diazepam has been researched along with clonidine in 192 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (40.63) | 18.7374 |
| 1990's | 39 (20.31) | 18.2507 |
| 2000's | 30 (15.63) | 29.6817 |
| 2010's | 42 (21.88) | 24.3611 |
| 2020's | 3 (1.56) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| Gong, Q; Li, J; Li, X; Liu, W; Mao, F; Qiu, X; Wang, H; Wang, W; Xu, Y; Zhang, H; Zhang, J; Zhu, J | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Dinnendahl, V; Gumulka, SW | 1 |
| Walters, WA | 1 |
| Canevari, A; Cugurra, F; Piredda, F | 1 |
| Glover, V; Grant, E; Orton, D; Rose, FC; Sandler, M; Stevens, D; Wilkinson, M | 1 |
| Ludin, HP | 1 |
| Beshara, D; Levy, JM; Stoll, C | 1 |
| Bolme, P; Fuxe, K | 1 |
| Dorokhova, MI | 1 |
| Poignant, JC; Rismondo, N | 1 |
| Evans, RH; Long, SK; Siarey, RJ | 1 |
| Buccafusco, JJ; Li, W | 1 |
| Ishizuki, M; Yanagisawa, M | 1 |
| Bhattacharya, A; Bose, S; Kumar, A; Kundra, P; Tandon, OP | 2 |
| Devi, K; Hrishikeshavan, HJ; Munonyedi, US; Shanbhogue, RS | 1 |
| Avrutskiĭ, MIa; Guseĭnov, TIu; Katkovskiĭ, DG; Musikhin, LV; Zhukov, VN | 1 |
| Barone, D; Spignoli, G | 1 |
| Asakura, N; Hamaya, Y; Harukuni, I; Nishikawa, T | 1 |
| Hartmann, M; Seitz, W; Verner, L | 1 |
| Dietz, V | 1 |
| Holtzman, SG | 1 |
| Pouttu, J; Rosenberg, PH; Scheinin, M; Tuominen, M | 1 |
| Luo, ZP; Yang, XM; Zhou, JH | 5 |
| Aley, KO; Kulkarni, SK | 1 |
| Ferrari, F; Mangiafico, V; Monti, A; Tartoni, PG | 1 |
| Baran, H; Hornykiewicz, O; Hörtnagl, H | 1 |
| Jørum, E | 1 |
| Carlsson, M; Eriksson, E; Nilsson, C; Söderpalm, B | 1 |
| Kulkarni, SK; Kunchandy, J | 1 |
| Dangoumau, L; Poncelet, M; Simon, P; Soubrié, P | 1 |
| Costall, B; Kelly, ME; Naylor, RJ | 1 |
| Chrousos, GP; Crawley, JN; Linnoila, M; Ninan, PT; Paul, SM; Pickar, D; Skolnick, P | 1 |
| Green, AR; Johnson, P; Mountford, JA; Nimgaonkar, VL | 1 |
| Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G | 1 |
| Forster, P; Stone, TW | 1 |
| Costa, LG; Murphy, SD | 1 |
| Molyneux, S; Nutt, D | 1 |
| Hao, W; Wei, H; Young, D | 1 |
| Kulkarni, SK; Parale, MP | 1 |
| Eisenhofer, G; Goldstein, DS; Keiser, HR; Kopin, IJ; Stull, R; Udelsman, R | 1 |
| Spealman, RD; Wettstein, JG | 1 |
| Mattila, M; Mattila, MJ; Seppala, T | 1 |
| Bailey, C; Brewer, C; Rezae, H | 1 |
| Calvillo, O; Ghignone, M; Noe, C; Quintin, L | 1 |
| Bes, A; Eyssette, M; Pierrot-Deseilligny, E; Rohmer, F; Warter, JM | 1 |
| Igarashi, S; Yamamura, H; Yanagita, T | 1 |
| Kulkarni, GK; Kulkarni, SK; Parale, MP | 1 |
| Ghignone, M; Orko, R; Pouttu, J; Rosenberg, PH | 1 |
| Fukuda, H; Kato, F; Kato, K; Matsumoto, K; Miyamoto, M; Mori, T; Nakamura, T; Oka, J; Ono, H | 1 |
| Lakić, N; Manev, H; Pericić, D | 1 |
| Baiguerra, G; Kostowski, W; Valzelli, L | 1 |
| Conrad, B; Meinck, HM | 1 |
| Delwaide, PJ | 1 |
| Caccia, MR; Mangoni, A | 1 |
| Martin, JD | 1 |
| Furukawa, T; Katsuragi, T; Ushijima, I | 1 |
| Adams, MA; Hirst, M | 1 |
| Handley, SL; Mithani, S | 1 |
| Cooke, RG; Homeida, AM | 2 |
| Galloway, MP; Roth, RH | 2 |
| Jurna, I | 1 |
| Doaré, L; Simon, P; Soubrié, P; Thiébot, MH | 1 |
| Aloi, J; Insel, TR; Jimerson, DC; Ninan, PT; Paul, SM; Skolnick, P | 1 |
| Decobert, M; Depoortere, H; Honoré, L | 1 |
| Kulkarni, SK; Mehta, AK | 1 |
| Emmett-Oglesby, MW; Lal, H; Lewis, MW; Spencer, DG | 1 |
| Grilly, DM; Jacoby, D; Johnson, SK; LaRiccia, J; Minardo, R | 1 |
| Hennies, OL | 1 |
| Fryda-Kaurimsky, Z; Müller-Fassbender, H | 1 |
| Johansson, G; Luostarinen, M; Virkkunen, P | 1 |
| Medvedev, OS; Val'dman, AV | 1 |
| McLellan, DL | 1 |
| Pappas, BA; Walsh, P | 1 |
| Conrad, B; Meinck, HM; Ricker, K | 1 |
| Haertzen, CA; Henningfield, JE; Jasinski, DR; Johnson, RE; Makhzoumi, HM; Miyasato, K | 1 |
| Trulson, ME; Trulson, VM | 1 |
| Huupponen, R; Koulu, M; Pihlajamäki, K | 1 |
| Charney, DS; Heninger, GR; Redmond, DE | 1 |
| Metz, G; Nebel, B | 1 |
| Inoue, K; Kasai, H; Kobayashi, M; Kohno, S; Murata, T; Nagasaka, Y; Ohata, K; Sakamoto, H | 1 |
| Baum, T; Moran, RM; Sabin, C | 1 |
| Bhavsar, VH; Dhumal, VR; Kelkar, VV | 1 |
| Berge, KH; Strickland, RA | 1 |
| Cheng, CH; Costall, B; Ge, J; Naylor, RJ | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S | 1 |
| Evans, RH; Long, SK; Siarey, RJ; Tulp, MT | 1 |
| Davis, C; Emre, M; Groves, L; Lataste, X | 1 |
| Adinoff, B | 1 |
| Fukuda, H; Iwata, N; Kozuka, M; Nakamura, T; Ono, H; Tanabe, M | 1 |
| Doak, GJ; Duke, PC | 1 |
| Friedman, LS; Mayo-Smith, MF; Saitz, R | 1 |
| Coull, JT; Middleton, HC; Robbins, TW; Sahakian, BJ | 2 |
| Coull, JT; Cowen, PJ; McShane, RH; Middleton, HC; Park, SB; Robbins, TW; Sahakian, BJ; Young, AH | 1 |
| Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H | 1 |
| Abduljawad, KA; Bradshaw, CM; Langley, RW; Szabadi, E | 2 |
| Berkovich, AN; Bulganin, AD; Kuznetsova, OIu; Mikhaĭlovich, VA | 1 |
| Batra, YK; Bhardwaj, N; Ramesh, VJ | 1 |
| Ikizler, Y; Koren, G; Selby, P; Theis, JG | 1 |
| Horikawa, Y; Kagawa, T; Kondo, M; Obara, H; Ohnishi, H | 1 |
| Ishizuka, I; Kakoi, H; Kawasaki, J; Kawazoe, T; Kodaka, M; Miyao, H; Okamoto, Y | 1 |
| Broderick, PA | 1 |
| Black, WD; Celly, CS; McDonell, WN; Young, SS | 1 |
| Batra, YK; Bhardwaj, N; Jatti, K; Malhotra, S | 1 |
| Bitsios, P; Bradshaw, CM; Szabadi, E | 1 |
| Imai, Y; Kagawa, K; Kirita, T; Kishi, Y; Kita, T; Mammoto, T; Murakami, K; Sakai, T; Sugimura, M | 1 |
| Farber, NB; Kim, SH; Olney, JW; Price, MT | 1 |
| Arnsten, AF; Franowicz, JS | 1 |
| Castro, JL; Ramirez, A; Ricci, D; Taira, CA | 1 |
| Fujii, Y; Saitoh, Y; Tanaka, H; Toyooka, H | 1 |
| Goodkin, DE; Kita, M | 1 |
| Fujii, Y; Handa, F | 1 |
| Kamanin, EI; Kasianov, AA; Mishunin, IuV; Reshed'ko, OA; Tikhonov, FG | 1 |
| Cole, MJ; Jeffery, HE; Osborn, DA | 3 |
| Mishunin, IuV | 1 |
| Axelsson, K; Berggren, L; Dobrydnjov, I; Holmström, B; Samarütel, J | 1 |
| Patel, DR; Soyode, O | 1 |
| Honda, K; Inomata, S; Nakamura, T; Tanaka, E | 1 |
| Abbate, M; Ferlazzo, E; Granata, F; Mazzù, I; Musolino, R; Narbone, MC | 1 |
| Hall, DL; Rezvan, E; Tatakis, DN; Walters, JD | 1 |
| Carvalho, HG; Modolo, NS; Nascimento, Jdos S; Santos, KP; Silva, RC | 1 |
| Aisen, M; Ashwal, S; Delgado, MR; Fehlings, DL; Hirtz, D; McLaughlin, J; Morrison, LA; Shrader, MW; Tilton, A; Vargus-Adams, J | 1 |
| Benecke, R; Patejdl, R | 1 |
| Kuks, JB; Lapeyre, E; Meijler, WJ | 1 |
| Delgado, MR; Tilton, A; Vargus-Adams, J | 1 |
| Muck-Šeler, D; Pivac, N; Švob Štrac, D | 1 |
| Zdziarski, P | 1 |
| Bamford, A; Clarke, A; Crowe, BH; Hacohen, Y; Lim, M; Lin, JP; Pullaperuma, SP; Sancho-Shimizu, V; Tudor-Williams, G; Vincent, A | 1 |
| Comi, G; Gold, R; Hartung, HP; Montalban, X; Otero-Romero, S; Sastre-Garriga, J; Soelberg Sørensen, P; Thompson, AJ; Vermersch, P | 1 |
| Kouzouna, A; Lindsay, C; Pandyan, AD; Simcox, C | 1 |
| Iyengar, AR; Pande, AH | 1 |
| Barnes, E; Kaufmann, H; Norcliffe-Kaufmann, L; Palma, JA; Spalink, CL | 1 |
| Fu, X; Li, J; Li, M; Ma, Q; Wang, C; Wang, Y; Wu, H; Yang, W | 1 |
| Assam, PN; Chan, E; Cheok, C; de Souza, NN; Guo, S; Kandasami, G; Koh, PK; Lee, KM; Manning, V; Pangjaya, J; Sultana, R; Wijesinghe, R; Wong, KE; Yang, Y | 1 |
| Amin, S; Basu, A; Cadwgan, J; Crowe, B; DeAlwis, Y; Devlin, A; Kumar, R; Lodh, R; Lumsden, DE; Lundy, CT; Mordekar, SR; Smith, M | 1 |
| Davey, JG; Martin, J; Osborn, DA; Zankl, A | 2 |
| Bengono Bengono, RS; Metogo, JM; Minkande, JZ; Ndikontar, R; Ngouatna, S; Ntock, FN; Tochie, JN | 1 |
20 review(s) available for diazepam and clonidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Spasticity: therapy of increased reflexes or movement disorder?].
Topics: Baclofen; Clonidine; Combined Modality Therapy; Dantrolene; Diazepam; Glycine; Humans; Locomotion; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Muscles; Phenothiazines; Reflex, Abnormal | 1990 |
Drug effects on the EEG of various species of laboratory animals.
Topics: 5-Hydroxytryptophan; Amantadine; Animals; Antihypertensive Agents; Azabicyclo Compounds; Brain; Cats; Chlormethiazole; Clonidine; Diazepam; Electroencephalography; Flunitrazepam; Guanabenz; Guanfacine; Guanidines; Imidazoles; Male; Nitrazepam; Pentobarbital; Phenylacetates; Piperazines; Piracetam; Rats; Sodium Oxybate; Yohimbine | 1983 |
Comparative profile of tizanidine in the management of spasticity.
Topics: Activities of Daily Living; Baclofen; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus | 1994 |
Current management of the neonatal abstinence syndrome: a critical analysis of the evidence.
Topics: Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clonidine; Diazepam; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; MEDLINE; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; Phenobarbital; Sympatholytics | 1997 |
Drugs used to treat spasticity.
Topics: Baclofen; Clonidine; Dantrolene; Diazepam; Drug Administration Schedule; Humans; Muscle Relaxants, Central; Muscle Spasticity | 2000 |
Sedatives for opiate withdrawal in newborn infants.
Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic | 2002 |
Sedatives for opiate withdrawal in newborn infants.
Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic | 2005 |
Pharmacologic interventions for reducing spasticity in cerebral palsy.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Age Factors; Anti-Infective Agents, Local; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child, Preschool; Clonidine; Dantrolene; Diazepam; Ethanol; Humans; Infant; Injections, Intramuscular; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Phenol; Time Factors | 2005 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Treatment Outcome | 2010 |
[New therapies for spastic movement disorders].
Topics: Administration, Oral; Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Injections, Intramuscular; Injections, Spinal; Movement Disorders; Muscle Relaxants, Central; Muscle Spasticity; Parasympatholytics; Physical Therapy Modalities; Tolperisone | 2009 |
Spasticity: revisiting the role and the individual value of several pharmacological treatments.
Topics: Amines; Baclofen; Botulinum Toxins; Calcium Channel Blockers; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diazepam; Gabapentin; gamma-Aminobutyric Acid; Humans; Muscle Relaxants, Central; Muscle Spasticity; Recovery of Function; Treatment Outcome | 2010 |
Sedatives for opiate withdrawal in newborn infants.
Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic | 2010 |
Pharmacologic treatment of spasticity in children.
Topics: Age Factors; Baclofen; Botulinum Toxins; Child; Clonidine; Dantrolene; Diazepam; Humans; Injections, Spinal; Muscle Spasticity; Neuromuscular Agents | 2010 |
Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.
Topics: Amines; Analgesics; Baclofen; Cannabidiol; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diazepam; Dronabinol; Drug Combinations; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Phenol | 2016 |
Pharmacological interventions other than botulinum toxin for spasticity after stroke.
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Controlled Trials as Topic; Stroke; Tolperisone | 2016 |
Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.
Topics: Antidotes; Atropine; Chemical Warfare; Clonidine; Diazepam; Excitatory Amino Acid Antagonists; Humans; Hydrolases; Hydrolysis; Nerve Agents; Organophosphates; Oximes; Purinergic P1 Receptor Agonists; Pyridostigmine Bromide; Renal Dialysis | 2016 |
A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis.
Topics: Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Transcutaneous Electric Nerve Stimulation | 2018 |
Sedatives for opioid withdrawal in newborn infants.
Topics: Bias; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Opioid treatment for opioid withdrawal in newborn infants.
Topics: Buprenorphine; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Opium; Phenobarbital; Randomized Controlled Trials as Topic | 2021 |
38 trial(s) available for diazepam and clonidine
| Article | Year |
|---|---|
[The effect of DS 103--282, a new type of myotonolyticum, on the contractile mechanism in human skeletal muscle (author's transl)].
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Humans; Muscle Contraction | 1977 |
Oral clonidine premedication for elderly patients undergoing intraocular surgery.
Topics: Administration, Oral; Aged; Anesthesia Recovery Period; Cataract Extraction; Clonidine; Diazepam; Double-Blind Method; Female; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Preanesthetic Medication | 1992 |
[Effects of epidural clonidine added to lidocaine solution upon the requirements of sedatives during epidural anesthesia].
Topics: Adult; Anesthesia, Epidural; Clonidine; Diazepam; Female; Humans; Hysterectomy; Injections, Intravenous; Lidocaine; Middle Aged; Thiamylal | 1991 |
[Clonidine supplemented analgesia and sedation in prevention of postoperative delirium].
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Anesthesia, General; Arousal; Clonidine; Critical Care; Diazepam; Drug Therapy, Combination; Esophageal Neoplasms; Female; Hemodynamics; Humans; Male; Middle Aged; Pirinitramide; Postoperative Complications; Prospective Studies | 1990 |
Effects of oral clonidine premedication on concentrations of cortisol and monoamine neurotransmitters and their metabolites in cerebrospinal fluid and plasma.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Adult; Anesthesia, Spinal; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Epinephrine; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Preanesthetic Medication; Random Allocation; Tryptophan | 1989 |
Effect of clonidine on cigarette cessation and in the alleviation of withdrawal symptoms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Behavior Therapy; Clinical Trials as Topic; Clonidine; Combined Modality Therapy; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Substance Withdrawal Syndrome; Tobacco Use Disorder | 1988 |
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam.
Topics: Adult; Anxiety; Arousal; Caffeine; Clonidine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Female; Growth Hormone; Humans; Hydrocortisone; Male; Panic; Prolactin; Yohimbine | 1988 |
Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement.
Topics: Anesthesia; Anesthesia, General; Anesthesia, Local; Animals; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Hemodynamics; Humans; Intraocular Pressure; Intraoperative Period; Male; Middle Aged; Ophthalmologic Surgical Procedures; Preanesthetic Medication; Random Allocation | 1988 |
A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Hemiplegia; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Random Allocation | 1988 |
Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo.
Topics: Adult; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Heart Rate; Humans; Male; Placebos; Substance-Related Disorders; Surveys and Questionnaires | 1988 |
Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Clonidine; Diazepam; Female; Gastric Acid; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Male; Middle Aged; Preanesthetic Medication; Random Allocation | 1987 |
A new skeletal muscle relaxant (DS 103-282) compared to diazepam in the treatment of muscle spasm of local origin.
Topics: Adult; Aged; Back Pain; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1981 |
Tizanidine (DS 103-282) in the treatment of acute paravertebral muscle spasm: a controlled trial comparing tizanidine and diazepam.
Topics: Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Random Allocation; Spasm; Spinal Diseases; Time Factors | 1981 |
Effect of the benzodiazepine derivative, diazepam, on the clonidine-stimulated human growth hormone secretion.
Topics: Adult; Clonidine; Diazepam; Growth Hormone; Humans; Infusions, Parenteral; Male; Pituitary Gland, Anterior; Stimulation, Chemical; Time Factors | 1983 |
Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Alprazolam; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Ethanol; Female; Heart Rate; Humans; Male; Middle Aged; Neurologic Examination; Receptors, GABA-A | 1994 |
Recovery from pre-operative sedation with clonidine--brain stem auditory evoked response.
Topics: Aged; Anesthesia Recovery Period; Anesthesia, Local; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Evoked Potentials, Auditory, Brain Stem; Female; Heart Rate; Humans; Male; Middle Aged; Ophthalmologic Surgical Procedures; Preanesthetic Medication; Time Factors | 1994 |
Oral clonidine premedication attenuates the haemodynamic effects associated with ketamine anaesthetic induction in humans.
Topics: Administration, Oral; Adult; Anesthesia, Intravenous; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Female; Hallucinations; Heart Rate; Hemodynamics; Humans; Ketamine; Male; Patient Satisfaction; Placebos; Preanesthetic Medication; Time Factors | 1993 |
Contrasting effects of clonidine and diazepam on tests of working memory and planning.
Topics: Adult; Clonidine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Female; Health Planning; Humans; Male; Memory; Task Performance and Analysis; Volunteers | 1995 |
Clonidine and diazepam have differential effects on tests of attention and learning.
Topics: Adult; Attention; Clonidine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Learning; Male; Placebo Effect; Task Performance and Analysis; Time Factors; Volunteers | 1995 |
Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search.
Topics: Adult; Attention; Clonidine; Diazepam; Haloperidol; Humans; Placebo Effect; Reaction Time; Tryptophan | 1995 |
Oral clonidine premedication reduces vomiting in children after strabismus surgery.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Child, Preschool; Clonidine; Diazepam; Diclofenac; Double-Blind Method; Female; Humans; Incidence; Length of Stay; Male; Midazolam; Neuromuscular Nondepolarizing Agents; Pain, Postoperative; Placebos; Postoperative Complications; Preanesthetic Medication; Premedication; Prospective Studies; Strabismus; Vecuronium Bromide; Vomiting | 1995 |
Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man.
Topics: Acoustic Stimulation; Adult; Blinking; Clonidine; Diazepam; Double-Blind Method; Electromyography; Flicker Fusion; Humans; Male; Oculomotor Muscles; Reaction Time; Reflex, Startle; Salivation | 1997 |
[Clofelin in the anesthesiological support system for surgical operations].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Anesthesia, General; Anesthetics, Combined; Anesthetics, General; Anesthetics, Intravenous; Clonidine; Diazepam; Female; Humans; Intraoperative Care; Male; Middle Aged; Pirinitramide; Postoperative Care; Surgical Procedures, Operative | 1996 |
Comparative study of oral clonidine and diazepam as premedicants in children.
Topics: Adrenergic alpha-Agonists; Anti-Anxiety Agents; Blood Pressure; Child; Clonidine; Diazepam; Double-Blind Method; Female; Heart Rate; Humans; Male; Premedication | 1997 |
[Influence of preanesthetic medication on the effect of a local anesthetic tape].
Topics: Adjuvants, Anesthesia; Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Catheterization, Peripheral; Clonidine; Diazepam; Drug Interactions; Humans; Lidocaine; Middle Aged; Pain; Preanesthetic Medication; Sympatholytics | 1997 |
[The effects of premedication on induction doses of propofol and hemodynamic responses during induction].
Topics: Adult; Atropine; Clonidine; Diazepam; Drug Interactions; Female; Hemodynamics; Humans; Hydroxyzine; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Preanesthetic Medication; Propofol | 1997 |
Comparison of psychomotor functions and sedation following premedication with oral diazepam and clonidine in children.
Topics: Administration, Oral; Anti-Anxiety Agents; Child; Child, Preschool; Clonidine; Conscious Sedation; Diazepam; Double-Blind Method; Female; Humans; Intelligence; Intelligence Tests; Male; Premedication; Prospective Studies; Psychometrics; Psychomotor Performance; Sympatholytics | 1998 |
The effects of clonidine on the fear-inhibited light reflex.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Clonidine; Diazepam; Double-Blind Method; Electroshock; Fear; Humans; Male; Neural Inhibition; Reflex, Pupillary; Sympatholytics | 1998 |
The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia.
Topics: Administration, Oral; Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Breast Neoplasms; Clonidine; Diazepam; Double-Blind Method; Drug Costs; Female; Fentanyl; Hemodynamics; Humans; Infusions, Intravenous; Intubation, Intratracheal; Lymph Node Excision; Mastectomy, Segmental; Middle Aged; Nitrous Oxide; Oxygen; Placebos; Preanesthetic Medication; Propofol | 1998 |
Pretreatment with oral clonidine attenuates cardiovascular responses to tracheal extubation in children.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, General; Antiemetics; Antihypertensive Agents; Blood Pressure; Child; Child, Preschool; Clonidine; Diazepam; Double-Blind Method; Female; Heart Rate; Humans; Intubation, Intratracheal; Male; Postoperative Complications; Tachycardia | 2000 |
The efficacy of oral clonidine premedication in the prevention of postoperative vomiting in children following strabismus surgery.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Antiemetics; Child; Child, Preschool; Clonidine; Diazepam; Double-Blind Method; Female; Humans; Male; Nitrous Oxide; Postoperative Nausea and Vomiting; Preanesthetic Medication; Propofol; Prospective Studies; Strabismus | 2001 |
[Potentiation of local anesthesia in endonasal surgery].
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Clonidine; Diazepam; Drug Synergism; Humans; Nasal Septum; Procaine | 2001 |
Effects of clonidine and diazepam on prepulse inhibition of the acoustic startle response and the N1/P2 auditory evoked potential in man.
Topics: Acoustic Stimulation; Adolescent; Adrenergic alpha-Agonists; Adult; Affect; Anti-Anxiety Agents; Clonidine; Diazepam; Double-Blind Method; Electromyography; Evoked Potentials, Auditory; Hemodynamics; Humans; Male; Oculomotor Muscles; Reflex, Startle; Salivation | 2001 |
Intrathecal and oral clonidine as prophylaxis for postoperative alcohol withdrawal syndrome: a randomized double-blinded study.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Alcoholism; Anesthesia; Central Nervous System Depressants; Clonidine; Diazepam; Double-Blind Method; Ethanol; Hemodynamics; Humans; Hypnotics and Sedatives; Injections, Spinal; Male; Middle Aged; Postoperative Complications; Psychomotor Agitation; Respiratory Mechanics; Substance Withdrawal Syndrome; Transurethral Resection of Prostate | 2004 |
Oral clonidine pre-treatment and diazepam/meperidine sedation.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Intravenous; Blood Pressure; Clonidine; Conscious Sedation; Cross-Over Studies; Diazepam; Electroencephalography; Female; Humans; Likelihood Functions; Male; Meperidine; Middle Aged; Preanesthetic Medication; Respiration; Statistics, Nonparametric; Surveys and Questionnaires | 2006 |
Sedative and cardiovascular effects of midazolam and diazepam alone or combined with clonidine in patients undergoing hemodynamic studies for suspected coronary artery disease.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Blood Pressure; Cineangiography; Clonidine; Conscious Sedation; Coronary Disease; Diazepam; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Monitoring, Physiologic; Prospective Studies | 2007 |
Lofexidine versus diazepam for the treatment of opioid withdrawal syndrome: A double-blind randomized clinical trial in Singapore.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Craving; Diazepam; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Opioid-Related Disorders; Pupil; Singapore; Substance Withdrawal Syndrome | 2018 |
The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study.
Topics: Analgesics, Opioid; Anesthesia, General; Clonidine; Dexamethasone; Dexmedetomidine; Diazepam; Female; Fentanyl; Gynecologic Surgical Procedures; Humans; Isoflurane; Ketamine; Lidocaine; Magnesium Sulfate; Pain, Postoperative; Pilot Projects; Propofol; Rocuronium; Saline Solution | 2022 |
134 other study(ies) available for diazepam and clonidine
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mice; Molecular Structure; Muscle Spasticity; Paralysis; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Strychnine; Triazoles | 1994 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 2018 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Depression; Drug Design; Ligands; Mice; Permeability; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Tacrine; Vilazodone Hydrochloride | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Stress-induced alterations of cyclic nucleotide levels in brain: effects of centrally acting drugs.
Topics: Aminooxyacetic Acid; Animals; Brain; Brain Chemistry; Chlorpromazine; Clonidine; Cyclic AMP; Cyclic GMP; Diazepam; Diphenhydramine; Haloperidol; Indomethacin; Male; Mice; Pentobarbital; Phentolamine; Propanolamines; Propranolol; Reserpine; Stress, Physiological | 1977 |
Review: the significance and management of raised blood pressure in pregnancy.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Chlormethiazole; Clonidine; Diazepam; Diazoxide; Diuretics; Female; Heparin; Humans; Hydralazine; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications, Cardiovascular | 1979 |
[Detoxication of heroin addicts in the area of Genoa].
Topics: Adolescent; Adult; Amino Acids; Clonidine; Diazepam; Female; Fructose; Heroin Dependence; Humans; Male; Methadone; ortho-Aminobenzoates; Substance Withdrawal Syndrome; Sulpiride; Vitamins | 1979 |
Transitory decrease in platelet monoamine-oxidase activity during migraine attacks.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Blood Proteins; Child; Child, Preschool; Clonidine; Diazepam; Ergotamine; Female; Humans; Male; Middle Aged; Migraine Disorders; Monoamine Oxidase; Tyramine | 1977 |
Roberts's syndrome and clonidine.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Lip; Cleft Palate; Clonidine; Diazepam; Ectromelia; Female; Humans; Hypertension; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Cardiovascular; Syndrome | 1979 |
Possible involvement of GABA mechanisms in central cardiovascular and respiratory control. Studies on the interaction between diazepam, picrotoxin and clonidine.
Topics: Aminobutyrates; Animals; Blood Pressure; Clonidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Male; Picrotoxin; Rats; Respiration | 1977 |
[Pharmacologic analysis of the cholinergic vasodilation in unanesthetized animals].
Topics: Animals; Blood Pressure; Cats; Cholinergic Fibers; Clonidine; Corpus Callosum; Diazepam; Hypothalamus; Iliac Artery; Norepinephrine; Reserpine; Vasodilation | 1978 |
[Influence of the administration of psychopharmacological compounds on the take up time of an alimentary material in the hamster and a study of the associated behaviour (author's transl)].
Topics: Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clonidine; Cricetinae; Dextroamphetamine; Diazepam; Feeding Behavior; Fenfluramine; Humans; Imipramine; Male; Meprobamate; Mesocricetus; Morphine; Motor Activity; Phenobarbital; Piribedil; Psychotropic Drugs; Stereotyped Behavior; Sulpiride; Time Factors | 1975 |
The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro.
Topics: Animals; Baclofen; Clonidine; Diazepam; In Vitro Techniques; Muscle Relaxants, Central; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission; Tetrodotoxin | 1992 |
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Cholinesterase Inhibitors; Clonidine; Diazepam; Dose-Response Relationship, Drug; Guanabenz; Guanfacine; Lethal Dose 50; Male; Motor Activity; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Soman | 1992 |
Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat.
Topics: Analgesics; Animals; Animals, Newborn; Clonidine; Diazepam; Evoked Potentials; In Vitro Techniques; Muscle Relaxants, Central; Physical Stimulation; Propiophenones; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Spinal Nerve Roots; Tail; Time Factors | 1992 |
Potentiation of poststartle activity by conditioned fear: effects of anxiolytic and anxiogenic drugs.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Clonidine; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Fear; Male; Rats; Rats, Inbred Strains; Reflex, Startle; Xylazine; Yohimbine | 1991 |
[Effects of transcranial laser irradiation in near infrared range on antinociceptive reactions in mice after administration of diazepam, clopheline and morphine].
Topics: Animals; Brain; Clonidine; Diazepam; Injections, Intraperitoneal; Lasers; Mice; Morphine; Pain Measurement | 1991 |
Investigations on the binding properties of the nootropic agent pyroglutamic acid.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Chloride Channels; Clonidine; Diazepam; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Guinea Pigs; Male; Membrane Proteins; Mianserin; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA-A; Receptors, Glutamate; Receptors, Glycine; Receptors, Histamine; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Purinergic; Receptors, Serotonin; Stereoisomerism | 1990 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Behavioral evidence for the role of noradrenaline in the putative anxiogenic actions of the inverse benzodiazepine receptor agonist methyl-4-ethyl-6,7-dimethoxy-beta-carboline-3-carboxylate.
Topics: Animals; Carbolines; Chlorpromazine; Clonidine; Conditioning, Operant; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Yohimbine | 1989 |
[Effect of clonidine on the schedule-controlled performance action of two benzodiazepine receptor agonists].
Topics: Animals; Bicuculline; Clonidine; Conditioning, Operant; Diazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement Schedule; Yohimbine | 1989 |
GABAergic agents and clonidine attenuate footshock-induced aggression in mice.
Topics: Aggression; Animals; Baclofen; Clonidine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Reserpine | 1989 |
Does anxiety underly imidazole-induced behavioural effects in the rat?
Topics: Animals; Anxiety; Arousal; Behavior, Animal; Blood Pressure; Clonidine; Diazepam; Emotions; Hemodynamics; Imidazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Social Behavior; Yohimbine | 1989 |
Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine.
Topics: alpha-Methyltyrosine; Animals; Clonidine; Diazepam; Dopamine; Epilepsy; Kainic Acid; Male; Methyltyrosines; Neurons; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Noradrenergic mechanisms in mediation of stress-induced hyperalgesia in rats.
Topics: Analgesia; Animals; Clonidine; Diazepam; Norepinephrine; Pain; Rats; Receptors, Adrenergic, alpha; Stress, Physiological; Vibration; Yohimbine | 1988 |
[Effects of agonist and inverse agonist of central benzodiazepine receptors on discriminative yohimbine stimulation].
Topics: Animals; Carbolines; Clonidine; Convulsants; Diazepam; Discrimination Learning; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Yohimbine | 1988 |
Does alprazolam, in contrast to diazepam, activate alpha 2-adrenoceptors involved in the regulation of rat growth hormone secretion?
Topics: Adrenergic alpha-Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Clonidine; Diazepam; Dioxanes; Growth Hormone; Idazoxan; Kinetics; Male; Rats; Receptors, Adrenergic, alpha; Reserpine; Yohimbine | 1986 |
Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Diazepam; Guanfacine; Guanidines; Male; Motor Activity; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine | 1986 |
Effects of neuroleptic drugs, clonidine and lithium on the expression of conditioned behavioral excitation in rats.
Topics: Animals; Antipsychotic Agents; Appetitive Behavior; Arousal; Clonidine; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Lithium; Male; Motor Activity; Rats; Rats, Inbred Strains | 1987 |
The anxiolytic and anxiogenic actions of ethanol in a mouse model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Weight; Clonidine; Diazepam; Drinking; Ethanol; Exploratory Behavior; Male; Mice; Substance Withdrawal Syndrome; Tiapamil Hydrochloride | 1988 |
Behavioral evidence for the role of noradrenaline in putative anxiolytic and sedative effects of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Clonidine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Norepinephrine; Rats; Rats, Inbred Strains; Reinforcement Schedule; Yohimbine | 1988 |
Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Cyproheptadine; Diazepam; Epinephrine; Heart Rate; Humans; Hydrocortisone; Indoles; Isoxazoles; Macaca mulatta; Male; Norepinephrine; Propranolol | 1985 |
Some anticonvulsant drugs alter monoamine-mediated behaviour in mice in ways similar to electroconvulsive shock; implications for antidepressant therapy.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Antidepressive Agents; Apomorphine; Behavior, Animal; Biogenic Amines; Clonidine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Radioligand Assay; Receptors, Adrenergic, beta; Receptors, Serotonin; Valproic Acid | 1985 |
Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures.
Topics: Animals; Brain Chemistry; Clonidine; Diazepam; Haloperidol; Kainic Acid; Male; Metergoline; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Seizures | 1985 |
Purine effects on (3H)-clonidine binding to rat brain.
Topics: Animals; Brain; Clonidine; Diazepam; In Vitro Techniques; Kinetics; Male; Phenylisopropyladenosine; Purines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tritium; Verapamil | 1986 |
Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study.
Topics: Amidines; Animals; Brain Chemistry; Chlorphenamidine; Clonidine; Diazepam; Dihydroalprenolol; Dioxanes; In Vitro Techniques; Kinetics; Male; Mice; Muscimol; Proteins; Quinuclidinyl Benzilate; Receptors, Adrenergic; Receptors, GABA-A | 1987 |
Benzodiazepines, plasma MHPG and alpha-2-adrenoceptor function in man.
Topics: Brain; Clonidine; Diazepam; Glycols; Humans; Male; Methoxyhydroxyphenylglycol; Psychomotor Performance; Receptors, Adrenergic; Substance Withdrawal Syndrome | 1987 |
Clonidine--induced behavioural despair in mice: reversal by antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Azepines; Clonidine; Depression; Diazepam; Guanfacine; Guanidines; Lithium; Male; Phenylacetates; Rats; Rats, Inbred Strains; Tranylcypromine; Yohimbine | 1986 |
Neuronal source of plasma dihydroxyphenylalanine.
Topics: Adolescent; Adrenalectomy; Adrenergic Fibers; Adult; Aged; alpha-Methyltyrosine; Anesthesia; Animals; Catecholamines; Clonidine; Diazepam; Dihydroxyphenylalanine; Dogs; Female; Humans; Isoproterenol; Macaca fascicularis; Male; Methyltyrosines; Middle Aged; Sympathectomy; Trimethaphan; Yohimbine | 1987 |
Distinctive behavioral effects of the pyrazoloquinoline CGS 8216 in squirrel monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Clonidine; Diazepam; Flumazenil; Male; Pyrazoles; Saimiri | 1988 |
[Potentiating effect of clonidine on the anxiolytic action of diazepam in a rat social interaction model of anxiety].
Topics: Animals; Anxiety; Behavior, Animal; Clonidine; Diazepam; Drug Synergism; Male; Rats | 1988 |
Opioid withdrawal and naltrexone induction in 48-72 hours with minimal drop-out, using a modification of the naltrexone-clonidine technique.
Topics: Adolescent; Adult; Clonidine; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naltrexone; Narcotics; Substance Withdrawal Syndrome; Time Factors | 1988 |
Clonidine in alcohol withdrawal: a clinical report.
Topics: Adult; Alcoholism; Clonidine; Diazepam; Humans; Male; Substance Withdrawal Syndrome | 1987 |
Effects of tizanidine, a centrally acting muscle relaxant, on motor systems.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Clonidine; Decerebrate State; Diazepam; Male; Membranes; Motor Neurons; Muscle Relaxants, Central; Neuromuscular Junction; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1986 |
Mechanisms by which picrotoxin and a high dose of diazepam elevate plasma corticosterone level.
Topics: Animals; Apomorphine; Atropine; Bicuculline; Clonidine; Corticosterone; Dexamethasone; Diazepam; Drug Interactions; Female; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Yohimbine | 1986 |
Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents.
Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Apomorphine; Benzodiazepines; Clonidine; Desipramine; Diazepam; Drug Interactions; Male; Mice; Rats; Rats, Inbred Strains | 1986 |
Neuropharmacological investigations in the stiff-man syndrome.
Topics: Adrenergic Fibers; Central Nervous System Diseases; Clonidine; Diazepam; Female; Humans; Methamphetamine; Muscle Rigidity; Reflex, Abnormal; Reserpine; Syndrome | 1986 |
Electrophysiological analysis of the mode of action of muscle relaxants in spasticity.
Topics: Baclofen; Clonidine; Diazepam; Electrophysiology; Ethanolamines; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1985 |
Clonidine in essential tremor: preliminary observations from an open trial.
Topics: Aged; Clonidine; Diazepam; Female; Handwriting; Humans; Levodopa; Male; Middle Aged; Piribedil; Tremor | 1985 |
A critical survey of drugs used in the treatment of hypertensive crises of pregnancy.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Barbiturates; Chlormethiazole; Clonidine; Diazepam; Diazoxide; Diuretics; Eclampsia; Female; Ferricyanides; Humans; Hydralazine; Magnesium; Paraldehyde; Pentolinium Tartrate; Pre-Eclampsia; Pregnancy; Reserpine; Sodium Chloride Symporter Inhibitors; Trimethaphan; Veratrum Alkaloids | 1974 |
Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.
Topics: Adenosine; Aggression; Animals; Apomorphine; Bicuculline; Clonidine; Diazepam; Dipyridamole; Humans; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1984 |
The ethanol withdrawal syndrome in the rat: effects of drug treatment on adrenal gland and urinary catecholamines.
Topics: Adrenal Glands; Alcohol Withdrawal Delirium; Animals; Catecholamines; Clonidine; Dexamethasone; Diazepam; Hexamethonium; Hexamethonium Compounds; Humans; Male; Propranolol; Psychoses, Alcoholic; Rats; Rats, Inbred Strains; Sympathetic Nervous System | 1982 |
Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Amobarbital; Animals; Clonidine; Diazepam; Exploratory Behavior; Fear; Male; Models, Psychological; Picrotoxin; Prazosin; Rats | 1984 |
Pharmacological aspects of metaldehyde poisoning in mice.
Topics: Acetaldehyde; Animals; Brain; Clonidine; Diazepam; Female; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains; Molluscacides; Norepinephrine; Seizures; Serotonin | 1982 |
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Axons; Brain; Clonidine; Diazepam; Dihydroxyphenylalanine; Hydroxylation; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase; Yohimbine | 1983 |
Pain-depressing agents and the spinal nociceptive system.
Topics: Analgesics; Animals; Ceruletide; Clonidine; Diazepam; Endorphins; Humans; Morphine; Motor Neurons; Neurons, Afferent; Nociceptors; Pentobarbital; Receptors, GABA-A; Receptors, Opioid; Reflex; Sincalide; Spinal Cord; Substance P; Synapses | 1984 |
Evidence against the involvement of a noradrenergic mechanism in the release by diazepam of novelty-induced hypophagia in rats.
Topics: Animals; Anxiety; Clonidine; Diazepam; Drug Interactions; Eating; Guanfacine; Guanidines; Humans; Male; Mice; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Yohimbine | 1984 |
A benzodiazepine receptor-mediated model of anxiety. Studies in nonhuman primates and clinical implications.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Diazepam; Dose-Response Relationship, Drug; Heart Rate; Humans; Hydrocortisone; Indoles; Ligands; Macaca mulatta; Male; Methoxyhydroxyphenylglycol; Models, Biological; Motor Activity; Propranolol; Receptors, Cell Surface; Receptors, GABA-A; Time Factors | 1984 |
Possible mechanism of digoxin-induced convulsions.
Topics: Animals; Calcium Chloride; Clonidine; Diazepam; Digoxin; Female; gamma-Aminobutyric Acid; Magnesium; Magnesium Chloride; Male; Phenytoin; Piracetam; Potassium Chloride; Rats; Rats, Inbred Strains; Seizures | 1983 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimination Learning; Flumazenil; Generalization, Stimulus; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
How do tranquilizing agents selectively inhibit conditioned avoidance responding?
Topics: Animals; Avoidance Learning; Chlordiazepoxide; Clonidine; Conditioning, Operant; Diazepam; Male; Morphine; Rats; Rats, Inbred Strains; Reaction Time; Tranquilizing Agents | 1984 |
Diazepam, alpha and beta neurotransmission modifying drugs and contrast media mortality in mice.
Topics: Animals; Clonidine; Diatrizoate; Diatrizoate Meglumine; Diazepam; Drug Interactions; Female; Lethal Dose 50; Male; Metoprolol; Mice; Phentolamine; Prazosin; Propranolol; Sympatholytics; Sympathomimetics | 1984 |
[Pharmacological analysis of the interactions of emotional-behavioral and hemodynamic reactions].
Topics: Animals; Blood Pressure; Cats; Clonidine; Diazepam; Humans; Motor Activity; Neurotensin; Pressoreceptors; Propranolol; Reflex; Stress, Psychological | 1984 |
The drug treatment of spasticity.
Topics: Baclofen; Clonidine; Dantrolene; Diazepam; Humans; Muscle Spasticity; Parasympatholytics | 1983 |
Behavioral comparison of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Chlordiazepoxide; Clonidine; Diazepam; Motor Activity; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1983 |
The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.
Topics: Adult; Brain Stem; Clomipramine; Clonidine; Diazepam; Electromyography; Female; Humans; Muscle Rigidity; Muscular Diseases; Physical Stimulation; Reflex, Abnormal; Spasm; Syndrome | 1984 |
Progress report of the NIDA Addiction Research Center.
Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institutes of Health (U.S.); Substance Withdrawal Syndrome; Substance-Related Disorders; Tobacco Use Disorder; Tolmetin; United States | 1982 |
Chloral hydrate anesthesia alters the responsiveness of dorsal raphe neurons to psychoactive drugs.
Topics: Animals; Brain Stem; Cats; Chloral Hydrate; Clomipramine; Clonidine; Diazepam; Drug Interactions; Electrophysiology; Female; Lysergic Acid Diethylamide; Male; Neurons; Phenoxybenzamine; Psychotropic Drugs; Raphe Nuclei; Wakefulness | 1983 |
Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.
Topics: Adult; Anxiety; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Diazepam; Drug Interactions; Female; Humans; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Yohimbine | 1983 |
[Clonidine in severe alcohol withdrawal delirium].
Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Clonidine; Diazepam; Haloperidol; Humans; Monitoring, Physiologic; Pneumonia; Psychoses, Alcoholic; Respiratory Insufficiency | 1983 |
Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity.
Topics: Acetaldehyde; Animals; Brain Chemistry; Clonidine; Diazepam; Female; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase; Seizures | 1982 |
[Pharmacological studies of guanabenz: effects of the central nervous system].
Topics: Animals; Anticonvulsants; Avoidance Learning; Body Temperature; Brain; Chlorpromazine; Clonidine; Diazepam; Guanabenz; Guanidines; Male; Mice; Muscle Relaxants, Central; Psychomotor Performance; Rabbits; Rats; Rats, Inbred Strains; Sleep | 1982 |
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hydralazine; Hypotension; Male; Mecamylamine; Methyldopa; Minoxidil; Phentolamine; Posture; Prazosin; Propranolol; Rats; Reserpine; Sympathetic Nervous System | 1981 |
The effect of some anti-epilepsy drugs on enhancement of the monoamine-mediated behavioural responses following the administration of electroconvulsive shocks to rats.
Topics: Animals; Anticonvulsants; Apomorphine; Behavior, Animal; Carbamazepine; Clonidine; Diazepam; Dopamine; Electroshock; Lithium; Male; Norepinephrine; Phenytoin; Rats; Rats, Inbred Strains; Serotonin | 1981 |
Management of alcohol withdrawal.
Topics: Adrenergic alpha-Agonists; Alcoholism; Anti-Anxiety Agents; Clonidine; Diazepam; Humans; Midazolam; Substance Withdrawal Syndrome | 1995 |
The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clonidine; Dialysis; Diazepam; Drug Interactions; Extracellular Space; Frontal Lobe; Hydroxyindoleacetic Acid; Male; Ondansetron; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Yohimbine | 1993 |
Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Bromouracil; Clonidine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Generalization, Stimulus; Imipramine; Male; Rats; Rats, Wistar | 1994 |
The effects of central myorelaxants on synaptically-evoked primary afferent depolarization in the immature rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Agonists; Animals; Baclofen; Clonidine; Diazepam; Electric Stimulation; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Muscle Relaxants, Central; Nerve Fibers; Neurons, Afferent; Rats; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses | 1994 |
Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine.
Topics: Animals; Cerebellar Nuclei; Clonidine; Decerebrate State; Deoxyglucose; Diazepam; Glucose; Male; Muscle Relaxants, Central; Rats; Rats, Wistar; Vestibular Nuclei | 1993 |
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine; Data Collection; Diazepam; Drug Administration Schedule; Hypnotics and Sedatives; Inpatients; Lorazepam; Oxazepam; Phenytoin; Substance Withdrawal Syndrome | 1995 |
Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.
Topics: Adrenergic alpha-Antagonists; Alprazolam; Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; Anxiety; Chloral Hydrate; Clonidine; Diazepam; Hippocampus; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Yohimbine | 1997 |
Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha 2 adrenoceptor agonist ST-91 in conscious sheep.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Animals; Clonidine; Diazepam; Female; Hemodynamics; Hypoxia; Pulmonary Gas Exchange; Respiration; Sheep | 1997 |
Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and alpha2-adrenergic agonists.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Ketamine; Microdialysis; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 1999 |
Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Clonidine; Cognition; Diazepam; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Memory; Reaction Time; Receptors, Adrenergic, alpha-2; Reserpine; Space Perception | 1999 |
Central benzodiazepine involvement in clonidine cardiovascular actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine Derivatives; Blood Pressure; Carbolines; Cardiovascular Agents; Clonidine; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Heart Rate; Infusions, Intravenous; Injections, Intraventricular; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Stereotaxic Techniques; Time Factors; Yohimbine | 1999 |
[A method for potentiation of local anesthesia for tooth removal and pulp extirpation].
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia, Dental; Anesthesia, Local; Anti-Anxiety Agents; Clonidine; Dental Anxiety; Dental Pulp Devitalization; Diazepam; Drug Synergism; Drug Therapy, Combination; Humans; Preanesthetic Medication; Tooth Extraction | 2002 |
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide | 2006 |
PRES: posterior or potentially reversible encephalopathy syndrome?
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Antihypertensive Agents; Brain; Brain Diseases; Clonidine; Dexamethasone; Diazepam; Diuretics, Osmotic; Eclampsia; Female; Humans; Magnesium Sulfate; Magnetic Resonance Imaging; Mannitol; Nifedipine; Pregnancy; Seizures | 2006 |
The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Adrenocorticotropic Hormone; alpha-Methyltyrosine; Analysis of Variance; Animals; Antihypertensive Agents; Clonidine; Corticosterone; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Female; Hypnotics and Sedatives; Rats; Rats, Wistar; Reserpine; Yohimbine | 2012 |
A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Benzodiazepines; Clonidine; Diazepam; Drug Therapy, Combination; Female; Glutamate Decarboxylase; Humans; Immunologic Factors; Muscle Relaxants, Central; Remission Induction; Rituximab; Stiff-Person Syndrome | 2015 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonidine; Diazepam; Encephalitis, Herpes Simplex; Encephalomalacia; Female; Fever; Humans; Immunocompromised Host; Immunosuppression Therapy; Infant; Leukoencephalopathies; Movement Disorders; Neurological Rehabilitation; Pakistan; Paresis; Phenobarbital; Phenytoin; Plasmapheresis; Receptors, N-Methyl-D-Aspartate; Seizures; Trihexyphenidyl; United Kingdom; Valproic Acid | 2015 |
Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia.
Topics: Administration, Intranasal; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Anxiety; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dexmedetomidine; Diazepam; Drug Resistance; Dysautonomia, Familial; Female; GABA Modulators; Heart Rate; Humans; Male; Pneumonia, Mycoplasma; Young Adult | 2017 |
Pharmacological management of abnormal tone and movement in cerebral palsy.
Topics: Adolescent; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child Health Services; Child, Preschool; Clonidine; Diazepam; Dystonia; Female; Humans; Infant; Male; Medical Records; Muscle Relaxants, Central; Muscle Spasticity; Prospective Studies; State Medicine; Trihexyphenidyl; United Kingdom | 2019 |