Compounds > diazepam

diazepam and isoxazoles

diazepam has been researched along with isoxazoles in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199031 (52.54)18.7374
1990's8 (13.56)18.2507
2000's10 (16.95)29.6817
2010's10 (16.95)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gallager, DW; Tallman, JF; Thomas, JW1
Biggio, G; Brodie, BB; Costa, E; Guidotti, A1
Guidotti, A; Kurosawa, A; Naik, SR1
Braestrup, C; Falch, E; Krogsgaard-Larsen, P; Nielsen, M1
Biggio, G; Casu, M; Corda, MG; Gessa, GL; Vernaleone, F1
Cheney, DL; Costa, E; Zsilla, G1
Fujita, T; Takano, K; Tanaka, S; Tanaka, T; Yonemasu, Y1
Diemer, NH; Johansen, FF1
Corbett, R; Cornfeldt, M; Dunn, RW; Fielding, S1
Pranzatelli, MR1
Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA1
Cosi, C; Wood, PL1
Mehta, AK; Ticku, MK1
Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM1
Meldrum, BS1
Iversen, LL; Wong, EH1
Chrousos, GP; Crawley, JN; Linnoila, M; Ninan, PT; Paul, SM; Pickar, D; Skolnick, P1
Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM1
Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L1
Zharkovskaia, TA; Zharkovskiĭ, AM1
Löscher, W1
Hirate, K; Shinozaki, H1
Ford, I; Kelly, PA; McCulloch, J1
Bloss, JL; Hammond, DL1
Cavagnini, F; Grandison, L; Guidotti, A; Invitti, SC; Schmid, R1
Wood, PL1
Johnston, GA; Skerritt, JH1
Appel, JB; Holohean, AM; Nielsen, EB; Valentine, JD1
Frey, HH; Löscher, W; Reiche, R; Schultz, D1
Altmann, H; Dose, M; Emrich, HM; von Zerssen, D1
Bjørndal, N; Christensson, E; Gerlach, J1
Macdonald, RL; Skerritt, JH1
Alger, BE; Nicoll, RA1
Ashton, D; Geerts, R; Leysen, JE; Waterkeyn, C1
Clark, WG; Menon, MK; Vivonia, C1
Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT1
Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB1
Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA1
Asnis, N; Barros, HM; Gomez, R; Tannhauser, SL1
Kanba, S; Miyaoka, H; Nakaki, T; Shintani, F; Suzuki, E1
Birnir, B; Ebert, B; Lindquist, CE1
Hansen, SL; Sánchez, C; Sperling, BB1
Cagetti, E; Liang, J; Olsen, RW; Spigelman, I1
Abílio, VC; Araujo, NP; Castro, JP; Faria, RR; Frussa-Filho, R; Fukushiro, DF; Medrano, WA; Peixoto, MF; Silva, RH; Zanier-Gomes, PH1
Polesin, A; Stern, M1
Airaksinen, MS; Kulesskaya, N; Segerstråle, M; Taira, T; Tornberg, J; Voikar, V1
Belelli, D; Haythornthwaite, AR; Herd, MB; Homanics, GE; Lambert, JJ; Rosahl, TW; Wafford, KA1
Ahring, PK; Erichsen, HK; Larsen, JS; Lopez-Garcia, JA; Mirza, NR; Munro, G; Nielsen, EØ; Rivera-Arconada, I1
Cook, JM; Groenink, L; Hopkins, SC; Klanker, M; Korte, SM; Olivier, B; Van Linn, ML; Vinkers, CH1
Kelly, KM; Kharlamov, EA; Lepsveridze, E; Lu, B; Mtchedlishvili, Z; Xu, H1
Alamo, C; Ferre, F; Jiménez-Arriero, MÁ; López-Muñoz, F; Martínez-Gras, I; Pascual, JM; Ponce, G; Rubio, G1
Atack, JR1
Ayissi Mbomo, R; Gartside, S; McQuade, R; Ngo Bum, E; Njikam, N; Okello, E1
Gielen, MC; Lumb, MJ; Smart, TG1
Ishibashi, H; Nabekura, J; Nielsen, M; Witt, MR1
Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG1
Marowsky, A; Vogt, KE1
Babateen, O; Bhandage, A; Birnir, B; Forsberg Nilsson, K; Jin, Z; Korol, SV; Smits, A; Uhrbom, L; Westermark, B1
Boia, E; Cagiano, R; Caprio, M; Damian, S; Haragus, H; Niculescu, M; Tattoli, M; Vermesan, D1

Reviews

2 review(s) available for diazepam and isoxazoles

ArticleYear
Drugs acting on amino acid neurotransmitters.
    Advances in neurology, 1986, Volume: 43

    Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid

1986
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:9

    Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles

2011

Trials

2 trial(s) available for diazepam and isoxazoles

ArticleYear
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid

1983
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
    Pharmacopsychiatry, 2010, Volume: 43, Issue:7

    Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult; Zonisamide

2010

Other Studies

55 other study(ies) available for diazepam and isoxazoles

ArticleYear
GABAergic modulation of benzodiazepine binding site sensitivity.
    Nature, 1978, Jul-27, Volume: 274, Issue:5669

    Topics: Amanita; Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Neurotransmitter Agents; Rats; Receptors, Drug; Receptors, Neurotransmitter

1978
Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:8

    Topics: Alkaloids; Animals; Cerebellar Cortex; Cyclic GMP; Diazepam; Haloperidol; Harmaline; Isoxazoles; Male; Morphine; Oxazoles; Purkinje Cells; Pyridines; Rats

1977
Possible role of gamma aminobutyric acid (GABA) in the regulation of cAMP system in rat anterior pituitary.
    Psychoneuroendocrinology, 1977, Volume: 2, Issue:3

    Topics: Aminobutyrates; Animals; Baclofen; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Hypothalamus; Isoniazid; Isoxazoles; Male; Nipecotic Acids; Pargyline; Picrotoxin; Pituitary Gland, Anterior; Protein Kinases; Rats; Reserpine

1977
Partial agonists for brain GABA/benzodiazepine receptor complex.
    Nature, 1979, Jul-26, Volume: 280, Issue:5720

    Topics: Animals; Benzodiazepines; Bicuculline; Brain; Crotonates; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, Drug; Sulfonic Acids

1979
Effect of muscimol, a GABA-mimetic agent, on dopamine metabolism in the mouse brain.
    Life sciences, 1977, Aug-15, Volume: 21, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aminobutyrates; Animals; Brain; Caudate Nucleus; Diazepam; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Homovanillic Acid; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Phenobarbital

1977
Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimol.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:3

    Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Oxazoles; Quaternary Ammonium Compounds; Rats; Receptors, Drug

1976
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus].
    No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:3

    Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarbital; Phenytoin; Regional Blood Flow; Status Epilepticus; Valproic Acid; Zonisamide

1992
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
    Acta neurologica Scandinavica, 1991, Volume: 84, Issue:1

    Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Motor Activity; Nerve Degeneration; Neurons; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine

1991
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
    Psychopharmacology, 1991, Volume: 104, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Exploratory Behavior; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Social Behavior; Valproic Acid

1991
Antimyoclonic effect of MK-801: a possible role for NMDA receptors in developmental myoclonus of the neonatal rat.
    Clinical neuropharmacology, 1990, Volume: 13, Issue:4

    Topics: Aminobutyrates; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Isoxazoles; Kynurenic Acid; Male; Myoclonus; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine

1990
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
    Brain research, 1988, Jun-14, Volume: 452, Issue:1-2

    Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscimol; Phenobarbital; Receptors, GABA-A; Time Factors

1988
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
    Neuroscience letters, 1988, May-03, Volume: 87, Issue:3

    Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus

1988
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine

1988
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
    Drug design and delivery, 1987, Volume: 1, Issue:4

    Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes

1987
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
    Journal of neurochemistry, 1985, Volume: 44, Issue:4

    Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine

1985
Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Cyproheptadine; Diazepam; Epinephrine; Heart Rate; Humans; Hydrocortisone; Indoles; Isoxazoles; Macaca mulatta; Male; Norepinephrine; Propranolol

1985
Diazepam antagonizes GABAmimetics in rats with spontaneous petit mal-like epilepsy.
    European journal of pharmacology, 1985, Jul-11, Volume: 113, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Cycloserine; Diazepam; Epilepsy, Absence; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vigabatrin

1985
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes

1985
[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:6

    Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrazoles; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Tranquilizing Agents

1987
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid

1986
Depression of drug-induced tremor by a new isoxazol derivative in mice.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:1

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxazoles; Tremor; Tremorine

1986
The effect of diazepam upon local cerebral glucose use in the conscious rat.
    Neuroscience, 1986, Volume: 19, Issue:1

    Topics: Animals; Autoradiography; Brain Chemistry; Deoxy Sugars; Deoxyglucose; Diazepam; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains

1986
Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Administration, Oral; Analgesics; Animals; Aspirin; Codeine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Ibuprofen; Injections, Intramuscular; Isoxazoles; Male; Morphine; Narcotics; Reaction Time; Sensory Thresholds; Time Factors

1985
gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:3

    Topics: Adult; Aged; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Middle Aged; Muscimol; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A

1982
Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Dopamine; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Neural Pathways; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra

1982
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
    Neuroscience letters, 1983, Aug-08, Volume: 38, Issue:3

    Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1983
Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists.
    Life sciences, 1983, Nov-28, Volume: 33, Issue:22

    Topics: Animals; Cues; Diazepam; Discrimination Learning; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1983
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid

1983
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
    Psychopharmacology, 1984, Volume: 82, Issue:1-2

    Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced

1984
Diazepam enhances the action but not the binding of the GABA analog, THIP.
    Brain research, 1984, Apr-09, Volume: 297, Issue:1

    Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord

1984
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
    The Journal of physiology, 1982, Volume: 328

    Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug

1982
Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding.
    Life sciences, 1981, Dec-21, Volume: 29, Issue:25

    Topics: Animals; Brain; Cerebellum; Diazepam; Etomidate; Female; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Membranes

1981
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex

1980
Effects of atypical antipsychotic agents on social behavior in rodents.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior

1993
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1994
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
    Psychopharmacology, 1999, Volume: 141, Issue:4

    Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A

1999
GABA agonists differentially modify blood glucose levels of diabetic rats.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:4

    Topics: Aminooxyacetic Acid; Animals; Baclofen; Benzodiazepines; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Female; GABA Agonists; Insulin; Isoxazoles; Rats; Rats, Wistar

1999
Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain.
    Neuroscience letters, 2002, Nov-29, Volume: 333, Issue:3

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Brain; Carbamazepine; Chlorpromazine; Diazepam; Fluvoxamine; Gene Expression; Haloperidol; Isoxazoles; Lithium; Male; Maprotiline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Zonisamide

2002
Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.
    Molecular and cellular neurosciences, 2003, Volume: 24, Issue:1

    Topics: Animals; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Pyramidal Cells; Rats; Reaction Time; Receptors, GABA-A; Synaptic Transmission

2003
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A

2004
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3

    Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; Hippocampus; Isoxazoles; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Zolpidem

2004
Effects of gabaergic drugs on reserpine-induced oral dyskinesia.
    Behavioural brain research, 2005, May-07, Volume: 160, Issue:1

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; GABA Agents; Immobility Response, Tonic; Isoxazoles; Locomotion; Male; Rats; Rats, Wistar; Reserpine

2005
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.
    Brain injury, 2006, Volume: 20, Issue:2

    Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Levetiracetam; Middle Aged; Myoclonus; Phenobarbital; Piracetam; Valproic Acid; Zonisamide

2006
KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4

    Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Diazepam; Ethanol; Exploratory Behavior; Hippocampus; Immobility Response, Tonic; In Vitro Techniques; Isoxazoles; K Cl- Cotransporters; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Skills Disorders; Neurons; Symporters

2007
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
    The Journal of physiology, 2008, Feb-15, Volume: 586, Issue:4

    Topics: Animals; Dentate Gyrus; Diazepam; Female; GABA Agonists; GABA Modulators; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Protein Isoforms; Receptors, GABA; Receptors, GABA-A; Synapses

2008
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans; Inflammation; Isoxazoles; Neuralgia; Pyridines; Rats; Receptors, GABA-A; Zolpidem

2008
Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.
    Psychopharmacology, 2009, Volume: 204, Issue:2

    Topics: Acute Disease; Anesthetics; Animals; Anti-Anxiety Agents; Body Temperature; Carbolines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA Agents; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Psychological; Telemetry; Zolpidem

2009
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
    Neurobiology of disease, 2010, Volume: 38, Issue:3

    Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Temperature; Time Factors

2010
Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; GABA Modulators; Isoxazoles; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mimosa; N-Methylaspartate; Phytotherapy; Plant Extracts; Raphe Nuclei; Receptors, GABA-A; Serotonin

2012
Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-25, Volume: 32, Issue:17

    Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Larva; Membrane Potentials; Models, Biological; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus

2012
Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro.
    Brain research, 2013, Jan-15, Volume: 1490

    Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Central Nervous System Depressants; Diazepam; Electrophysiological Phenomena; Ethanol; GABA Modulators; Isoxazoles; Male; Membranes; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Thyroid Hormones; Thyroxine

2013
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
    Journal of neuroendocrinology, 2014, Volume: 26, Issue:1

    Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation

2014
Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala.
    Frontiers in neural circuits, 2014, Volume: 8

    Topics: Amygdala; Animals; Desoxycorticosterone; Diazepam; GABA Modulators; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Mice; Neural Inhibition; Receptors, GABA-A

2014
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.
    European journal of pharmacology, 2015, Feb-05, Volume: 748

    Topics: Anesthetics, General; Cell Line, Tumor; Diazepam; Drug Synergism; Electrophysiological Phenomena; Etomidate; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Ion Channel Gating; Isoxazoles; Propofol; Protein Subunits; Protein Transport; Receptors, GABA-A

2015
The anxiolitic effects of BTG1640 and BTG1675A on ultrasonic isolation calls and locomotor activity of rat pups.
    European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:23

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Female; Isoxazoles; Male; Motor Activity; Rats; Ultrasonics

2016