diazepam and mephenytoin

diazepam has been researched along with mephenytoin in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19905 (25.00)18.7374
1990's11 (55.00)18.2507
2000's0 (0.00)29.6817
2010's4 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bohlen, N; Hertl, M1
Kullander, S1
Beischlag, TV; Inaba, T; Kalow, W; Mahon, WA1
Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, JG; Shin, SG; Sohn, DR1
Bertilsson, L; Lou, YQ; Reviriego, J; Sjöqvist, F; Zhang, YA1
Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T1
Bertilsson, L; Buemi, AL; Sanz, E; Spina, E1
Chmela, Z; Sklenovský, A1
Caraco, Y; Tateishi, T; Wood, AJ1
Chiba, K; Hayashi, M; Horai, Y; Ishizaki, T; Koyama, E; Manabe, K; Tomono, Y; Toyoki, T; Yamato, C; Yasuda, S1
Kato, R; Li, QH; Tsuzuki, T; Ueda, M; Yamazoe, Y; Yasumori, T1
Kato, R; Yamazoe, Y1
Andersson, T; Birkett, DJ; Miners, JO; Veronese, ME1
Bertilsson, L; Kalow, W1
He, N; Lu, YQ; Wan, J; Xia, H; Zhou, HH1
Boothe, DM1

Reviews

3 review(s) available for diazepam and mephenytoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo.
    Pharmacogenetics, 1994, Volume: 4, Issue:6

    Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Humans; Imipramine; Kinetics; Liver; Mephenytoin; Substrate Specificity

1994
Anticonvulsant therapy in small animals.
    The Veterinary clinics of North America. Small animal practice, 1998, Volume: 28, Issue:2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexanecarboxylic Acids; Diazepam; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Mephenytoin; Pentobarbital; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Seizures; Valproic Acid

1998

Trials

2 trial(s) available for diazepam and mephenytoin

ArticleYear
Interethnic difference in omeprazole's inhibition of diazepam metabolism.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:1

    Topics: Adult; Asian People; China; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Diazepam; Double-Blind Method; Drug Interactions; Ethnicity; Humans; Male; Mephenytoin; Nordazepam; Omeprazole; Tennessee; White People

1995
Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Half-Life; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Omeprazole; Proton Pump Inhibitors; Rabeprazole; Reference Values; Single-Blind Method

1995

Other Studies

15 other study(ies) available for diazepam and mephenytoin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid

1975
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
    Annales chirurgiae et gynaecologiae, 1976, Volume: 65, Issue:4

    Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines; Female; Humans; Mephenytoin; Phenobarbital; Pregnancy; Pregnancy Complications; Prolactin

1976
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5

    Topics: Animals; Chromatography, Gas; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Mephenytoin; Methylation; Nordazepam; Polymorphism, Genetic; Rats; Temazepam

1992
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2

    Topics: Adult; Asian People; Creatinine; Diazepam; Female; Humans; Hydroxylation; Korea; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Polymorphism, Genetic

1992
Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:5

    Topics: Administration, Oral; Adult; Asian People; Diazepam; Female; Humans; Hydroxylation; Male; Mephenytoin; White People

1990
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4

    Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking

1989
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:6

    Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype

1989
The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state.
    Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 1984, Volume: 106

    Topics: Animals; Anticonvulsants; Bemegride; Brain; Diazepam; Drug Evaluation, Preclinical; Fatty Acids, Nonesterified; Male; Mephenytoin; Rats; Rats, Inbred Strains; Seizures; Trimethadione

1984
Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation.
    Pharmacogenetics, 1994, Volume: 4, Issue:6

    Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype

1994
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; In Vitro Techniques; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Nordazepam; Temazepam

1994
Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:5

    Topics: Asian People; China; Diazepam; Humans; Hydroxylation; Korea; Mephenytoin; White People

1993
The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype.
    British journal of clinical pharmacology, 1996, Volume: 42, Issue:4

    Topics: Asian People; China; Chromatography, High Pressure Liquid; Diazepam; Genotype; Half-Life; Humans; Hydroxylation; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Polymorphism, Genetic

1996