diazepam and citalopram

diazepam has been researched along with citalopram in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.86)18.7374
1990's3 (8.57)18.2507
2000's12 (34.29)29.6817
2010's19 (54.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Artursson, P; Mateus, A; Matsson, P1
Bojarski, AJ; Canale, V; Jastrzębska-Więsek, M; Kurczab, R; Lenda, T; Partyka, A; Satała, G; Wesołowska, A; Zajdel, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bucki, A; Gryboś, A; Głuch-Lutwin, M; Jastrzębska-Więsek, M; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Pytka, K; Siwek, A; Śniecikowska, J; Wesołowska, A; Więckowski, K1
Gong, Q; Li, J; Li, X; Liu, W; Mao, F; Qiu, X; Wang, H; Wang, W; Xu, Y; Zhang, H; Zhang, J; Zhu, J1
Kostowski, W; Płaźnik, A; Stefański, R1
Sams-Dodd, F1
Dekeyne, A; Girardon, S; Gobert, A; Millan, MJ1
Kivistö, KT; Lapatto-Reiniluoto, O; Neuvonen, PJ1
Juvonen, R; Korhonen, LE; Pelkonen, O; Raunio, H; Tolonen, A; Turpeinen, M; Uusitalo, J1
Barberi, C; Danysz, W; Gravius, A; Schäfer, D; Schmidt, WJ1
Bär, KJ; Beiderbeck, D; Boettger, MK; Jochum, T; Landgraf, R; Neumann, ID; Sauer, H; Wigger, A1
Bortolato, M; Frau, R; Gessa, GL; Marrosu, F; Mereu, G; Orrù, M; Puligheddu, M1
Birkett, MA; Kessler, EJ; Meyer, JS; Ritchie, S; Rowlett, JK; Shinday, NM1
Baud, FJ; Beaune, S; Callebert, J; Juvin, P; Mégarbane, B; Risède, P1
Gruca, P; Lason-Tyburkiewicz, M; Litwa, E; Papp, M; Willner, P1
Lubszky, S; Reinhart, WH; Schulzki, T; Thöny, S1
Hashimoto, S; Hattori, T; Kasahara, K; Kawakubo, H; Kawasaki, K; Nagatani, T; Nakazono, O; Takao, K; Tsujita, R1
Marston, HM; Mitchell, EN; Nutt, DJ; Phelps, CE; Robinson, ES1
Chourbaji, S; Lerch, S; Taylor, GT1

Reviews

1 review(s) available for diazepam and citalopram

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for diazepam and citalopram

ArticleYear
Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Area Under Curve; Charcoal; Citalopram; Cross-Over Studies; Diazepam; Female; Gastric Lavage; Humans; Ibuprofen; Intestinal Absorption; Male; Selective Serotonin Reuptake Inhibitors

1999

Other Studies

33 other study(ies) available for diazepam and citalopram

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Amines; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Dose-Response Relationship, Drug; Drug Design; HEK293 Cells; Humans; Mice; Models, Molecular; Molecular Structure; Motor Activity; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides

2016
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Affect; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Dementia; Dopamine Agonists; Drug Design; Humans; Indoles; Ligands; Models, Molecular; Pyridines; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists

2017
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
    Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Depression; Drug Design; Ligands; Mice; Permeability; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Tacrine; Vilazodone Hydrochloride

2018
Restraint stress-induced changes in saccharin preference: the effect of antidepressive treatment and diazepam.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4

    Topics: Animals; Citalopram; Desipramine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food Preferences; Male; Rats; Rats, Inbred Strains; Restraint, Physical; Saccharin; Stress, Physiological; Time Factors

1989
Effects of diazepam, citalopram, methadone and naloxone on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test.
    Neuroscience and biobehavioral reviews, 1998, Volume: 23, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Citalopram; Diazepam; Drug Interactions; Hallucinogens; Interpersonal Relations; Male; Methadone; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stereotyped Behavior

1998
Citalopram elicits a discriminative stimulus in rats at a dose selectively increasing extracellular levels of serotonin vs. dopamine and noradrenaline.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: Animals; Biogenic Monoamines; Cerebral Cortex; Citalopram; Clozapine; Corpus Striatum; Diazepam; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; GABA Agents; Male; Norepinephrine; Nucleus Accumbens; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline

1999
Cytochrome P450 (CYP) inhibition screening: comparison of three tests.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Oct-01, Volume: 29, Issue:2

    Topics: Citalopram; Cytochrome P-450 Enzyme Inhibitors; Diazepam; Enzyme Inhibitors; Fluoxetine; Humans; Oxazepam; Propranolol; Sotalol

2006
The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison.
    Neuropharmacology, 2006, Volume: 51, Issue:7-8

    Topics: Acoustic Stimulation; Animals; Avoidance Learning; Citalopram; Conditioning, Classical; Diazepam; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Freezing Reaction, Cataleptic; Hippocampus; Long-Term Potentiation; Male; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Scopolamine; Thiazoles

2006
Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment.
    Behavioural brain research, 2007, Oct-01, Volume: 183, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Citalopram; Crosses, Genetic; Diazepam; Disease Models, Animal; Hot Temperature; Male; Pain Threshold; Rats; Rats, Inbred Strains; Rats, Wistar; Reaction Time; Species Specificity; Statistics, Nonparametric

2007
Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs.
    The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:7

    Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Citalopram; Data Interpretation, Statistical; Diazepam; Hypnotics and Sedatives; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Reflex, Startle; Selective Serotonin Reuptake Inhibitors; Sleep Deprivation; Sleep, REM

2008
Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Citalopram; Corticosterone; Diazepam; Drug Interactions; Fluoxetine; Male; Mice; Mice, Inbred BALB C; Selective Serotonin Reuptake Inhibitors

2011
Mechanisms of high-dose citalopram-induced death in a rat model.
    Toxicology, 2012, Dec-16, Volume: 302, Issue:2-3

    Topics: Animals; Body Temperature; Citalopram; Cyproheptadine; Diazepam; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Rats; Rats, Sprague-Dawley; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndrome

2012
Effects of chronic mild stress on the development of drug dependence in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:5-6

    Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders

2014
Interaction of injectable neurotropic drugs with the red cell membrane.
    Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:7

    Topics: Central Nervous System Agents; Chlorpromazine; Citalopram; Clomipramine; Clonazepam; Diazepam; Erythrocytes; Humans; Injections; Levetiracetam; Microscopy, Electron, Scanning; Neurotransmitter Agents; Phenobarbital; Phenytoin; Piracetam; Valproic Acid

2014
The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats.
    Journal of pharmacological sciences, 2015, Volume: 127, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Cells, Cultured; Citalopram; Diazepam; Disease Models, Animal; Drug Synergism; Humans; Isoindoles; Male; Piperazines; Prefrontal Cortex; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Synaptic Transmission; Thiophenes

2015
Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Psychopharmacology, 2015, Volume: 232, Issue:15

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Carbolines; Citalopram; Diazepam; Dopamine Agents; Dopamine Antagonists; Emotions; Flupenthixol; GABA Antagonists; Male; Rats; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists

2015
Marble burying as compulsive behaviors in male and female mice.
    Acta neurobiologiae experimentalis, 2017, Volume: 77, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Citalopram; Compulsive Behavior; Diazepam; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Nesting Behavior; Sex Characteristics

2017