diazepam and guanfacine

diazepam has been researched along with guanfacine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's1 (7.69)18.2507
2000's3 (23.08)29.6817
2010's4 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Buccafusco, JJ; Li, W1
Kulkarni, SK; Kunchandy, J1
Kulkarni, SK; Parale, MP1
Doaré, L; Simon, P; Soubrié, P; Thiébot, MH1
Decobert, M; Depoortere, H; Honoré, L1

Reviews

2 review(s) available for diazepam and guanfacine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drug effects on the EEG of various species of laboratory animals.
    Neuropsychobiology, 1983, Volume: 9, Issue:4

    Topics: 5-Hydroxytryptophan; Amantadine; Animals; Antihypertensive Agents; Azabicyclo Compounds; Brain; Cats; Chlormethiazole; Clonidine; Diazepam; Electroencephalography; Flunitrazepam; Guanabenz; Guanfacine; Guanidines; Imidazoles; Male; Nitrazepam; Pentobarbital; Phenylacetates; Piperazines; Piracetam; Rats; Sodium Oxybate; Yohimbine

1983

Other Studies

11 other study(ies) available for diazepam and guanfacine

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition.
    Research communications in chemical pathology and pharmacology, 1992, Volume: 75, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Cholinesterase Inhibitors; Clonidine; Diazepam; Dose-Response Relationship, Drug; Guanabenz; Guanfacine; Lethal Dose 50; Male; Motor Activity; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Soman

1992
Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats.
    Psychopharmacology, 1986, Volume: 90, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Diazepam; Guanfacine; Guanidines; Male; Motor Activity; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine

1986
Clonidine--induced behavioural despair in mice: reversal by antidepressants.
    Psychopharmacology, 1986, Volume: 89, Issue:2

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Azepines; Clonidine; Depression; Diazepam; Guanfacine; Guanidines; Lithium; Male; Phenylacetates; Rats; Rats, Inbred Strains; Tranylcypromine; Yohimbine

1986
Evidence against the involvement of a noradrenergic mechanism in the release by diazepam of novelty-induced hypophagia in rats.
    European journal of pharmacology, 1984, Apr-20, Volume: 100, Issue:2

    Topics: Animals; Anxiety; Clonidine; Diazepam; Drug Interactions; Eating; Guanfacine; Guanidines; Humans; Male; Mice; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Yohimbine

1984