diazepam has been researched along with bretazenil in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 20 (62.50) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Facklam, M; Haefely, WE; Schoch, P | 1 |
| Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P | 1 |
| Busto, UE; Kaplan, HL; Sellers, EM | 1 |
| Costa, E; Ducic, I; Puia, G; Vicini, S | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Pieri, L; Schoch, P | 1 |
| Di Scala, G; Rohmer, JG; Sandner, G | 1 |
| Haefely, W | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA | 1 |
| Chapouthier, G; Potier, MC; Prado de Carvalho, L; Rossier, J; Venault, P | 1 |
| Bonetti, EP; Burkard, WP; Cumin, R; Haefely, WE; Martin, JR; Pieri, L; Schaffner, R | 1 |
| Grünberger, J; Linzmayer, L; Saletu, B | 1 |
| Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Mehta, AK; Shank, RP | 1 |
| Ator, NA; Sannerud, CA | 1 |
| Acri, JB; Witkin, JM; Wong, G | 1 |
| Auta, J; Costa, E; Giusti, P; Guidotti, A | 1 |
| Busto, U; Kaplan, HL; Sellers, EM; Zawertailo, L | 1 |
| Chiu, TH; Li, M; Rosenberg, HC | 1 |
| Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A | 1 |
| Breimer, DD; Cohen, AF; Gieschke, R; Pieters, MS; Roncari, G; Schoemaker, RC; Tuk, B; van Steveninck, AL | 1 |
| Benke, D; Benson, JA; Carter, DB; Hamilton, BJ; Knoflach, F; Lüddens, H; Mohler, H; Scheurer, L; Wang, Y | 1 |
| Benke, D; Michel, C; Mohler, H | 1 |
| Benson, JA; Keist, R; Löw, K; Mohler, H; Rudolph, U | 1 |
| Griebel, G; Perrault, G; Sanger, DJ | 1 |
| Reddy, DS; Rogawski, MA | 1 |
| Cagetti, E; Liang, J; Olsen, RW; Spigelman, I | 1 |
| Craig, CK; French, AM; Smith, MA | 1 |
| Brown, TA; Dawson, GR; Lincoln, RJ; McDonald, LM; Reynolds, DS; Stanley, JL | 1 |
| Ahring, PK; Erichsen, HK; Larsen, JS; Lopez-Garcia, JA; Mirza, NR; Munro, G; Nielsen, EØ; Rivera-Arconada, I | 1 |
| Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH | 1 |
4 trial(s) available for diazepam and bretazenil
| Article | Year |
|---|---|
Abuse liability of bretazenil and other partial agonists.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Double-Blind Method; Humans; Male; Receptors, GABA-A; Substance-Related Disorders | 1992 |
On the central effects of a new partial benzodiazepine agonist Ro 16-6028 in man: pharmaco-EEG and psychometric studies.
Topics: Adult; Affect; Analysis of Variance; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Fatigue; Female; Humans; Male; Prospective Studies; Psychometrics; Random Allocation; Reaction Time; Reflex, Pupillary | 1989 |
Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans.
Topics: Adult; Alprazolam; Analysis of Variance; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Memory; Middle Aged; Psychomotor Performance; Substance-Related Disorders | 1994 |
Pharmacokinetic and pharmacodynamic interactions of bretazenil and diazepam with alcohol.
Topics: Administration, Oral; Administration, Sublingual; Adult; Affect; Anticonvulsants; Benzodiazepinones; Diazepam; Double-Blind Method; Ethanol; Humans; Infusions, Intravenous; Male; Postural Balance; Pursuit, Smooth; Saccades | 1996 |
28 other study(ies) available for diazepam and bretazenil
| Article | Year |
|---|---|
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies.
Topics: Animals; Benzodiazepinones; Cell Membrane; Cerebral Cortex; Chlorides; Diazepam; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Rats; Receptors, GABA-A; Triazolam | 1992 |
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Male; Mice; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Seizures; Triazolam | 1992 |
Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Benzodiazepinones; Cell Line; Cells, Cultured; Cerebral Cortex; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Ion Channels; Kidney; Membrane Potentials; Membrane Proteins; Neurons; Rats; Receptors, GABA-A; Transfection | 1992 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Physical dependence induced in DBA/2J mice by benzodiazepine receptor full agonists, but not by the partial agonist Ro 16-6028.
Topics: Administration, Oral; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Drug Implants; Mice; Mice, Inbred DBA; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam | 1990 |
Behavioral analysis of the effects of benzodiazepine receptor ligands in the conditioned burying paradigm.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Carbolines; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Electroshock; Fear; Flumazenil; Grooming; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereotyped Behavior | 1990 |
Partial agonists of the benzodiazepine receptor: from animal data to results in patients.
Topics: Affinity Labels; Allosteric Site; Animals; Azides; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chlorides; Clonazepam; Diazepam; Drug Interactions; Ethanol; Flumazenil; Flurazepam; Humans; Ion Channels; Ligands; Models, Neurological; Neurons; Receptors, GABA-A | 1988 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1989 |
Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Brain; Conflict, Psychological; Diazepam; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Receptors, GABA-A | 1988 |
Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Cats; Conflict, Psychological; Cyclic GMP; Diazepam; Dogs; Flunitrazepam; Mice; Rats; Receptors, GABA-A; Saimiri; Substance Withdrawal Syndrome | 1988 |
Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Carbolines; Diazepam; Disease Models, Animal; Drug Tolerance; Male; Mice; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome | 1995 |
Interaction of abecarnil, bretazenil, and RO 19-8022 with diazepam-sensitive and -insensitive benzodiazepine sites in the rat cerebellum and cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Diazepam; Male; Pyrrolidines; Quinolizines; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Drug discrimination analysis of midazolam under a three-lever procedure. II: Differential effects of benzodiazepine receptor agonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Rats; Rats, Sprague-Dawley; Zolpidem | 1995 |
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Columbidae; Diazepam; Discrimination Learning; Flumazenil; GABA Modulators; Imidazoles; Male; Midazolam; Oxadiazoles; Radioligand Assay; Receptors, GABA-A; Sensitivity and Specificity; Stereoisomerism | 1995 |
Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the rat.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Diazepam; Drug Interactions; Drug Tolerance; GABA Modulators; Imidazoles; Male; Rats; Rats, Sprague-Dawley; Substance-Related Disorders; Triazolam | 1994 |
Tolerance to the effects of diazepam, clonazepam and bretazenil on GABA-stimulated Cl- influx in flurazepam tolerant rats.
Topics: Animals; Benzodiazepinones; Chloride Channels; Clonazepam; Diazepam; Drug Tolerance; Flurazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA | 1993 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psychological; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Seizures | 1993 |
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Carbolines; Diazepam; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Imidazoles; Kinetics; Membrane Potentials; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sensitivity and Specificity; Zinc | 1996 |
GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Cell Membrane; Cerebellum; Diazepam; Flumazenil; Immunohistochemistry; Immunosorbent Techniques; Macromolecular Substances; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins | 1997 |
Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.
Topics: Amino Acid Sequence; Animals; Azides; Base Sequence; Benzodiazepines; Benzodiazepinones; Cell Line; Diazepam; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Recombinant Proteins | 1998 |
Study of the modulatory activity of BZ (omega) receptor ligands on defensive behaviors in mice: evaluation of the importance of intrinsic efficacy and receptor subtype selectivity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Carbolines; Diazepam; Escape Reaction; Male; Mice; Motor Activity; Rats; Receptors, GABA-A | 1999 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
Topics: Affinity Labels; Alcoholism; Allosteric Regulation; Anesthetics; Animals; Anxiety; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Diazepam; Electrophysiology; Ethanol; GABA Modulators; Hippocampus; Hypnosis; Immunoblotting; Kinetics; Male; Maze Learning; Neurons; Pregnanediones; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Sleep | 2003 |
Agonist and antagonist effects of benzodiazepines on motor performance: influence of intrinsic efficacy and task difficulty.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Drug Interactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Motor Activity; Rats; Rats, Long-Evans | 2004 |
The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Ethanol; GABA Agonists; GABA-A Receptor Agonists; Hypnotics and Sedatives; Locomotion; Lorazepam; Male; Mice; Postural Balance; Predictive Value of Tests | 2005 |
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans; Inflammation; Isoxazoles; Neuralgia; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 2008 |
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem | 2012 |