diazepam and clozapine

diazepam has been researched along with clozapine in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (27.40)	18.7374
1990's	8 (10.96)	18.2507
2000's	22 (30.14)	29.6817
2010's	23 (31.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP	1
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Bojarski, AJ; Duszyńska, B; Jastrzębska-Więsek, M; Marciniec, K; Maślankiewicz, A; Partyka, A; Pawłowski, M; Satała, G; Wesołowska, A; Wróbel, D; Zajdel, P	1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S	1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bojarski, AJ; Bucki, A; Chłoń-Rzepa, G; Jastrzębska-Więsek, M; Kołaczkowski, M; Partyka, A; Satała, G; Wasik, A; Wesołowska, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E	1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E	1
Handzlik, J; Jankowska, A; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Kurczab, R; Nitek, W; Partyka, A; Satała, G; Siwek, A; Wesołowska, A; Żesławska, E	1
Kozlovskaia, MM; Val'dman, AV	1
Bertilsson, L; Costa, E; Mao, CC; Marco, E; Revuelta, A	1
Canon, JG; Lippa, AS	2
Cain, JC; Dren, AT; Grant, DS; Minard, FN	1
Lassen, JB	1
Gillin, JC; Moja, EA; Stoff, DM; Wyatt, RJ	1
Carlson, KR; Eibergen, RD	2
Ito, T; Shimizu, M	1
Marsden, CD; Pycock, C; Tarsy, D	1
Barnes, NM; Costall, B; Domeney, AM; Gerrard, PA; Kelly, ME; Krähling, H; Naylor, RJ; Tomkins, DM; Williams, TJ	1
Sano, T; Suzuki-Nishimura, T; Uchida, MK	1
Abrosimov, AI; Smulevich, AB; Tarasova, TP; Vorob'ev, VIu	1
Fuchs, A; Krähling, H; Ruhland, M; Schön, U	1
Fuchs, A; Krähling, H; Mol, F; Ruhland, M; Schön, U; Tulp, M	1
Spealman, RD	1
Liebman, J; Neale, R	1
Hertrich, O	1
Gold, R; Lemme, P; Mende, T; Morgenstern, R; Oelssner, W	1
Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT	1
Dorevitch, A; Durst, R; Fraenkel, Y	1
Bridler, R; Hell, D	1
Dekeyne, A; Girardon, S; Gobert, A; Millan, MJ	1
Niskanen, L; Tiihonen, J; Tupala, E	1
Böhmer, C; Centelles, JJ; Kinne, RK; Palmada, M	1
Cassella, JV; Coverdale, S; Hoffman, DC; Kehne, JH; McCloskey, TC	1
Cilia, J; Hagan, JJ; Piper, DC; Upton, N	1
Davies, AE; Morrison, D; Watt, AP	1
Borgheini, G	1
Bowers, L; Callaghan, P; Clark, N; Evers, C	1
Henderson, JM; Johnston, GA; Schleimer, SB	1
Bailey, AJ; Fineberg, NA; Krishnaiah, R; Mukhopadhaya, K; Nigam, A; Sivakumaran, T; Taye, T	1
Kovacević, D; Margetić, B; Palijan, TZ	1
Horsfall, W; Mielnik, CA; Ramsey, AJ	1
Huang, TL; Hung, YY; Lin, CC; Tsai, MC	1

Reviews

4 review(s) available for diazepam and clozapine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Acute life threatening catatonia--clinical significance and therapeutic possibilities]. Schweizerische medizinische Wochenschrift, 1997, Sep-13, Volume: 127, Issue:37 Topics: Adult; Biperiden; Catatonia; Clopenthixol; Clozapine; Diagnosis, Differential; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; Humans; Injections, Intramuscular; Male; Schizophrenia, Disorganized	1997
The bioequivalence and therapeutic efficacy of generic versus brand-name psychoactive drugs. Clinical therapeutics, 2003, Volume: 25, Issue:6 Topics: Anticonvulsants; Biological Availability; Clinical Trials as Topic; Clozapine; Diazepam; Drug Approval; Drugs, Generic; Excipients; Humans; Paroxetine; Psychotropic Drugs; Therapeutic Equivalency	2003
Homicide and subsequent catatonia associated with a large arachnoid cyst: case report. Acta clinica Croatica, 2013, Volume: 52, Issue:4 Topics: Adult; Antipsychotic Agents; Arachnoid Cysts; Catatonia; Clozapine; Delusions; Diazepam; Homicide; Humans; Male	2013

Other Studies

69 other study(ies) available for diazepam and clozapine

Article	Year
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship	1989
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22 Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19 Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4 Topics: Animals; Antipsychotic Agents; Central Nervous System; Isoquinolines; Mice; Piperazines; Quinolines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Structure-Activity Relationship; Sulfonamides	2012
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. European journal of medicinal chemistry, 2013, Volume: 63 Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship	2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10 Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry, 2015, Jan-01, Volume: 23, Issue:1 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Mice; Purines; Receptor, Serotonin, 5-HT1A; Structure-Activity Relationship	2015
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8 Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine	2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship	2017
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT European journal of medicinal chemistry, 2018, Mar-10, Volume: 147 Topics: Animals; Antidepressive Agents; Behavior, Animal; Computer-Aided Design; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Hydantoins; Male; Mice; Models, Molecular; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship	2018
[An experimental study of the spectrum of individual psychotropic activity of clozapine (Leponex)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:11 Topics: Animals; Antipsychotic Agents; Cats; Clozapine; Diazepam; Dibenzazepines; Disease Models, Animal; Haloperidol; Humans; Mental Disorders; Neurotic Disorders; Psychotic Disorders; Social Behavior; Tranquilizing Agents	1975
The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer. Biological psychiatry, 1977, Volume: 12, Issue:3 Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Caudate Nucleus; Clozapine; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Haloperidol; Male; Parasympathomimetics; Rats; Substantia Nigra; Telencephalon	1977
Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs. Pharmacology, biochemistry, and behavior, 1977, Volume: 6, Issue:5 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chlorpromazine; Clozapine; Conditioning, Operant; Dextroamphetamine; Diazepam; Drug Evaluation, Preclinical; Male; Psychotropic Drugs; Rats; Reinforcement Schedule; Tranquilizing Agents	1977
N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:2 Topics: Animals; Apomorphine; Brain; Brain Chemistry; Clozapine; Dextroamphetamine; Diazepam; Homovanillic Acid; Hydroxydopamines; In Vitro Techniques; Male; Pargyline; Piperazines; Rats; Receptors, Dopamine; Time Factors	1979
Evidence for a noradrenergic mechanism in the grooming produced by (+)-amphetamine and 4, alpha-dimethyl-m-tyramine (H 77/77) in rats. Psychopharmacology, 1977, Oct-20, Volume: 54, Issue:2 Topics: Amphetamine; Animals; Butyrophenones; Clozapine; Diazepam; Diphenhydramine; Grooming; Haloperidol; Male; Norepinephrine; Phenothiazines; Rats; Tyramine	1977
Neuroleptics attentuate stereotyped behavior induced by beta-phenylethylamine in rats. Biological psychiatry, 1978, Volume: 13, Issue:2 Topics: Animals; Behavior; Chlorpromazine; Clozapine; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation; Haloperidol; Humans; Male; Phenethylamines; Pimozide; Rats; Receptors, Dopamine; Stereotyped Behavior; Tranquilizing Agents	1978
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment. Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2 Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior	1976
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys. Annals of the New York Academy of Sciences, 1976, Volume: 281 Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors	1976
Effects of clozapine, chlorpromazine and diazepam upon adjunctive and schedule controlled behaviors. Pharmacology, biochemistry, and behavior, 1977, Volume: 6, Issue:5 Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dibenzazepines; Drinking Behavior; Male; Rats; Reinforcement Schedule	1977
Effect of psychotropic drugs on caudate spindle in cats. Japanese journal of pharmacology, 1976, Volume: 26, Issue:5 Topics: Animals; Arousal; Biperiden; Cats; Caudate Nucleus; Chlorpromazine; Clozapine; Diazepam; Electric Stimulation; Electroencephalography; Female; Haloperidol; Imipramine; Male; Pentobarbital; Psychotropic Drugs; Time Factors	1976
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum. Psychopharmacologia, 1975, Dec-31, Volume: 45, Issue:2 Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents	1975
The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Buspirone; Callithrix; Clozapine; Diazepam; Dopamine; Female; Interpersonal Relations; Limbic System; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Drug; Substance Withdrawal Syndrome; Tetrahydronaphthalenes	1991
The effects of clozapine on rat mast cells are different from those of benzodiazepines. General pharmacology, 1990, Volume: 21, Issue:4 Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Calcimycin; Calcium; Calcium Radioisotopes; Clozapine; Concanavalin A; Diazepam; Dibenzazepines; In Vitro Techniques; Male; Mast Cells; Rats; Rats, Inbred Strains; Serotonin	1990
[Psychotropic drug therapy using maintenance dosage pumps]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1987, Volume: 87, Issue:6 Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Diazepam; Dibenzazepines; Female; Humans; Infusion Pumps; Male; Neurotic Disorders; Schizophrenia; Skin Diseases	1987
KC 9172 (free base of KC 7218)--an antipsychotic/anxiolytic compound. I. Antipsychotic and anxiolytic activity in comparison with chlorpromazine, clozapine, diazepam and buspirone. Pharmacopsychiatry, 1988, Volume: 21, Issue:6 Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Buspirone; Chlorpromazine; Clozapine; Diazepam; Male; Mice; Rats; Rats, Inbred Strains; Time Factors	1988
KC 9172 (free base of KC 7218)--an antipsychotic/anxiolytic compound. II. Discrimination from typical neuroleptics and benzodiazepine-like minor tranquilizers. Pharmacopsychiatry, 1988, Volume: 21, Issue:6 Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Buspirone; Chlorpromazine; Clozapine; Conflict, Psychological; Diazepam; Rats; Rats, Inbred Strains; Receptors, Serotonin	1988
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2 Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine	1985
Neuroleptic-induced acute dyskinesias in squirrel monkeys: correlation with propensity to cause extrapyramidal side effects. Psychopharmacology, 1980, Volume: 68, Issue:1 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Baclofen; Basal Ganglia Diseases; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Male; Saimiri	1980
[Ataractic treatment in psychiatry and general medicine. Survey of drugs, 4]. Fortschritte der Medizin, 1983, Jul-07, Volume: 101, Issue:25 Topics: Azepines; Chemical Phenomena; Chemistry; Clozapine; Desipramine; Diazepam; Dibenzazepines; Family Practice; Humans; Mental Disorders; Phenothiazines; Tranquilizing Agents	1983
Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens. Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4 Topics: Animals; Apomorphine; Carbachol; Clozapine; Diazepam; Haloperidol; Lisuride; Lysergic Acid Diethylamide; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Reserpine; Septal Nuclei; Sulpiride	1984
Effects of atypical antipsychotic agents on social behavior in rodents. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior	1993
Platelet dysfunction associated with clozapine therapy. Southern medical journal, 1993, Volume: 86, Issue:10 Topics: Amobarbital; Blood Cell Count; Clozapine; Delayed-Action Preparations; Diazepam; Drug Monitoring; Drug Therapy, Combination; Epistaxis; Fluphenazine; Hemoglobins; Humans; Male; Middle Aged; Platelet Count; Schizophrenia, Paranoid; Thrombocytopenia	1993
Citalopram elicits a discriminative stimulus in rats at a dose selectively increasing extracellular levels of serotonin vs. dopamine and noradrenaline. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Animals; Biogenic Monoamines; Cerebral Cortex; Citalopram; Clozapine; Corpus Striatum; Diazepam; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; GABA Agents; Male; Norepinephrine; Nucleus Accumbens; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline	1999
Transient syncope and ECG changes associated with the concurrent administration of clozapine and diazepam. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:9 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Bradycardia; Clozapine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Schizophrenia, Paranoid; Syncope	1999
Effect of benzodiazepines on the epithelial and neuronal high-affinity glutamate transporter EAAC1. Journal of neurochemistry, 1999, Volume: 73, Issue:6 Topics: Amino Acid Transport System X-AG; Animals; Anti-Anxiety Agents; Binding Sites; Carrier Proteins; CHO Cells; Clozapine; Cricetinae; Cricetulus; Diazepam; Epithelial Cells; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ion Transport; Lorazepam; Medazepam; Nerve Tissue Proteins; Neurons; Oocytes; Oxazepam; Recombinant Fusion Proteins; Sodium; Symporters; Xenopus laevis	1999
Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups. Neuropharmacology, 2000, Jun-08, Volume: 39, Issue:8 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Behavior, Animal; Buspirone; Clozapine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Female; Haloperidol; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation; Stress, Psychological; Vocalization, Animal; Zimeldine	2000
Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule. Psychopharmacology, 2001, Volume: 155, Issue:2 Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Callithrix; Central Nervous System Stimulants; Clozapine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Eating; Female; Injections, Intramuscular; Male; Reinforcement Schedule	2001
An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis. Analytical chemistry, 2002, Apr-15, Volume: 74, Issue:8 Topics: Clozapine; Diazepam; GABA Modulators; Gas Chromatography-Mass Spectrometry; Nitrazepam; Spectrometry, Mass, Electrospray Ionization	2002
Comparisons of psychotropic drug prescribing patterns in acute psychiatric wards across Europe. European journal of clinical pharmacology, 2004, Volume: 60, Issue:1 Topics: Adult; Benzodiazepines; Biperiden; Chlorpromazine; Clozapine; Cyclohexanols; Diazepam; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization Review; Europe; Female; Humans; Male; Mood Disorders; Olanzapine; Pharmacoepidemiology; Practice Patterns, Physicians'; Psychiatric Department, Hospital; Psychotropic Drugs; Schizophrenia; Time Factors; Venlafaxine Hydrochloride	2004
Novel oral drug administration in an animal model of neuroleptic therapy. Journal of neuroscience methods, 2005, Aug-15, Volume: 146, Issue:2 Topics: Administration, Oral; Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Brain; Clozapine; Diazepam; Disease Models, Animal; Dyskinesia, Drug-Induced; Grooming; Haloperidol; Male; Mastication; Motivation; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time	2005
Obsessive-compulsive disorder in UK clozapine-treated schizophrenia and schizoaffective disorder: a cause for clinical concern. Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:1 Topics: Adult; Antipsychotic Agents; Clozapine; Cohort Studies; Cross-Sectional Studies; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Muscarinic Antagonists; Obsessive-Compulsive Disorder; Psychotic Disorders; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; United Kingdom	2009
Diazepam improves aspects of social behaviour and neuron activation in NMDA receptor-deficient mice. Genes, brain, and behavior, 2014, Volume: 13, Issue:7 Topics: Animals; Brain; Clozapine; Diazepam; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Organ Specificity; Receptors, N-Methyl-D-Aspartate; Social Behavior	2014
Relapses and recurrences of catatonia: 30-case analysis and literature review. Comprehensive psychiatry, 2016, Volume: 66 Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Catatonia; Clozapine; Depressive Disorder, Major; Diazepam; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; Recurrence; Schizophrenia, Catatonic; Young Adult	2016