diazepam has been researched along with mephenytoin in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 11 (55.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bohlen, N; Hertl, M | 1 |
| Kullander, S | 1 |
| Beischlag, TV; Inaba, T; Kalow, W; Mahon, WA | 1 |
| Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, JG; Shin, SG; Sohn, DR | 1 |
| Bertilsson, L; Lou, YQ; Reviriego, J; Sjöqvist, F; Zhang, YA | 1 |
| Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T | 1 |
| Bertilsson, L; Buemi, AL; Sanz, E; Spina, E | 1 |
| Chmela, Z; Sklenovský, A | 1 |
| Caraco, Y; Tateishi, T; Wood, AJ | 1 |
| Chiba, K; Hayashi, M; Horai, Y; Ishizaki, T; Koyama, E; Manabe, K; Tomono, Y; Toyoki, T; Yamato, C; Yasuda, S | 1 |
| Kato, R; Li, QH; Tsuzuki, T; Ueda, M; Yamazoe, Y; Yasumori, T | 1 |
| Kato, R; Yamazoe, Y | 1 |
| Andersson, T; Birkett, DJ; Miners, JO; Veronese, ME | 1 |
| Bertilsson, L; Kalow, W | 1 |
| He, N; Lu, YQ; Wan, J; Xia, H; Zhou, HH | 1 |
| Boothe, DM | 1 |
3 review(s) available for diazepam and mephenytoin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Humans; Imipramine; Kinetics; Liver; Mephenytoin; Substrate Specificity | 1994 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexanecarboxylic Acids; Diazepam; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Mephenytoin; Pentobarbital; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Seizures; Valproic Acid | 1998 |
2 trial(s) available for diazepam and mephenytoin
| Article | Year |
|---|---|
Interethnic difference in omeprazole's inhibition of diazepam metabolism.
Topics: Adult; Asian People; China; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Diazepam; Double-Blind Method; Drug Interactions; Ethnicity; Humans; Male; Mephenytoin; Nordazepam; Omeprazole; Tennessee; White People | 1995 |
Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Half-Life; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Omeprazole; Proton Pump Inhibitors; Rabeprazole; Reference Values; Single-Blind Method | 1995 |
15 other study(ies) available for diazepam and mephenytoin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid | 1975 |
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines; Female; Humans; Mephenytoin; Phenobarbital; Pregnancy; Pregnancy Complications; Prolactin | 1976 |
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
Topics: Animals; Chromatography, Gas; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Mephenytoin; Methylation; Nordazepam; Polymorphism, Genetic; Rats; Temazepam | 1992 |
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.
Topics: Adult; Asian People; Creatinine; Diazepam; Female; Humans; Hydroxylation; Korea; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Polymorphism, Genetic | 1992 |
Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.
Topics: Administration, Oral; Adult; Asian People; Diazepam; Female; Humans; Hydroxylation; Male; Mephenytoin; White People | 1990 |
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking | 1989 |
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype | 1989 |
The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state.
Topics: Animals; Anticonvulsants; Bemegride; Brain; Diazepam; Drug Evaluation, Preclinical; Fatty Acids, Nonesterified; Male; Mephenytoin; Rats; Rats, Inbred Strains; Seizures; Trimethadione | 1984 |
Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation.
Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype | 1994 |
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; In Vitro Techniques; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Nordazepam; Temazepam | 1994 |
Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?
Topics: Asian People; China; Diazepam; Humans; Hydroxylation; Korea; Mephenytoin; White People | 1993 |
The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype.
Topics: Asian People; China; Chromatography, High Pressure Liquid; Diazepam; Genotype; Half-Life; Humans; Hydroxylation; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1996 |