potentials; Nicotinic Acids; Nitriles; Pentobarbital; Picrotoxin; Pyrethrins; Rats; Rats, Inbred Strains | 1991 |
Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones.
Topics: Animals; Baclofen; Bicuculline; Crotonates; Diazepam; Dibenzazepines; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Neurons; Pentobarbital; Picrotoxin; Receptors, GABA-A; Snails | 1990 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Spinal Cord | 1990 |
[The role of the substantia nigra in the anticonvulsive and antiaggressive effects of diazepam during pharmacological kindling].
Topics: Aggression; Animals; Anticonvulsants; Diazepam; Diazepam Binding Inhibitor; Electric Stimulation; Kindling, Neurologic; Male; Microinjections; Neuropeptides; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
Influence of gamma-aminobutyric acid on the changes of blood pressure in rats.
Topics: Animals; Atropine; Blood Pressure; Chlorisondamine; Debrisoquin; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Prazosin; Rats; Rats, Inbred Strains | 1990 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chick Embryo; Diazepam; Furans; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Phenobarbital; Picrotoxin; Spinal Cord | 1988 |
Macrolide compounds, ivermectin and milbemycin D, stimulate chloride channels sensitive to GABAergic drugs in cultured chick spinal neurons.
Topics: Animals; Anti-Bacterial Agents; Bicuculline; Cells, Cultured; Chick Embryo; Chlorides; Diazepam; gamma-Aminobutyric Acid; Ion Channels; Ivermectin; Lactones; Macrolides; Membrane Potentials; Muscimol; Neurons; Picrotoxin; Sesterterpenes; Spinal Cord | 1989 |
The effect of diazepam on ventricular automaticity induced by a local injury. Evidence of involvement of "peripheral type" benzodiazepine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diazepam; Diltiazem; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Ventricles; Isoquinolines; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ventricular Function | 1989 |
Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus.
Topics: Animals; Benzodiazepines; Carbolines; Chromatography, High Pressure Liquid; Dialysis; Diazepam; Flumazenil; Flurazepam; Hippocampus; Hydroxyindoleacetic Acid; Ion Channels; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1989 |
The rat beta 1-subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA.
Topics: Animals; Anions; Carbolines; Diazepam; gamma-Aminobutyric Acid; Ion Channels; Macromolecular Substances; Membrane Potentials; Picrotoxin; Rats; Receptors, GABA-A; Xenopus laevis | 1989 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol; Male; Motor Activity; Pentobarbital; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Stereotyped Behavior | 1989 |
SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade?
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzazepines; Choice Behavior; Diazepam; Injections, Subcutaneous; Male; Morphine; Motivation; Naloxone; Nicotine; Phencyclidine; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1989 |
Modulatory roles of GABAergic mechanisms in post-rotatory nystagmus in the rabbit.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Nystagmus, Pathologic; Picrotoxin; Rabbits; Rotation; Semicarbazides; Strychnine; Time Factors | 1989 |
[Inhibitory effects of gamma-aminobutyric acid and diazepam on ventricular arrhythmias induced by hypothalamic electric stimulation].
Topics: Animals; Arrhythmias, Cardiac; Diazepam; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hypothalamus; Injections, Intraventricular; Male; Picrotoxin; Rabbits | 1989 |
[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
Topics: Animals; Anti-Anxiety Agents; Barbital; Barbiturates; Benzodiazepines; Benzodiazepinones; Bicuculline; Diazepam; Drug Antagonism; Female; Ligands; Mice; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
[The GABA-ergic system and brain edema].
Topics: Animals; Anti-Anxiety Agents; Benactyzine; Benzodiazepines; Benzodiazepinones; Brain Edema; Brain Injuries; Diazepam; Drug Evaluation, Preclinical; Drug Interactions; Female; gamma-Aminobutyric Acid; Male; Nicotine; Parasympatholytics; Phentolamine; Picrotoxin; Rats; Receptors, GABA-A | 1985 |
Involvement of noradrenaline in potentiation of the head-twitch response by GABA-related drugs.
Topics: Adrenergic beta-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Catecholamines; Diazepam; Dopamine; Drug Synergism; gamma-Aminobutyric Acid; Male; Methoxydimethyltryptamines; Metoprolol; Mice; Muscimol; Norepinephrine; Pentobarbital; Picrotoxin; Stereotyped Behavior; Taurine | 1986 |
Benzodiazepine, beta-carboline, and barbiturate actions on GABA responses.
Topics: Animals; Anti-Anxiety Agents; Barbiturates; Bicuculline; Carbolines; Cells, Cultured; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Membrane Potentials; Mice; Neurons; Nitrazepam; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Spinal Cord | 1986 |
Diazepam facilitates reflex bradycardia in conscious rats.
Topics: Animals; Blood Pressure; Diazepam; Epinephrine; Heart Rate; Injections, Intravenous; Male; Picrotoxin; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Pharmacologically induced changes in the latency of digastric reflexes in 1-7 day old rabbits.
Topics: Animals; Animals, Newborn; Bicuculline; Decerebrate State; Diazepam; Electromyography; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rabbits; Reflex; Stomach; Strychnine; Synaptic Transmission | 1988 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
Sex differences in the response of rats to drugs affecting GABAergic transmission.
Topics: Animals; Corticosterone; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Characteristics; Synaptic Transmission | 1985 |
The picrotoxinin binding site and its relationship to the GABA receptor complex.
Topics: Acetates; Acetic Acid; Animals; Brain; Chlorides; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, GABA-A; Sesterterpenes; Sodium | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Evidence for gamma-aminobutyric acid mediation of the sympathetic nerve inhibitory response to vagal afferent stimulation.
Topics: Afferent Pathways; Animals; Bicuculline; Blood Pressure; Cats; Diazepam; Female; gamma-Aminobutyric Acid; Heart; Male; Neural Inhibition; Picrotoxin; Receptors, GABA-A; Reflex; Sympathetic Nervous System; Urethane; Vagus Nerve | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.
Topics: Analgesics; Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Morphine; Picrotoxin; Receptors, GABA-A | 1986 |
Hippocampal sharp waves: their origin and significance.
Topics: Animals; Atropine; Behavior, Animal; Diazepam; Electrophysiology; Hippocampus; Male; Neural Pathways; Picrotoxin; Rats; Sleep Stages; Synapses; Synaptic Transmission | 1986 |
Release of cholecystokinin from rat cerebral cortex in vivo: role of GABA and glutamate receptor systems.
Topics: Amino Acids; Animals; Calcium; Cerebral Cortex; Cholecystokinin; Diazepam; Male; Picrotoxin; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1987 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
The facilitation by diazepam of the electrically evoked release of [3H]5-HT from rat cortical slices is antagonized by picrotoxin and Ro 5-4864.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Diazepam; Electric Stimulation; In Vitro Techniques; Picrotoxin; Rats; Serotonin | 1988 |
Effects of naloxone and picrotoxin on diazepam- or pentobarbital-induced hyperphagia in nondeprived rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Feeding Behavior; Hyperphagia; Male; Naloxone; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains | 1988 |
Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.
Topics: Animals; Carbolines; Diazepam; Discrimination Learning; Harmine; Male; Picrotoxin; Rats; Rats, Inbred F344 | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Interactions of acoustic and somatosensory evoked responses in a polysensory cortex of the cat.
Topics: Acoustic Stimulation; Amphetamine; Animals; Baclofen; Bicuculline; Cats; Diazepam; Electric Stimulation; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Glutamine; Haloperidol; Microelectrodes; Neurons; Parathyroid Hormone; Picrotoxin; Reserpine; Somatosensory Cortex; Taurine | 1987 |
Spinal and supraspinal components of GABAergic inhibition of the micturition reflex in rats.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Kinetics; Male; Picrotoxin; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Taurine; Urination | 1987 |
In vivo effects of gamma-aminobutyric acid on the urinary bladder contraction accompanying micturition.
Topics: Aminooxyacetic Acid; Animals; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Hexamethonium Compounds; Male; Muscimol; Neurons, Efferent; Picrotoxin; Rats; Rats, Inbred Strains; Semicarbazides; Urinary Bladder; Urination | 1987 |
Asymmetric diffusion into the postsynaptic neuron: an extremely efficient mechanism for removing excess GABA from synaptic clefts on the Deiters' neurone plasma membrane.
Topics: Animals; Biological Transport; Cell Membrane; Diazepam; Diffusion; gamma-Aminobutyric Acid; Mathematics; Muscimol; Neurons; Picrotoxin; Rabbits; Sodium; Synapses; Vestibular Nuclei; Vestibular Nucleus, Lateral | 1986 |
Mechanisms by which picrotoxin and a high dose of diazepam elevate plasma corticosterone level.
Topics: Animals; Apomorphine; Atropine; Bicuculline; Clonidine; Corticosterone; Dexamethasone; Diazepam; Drug Interactions; Female; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Yohimbine | 1986 |
Kindling induced changes in EEG recorded during stimulation from the site of stimulation: collapse of GABA-mediated inhibition and onset of rhythmic synchronous burst.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Inbred Strains | 1986 |
On the action of intravenous picrotoxin in the sensorimotor cortex of the cat.
Topics: Animals; Cats; Cerebral Cortex; Diazepam; Evoked Potentials; Injections, Intravenous; Medulla Oblongata; Neural Pathways; Picrotoxin; Reflex; Thalamus | 1987 |
[Analysis of the depressant effect of diazepam on the amplitude of phrenic nerve discharge in rabbits].
Topics: Action Potentials; Animals; Blood Pressure; Cyproheptadine; Depression, Chemical; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Naloxone; Phrenic Nerve; Picrotoxin; Rabbits | 1985 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Diazepam-induced place preference conditioning: appetitive and antiaversive properties.
Topics: Animals; Appetitive Behavior; Avoidance Learning; Cocaine; Conditioning, Operant; Convulsants; Diazepam; Male; Meprobamate; Naloxone; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
The mesencephalic locomotor region in cat: effects of local applications of diazepam and gamma-aminobutyric acid.
Topics: Animals; Cats; Cerebral Decortication; Diazepam; gamma-Aminobutyric Acid; Locomotion; Muscimol; Picrotoxin; Reaction Time; Reflex; Tegmentum Mesencephali | 1985 |
Respiratory depression produced by injection of GABA into the fourth ventricle of the rabbit.
Topics: Animals; Bicuculline; Depression, Chemical; Diazepam; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Picrotoxin; Rabbits; Respiration | 1985 |
gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]-t-butylbicyclophosphorothionate binding to cerebellar granule cells.
Topics: Animals; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Muscimol; Picrotoxin; Rats; Sulfur Radioisotopes; Temperature | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalography; Picrotoxin; Rabbits; Respiration; Seizures | 1970 |
Diazepam and presynaptic inhibition.
Topics: Animals; Cats; Cold Temperature; Diazepam; Lumbosacral Plexus; Microelectrodes; Neural Inhibition; Neurons, Afferent; Picrotoxin; Reflex, Monosynaptic; Spinal Cord; Spinal Nerves; Synaptic Transmission | 1971 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Diphenhydramine; Electroencephalography; Ethers; Fluorine; Haplorhini; Hydroxides; Hydroxylamines; Isoflurophate; Pentylenetetrazole; Picrotoxin; Pyridoxine; Reserpine; Seizures; Semicarbazides; Strychnine | 1969 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents | 1970 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
Effects of diazepam and picrotoxin on the visual system.
Topics: Animals; Cats; Dark Adaptation; Diazepam; Electric Stimulation; Evoked Potentials; Injections, Intravenous; Light; Ocular Physiological Phenomena; Picrotoxin; Time Factors; Vision, Ocular; Visual Perception | 1971 |
[Action of diazepam on the spinal cord reflex, with special reference to dorsal root reflex].
Topics: Animals; Cats; Chlordiazepoxide; Denervation; Diazepam; Electric Stimulation; Evoked Potentials; Female; Injections, Intraperitoneal; Male; Mice; Picrotoxin; Reflex; Seizures; Solvents; Spinal Cord; Strychnine; Synapses; Time Factors | 1969 |
Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration.
Topics: Animals; Anticonvulsants; Diazepam; Electroshock; Injections, Intraventricular; Male; Peptide Fragments; Picrotoxin; Rats; Seizures; Sincalide | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine | 1984 |
[Effect of diazepam on various effects of morphine use in mice and rats].
Topics: Animals; Bicuculline; Diazepam; Drug Interactions; Etorphine; Male; Mice; Morphine; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Respiration; Synaptic Transmission | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
[Effect of GABA-negative preparations on the anxiolytic and sedative effects of diazepam].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Picrotoxin; Rats | 1981 |
Gabamimetic properties of anxiolytic drugs.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Caudate Nucleus; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Male; Movement; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
[Effects of pentylenetetrazol on conflict behavior and interactions with anxiolytics in rats].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
Rat hippocampal neurons in culture: voltage-clamp analysis of inhibitory synaptic connections.
Topics: Animals; Chlorides; Culture Techniques; Diazepam; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Ion Channels; Kinetics; Membrane Potentials; Neural Inhibition; Neurons; Pentobarbital; Picrotoxin; Rats; Reaction Time; Synapses | 1984 |
Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Amobarbital; Animals; Clonidine; Diazepam; Exploratory Behavior; Fear; Male; Models, Psychological; Picrotoxin; Prazosin; Rats | 1984 |
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Picrotoxin; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures | 1984 |
GABAB receptor-mediated inhibition of serotonin release in the rat brain.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Brain Chemistry; Cerebral Cortex; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Nipecotic Acids; Phentolamine; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Serotonin | 1984 |
Effect of picrotoxin on benzodiazepine receptors and GABA receptors with reference to the effect of C1- ion.
Topics: Animals; Cerebellum; Chlorides; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Intracellular Membranes; Male; Models, Biological; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Synaptosomes | 1981 |
Evidence that ethanol and pentobarbital enhance [3H]diazepam binding at the benzodiazepine-GABA receptor-ionophore complex indirectly.
Topics: Animals; Diazepam; Ethanol; Muscimol; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
Pentobarbital enhances [3H]diazepam binding to soluble receptors at the benzodiazepine--GABA-receptor-ionophore complex.
Topics: Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; In Vitro Techniques; Ionophores; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Diazepam; Kinetics; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Valproic Acid | 1981 |
Picrotoxinin and diazepam bind to two distinct proteins: further evidence that pentobarbital may act at the picrotoxinin site.
Topics: Animals; Brain; Cell Membrane; Diazepam; Kinetics; Male; Molecular Weight; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Sesterterpenes | 1981 |
Ethanol enhances [3H]diazepam binding at the benzodiazepine-gamma-aminobutyric acid receptor-ionophore complex.
Topics: Alcohols; Animals; Brain; Diazepam; Ethanol; In Vitro Techniques; Ionophores; Kinetics; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1981 |
Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites.
Topics: Animals; Brain; Diazepam; Etazolate; Microsomes; Mitochondria; Nicotinic Acids; Picrotoxin; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1982 |
Convulsant and anticonvulsant effects of opioids: relationship to GABA-mediated transmission.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Brain; Convulsants; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Morphine; Naloxone; Narcotics; Picrotoxin; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Transmission | 1982 |
Anisatin modulation of GABA- and pentobarbital-induced enhancement of diazepam binding in rat brain.
Topics: Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Lactones; Male; Neurotoxins; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Sesquiterpenes; Sesterterpenes; Spiro Compounds | 1982 |
[Effect of diazepam on reactivity of hippocampal neurons during blocking of GABA-ergic system].
Topics: Action Potentials; Animals; Bicuculline; Depression, Chemical; Diazepam; Drug Antagonism; Evoked Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons; Picrotoxin; Receptors, Neurotransmitter | 1982 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscle Contraction; Muscle Relaxation; Picrotoxin; Rats; Rats, Mutant Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Pyrethroids of the most potent class antagonize GABA action at the crayfish neuromuscular junction.
Topics: Animals; Astacoidea; Clonazepam; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Neuromuscular Junction; Picrotoxin; Pyrethrins; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptic Transmission | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat.
Topics: Animals; Bicuculline; Cerebellar Nuclei; Diazepam; Functional Laterality; gamma-Aminobutyric Acid; Kainic Acid; Male; Motor Activity; Muscle Tonus; Picrotoxin; Posture; Pyrrolidines; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1984 |
Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Pentylenetetrazole; Picrotoxin; Time Factors | 1983 |
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions.
Topics: Animals; Anticonvulsants; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1983 |
Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens.
Topics: Animals; Apomorphine; Carbachol; Clozapine; Diazepam; Haloperidol; Lisuride; Lysergic Acid Diethylamide; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Reserpine; Septal Nuclei; Sulpiride | 1984 |
[Analysis of the mechanism of the hypothermic action of neurotropic drugs].
Topics: Animals; Cats; Diazepam; Isoproterenol; Nervous System; Nicotine; Oxotremorine; Picrotoxin; Propranolol; Scopolamine; Shivering | 1983 |
Involvement of GABA in palate morphogenesis and its relation to diazepam teratogenesis in two mouse strains.
Topics: Animals; Cells, Cultured; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Palate; Picrotoxin; Pregnancy; Species Specificity; Teratogens | 1983 |
Studies on the interaction between cerebral 5-hydroxytryptamine and gamma-aminobutyric acid in the mode of action of diazepam in the rat.
Topics: Aminobutyrates; Animals; Benzodiazepines; Cats; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Picrotoxin; Serotonin | 1983 |
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; Diazepam; Etomidate; gamma-Aminobutyric Acid; Male; Membranes; Pentobarbital; Picrotoxin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sesterterpenes | 1984 |
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Growth Hormone; In Vitro Techniques; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Strychnine | 1984 |
Comparison of the effects of naloxone and picrotoxin on schedule-controlled responding in the pigeon: possible GABA-antagonistic effects of naloxone.
Topics: Animals; Clonazepam; Columbidae; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; GABA Antagonists; Male; Naloxone; Pentobarbital; Picrotoxin | 1984 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Effects of diazepam and picrotoxin on hyponeophagia in rats.
Topics: Animals; Conflict, Psychological; Diazepam; Feeding Behavior; Female; Food Deprivation; Male; Picrotoxin; Rats; Sex Factors | 1982 |
The inhibitory effect of diazepam on conditioned defensive burying is reversed by picrotoxin.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Diazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Muridae; Picrotoxin | 1982 |
In vivo modulations by GABA-related drugs of met-enkephalin release in basal ganglia of the cat brain.
Topics: Animals; Bicuculline; Cats; Caudate Nucleus; Diazepam; Drug Interactions; Enkephalin, Methionine; Female; gamma-Aminobutyric Acid; Globus Pallidus; Male; Muscimol; Picrotoxin | 1982 |
Interaction between phenytoin and diazepam in mutant Han-Wistar rats with progressive spastic paresis.
Topics: Animals; Diazepam; Drug Interactions; Electromyography; Female; Male; Muscle Spasticity; Muscles; Paralysis; Phenytoin; Picrotoxin; Rats; Rats, Mutant Strains; Time Factors | 1982 |
Differential actions of diazepam on the release of [3H]5-hydroxytryptamine from cortical and midbrain raphe slices in the rat.
Topics: Animals; Brain Stem; Calcium; Cerebral Cortex; Diazepam; Drug Interactions; Male; Picrotoxin; Potassium; Raphe Nuclei; Rats; Serotonin; Time Factors | 1982 |
Pyrethroid toxicology: protective effects of diazepam and phenobarbital in the mouse and the cockroach.
Topics: Allethrins; Animals; Cockroaches; Diazepam; Male; Motor Neurons; Nitriles; Permethrin; Phenobarbital; Picrotoxin; Pyrethrins; Sesterterpenes; Temperature | 1982 |
Picrotoxin-induced disruption of bidirectional active avoidance behavior and locomotor activity.
Topics: Animals; Avoidance Learning; Dextroamphetamine; Diazepam; Lysergic Acid Diethylamide; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains | 1982 |
The stereotyped behavior syndrome: a new model and proposed therapy.
Topics: Animals; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Haloperidol; Humans; Lithium; Male; Models, Psychological; Penicillins; Picrotoxin; Rats; Stereotyped Behavior; Tetanus Toxin | 1981 |
Modification of the macaque's vestibulo-ocular reflex by picrotoxin.
Topics: Animals; Cerebellum; Diazepam; Drug Antagonism; Electrooculography; Eye Movements; gamma-Aminobutyric Acid; Macaca; Picrotoxin | 1981 |
The effect of diazepam on nystagmus induced by stimulation of the lateral geniculate body in the rabbit.
Topics: Animals; Diazepam; Electric Stimulation; Eye Movements; Geniculate Bodies; Kinetics; Male; Picrotoxin; Rabbits; Semicarbazides | 1981 |
Interaction of diphenylhydantoin and benzodiazepines in the CNS.
Topics: Animals; Brain; Diazepam; Electric Conductivity; Lysergic Acid Diethylamide; Phenytoin; Picrotoxin; Raphe Nuclei; Rats; Receptors, Drug | 1980 |
Evidence for a tonic GABAergic control of serotonin neurons in the median raphe nucleus.
Topics: Animals; Bicuculline; Brain Stem; Diazepam; gamma-Aminobutyric Acid; Male; Muscimol; Neurons; Picrotoxin; Probenecid; Raphe Nuclei; Rats; Serotonin | 1981 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1995 |
Involvement of benzodiazepine/GABA-A receptor complex in ethanol-induced state-dependent learning in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Bicuculline; Diazepam; Ethanol; Evaluation Studies as Topic; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A | 1995 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Hypnotics and Sedatives; Male; Medicine, Arabic; Mice; Motor Activity; Naloxone; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Tail | 1995 |
GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Astrocytes; Bicuculline; Brain; Calcium; Calcium Channels; Carbolines; Cell Separation; Chlorides; Diazepam; Evoked Potentials; gamma-Aminobutyric Acid; Gene Expression; Glial Fibrillary Acidic Protein; Hippocampus; Immunoblotting; In Vitro Techniques; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Muscimol; Patch-Clamp Techniques; Peptide Fragments; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Effects of desipramine and alprazolam on forced swimming behaviour of adult rats exposed to prenatal diazepam.
Topics: Alprazolam; Animals; Behavior, Animal; Depression; Desipramine; Diazepam; Electroencephalography; Electrophysiology; Female; Hippocampus; Injections; Locus Coeruleus; Male; Motor Activity; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA; Swimming | 1995 |
The electrophysiological effects of endogenous GABA in the guinea-pig inferior mesenteric ganglion.
Topics: Acetylcholine; Afferent Pathways; Animals; Bicuculline; Colon; Diazepam; Efferent Pathways; Electric Stimulation; Electrophysiology; Evoked Potentials; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Mesentery; Physical Stimulation; Picrotoxin; Receptors, GABA | 1993 |
Increase of tyrosine hydroxylase and its mRNA in the rat substantia nigra pars reticulata by diazepam and picrotoxin.
Topics: Animals; Diazepam; Dopamine Agents; Ergolines; Haloperidol; Male; Picrotoxin; Quinpirole; Rats; Rats, Wistar; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
The cell surface progesterone receptor which stimulates calcium influx in human sperm is unlike the A ring reduced steroid site on the GABAA receptor/chloride channel.
Topics: Acrosome; Binding Sites; Calcium; Chloride Channels; Chlorides; Diazepam; gamma-Aminobutyric Acid; Humans; Male; Pentobarbital; Picrotoxin; Progesterone; Receptors, GABA; Receptors, Progesterone; Spermatozoa | 1994 |
[Effect of preliminary administration of phenobarbital on the toxicity of GABA-lytics in mice].
Topics: 3-Mercaptopropionic Acid; Animals; Antidotes; Barbiturates; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Phenobarbital; Picrotoxin; Time Factors | 1993 |
Studies on picrotoxin binding sites of GABAA receptors in rat cortical synaptoneurosomes.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorine; Desoxycorticosterone; Diazepam; In Vitro Techniques; Male; Membranes; Muscimol; Pentobarbital; Picrotoxin; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Synaptosomes | 1994 |
Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cerebellum; Cloning, Molecular; Convulsants; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Humans; Kidney; Muscimol; Mutation; Picrotoxin; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
Pentobarbital, diazepam, and ethanol abolish the interphase diminution of pain in the formalin test: evidence for pain modulation by GABAA receptors.
Topics: Analgesics; Animals; Chloride Channels; Diazepam; Ethanol; Flumazenil; Formaldehyde; Male; Pain Measurement; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1993 |
Comparison of the effects of propofol, diazepam and pentobarbital on hippocampal potentials evoked by prepyriform stimulation in the freely behaving rat.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Electric Stimulation; Electroencephalography; Evoked Potentials; Female; Hippocampus; Pentobarbital; Picrotoxin; Propofol; Rats; Sleep | 1993 |
Interaction between benzodiazepine and GABA-A receptors in state-dependent learning.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
The anticonvulsant effects of propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat.
Topics: Animals; Anticonvulsants; Diazepam; Female; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Seizures; Thiopental | 1993 |
Electrophysiological characterization of GABAA receptors in anterior pituitary cells of newborn rats.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Diazepam; Drug Tolerance; Electric Conductivity; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA; Zinc | 1995 |
L-lysine is a barbiturate-like anticonvulsant and modulator of the benzodiazepine receptor.
Topics: Animals; Anions; Anticonvulsants; Barbiturates; Bicuculline; Brain Chemistry; Cattle; Central Nervous System Depressants; Diazepam; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentobarbital; Picrotoxin; Radioligand Assay; Receptors, GABA-A; Stimulation, Chemical | 1995 |
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.
Topics: Animals; Carbolines; Cerebellum; Convulsants; Diazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channels; Isomerism; Membrane Potentials; Mice; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Transfection | 1996 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepines; Carbolines; Catecholamines; Corticosterone; Diazepam; Disease Models, Animal; Female; GABA-A Receptor Agonists; Glucocorticoids; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mifepristone; Nadolol; Naltrexone; Neurosecretory Systems; Oxidopamine; Phentolamine; Picrotoxin; Propranolol; Receptors, GABA-A; Spleen; Sympathetic Nervous System | 1996 |
Signaling pathway downstream of GABAA receptor in the growth cone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Axons; Binding Sites; Calcium; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; GTPase-Activating Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Models, Neurological; Muscimol; Myristoylated Alanine-Rich C Kinase Substrate; Neurites; Picrotoxin; Prosencephalon; Proteins; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction; Verapamil | 1996 |
Expression of native GABAA receptors in Xenopus oocytes injected with rat brain synaptosomes.
Topics: Anesthetics; Animals; Brain; Cell Membrane; Chloride Channels; Chlorides; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Picrotoxin; Pregnanediones; Pyridazines; Rats; Receptors, GABA-A; Synaptosomes; Xenopus laevis; Zinc Compounds | 1996 |
The possible involvement of GABAA systems in the antinarcotic effect of majonoside-R2, a major constituent of Vietnamese ginseng, in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Ginsenosides; Male; Mice; Morphine; Pain Measurement; Picrotoxin; Pyrrolidines; Saponins | 1996 |
Picrotoxin induces both hypertension and dopamine release in the rat amygdala.
Topics: Amygdala; Animals; Anticonvulsants; Cardiovascular System; Convulsants; Diazepam; Dopamine; Dopamine Antagonists; Haloperidol; Hypertension; Injections, Intraventricular; Male; Neurons; Norepinephrine; Oxidopamine; Picrotoxin; Rats; Rats, Sprague-Dawley; Serotonin; Sympatholytics | 1996 |
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Behavior, Animal; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mitochondria; Motor Activity; Pain Measurement; Picrotoxin; Progesterone; Receptors, GABA-A; RNA; Stress, Psychological; Triazolam | 1996 |
GABAergic influences on plus-maze behaviour in mice.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Diazepam; GABA Modulators; Male; Mice; Mice, Inbred DBA; Muscimol; Nipecotic Acids; Oximes; Picrotoxin; Valproic Acid | 1996 |
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Seizures; Zolpidem | 1995 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Diazepam-insensitive GABAA receptors on postnatal spiral ganglion neurones in culture.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Carbolines; Cells, Cultured; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Spiral Ganglion; Zinc | 1997 |
[The effect of aminooxyacetic acid on the antidote activity of diazepam after exposure to GABA-lytics].
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Drug Interactions; GABA Agents; Male; Mice; Picrotoxin; Seizures | 1994 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Synergism; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures | 1999 |
GABAergic modulation of neocortical long-term potentiation in the freely moving rat.
Topics: Animals; Diazepam; Electric Stimulation; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Long-Term Potentiation; Male; Neocortex; Picrotoxin; Rats; Rats, Long-Evans; Receptors, GABA-A | 2000 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits.
Topics: Animals; Bass; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Humans; Neurons; Oocytes; Perches; Picrotoxin; Receptors, GABA; Retina; Xenopus; Zinc | 1999 |
The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.
Topics: Amino Acid Sequence; Animals; Anti-Ulcer Agents; Anticonvulsants; Antitubercular Agents; Brain Chemistry; Diazepam; Drug Interactions; Drug Tolerance; Epilepsy; Isoniazid; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Peptide Fragments; Picrotoxin; Proteins; Receptors, GABA-A; Substance Withdrawal Syndrome | 1999 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2000 |
Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats.
Topics: Ammonia; Animals; Anticonvulsants; Arginine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Tissue Distribution | 1999 |
Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anticonvulsants; Arachidonic Acid; Binding, Competitive; Cells, Cultured; Cyclooxygenase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Monounsaturated; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Indomethacin; Kidney; Linoleic Acid; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazoles | 2000 |
Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Male; Maze Learning; Mice; Motor Activity; Picrotoxin | 2000 |
Pharmacological evidence for a role of gamma-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain.
Topics: Animals; Brain; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Nitric Oxide Synthase; Picrotoxin; Rats; Receptors, GABA-A | 2001 |
Anxiolytic effects of valproate and diazepam in mice are differentially sensitive to picrotoxin antagonism.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Decision Making; Diazepam; Exploratory Behavior; GABA Antagonists; Male; Mice; Mice, Inbred DBA; Motor Activity; Picrotoxin; Valproic Acid | 2001 |
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
Topics: Animals; Bicarbonates; Bicuculline; Chlorides; Diazepam; Electrophysiology; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Organ Culture Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Subthalamic Nucleus | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hyperammonemia; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail | 2002 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2002 |
Possible anxiolytic effects of ivermectin in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Ivermectin; Locomotion; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2002 |
Gaba-benzodiazepine receptor complex in brain oxidative metabolism regulation.
Topics: Animals; Diazepam; Flumazenil; Frontal Lobe; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Oxygen Consumption; Picrotoxin; Rats; Rats, Wistar | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny.
Topics: Age Factors; Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Convulsants; Diazepam; Exploratory Behavior; Female; GABA Agonists; Habituation, Psychophysiologic; Handling, Psychological; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Reflex; Reflex, Startle; Stress, Physiological; Swimming; Zolpidem | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
GABAergic system in the anxiolytic effect of Proproten: experimental study.
Topics: Animals; Anti-Anxiety Agents; Antibodies; Behavior, Animal; Bicuculline; Diazepam; GABA-A Receptor Antagonists; Male; Picrotoxin; Rats; Receptors, GABA-A; S100 Proteins | 2003 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
Increased fear learning coincides with neuronal dysinhibition and facilitated LTP in the basolateral amygdala following benzodiazepine withdrawal in rats.
Topics: Amygdala; Animals; Benzodiazepines; Diazepam; Electric Stimulation; Evoked Potentials; Fear; GABA Antagonists; GABA Modulators; Learning; Long-Term Potentiation; Male; Neurons; Picrotoxin; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2004 |
Electrophysiological properties of mouse horizontal cell GABAA receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Electrophysiology; GABA Agonists; GABA Antagonists; GABA Modulators; In Vitro Techniques; Interneurons; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Picrotoxin; Pyridines; Receptors, GABA-A; Retina; Zolpidem | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Electroshock; Epilepsy; Exploratory Behavior; Isoniazid; Male; Mice; Motor Activity; Penicillins; Phytotherapy; Picrotoxin; Plant Preparations; Psychomotor Performance; Rats; Reaction Time; Time Factors; Tubocurarine | 2004 |
Blockade of the picrotoxin-induced in vivo release of dopamine in the cat caudate nucleus by diazepam.
Topics: Animals; Catheterization; Cats; Caudate Nucleus; Central Nervous System Stimulants; Diazepam; Dopamine; Drug Therapy, Combination; Female; Male; Picrotoxin; Tyrosine | 1977 |
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons.
Topics: Animals; Bicuculline; Cocaine; Diazepam; Dopamine; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Mesencephalon; Neuronal Plasticity; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 2005 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
Topics: Animals; Diazepam; Fossils; Hypnotics and Sedatives; Male; Mammals; Mice; Mice, Inbred ICR; Motor Activity; Pentobarbital; Picrotoxin; Seizures; Sleep; Tissue Extracts | 2006 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Interaction of diazepam and swim stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming | 2007 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine | 2008 |
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mice; Mice, Inbred BALB C; Phytotherapy; Picrotoxin; Plant Preparations; Seizures; Vicia faba | 2008 |
Neuroendocrine, behavioral and macrophage activity changes induced by picrotoxin effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Diazepam; Flow Cytometry; GABA Antagonists; Hypothalamus; Immunity, Innate; Macrophages, Alveolar; Methoxyhydroxyphenylglycol; Mice; Neurosecretory Systems; Norepinephrine; Picrotoxin; Prefrontal Cortex; Respiratory Burst; Stress, Psychological | 2008 |
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; GABA Antagonists; Interpersonal Relations; Male; Mice; Picrotoxin; Pregnanolone; Progesterone; Purines; Receptors, GABA-A | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem | 2008 |
Behavioral differences on memory retrieval between two variants of step-through inhibitory avoidance task in mice.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Diazepam; Drug Interactions; Electroshock; GABA Antagonists; Inhibition, Psychological; Male; Memory; Mice; Picrotoxin; Reaction Time; Retention, Psychology | 2008 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Hypnotics and Sedatives; Isoniazid; Male; Medicine, African Traditional; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Sleep Initiation and Maintenance Disorders; Stereotyped Behavior; Strychnine | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Capsaicin; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Epilepsy; GABA Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Serotonin; TRPV Cation Channels | 2009 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; Dizocilpine Maleate; Fever; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Humans; Infant; Japan; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Picrotoxin; Purinergic P1 Receptor Agonists; Saccharomyces cerevisiae; Seizures | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures | 2010 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine | 2011 |
Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system.
Topics: Benzodiazepines; Bicuculline; Diazepam; GABA Agents; GABA Agonists; GABA Antagonists; GABA Modulators; Gene Expression; HEK293 Cells; High-Throughput Screening Assays; Humans; Imidazoles; Ion Channel Gating; Microfluidic Analytical Techniques; Muscimol; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection | 2012 |
The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: involvement of GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; GABA Antagonists; Male; Montanoa; Motor Activity; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Receptors, GABA-A; Water | 2012 |
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 2012 |
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Lavandula; Male; Mice; Motor Activity; Oils, Volatile; Picrotoxin; Piperazines; Plant Oils; Pyridines; Rats; Receptors, GABA-A; Serotonin Antagonists; Serotonin Receptor Agonists; Serotonin Syndrome; Synaptic Transmission | 2013 |
p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo.
Topics: Animals; Anti-Anxiety Agents; Coumaric Acids; Diazepam; GABA Antagonists; Male; Motor Activity; Phytochemicals; Picrotoxin; Propionates; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2014 |
Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Castration; Diazepam; Dioxanes; Dioxoles; Dopamine; Fluvoxamine; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Mice; Norepinephrine; Nucleus Accumbens; Orchiectomy; Phenazocine; Picrotoxin; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1A; Receptors, GABA; Receptors, GABA-A; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Sigma-1 Receptor; Synaptic Transmission; Ventral Tegmental Area | 2016 |
Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity.
Topics: Acetylcholinesterase; Acyclic Monoterpenes; Adjuvants, Anesthesia; Analysis of Variance; Anesthesia; Anesthetics; Animals; Brain; Catfishes; Cymenes; Diazepam; GABA Antagonists; Monoterpenes; Muscles; Oils, Volatile; Picrotoxin; Receptors, GABA-A; Reproducibility of Results; Statistics, Nonparametric; Thymol; Time Factors | 2017 |
GABA
Topics: Allosteric Regulation; Alprazolam; Benzodiazepines; Bicuculline; Binding, Competitive; Cryoelectron Microscopy; Diazepam; GABA Modulators; Humans; Ligands; Models, Molecular; Nanostructures; Picrotoxin; Receptors, GABA-A; Signal Transduction | 2019 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water | 2021 |
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Picrotoxin; Seizures; Synaptic Transmission | 2021 |