Compounds > diazepam

diazepam and flupirtine

diazepam has been researched along with flupirtine in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (18.18)	18.7374
1990's	2 (18.18)	18.2507
2000's	3 (27.27)	29.6817
2010's	4 (36.36)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Borbe, HO; Nickel, B; Szelenyi, I	1
Jakovlev, V; Nickel, B; Szelenyi, I	1
Dimpfel, W; Nickel, B; Spüler, M	1
Müller-Limmroth, W	1
Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH	1

Trials

1 trial(s) available for diazepam and flupirtine

Article	Year
[The effect of a new analgesic, flupirtine, on psychomotor performance in humans]. Arzneimittel-Forschung, 1985, Volume: 35, Issue:7 Topics: Aminopyridines; Analgesics; Chlorpheniramine; Diazepam; Humans; Hypnotics and Sedatives; Male; Mental Processes; Psychomotor Performance; Reaction Time	1985

Other Studies

10 other study(ies) available for diazepam and flupirtine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential. Arzneimittel-Forschung, 1990, Volume: 40, Issue:8 Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Binding, Competitive; Body Weight; Brain Chemistry; Conditioning, Operant; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Lorazepam; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders	1990
[The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat]. Arzneimittel-Forschung, 1990, Volume: 40, Issue:8 Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Codeine; Dantrolene; Diazepam; Female; Mephenesin; Morphine; Motor Activity; Muscle Relaxants, Central; Muscle Tonus; Rats; Rats, Inbred Strains; Tramadol	1990
Radioelectroencephalography (Tele-Stereo-EEG) in the rat as a pharmacological model to differentiate the central action of flupirtine from that of opiates, diazepam and phenobarbital. Neuropsychobiology, 1986, Volume: 16, Issue:2-3 Topics: Aminopyridines; Animals; Brain; Buprenorphine; Diazepam; Electroencephalography; Male; Morphine; Phenobarbital; Rats; Rats, Inbred Strains; Tramadol	1986
A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Annals of neurology, 2009, Volume: 65, Issue:3 Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors	2009