diazepam and nicotine

diazepam has been researched along with nicotine in 83 studies

Research

Studies (83)

TimeframeStudies, this research(%)All Research%
pre-199028 (33.73)18.7374
1990's15 (18.07)18.2507
2000's24 (28.92)29.6817
2010's16 (19.28)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Butler, DE; Marriott, JG; Poschel, BP1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Caron, G; Ermondi, G1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Carrupt, PA; Martel, S; Ottaviani, G1
Abraham, MH; Acree, WE; Ibrahim, A1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Garibova, TL; Klygul', TA; Vikhliaev, IuI1
Ando, K; Hironaka, N; Miyata, H1
Burkhart-Kasch, S; Crabbe, JC; Gwiazdon, CC; Phillips, TJ1
Barnes, NM; Costall, B; Kelly, ME; Naylor, RJ; Onaivi, ES1
Furusawa, K; Tadokoro, S1
Vig, MM1
Costall, B; Kelly, ME; Naylor, RJ; Onaivi, ES1
Balfour, DJ; Graham, CA; Vale, AL1
Emmett-Oglesby, MW; Harris, CM; Lal, H1
Acquas, E; Carboni, E; Di Chiara, G; Leone, P1
White, JM1
Iasnetsov, VS; Novikov, VE1
Dam, M; London, ED; Szikszay, M1
Emmett-Oglesby, MW; Harris, CM; Lal, H; Robinson, NG1
Ellison, G; Potthoff, A1
Alvarado-Garcia, R; Lee, MA; Witkin, JM; Witkin, KM1
de la Garza, R; Johanson, CE1
Calabrese, P; Campese, VM; Cuomo, V; Marino, A1
Bishun, NP; Lloyd, N; Mills, J; Parke, DV; Raven, RW; Williams, DC1
Jaques, R; Rüegg, M1
Rohmert, W; Sälzer, M1
Bhagat, B; Wheeler, N1
Morrison, C; Stephenson, JA1
Inoki, R; Iwatsubo, K; Shigenaga, Y1
Inoki, R; Iwatsubo, K; Toyata, T1
Hester, JB; Rudzik, AD; Veldkamp, W1
Dretchen, K; Ghoneim, MM; Long, JP1
de Carolis, AS; Longo, VG1
Ator, NA; Bigelow, GE; Brady, JV; Emurian, HH; Griffiths, RR; Hienz, RD; Lukas, SE; Nellis, MJ; Pearlson, GD; Ray, RL1
Lupandin, IuV1
Emley, GS; Hutchinson, RR1
Brandt, K; Daub, D; Hunger, L; Lehmann, KA1
Brioni, JD; O'Neill, AB1
Kuribara, H1
Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB1
Burkholder, T; Cao, W; Collins, AC; Wilkins, L1
Elsner, J; Liu, G1
Ahtee, L; Lahtinen, S; Salminen, O1
Gomita, Y; Kawasaki, H; Suemaru, K1
Bienkowski, P; Kostowski, W1
Bizot, JC1
Iida, Y; Kitano, H; Konishi, J; Magata, Y; Nishizawa, S; Saji, H; Shiozaki, T1
Gulbis, B; Jauniaux, E1
Akanezi, C; Cheeta, S; File, SE1
Kurasawa, M; Nakamura, K1
Quertemont, E1
Puura, A1
Liu, Y; Sun, X; Wang, H; Wang, Y1
Druid, H; Kronstrand, R; Nyström, I; Strandberg, J1
Chau, PP; Löf, E; Söderpalm, B; Stomberg, R1
Baarendse, PJ; Trezza, V; Vanderschuren, LJ1
Braun, AA; Skelton, MR; Vorhees, CV; Williams, MT1
Cheng, K; Koek, W; Rice, KC1
Gruca, P; Lason-Tyburkiewicz, M; Litwa, E; Papp, M; Willner, P1
Ali Beig, H; Bourbour, Z; Chalabi-Yani, D; Hosseini, SB; Meftahi, GH; Ranjabaran, M; Sadeghi-Gharajehdaghi, S; Sahraei, H1
Axelsen, MC; Jacobsen, J; Marxen, E; Pedersen, AML1
Asanuma, M; Kanemoto, E; Kanzaki, H; Kitamura, Y; Machida, A; Miyazaki, I; Naito, N; Nakamura, Y; Sendo, T; Sugimoto, M1
Alves-Gomes, JA; de Jesus, IS; Ferreira, M; Silva-Júnior, UL1
Adermark, L; Andrén, A; Ericson, M; Morud, J; Söderpalm, B; Strandberg, J1
Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S1

Reviews

3 review(s) available for diazepam and nicotine

ArticleYear
Chromosome damage induced by chemicals.
    Chemico-biological interactions, 1973, Volume: 6, Issue:6

    Topics: Antineoplastic Agents; Aspirin; Benzene; Caffeine; Chloramphenicol; Chlorine; Chlorpromazine; Chromosome Aberrations; Chromosomes; Colchicine; Contraceptives, Oral; Cyclamates; Diazepam; Dibenzazepines; Drug Evaluation; Ethanol; Humans; Hydroxylamines; Lithium; Lymphocyte Culture Test, Mixed; Lysergic Acid Diethylamide; Nicotine; Organophosphorus Compounds; Ozone; Pesticides; Phenylbutazone

1973
Review of the multiple chemical exposure factors which may disturb human behavioral development.
    Sozial- und Praventivmedizin, 1995, Volume: 40, Issue:4

    Topics: Animals; Behavior, Animal; Cadmium; Child Behavior; Child Development; Child, Preschool; Diazepam; Environmental Pollutants; Ethanol; Humans; Infant; Lead; Nicotine; Polychlorinated Biphenyls; Primates; Rats; Solvents

1995
In vivo investigation of placental transfer early in human pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 2000, Volume: 92, Issue:1

    Topics: Body Fluids; Diazepam; Female; Humans; Inulin; Nicotine; Pharmaceutical Preparations; Placenta; Pregnancy; Pregnancy Trimesters; Propofol; Suction; Ultrasonography, Prenatal; Yolk Sac

2000

Trials

2 trial(s) available for diazepam and nicotine

ArticleYear
[Investigation on the time series of the hand-tremor amplitude under the influence of different pharmacas (author's transl)].
    European journal of applied physiology and occupational physiology, 1974, Volume: 33, Issue:1

    Topics: Adult; Body Height; Body Weight; Caffeine; Diazepam; Ethanol; Glucose; Hand; Humans; Nicotine; Placebos; Rest; Smoking; Time Factors; Tremor

1974
Transdermal nicotine increases heart rate after endotracheal intubation.
    Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:5

    Topics: Adjuvants, Anesthesia; Administration, Cutaneous; Adult; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Diazepam; Double-Blind Method; Female; Fentanyl; Heart Rate; Humans; Intubation, Intratracheal; Male; Middle Aged; Nicotine; Perioperative Care; Prospective Studies; Smoking; Substance Withdrawal Syndrome; Thiopental

2003

Other Studies

78 other study(ies) available for diazepam and nicotine

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Cognition-activating properties of 3-(Aryloxy)pyridines.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:3

    Topics: Animals; Cognition; Dose-Response Relationship, Drug; Male; Mice; Psychotropic Drugs; Pyridines; Structure-Activity Relationship

1981
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Experimental characteristics of the spectrum of pharmacologic activity of the tranquilizer lorazepam].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Chlordiazepoxide; Conflict, Psychological; Diazepam; Drug Synergism; Hexobarbital; Humans; Hypnotics and Sedatives; Inhibition, Psychological; Mice; Muscle Relaxants, Central; Nicotine; Nitrazepam; Pentylenetetrazole; Rats; Reaction Time

1975
Effects of psychoactive drugs on short-term memory in rats and rhesus monkeys.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:1

    Topics: Animals; Chlorpromazine; Diazepam; Discrimination Learning; Injections, Subcutaneous; Macaca mulatta; Male; Memory, Short-Term; Nicotine; Rats; Scopolamine

1992
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Pentobarbital; Substance-Related Disorders

1992
Ketotifen and its analogues reduce aversive responding in the rodent.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4

    Topics: Animals; Avoidance Learning; Behavior, Animal; Benzamides; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Diazepam; Ethanol; Exploratory Behavior; Granisetron; Indazoles; Ketotifen; Male; Mice; Mice, Inbred Strains; Nicotine; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin Antagonists; Social Behavior

1990
Effects of psychoactive drugs on the conflict behavior under operant situation in Mongolian gerbils (Meriones unguiculatus).
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1990, Volume: 10, Issue:2

    Topics: Animals; Caffeine; Conditioning, Operant; Conflict, Psychological; Diazepam; Ethanol; Gerbillinae; Male; Morphine; Nicotine; Pentobarbital; Psychotropic Drugs

1990
Nicotine poisoning in a dog.
    Veterinary and human toxicology, 1990, Volume: 32, Issue:6

    Topics: Animals; Charcoal; Diazepam; Dogs; Nicotine; Poisoning

1990
The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuse.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:6

    Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Diazepam; Ethanol; Ketotifen; Male; Mice; Nicotine; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders

1990
Studies on the possible role of brain 5-HT systems and adrenocortical activity in behavioural responses to nicotine and diazepam in an elevated X-maze.
    Psychopharmacology, 1986, Volume: 90, Issue:4

    Topics: Animals; Brain Chemistry; Corticosterone; Diazepam; Drug Administration Schedule; Hydroxyindoleacetic Acid; Male; Motor Activity; Nicotine; Rats; Rats, Inbred Strains; Serotonin

1986
Sensitivity of pentylenetetrazol discrimination increased by a stimulus fading technique.
    Psychopharmacology, 1989, Volume: 98, Issue:4

    Topics: Animals; Benzodiazepinones; Diazepam; Discrimination, Psychological; Male; Nicotine; Pentylenetetrazole; Rats

1989
SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade?
    Psychopharmacology, 1989, Volume: 99, Issue:2

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzazepines; Choice Behavior; Diazepam; Injections, Subcutaneous; Male; Morphine; Motivation; Naloxone; Nicotine; Phencyclidine; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine

1989
Behavioral interactions between nicotine and diazepam.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Nicotine; Rats; Rats, Inbred Strains; Reinforcement Schedule

1989
[The GABA-ergic system and brain edema].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benactyzine; Benzodiazepines; Benzodiazepinones; Brain Edema; Brain Injuries; Diazepam; Drug Evaluation, Preclinical; Drug Interactions; Female; gamma-Aminobutyric Acid; Male; Nicotine; Parasympatholytics; Phentolamine; Picrotoxin; Rats; Receptors, GABA-A

1985
Metabolic mapping of the cerebral effects of abused drugs.
    NIDA research monograph, 1986, Volume: 67

    Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxy Sugars; Deoxyglucose; Diazepam; Humans; Nicotine; Phencyclidine; Rats; Substance-Related Disorders; Tissue Distribution

1986
Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ).
    Psychopharmacology, 1986, Volume: 90, Issue:1

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome

1986
Increased alcohol intake induced by chronic stimulants: is "orality" involved?
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1

    Topics: Alcohol Drinking; Animals; Dextroamphetamine; Diazepam; Humans; Nicotine; Rats; Taste

1987
Nonmuscarinic neurotoxicity of oxotremorine.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Nervous System; Nicotine; Oxotremorine; Pilocarpine; Rats; Rats, Inbred Strains; Salivation; Scopolamine; Seizures; Time Factors

1987
The effects of food deprivation on the self-administration of psychoactive drugs.
    Drug and alcohol dependence, 1987, Volume: 19, Issue:1

    Topics: Animals; Cocaine; Dextroamphetamine; Diazepam; Food Deprivation; Macaca mulatta; Male; Nicotine; Perphenazine; Reinforcement, Psychology; Self Administration; Substance-Related Disorders

1987
[Influence of bromazepam and of diazepam on the acute toxicity and ECG changes caused by nicotine in guinea pigs].
    Bollettino della Societa italiana di biologia sperimentale, 1974, Jun-15, Volume: 50, Issue:11

    Topics: Acute Disease; Animals; Anti-Anxiety Agents; Arrhythmias, Cardiac; Diazepam; Electrocardiography; Guinea Pigs; Heart; Heart Block; Heart Conduction System; Nicotine

1974
Some peripheral pharmacological characteristics of benzoctamine.
    Pharmacology, 1971, Volume: 6, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Anaphylaxis; Animals; Anthracenes; Arachidonic Acids; Bradykinin; Chlordiazepoxide; Chlorpromazine; Diazepam; Epinephrine; Guinea Pigs; Histamine H1 Antagonists; Isoproterenol; Male; Mescaline; Mice; Nicotine; Norepinephrine; Serotonin Antagonists; Species Specificity; Sympatholytics; Tranquilizing Agents

1971
Effect of nicotine on the swimming endurance of rats.
    Neuropharmacology, 1973, Volume: 12, Issue:12

    Topics: Amphetamine; Animals; Chlordiazepoxide; Dextroamphetamine; Diazepam; Injections, Intramuscular; Injections, Subcutaneous; Male; Methylphenidate; Nicotine; Rats; Swimming; Time Factors

1973
Drug effects on unconditioned light-avoidance in the rat.
    Psychopharmacologia, 1972, Volume: 24, Issue:4

    Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Chlordiazepoxide; Dextroamphetamine; Diazepam; Exploratory Behavior; Female; Light; Nicotine; Rats; Stimulation, Chemical

1972
[Pharmacological studies of a new minor tranquilizer, dipotassium chlorazepate (7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine 3-carboxylic acid monopotassium salt monopotassium hydroxide). 1. Central action].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:3

    Topics: Animals; Anticonvulsants; Apomorphine; Bemegride; Benzazepines; Central Nervous System; Cerebral Cortex; Diazepam; Dogs; Electroencephalography; Evoked Potentials; Hexobarbital; Hypothalamus; Limbic System; Male; Mice; Morphine; Nicotine; Pentylenetetrazole; Rats; Strychnine; Tranquilizing Agents; Tremorine

1972
[Pharmacological studies of a new minor tranquilizing agent, dipotassium chlorazepate (7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine-3-carboxylic acid monopotassium salt monopotassium hydroxide). 2. General pharmacology].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:3

    Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Benzazepines; Blood Pressure; Body Temperature; Carboxylic Acids; Cats; Diazepam; Epinephrine; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Junction; Nicotine; Norepinephrine; Potassium; Rabbits; Rats; Reflex; Respiration; Spinal Cord; Tranquilizing Agents

1972
Pyrrolo[3,2,1-jk][1,4]benzodiazepines and pyrrolo[1,2,3-ef][1,5]benzodiazepines which have central nervous system activity.
    Journal of medicinal chemistry, 1970, Volume: 13, Issue:5

    Topics: Animals; Behavior, Animal; Benzazepines; Central Nervous System; Chemical Phenomena; Chemistry; Diazepam; Male; Mice; Muscle Contraction; Nicotine; Pyrroles; Reflex; Seizures

1970
The interaction of diazepam with myoneural blocking agents.
    Anesthesiology, 1971, Volume: 34, Issue:5

    Topics: Acetylcholine; Adjuvants, Anesthesia; Adult; Animals; Cats; Chickens; Decamethonium Compounds; Diazepam; Dogs; Electric Stimulation; Female; Gallamine Triethiodide; Halothane; Humans; Male; Muscle Contraction; Muscles; Neuromuscular Junction; Nicotine; Nitrous Oxide; Sciatic Nerve; Tubocurarine; Ulnar Nerve

1971
Studies on the anticonvulsant properties of some benzodiazepines. (Chlordiazepoxide, diazepam, oxazepam).
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:12

    Topics: Action Potentials; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Electroencephalography; Female; Male; Morphine; Nicotine; Oxazepam; Phenobarbital; Phenytoin; Rabbits; Seizures; Strychnine

1967
Abuse liability and behavioral toxicity assessment: progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.
    NIDA research monograph, 1984, Volume: 49

    Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Caffeine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Marijuana Abuse; Nicotine; Papio; Phencyclidine; Phencyclidine Abuse; Smoking; Substance-Related Disorders

1984
[Analysis of the mechanism of the hypothermic action of neurotropic drugs].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1983, Volume: 69, Issue:8

    Topics: Animals; Cats; Diazepam; Isoproterenol; Nervous System; Nicotine; Oxotremorine; Picrotoxin; Propranolol; Scopolamine; Shivering

1983
Unique influences of ten drugs upon post-shock biting attack and pre-shock manual responding.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:1

    Topics: Aggression; Animals; Bites and Stings; Caffeine; Chlordiazepoxide; Chlorpromazine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diazepam; Electroshock; Ethanol; Female; Humans; Male; Morphine; Nicotine; Phenobarbital; Saimiri

1983
[Biotransformation of fentanyl. III. Effect of chronic drug exposure on the distribution, metabolism and excretion in the rat].
    Der Anaesthesist, 1983, Volume: 32, Issue:4

    Topics: Animals; Biotransformation; Central Nervous System Depressants; Dealkylation; Diazepam; Ethanol; Fentanyl; In Vitro Techniques; Male; Nicotine; Promethazine; Rats; Rats, Inbred Strains; Tissue Distribution

1983
Benzodiazepine receptor mediation of the anxiolytic-like effect of (-)-nicotine in mice.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Flumazenil; Male; Mecamylamine; Mice; Nicotine; Receptors, GABA-A; Receptors, Nicotinic

1994
Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.
    The Japanese journal of psychiatry and neurology, 1994, Volume: 48, Issue:3

    Topics: Animals; Avoidance Learning; Caffeine; Chlorpromazine; Diazepam; Electroshock; Imipramine; Male; Mice; Morphine; Nicotine; Psychotropic Drugs; Signal Detection, Psychological

1994
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1994
A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: Animals; Behavior, Animal; Conflict, Psychological; Diazepam; Ethanol; Genetics, Behavioral; Male; Mice; Mice, Inbred Strains; Nicotine; Sleep

1993
Expression of Fos protein in various rat brain areas following acute nicotine and diazepam.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 54, Issue:1

    Topics: Amino Acid Sequence; Animals; Brain Chemistry; Diazepam; GABA Modulators; Gene Expression Regulation; Immunohistochemistry; Male; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stress, Psychological

1996
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1997, Volume: 17, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pindolol; Propranolol; Rats; Rats, Wistar; Tail; Tremor

1997
Discrimination of ethanol in rats: effects of nicotine, diazepam, CGP 40116, and 1-(m-chlorophenyl)-biguanide.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Biguanides; Diazepam; Discrimination Learning; Drug Interactions; Ethanol; GABA Modulators; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Serotonin Receptor Agonists

1998
Effects of psychoactive drugs on temporal discrimination in rats.
    Behavioural pharmacology, 1997, Volume: 8, Issue:4

    Topics: Animals; Atropine; Clomipramine; Desipramine; Diazepam; Discrimination Learning; Discrimination, Psychological; Haloperidol; Male; Nicotine; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine

1997
Effect of chronic (-)-nicotine treatment on rat cerebral benzodiazepine receptors.
    Nuclear medicine and biology, 2000, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Flumazenil; Iodine Radioisotopes; Male; Nicotine; Nicotinic Agonists; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, GABA-A; Tissue Distribution

2000
Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action.
    Brain research, 2001, Jan-12, Volume: 888, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Gerbillinae; Interpersonal Relations; Male; Motor Activity; Nicotine; Reaction Time

2001
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
    European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological

2001
Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: lack of acetaldehyde substitution.
    Behavioural pharmacology, 2003, Volume: 14, Issue:4

    Topics: Acetaldehyde; Animals; Conditioning, Psychological; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Male; Nicotine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Taste

2003
Evidence that muscarinic receptors are involved in nicotine-facilitated spatial memory.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:4

    Topics: Animals; Atropine; Diazepam; GABA Modulators; Male; Maze Learning; Memory; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Psychomotor Performance; Rats; Receptors, Muscarinic; Space Perception

2004
Screening for drugs of abuse in hair with ion spray LC-MS-MS.
    Forensic science international, 2004, Oct-29, Volume: 145, Issue:2-3

    Topics: Amphetamines; Anti-Anxiety Agents; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Cotinine; Diazepam; Dopamine Uptake Inhibitors; Drug Overdose; Flunitrazepam; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Morphine; Morphine Derivatives; Narcotics; Nicotine; Nicotinic Agonists; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection

2004
Ethanol-induced dopamine elevation in the rat--modulatory effects by subchronic treatment with nicotinic drugs.
    European journal of pharmacology, 2007, Jan-26, Volume: 555, Issue:2-3

    Topics: Animals; Central Nervous System Depressants; Corpus Striatum; Diazepam; Dopamine; Ethanol; GABA Modulators; Hexamethonium; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, GABA

2007
Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:12

    Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Diazepam; Dopamine Antagonists; Ethanol; Exploratory Behavior; Flupenthixol; Locomotion; Male; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Social Behavior

2009
Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 97, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Female; Male; Maze Learning; Nicotine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Yohimbine

2011
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3

    Topics: Animals; Baclofen; Benzodiazepines; Benzofurans; Cocaine; Columbidae; Diazepam; Discrimination, Psychological; Ethanol; GABA-B Receptor Agonists; Illicit Drugs; Nicotine; Organophosphorus Compounds; Phenols; Sodium Oxybate

2013
Effects of chronic mild stress on the development of drug dependence in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:5-6

    Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders

2014
Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
    Iranian biomedical journal, 2015, Volume: 19, Issue:4

    Topics: Anesthetics, Local; Animals; Conditioning, Psychological; Diazepam; Dopaminergic Neurons; Ketamine; Lidocaine; Male; Nicotine; Rats; Rats, Wistar; Reward; Ventral Tegmental Area

2015
Effect of cryoprotectants for maintaining drug permeability barriers in porcine buccal mucosa.
    International journal of pharmaceutics, 2016, Sep-10, Volume: 511, Issue:1

    Topics: Animals; Cryoprotective Agents; Diazepam; Mouth Mucosa; Nicotine; Permeability; Swine

2016
Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antineoplastic Agents; Anxiety; Behavior, Animal; Cell Proliferation; Cognitive Dysfunction; Cyclophosphamide; Diazepam; Doxorubicin; Drug Interactions; Hippocampus; Male; Nicotine; Nicotinic Antagonists; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger; Spatial Memory

2017
Effects of Neuroactive Drugs in the Discharge Patterns of Microsternarchus (Hypopomidae: Gymnotiformes) Electric Organ.
    Zebrafish, 2017, Volume: 14, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Central Nervous System Stimulants; Diazepam; Doxapram; Electric Organ; Gymnotiformes; Nicotine; Nicotinic Agonists

2017
Progressive modulation of accumbal neurotransmission and anxiety-like behavior following protracted nicotine withdrawal.
    Neuropharmacology, 2018, Volume: 128

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Corpus Striatum; Dendritic Spines; Diazepam; Disease Models, Animal; Evoked Potentials; Excitatory Postsynaptic Potentials; Locomotion; Male; Neurons; Nicotine; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA; Substance Withdrawal Syndrome; Synaptic Transmission

2018
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
    Journal of pharmacological sciences, 2018, Volume: 137, Issue:2

    Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbamazepine; Diazepam; Disease Models, Animal; Essential Tremor; Ethosuximide; Male; Mice, Inbred Strains; Nicotine; Phenobarbital; Propranolol; Pyridines; Valproic Acid

2018