diazepam and fluvoxamine

diazepam has been researched along with fluvoxamine in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.03)18.7374
1990's5 (15.15)18.2507
2000's14 (42.42)29.6817
2010's13 (39.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Glen, RC; Lowe, R; Mitchell, JB1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Mos, J; Olivier, B; Tilders, FJ; Van Dijken, HH1
Brouwer, GJ; Doogan, D; Klok, CJ; van Praag, HM1
Belmadani, A; Bonini, M; Combourieu, I; Creppy, EE1
Barel, S; Bialer, M; Cipolla, G; Gatti, G; Gips, M; Perucca, E; Soback, S; Spina, E1
Bardou, LG; Berthou, F; Dréano, Y; Iribarne, C; Ménez, JF1
Deakin, JF; Guimaraes, FS; Hellewell, JS; Wang, M1
Matsumiya, T; Miyamoto, J; Nawa, H; Takeda, H; Tsuji, M1
Kurasawa, M; Nakamura, K1
Baba, J; Hayashi, A; Imanishi, T; Onozawa, K1
Kanba, S; Miyaoka, H; Nakaki, T; Shintani, F; Suzuki, E1
Araiso, T; Kikukawa, T; Ohashi, S; Tamura, M; Yano, S; Yoshioka, M1
Kamei, J; Miyata, S; Morita, K; Saitoh, A; Takeda, H1
Yao, TW; Yu, LS; Zeng, S1
Ben-Amir, E; Doljansky, J; Flaisher, S; Joel, D1
Kawashima, Y; Shioiri, T; Someya, T; Suzuki, Y1
Fukui, K; Kitabayashi, Y; Tani, N; Tsuchida, H; Watanabe, A; Yamashita, T1
Birkenhäger, TK; Heijnen, WT; Mulder, PG; van den Broek, WW1
Balci, F; Campbell, U; Hanania, T; Olivier, BE; Paterson, NE1
Hara, H; Hayashi, E; Kinoshita, M; Kuratani, K1
Chaki, S; Fukumoto, K; Iijima, M1
Coffman, CF; Fiacco, NR; Granger, JC; Helton, BM; Jackson, JC; Kim, LV; Kreiss, DS; Mistry, RS; Mizer, TM; Palmer, LV; Vacca, JA; Winkler, SS; Zimmer, BA1
Ioannides, C; Papagiannidou, E; Skene, DJ1
Ago, Y; Hasebe, S; Hashimoto, H; Hiramatsu, N; Matsuda, T; Mori, K; Onaka, Y; Takuma, K; Watabe, Y1

Reviews

1 review(s) available for diazepam and fluvoxamine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for diazepam and fluvoxamine

ArticleYear
Fluvoxamine and clomipramine in depressed patients. A double-blind clinical study.
    Acta psychiatrica Scandinavica, 1981, Volume: 64, Issue:1

    Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Clomipramine; Depression; Diazepam; Double-Blind Method; Electrocardiography; Female; Fluvoxamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Middle Aged; Oximes; Psychiatric Status Rating Scales

1981
Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:5

    Topics: Adult; Biotransformation; Diazepam; Female; Fluvoxamine; Humans; Male; Nordazepam

1994
Comparison of buspirone with diazepam and fluvoxamine on aversive classical conditioning in humans.
    Journal of psychopharmacology (Oxford, England), 1999, Volume: 13, Issue:2

    Topics: Acoustic Stimulation; Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Arousal; Avoidance Learning; Buspirone; Conditioning, Classical; Diazepam; Female; Fluvoxamine; Galvanic Skin Response; Humans; Male; Sex Factors

1999
Prevalence of trait anxiety in a sample of depressed inpatients and its influence on response to antidepressants.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:4

    Topics: Adult; Aged; Antidepressive Agents; Anxiety; Depressive Disorder; Diazepam; Double-Blind Method; Female; Fluvoxamine; Humans; Imipramine; Inpatients; Male; Middle Aged; Netherlands; Predictive Value of Tests; Prevalence; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome

2010

Other Studies

28 other study(ies) available for diazepam and fluvoxamine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats.
    Psychopharmacology, 1992, Volume: 109, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Desipramine; Diazepam; Electroshock; Fluvoxamine; Male; Motor Activity; Noise; Piperazines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Stress, Psychological

1992
High performance liquid chromatography with ultraviolet detection used for laboratory routine determination of fluvoxamine in human plasma.
    Human & experimental toxicology, 1995, Volume: 14, Issue:1

    Topics: Antidepressive Agents; Bromazepam; Chromatography, High Pressure Liquid; Diazepam; Drug Monitoring; Fluvoxamine; Humans

1995
Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.
    Toxicology, 1997, Feb-14, Volume: 117, Issue:1

    Topics: Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diazepam; Fluvoxamine; Humans; Methadone; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Rifampin

1997
Pretreatment with diazepam suppresses the reduction in defensive freezing behavior induced by fluvoxamine in the conditioned fear stress paradigm in mice.
    European journal of pharmacology, 2000, Dec-01, Volume: 409, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Conditioning, Psychological; Diazepam; Fear; Fluvoxamine; Male; Mice; Stress, Psychological

2000
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
    European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological

2001
[Effects of fluvoxamine on both the desired anxiolytic effect and the adverse motor incoordination and amnesia induced by benzodiazepines].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:6

    Topics: Amnesia; Animals; Anti-Anxiety Agents; Ataxia; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Fluvoxamine; Male; Mice; Mice, Inbred Strains; Selective Serotonin Reuptake Inhibitors

2001
Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain.
    Neuroscience letters, 2002, Nov-29, Volume: 333, Issue:3

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Brain; Carbamazepine; Chlorpromazine; Diazepam; Fluvoxamine; Gene Expression; Haloperidol; Isoxazoles; Lithium; Male; Maprotiline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Zonisamide

2002
[Effects of anxiolytics on hemodynamic responses to acute microgravity environment].
    Uchu Seibutsu Kagaku, 2000, Volume: 14, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Diazepam; Fluvoxamine; Isoindoles; Piperazines; Pyrimidines; Rats; Rats, Wistar; Weightlessness

2000
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Blood Glucose; Body Weight; Desipramine; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Hindlimb Suspension; Male; Mice; Mice, Inbred ICR; Motor Activity; Selective Serotonin Reuptake Inhibitors

2003
In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan.
    Chemico-biological interactions, 2003, Dec-15, Volume: 146, Issue:3

    Topics: Animals; beta-Naphthoflavone; Cimetidine; Cytochrome P-450 CYP1A2; Diazepam; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fluvoxamine; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Moclobemide; Oxazolidinones; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Tryptamines

2003
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.
    Behavioural pharmacology, 2004, Volume: 15, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Compulsive Behavior; Conditioning, Operant; Desipramine; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Fluvoxamine; Male; Paroxetine; Rats; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors

2004
Effects of concomitant fluvoxamine on the plasma concentration of etizolam in Japanese psychiatric patients: wide interindividual variation in the drug interaction.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:6

    Topics: Adult; Aged; Ambulatory Care; Asian People; Diazepam; Drug Interactions; Drug Therapy, Combination; Female; Fluvoxamine; Humans; Male; Mental Disorders; Middle Aged

2004
[Case report of pentazocine dependence from a standpoint of the cognitive therapy].
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2004, Volume: 39, Issue:5

    Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Cognitive Behavioral Therapy; Diazepam; Fluvoxamine; Humans; Male; Opioid-Related Disorders; Pentazocine; Substance Withdrawal Syndrome; Tranquilizing Agents; Treatment Outcome

2004
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:10

    Topics: Animals; Antidepressive Agents; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Desipramine; Diazepam; Dopamine Uptake Inhibitors; Fluvoxamine; Haloperidol; Imipramine; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology

2011
Pharmacologically distinctive behaviors other than burying marbles during the marble burying test in mice.
    Pharmacology, 2010, Volume: 86, Issue:5-6

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bupropion; Diazepam; Exploratory Behavior; Fluvoxamine; Imipramine; Male; Mice; Motor Activity

2010
Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.
    Behavioural brain research, 2012, Dec-01, Volume: 235, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Carbazoles; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Exploratory Behavior; Feeding Behavior; Fluvoxamine; Immunosuppressive Agents; Indole Alkaloids; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Pyridines; Reaction Time; Sirolimus; Time Factors

2012
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 104

    Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Fluvoxamine; GABA Modulators; Haloperidol; Male; Mastication; Mianserin; Obsessive-Compulsive Disorder; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists

2013
Potential drug interactions with melatonin.
    Physiology & behavior, 2014, May-28, Volume: 131

    Topics: 5-Methoxypsoralen; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Antineoplastic Agents, Hormonal; Central Nervous System Depressants; Diazepam; Drug Interactions; Estrogens; Fluvoxamine; Humans; Hypnotics and Sedatives; Male; Melatonin; Methoxsalen; Microsomes, Liver; Middle Aged; Rats, Wistar; Tamoxifen

2014
Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency.
    Psychopharmacology, 2016, Volume: 233, Issue:17

    Topics: Adrenalectomy; Animals; Antipsychotic Agents; Castration; Diazepam; Dioxanes; Dioxoles; Dopamine; Fluvoxamine; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Mice; Norepinephrine; Nucleus Accumbens; Orchiectomy; Phenazocine; Picrotoxin; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1A; Receptors, GABA; Receptors, GABA-A; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Sigma-1 Receptor; Synaptic Transmission; Ventral Tegmental Area

2016