diazepam and metoprolol

diazepam has been researched along with metoprolol in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199010 (20.00)18.7374
1990's3 (6.00)18.2507
2000's21 (42.00)29.6817
2010's16 (32.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Ghuloum, AM; Jain, AN; Sage, CR1
Topliss, JG; Yoshida, F1
Ertl, P; Rohde, B; Selzer, P1
Artursson, P; Luthman, K; Norinder, U; Stenberg, P1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Caron, G; Ermondi, G1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Abraham, MH; Acree, WE; Ibrahim, A1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Avdeef, A; Tam, KY1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Artursson, P; Mateus, A; Matsson, P1
Beaumont, K; Di, L; Maurer, TS; Smith, DA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Deeg, P; Heidland, A; Reuther, P; Röckel, A1
Blom, L; Brondbjerg, M; Jakobsen, CJ; Lenler-Petersen, P1
Forssell, H; Kaila, T; Lehmijoki, O; Salonen, M; Scheinin, M1
Betts, TA; Blake, A; Crowe, A; Harvey, P; Knight, R; Mortiboy, D1
Handley, SL; Heaton, JC; Rea, PJ; Singh, L1
Hayashi, F; Kataoka, Y; Kitada, O; Kurosu, I; Miyauchi, N; Nishioka, Y; Suenaga, N; Sugita, M1
Hanak, T1
Betts, T; Crowe, A; Hawksworth, G; Knight, R; Nyemitei-Addo, I; Parry, K; Parsons, A; Petrie, JC; Raffle, A1
Johansson, G; Luostarinen, M; Virkkunen, P1
Klotz, U; Reimann, IW1
Motokawa, K; Naito, H; Ohashi, N; Sato, S; Takahashi, H1
Noma, T; Sugimoto, Y; Yamada, J1
Baron, MG; Hetheridge, MJ; Jackson, SK; Jha, AN; Mintram, KS; Moody, AJ; Owen, SF; Purcell, WM1
Harwood, MD; Jamei, M; Musther, H; Rostami-Hodjegan, A; Turner, DB; Yang, J1
Coboeken, K; Dallmann, A; Eissing, T; Hempel, G; Ince, I1

Reviews

1 review(s) available for diazepam and metoprolol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for diazepam and metoprolol

ArticleYear
Effect of metoprolol and diazepam on pre-operative anxiety.
    Anaesthesia, 1990, Volume: 45, Issue:1

    Topics: Adult; Anxiety; Blood Pressure; Diazepam; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Male; Metoprolol; Orthopedics; Preanesthetic Medication

1990
A comparison of two sedative premedications for minor oral surgery under local anaesthesia.
    International journal of oral and maxillofacial surgery, 1989, Volume: 18, Issue:4

    Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Blood Pressure; Diazepam; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Metoprolol; Molar, Third; Morphine; Preanesthetic Medication; Random Allocation; Scopolamine; Tooth Extraction

1989
[Treatment of functional sympathicotonic circulatory regulation disorders with metoprolol in depot form. Cross-over double-blind study with diazepam and Beloc-Duriles].
    Die Medizinische Welt, 1983, Jun-24, Volume: 34, Issue:25-26

    Topics: Adrenergic beta-Antagonists; Adult; Cardiovascular Diseases; Delayed-Action Preparations; Diazepam; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Metoprolol; Propanolamines; Random Allocation

1983
Diazepam/beta-adrenoceptor antagonist interactions.
    British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Animals; Atenolol; Diazepam; Drug Interactions; Emotions; Humans; In Vitro Techniques; Kinetics; Male; Metoprolol; Microsomes, Liver; Nordazepam; Propranolol; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Visual Acuity

1984

Other Studies

45 other study(ies) available for diazepam and metoprolol

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Molecular hashkeys: a novel method for molecular characterization and its application for predicting important pharmaceutical properties of molecules.
    Journal of medicinal chemistry, 1999, May-20, Volume: 42, Issue:10

    Topics: Drug Design; Intestinal Absorption; Models, Molecular; Pharmaceutical Preparations; Structure-Activity Relationship

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties.
    Journal of medicinal chemistry, 2000, Oct-05, Volume: 43, Issue:20

    Topics: Biological Availability; Biological Transport; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Reproducibility of Results

2000
Experimental and computational screening models for the prediction of intestinal drug absorption.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil

2001
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
    Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20

    Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Volume of Distribution in Drug Design.
    Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15

    Topics: Drug Design; Half-Life; Pharmacokinetics

2015
Stimulation of the sympathico-adrenergic (SAS) and renin-angiotensin-system (RAS) in hypertensive crisis.
    Klinische Wochenschrift, 1979, Nov-02, Volume: 57, Issue:21

    Topics: Adult; Catecholamines; Diazepam; Dihydralazine; Female; Furosemide; Humans; Hypertension, Malignant; Male; Metoprolol; Pheochromocytoma; Saralasin; Sympathetic Nervous System; Vanilmandelic Acid

1979
Effect of beta-blockers on psychomotor performance in normal volunteers.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anxiety; Arousal; Atenolol; Diazepam; Drug Interactions; Electroencephalography; Emotions; Evoked Potentials; False Positive Reactions; Female; Health Planning; Humans; Kinetics; Male; Methyldopa; Metoprolol; Propranolol; Psychometrics; Psychomotor Performance; Reaction Time; Reference Values; Reserpine; Time Factors; Visual Acuity

1985
Involvement of noradrenaline in potentiation of the head-twitch response by GABA-related drugs.
    Psychopharmacology, 1986, Volume: 88, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Catecholamines; Diazepam; Dopamine; Drug Synergism; gamma-Aminobutyric Acid; Male; Methoxydimethyltryptamines; Metoprolol; Mice; Muscimol; Norepinephrine; Pentobarbital; Picrotoxin; Stereotyped Behavior; Taurine

1986
[A case of chronic hyperventilation syndrome effectively treated by metoprolol].
    Nihon Kyobu Shikkan Gakkai zasshi, 1988, Volume: 26, Issue:8

    Topics: Adult; Chronic Disease; Diazepam; Drug Therapy, Combination; Female; Humans; Hyperventilation; Metoprolol; Syndrome

1988
Diazepam, alpha and beta neurotransmission modifying drugs and contrast media mortality in mice.
    Acta radiologica: diagnosis, 1984, Volume: 25, Issue:3

    Topics: Animals; Clonidine; Diatrizoate; Diatrizoate Meglumine; Diazepam; Drug Interactions; Female; Lethal Dose 50; Male; Metoprolol; Mice; Phentolamine; Prazosin; Propranolol; Sympatholytics; Sympathomimetics

1984
Pharmacokinetic and pharmacodynamic interaction study of diazepam and metoprolol.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:2

    Topics: Adult; Blood Pressure; Diazepam; Drug Interactions; Heart Rate; Humans; Kinetics; Male; Metoprolol; Psychomotor Performance

1984
Poisoning caused by the combined ingestion of nifedipine and metoprolol.
    Journal of toxicology. Clinical toxicology, 1993, Volume: 31, Issue:4

    Topics: Administration, Oral; Adult; Calcium Chloride; Diazepam; Drug Combinations; Gastric Lavage; Humans; Male; Methylprednisolone; Metoprolol; Nifedipine; Tranquilizing Agents

1993
Involvement of adrenaline in diazepam-induced hyperglycemia in mice.
    Life sciences, 2000, Feb-18, Volume: 66, Issue:13

    Topics: Adrenergic beta-Antagonists; alpha-Methyltyrosine; Animals; Blood Glucose; Diazepam; Epinephrine; Hyperglycemia; Idazoxan; Insulin; Isoquinolines; Male; Metoprolol; Mice; Propanolamines

2000
Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Animals; Atenolol; Biotransformation; Carbamazepine; Diazepam; Diclofenac; Drug Evaluation, Preclinical; Female; Kinetics; Liver; Metoprolol; Models, Animal; Oncorhynchus mykiss; Phenylbutazone; Propranolol; Tandem Mass Spectrometry; Water Pollutants, Chemical; Xenobiotics

2017
The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:9

    Topics: Adjuvants, Anesthesia; Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Computer Simulation; Diazepam; Hepatocytes; Male; Metabolic Clearance Rate; Metoprolol; Midazolam; Models, Biological; Rats, Sprague-Dawley

2017
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
    Clinical pharmacokinetics, 2018, Volume: 57, Issue:6

    Topics: Caffeine; Cytochrome P-450 Enzyme System; Diazepam; Female; Granisetron; Humans; Metoprolol; Metronidazole; Midazolam; Models, Biological; Nifedipine; Ondansetron; Pharmaceutical Preparations; Pregnancy

2018