Compounds > diadenosine tetraphosphate
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diadenosine tetraphosphate and diadenosine triphosphate

diadenosine tetraphosphate has been researched along with diadenosine triphosphate in 85 studies

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-199019 (22.35)18.7374
1990's39 (45.88)18.2507
2000's19 (22.35)29.6817
2010's6 (7.06)24.3611
2020's2 (2.35)2.80

Authors

AuthorsStudies
Kaczmarek, R; Krakowiak, A; Nawrot, B; Pęcherzewska, R; Stec, WJ; Tomaszewska, A1
Camden, J; Fischer, B; Weisman, GA; Yelovitch, S1
Ieda, N; Kawaguchi, M; Murakami, T; Nakagawa, H; Ohta, Y; Sekimoto, E1
Kisteneff, E; Kolodny, NH; Rapaport, E; Redfield, C1
Blanquet, S; Brevet, A; Chen, J; Fromant, M; Plateau, P1
Ankilova, VN; Biryukov, AI; Lavrik, OI1
Günther Sillero, MA; Sillero, A; Wasternack, C1
Busse, R; Lamontagne, D; Ogilvie, A; Pohl, U1
Hoyle, CH1
McLennan, AG; Prescott, M1
Castro, E; Gonzalez, MP; Miras-Portugal, MT; Torres, M1
Busse, R; Lüthje, J; Ogilvie, A; Pohl, U1
Busshardt, E; Gerok, W; Häussinger, D1
Lüthje, J; Ogilvie, A5
Lüthje, J; Miller, D; Ogilvie, A1
Kiselev, LL; Kovaleva, GK; Merkulova, TI1
Biriukov, AP; Lavrik, OI; Zakharova, OD1
Busse, R; Ogilvie, A; Pohl, U1
Baker, JC; Jacobson, MK1
Befort, NM; Ebel, JP; Gilson, GJ; Guédon, GF; Remy, PM1
Baringer, J; Lüthje, J; Ogilvie, A1
Guranowski, A; Jakubowski, H1
Jakob, P; Ogilvie, A1
Litvak, S; Solari, A; Tarrago-Litvak, L; Tharaud, D; Zourgui, L1
Heidenreich, S; Hirsch, J; Kleta, R; Schlatter, E; Schlüter, H; Zidek, W1
Ankorina, I; Haxelmans, S; Kleta, R; Schlatter, E1
Ogilvie, A; Schulze-Lohoff, E; Sterzel, RB; Zanner, S1
Cobbold, PH; Dixon, CJ; Green, AK1
Günther Sillero, MA; Guranowski, A; Sillero, A; Starzyńska, E1
Edwards, SW; Gasmi, L; McLennan, AG3
Kisselev, L; Kovaleva, G; Merkulova, T1
Dimmick, MA; Hilderman, RH; Jones, GB; Lilien, JE; Tate, DH; Zimmerman, JK1
Cobbold, PH; Dixon, CJ; Fisher, MJ; Green, AK; McLennan, AG1
Amchenkova, AM; Kiselev, LL; Narovlianskiĭ, AN; Turpaev, KT; Vartanian, AA1
Keppens, S1
Burnstock, G; Hoyle, CH; Postorino, A1
Manuel Rovira, J; Martin, F; Miras-Portugal, MT; Pintor, J; Ripoll, C; Soria, B1
Borucki, U; Enck, G; Hohage, H; Reinhardt, C; Schlatter, E; Schlüter, H; Zidek, W1
Burnstock, G; King, BF; Miras-Portugal, MT; Pintor, J1
Bläsius, R; Ogilvie, A; Schulze-Lohoff, E; Sterzel, RB1
Gomez De Aranda, I; Marti, E; Mateo, J; Miras-Portugal, MT; Rotllan, P; Solsona, C1
Hartmann, R; Justesen, J; Kisselev, L; Turpaev, K1
Mezzasoma, I; Minelli, A; Moroni, M1
Mateo, J; Miras-Portugal, MT; Rotllán, P1
Dal Pra, I; Kisselev, L; Prudovsky, I; Suzuki, H; Vartanian, A1
Jankowski, J; Schlüter, H; Spieker, C; Tepel, M; Zidek, W1
Frolova, LY; Justesen, J; Kisselev, LL; Wolfson, AD1
Asensio, AC; Oaknin, S; Rodríguez-Ferrer, CR; Rotllán, P1
Hohage, H; Rahn, KH; Schlatter, E; Stachon, A; Stegemann, H1
Bailey, SJ; Hourani, SM; Johnson, CR; Tennant, JP1
Brown, SG; Burnstock, G; King, BF; Wildman, SS1
Jankowski, J; Potthoff, W; Schlüter, H; Tepel, M; van der Giet, M; Zidek, W1
Flores, NA; Sheridan, DJ; Stavrou, BM1
Alexandrov, I; Kisselev, L; McLennan, A; Prudowski, I; Vartanian, A1
Galbas, M; Guranowski, A; Hartmann, R; Justesen, J1
Courtois, P; Jijakli, H; Laghmich, A; Louchami, K; Malaisse, WJ; Picton, S; Sener, A1
Halliday, D; McLennan, AG; Murphy, GA1
Castagnola, M; Floris, G; Medda, R; Messana, I; Padiglia, A1
Barenbrock, M; Hausberg, M; Hollah, P; Kosch, M; Letzel, M; Rahn, KH; Schlatter, E1
Blackburn, GM; Cohen, T; Flores, NA; Lawrence, C; Sheridan, DJ; Stavrou, BM1
Szalata, M1
Claes, P; Grobben, B; Roymans, D; Slegers, H; Van Kolen, K1
Barnes, A; Boughtflower, R; Camacho, J; Cousens, D; Marshall, F; Patel, K; Paterson, C1
Alonso, MC; Bautista, A; Carracedo, G; Peral, A; Pintor, J1
Bianchi, BR; Briggs, CA; Burgard, EC; Cartmell, J; Chu, KL; Faltynek, C; Jarvis, MF; Lynch, KJ; McDonald, HA; McKenna, DG1
Janssen, AK; Pelster, F; Rahn, KH; Schlatter, E; Steinmetz, M1
Henning, L; Jankowski, J; Jankowski, V; Laufer, U; Schlüter, H; Tepel, M; van der Giet, M; Zidek, W1
Bellezza, I; Castellini, C; Liguori, L; Minelli, A; Renieri, T1
Acharya, KR; Baker, MD; Holloway, DE; Swaminathan, GJ1
Boonyalai, N; Hindley, AD; Miller, AD; Tanner, JA; Wright, M1
Mediero, A; Peral, A; Pintor, J1
Pintor, J1
Fisher, DI; McLennan, AG1
Guranowski, A; Starynska, E; Wasternack, C1
Albright, RA; Braddock, DT; Cao, W; Chang, WC; De La Cruz, EM; Liu, L; Ornstein, DL; Redick, ME; Robert, D; Young, JI1
Jankowski, J; Jankowski, V; Schulz, A; Zidek, W1
Anashkin, VA; Baykov, AA; Lahti, R; Orlov, VN; Salminen, A; Tuominen, HK1
Götz, KH; Marx, A; Mex, M; Offensperger, F; Scheffner, M; Stuber, K1
Albrecht, CJ; Krüger, L; Marx, A; Niedermeier, ML; Schammann, HK; Scheffner, M; Stengel, F; Stuber, K; Stumpf, FM; Wimmer, J; Yuan, Y1

Reviews

4 review(s) available for diadenosine tetraphosphate and diadenosine triphosphate

ArticleYear
Adenine dinucleotides: a novel class of signalling molecules.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:6

    Topics: Animals; Cell Division; Dinucleoside Phosphates; DNA; Humans; Muscle, Smooth, Vascular; Platelet Activation; Rats; Signal Transduction

1996
Diadenosine oligophosphates (Ap(n)A), a novel class of signalling molecules?
    FEBS letters, 1998, May-08, Volume: 427, Issue:2

    Topics: Animals; Dinucleoside Phosphates; Eukaryotic Cells; Humans; Models, Chemical; Signal Transduction

1998
The effects of diadenosine polyphosphates on the cardiovascular system.
    Cardiovascular research, 1999, Volume: 42, Issue:1

    Topics: Action Potentials; Animals; Cardiovascular System; Dinucleoside Phosphates; Endothelium, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Potassium Channels; Receptors, Purinergic; Second Messenger Systems; Vascular Resistance; Vasodilation

1999
[Dinucleoside polyphosphates: occurrence, metabolism and function].
    Postepy biochemii, 2001, Volume: 47, Issue:1

    Topics: Animals; Bacterial Proteins; Cardiovascular System; Dinucleoside Phosphates; Escherichia coli Proteins; Humans; Neurotransmitter Agents; Nudix Hydrolases; Phosphoric Monoester Hydrolases; Proteins; Pyrophosphatases; Stress, Physiological

2001

Other Studies

81 other study(ies) available for diadenosine tetraphosphate and diadenosine triphosphate

ArticleYear
Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis.
    Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16

    Topics: Acid Anhydride Hydrolases; Annexin A5; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Cytotoxins; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Fluorescent Dyes; Genes, Tumor Suppressor; HEK293 Cells; Humans; Neoplasm Proteins; Neoplasms; RNA, Small Interfering

2011
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Boranes; Calcium; Cell Line, Tumor; Dinucleoside Phosphates; Drug Stability; Humans; Hydrolysis; Models, Molecular; Molecular Conformation; Phosphoric Diester Hydrolases; Purinergic P2Y Receptor Agonists; Pyrophosphatases; Receptors, Purinergic P2Y; Stereoisomerism; Structure-Activity Relationship; Turkey

2012
Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors.
    Journal of medicinal chemistry, 2021, 07-08, Volume: 64, Issue:13

    Topics: Acid Anhydride Hydrolases; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorescent Dyes; Humans; Molecular Structure; Neoplasm Proteins; Structure-Activity Relationship

2021
Ap4A and Ap5A prefer folded unstacked conformations at pH 4-5, in sharp contrast with Ap2A and Ap3A.
    FEBS letters, 1979, Nov-01, Volume: 107, Issue:1

    Topics: Adenine Nucleotides; Adenosine Monophosphate; Dinucleoside Phosphates; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation

1979
Isolation and characterization of a dinucleoside triphosphatase from Saccharomyces cerevisiae.
    Journal of bacteriology, 1991, Volume: 173, Issue:17

    Topics: Acid Anhydride Hydrolases; Cations, Divalent; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Electrophoresis, Polyacrylamide Gel; Hydrolases; Hydrolysis; Phosphoric Monoester Hydrolases; Saccharomyces cerevisiae; Substrate Specificity

1991
Diadenosine oligophosphates: peculiarities of synthesis by phenylalanyl-tRNA synthetases from E. coli MRE-600 and Thermus thermophilus HB8.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Dinucleoside Phosphates; Escherichia coli; Indicators and Reagents; Kinetics; Phenylalanine-tRNA Ligase; Thermodynamics; Thermus thermophilus

1991
Diadenosine polyphosphates inhibit the action of ribonucleotide reductase on ADP.
    Biochemistry international, 1991, Volume: 23, Issue:1

    Topics: Adenosine Diphosphate; Cell Membrane Permeability; Chromatography, Gel; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Enzyme Inhibitors; Oxidation-Reduction; Ribonucleotide Reductases; Yeasts

1991
Potent effects of AP3A and AP4A on coronary resistance and autacoid release of intact rabbit hearts.
    The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 2

    Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Drug Stability; Epoprostenol; Female; Male; Myocardium; Nitric Oxide; Rabbits; Vascular Resistance; Vasodilator Agents

1991
Pharmacological activity of adenine dinucleotides in the periphery: possible receptor classes and transmitter function.
    General pharmacology, 1990, Volume: 21, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenal Medulla; Animals; Blood Platelets; Chromaffin Granules; Dinucleoside Phosphates; Humans; NAD; NADP; Receptors, Purinergic

1990
Synthesis and applications of 8-azido photoaffinity analogs of P1,P3-bis(5'-adenosyl)triphosphate and P1,P4-bis(5'-adenosyl)tetraphosphate.
    Analytical biochemistry, 1990, Feb-01, Volume: 184, Issue:2

    Topics: Adenosine; Affinity Labels; Animals; Artemia; Azides; Bacterial Proteins; Carrier Proteins; Clostridium; Dinucleoside Phosphates; Peptides; Vero Cells

1990
Effect of diadenosine polyphosphates on catecholamine secretion from isolated chromaffin cells.
    British journal of pharmacology, 1990, Volume: 100, Issue:2

    Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Chromaffin System; Dinucleoside Phosphates; In Vitro Techniques; Nicotine; Perfusion; Potassium

1990
Identification and partial characterization of an adenosine(5')tetraphospho(5')adenosine hydrolase on intact bovine aortic endothelial cells.
    The Biochemical journal, 1989, Apr-01, Volume: 259, Issue:1

    Topics: Acid Anhydride Hydrolases; Animals; Aorta; Cattle; Cells, Cultured; Dinucleoside Phosphates; Endothelium, Vascular; Hydrolysis; Kinetics; Phosphoric Monoester Hydrolases

1989
Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A.
    Biochimica et biophysica acta, 1989, Feb-09, Volume: 1010, Issue:2

    Topics: Animals; Calcium; Carbon Dioxide; Cells, Cultured; Dinucleoside Phosphates; Glucose; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Phosphorylase a; Potassium; Prostaglandin D2; Rats; Rats, Inbred Strains; Thromboxane B2

1989
Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization.
    European journal of biochemistry, 1987, Dec-01, Volume: 169, Issue:2

    Topics: Adenine Nucleotides; Dinucleoside Phosphates; Humans; Isoenzymes; Kinetics; Phosphodiesterase I; Phosphoric Diester Hydrolases

1987
Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity.
    European journal of biochemistry, 1985, May-15, Volume: 149, Issue:1

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Chromatography; Dinucleoside Phosphates; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Metals; Molecular Weight; Nucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Substrate Specificity

1985
Unproportionally high concentrations of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) in heavy platelets. Consequences for in vitro studies with human platelets.
    Blut, 1987, Volume: 54, Issue:4

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Cell Separation; Centrifugation, Density Gradient; Dinucleoside Phosphates; Humans; Povidone; Silicon Dioxide

1987
[Tryptophanyl-tRNA-synthetase catalyzes synthesis of Ap3A but not Ap4A].
    Doklady Akademii nauk SSSR, 1988, Volume: 301, Issue:6

    Topics: Amino Acyl-tRNA Synthetases; Animals; Catalysis; Cattle; Dinucleoside Phosphates; Kinetics; Pancreas; Tryptophan-tRNA Ligase

1988
[Effect of diadenosine oligophosphates (Ap4A and Ap3A) and their phosphonate analogs on catalytic properties of phenylalanyl-tRNA synthetase from E. coli].
    Bioorganicheskaia khimiia, 1987, Volume: 13, Issue:9

    Topics: Adenine Nucleotides; Amino Acyl-tRNA Synthetases; Catalysis; Dinucleoside Phosphates; Escherichia coli; Kinetics; Phenylalanine-tRNA Ligase

1987
Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes.
    European journal of biochemistry, 1988, Apr-05, Volume: 173, Issue:1

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Blood Platelets; Body Fluids; Dinucleoside Phosphates; Erythrocytes; Half-Life; Humans; Intracellular Fluid; Plasma

1988
Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries.
    The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 2

    Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Gossypol; Mesenteric Arteries; Rabbits; Vasodilation; Vasomotor System

1988
Alteration of adenyl dinucleotide metabolism by environmental stress.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:8

    Topics: Adenine Nucleotides; Animals; Cells, Cultured; Dinucleoside Phosphates; Ethanol; Heat-Shock Proteins; Hot Temperature; Mice; Stress, Physiological

1986
Lack of correlation between extensive accumulation of bisnucleoside polyphosphates and the heat-shock response in eukaryotic cells.
    The Journal of biological chemistry, 1986, Dec-15, Volume: 261, Issue:35

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Dinucleoside Phosphates; Female; Heat-Shock Proteins; Hot Temperature; Kinetics; Liver Neoplasms, Experimental; Methionine; Oocytes; Rats; Sulfur Radioisotopes; Xenopus

1986
Effects of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) on platelet aggregation in unfractionated human blood.
    Blut, 1985, Volume: 51, Issue:6

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Heparin; Humans; Kinetics; Platelet Aggregation; Platelet Count

1985
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
    The Journal of biological chemistry, 1983, Aug-25, Volume: 258, Issue:16

    Topics: Acid Anhydride Hydrolases; Adenine Nucleotides; Dinucleoside Phosphates; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Plants; Seeds

1983
The presence of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) in human platelets.
    Biochemical and biophysical research communications, 1983, Aug-30, Volume: 115, Issue:1

    Topics: Acid Anhydride Hydrolases; Adenine Nucleotides; Blood Platelets; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans; Hydrolysis; Kinetics; Neoplasm Proteins; Phosphoric Diester Hydrolases

1983
Diadenosine 5',5"'-P1,P3-triphosphate in eukaryotic cells: identification and quantitation.
    Analytical biochemistry, 1983, Oct-15, Volume: 134, Issue:2

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Eukaryotic Cells; Mice

1983
Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP.
    Biochemical and biophysical research communications, 1984, Feb-14, Volume: 118, Issue:3

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Alkaline Phosphatase; Dinucleoside Phosphates; Humans; Platelet Activating Factor; Platelet Aggregation

1984
Stimulation of DNA synthesis by microinjection of diadenosine 5',5''-P1, P4-tetraphosphate (Ap4A) into Xenopus laevis oocytes.
    Developmental biology, 1984, Volume: 103, Issue:2

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Dinucleoside Phosphates; DNA; Female; Microinjections; Oocytes; Ovum; Poly dA-dT; Poly T; Templates, Genetic; Xenopus laevis

1984
Effects of diadenosine polyphosphates, ATP and angiotensin II on membrane voltage and membrane conductances of rat mesangial cells.
    Pflugers Archiv : European journal of physiology, 1995, Volume: 430, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Angiotensin II; Animals; Cell Line; Dinucleoside Phosphates; Glomerular Mesangium; Hypertension; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1995
Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells.
    Pflugers Archiv : European journal of physiology, 1995, Volume: 430, Issue:5

    Topics: Adenosine Triphosphate; Angiotensin II; Animals; Calcium; Cell Line; Cytosol; Dinucleoside Phosphates; Fura-2; Glomerular Mesangium; Hypertension; Muscle Contraction; Patch-Clamp Techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1995
Vasoactive diadenosine polyphosphates promote growth of cultured renal mesangial cells.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:6 Pt 1

    Topics: Analysis of Variance; Animals; Blotting, Northern; Cells, Cultured; Dinucleoside Phosphates; DNA; Epidermal Growth Factor; Glomerular Mesangium; Male; Mitosis; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Serotonin

1995
Cytosolic free Ca2+ oscillations induced by diadenosine 5',5"'-P1,P3-triphosphate and diadenosine 5',5"'-P1,P4-tetraphosphate in single rat hepatocytes are indistinguishable from those induced by ADP and ATP respectively.
    The Biochemical journal, 1995, Sep-01, Volume: 310 ( Pt 2)

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Dinucleoside Phosphates; Diterpenes; Kinetics; Liver; Male; Phorbol 12,13-Dibutyrate; Rats; Rats, Wistar; Time Factors

1995
Conversion of adenosine(5') oligophospho(5') adenosines into inosine(5') oligophospho(5') inosines by non-specific adenylate deaminase from the snail Helix pomatia.
    Biochimica et biophysica acta, 1995, Jan-18, Volume: 1243, Issue:1

    Topics: Adenine; AMP Deaminase; Animals; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Helix, Snails; Inosine; Organophosphonates; Spectrophotometry, Ultraviolet; Thionucleotides

1995
Priming of the respiratory burst of human neutrophils by the diadenosine polyphosphates, AP4A and AP3A: role of intracellular calcium.
    Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1

    Topics: Adenosine Triphosphate; Calcium; Dinucleoside Phosphates; Humans; In Vitro Techniques; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides

1994
P1,P3-bis(5'-adenosyl)triphosphate (Ap3A) as a substrate and a product of mammalian tryptophanyl-tRNA synthetase.
    FEBS letters, 1994, Aug-22, Volume: 350, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Cattle; Dinucleoside Phosphates; Kinetics; Pancreas; Transfer RNA Aminoacylation; Tryptophan; Tryptophan-tRNA Ligase

1994
Adenylated dinucleotide binding to the adenosine 5',5'''-P1,P4-tetraphosphate mouse heart receptor.
    Biochemical and biophysical research communications, 1994, Apr-29, Volume: 200, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Cell Membrane; Dinucleoside Phosphates; Female; In Vitro Techniques; Kinetics; Mice; Models, Molecular; Myocardium; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thermodynamics

1994
Adenine dinucleotide-mediated cytosolic free Ca2+ oscillations in single hepatocytes.
    FEBS letters, 1993, May-10, Volume: 322, Issue:2

    Topics: Aequorin; Animals; Calcium; Dinucleoside Phosphates; In Vitro Techniques; Liver; Male; Rats; Rats, Wistar

1993
[Interferons cause accumulation of diadenosine triphosphate (Ap3A) in human monocyte cultures].
    Doklady Akademii nauk, 1995, Volume: 344, Issue:2

    Topics: Cell Line; Chromatography, Thin Layer; Dinucleoside Phosphates; Humans; Interferons; Monocytes

1995
The diadenosine polyphosphates Ap3A and Ap4A and adenosine triphosphate interact with granulocyte-macrophage colony-stimulating factor to delay neutrophil apoptosis: implications for neutrophil: platelet interactions during inflammation.
    Blood, 1996, Apr-15, Volume: 87, Issue:8

    Topics: Adenosine Triphosphate; Apoptosis; Biomarkers; Blood Platelets; Chromatin; Depression, Chemical; Dinucleoside Phosphates; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activation; Receptors, IgG

1996
Effects of diadenosine triphosphate and diadenosine tetraphosphate on rat liver cells. Differences and similarities with ADP and ATP.
    Biochemical pharmacology, 1996, Aug-09, Volume: 52, Issue:3

    Topics: Animals; Cells, Cultured; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Liver; Male; Phosphorylases; Rats; Rats, Wistar

1996
Pre- and postjunctional effects of diadenosine polyphosphates in the guinea-pig vas deferens.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:11

    Topics: Animals; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Receptors, Purinergic; Vas Deferens

1995
Diadenosine polyphosphates. A novel class of glucose-induced intracellular messengers in the pancreatic beta-cell.
    Diabetes, 1996, Volume: 45, Issue:10

    Topics: Adenosine Triphosphate; Animals; Cell Membrane; Cells, Cultured; Chromatography, High Pressure Liquid; Cytosol; Dinucleoside Phosphates; Glucose; Islets of Langerhans; Kinetics; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Potassium Channels; Second Messenger Systems

1996
Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats.
    Journal of the American Society of Nephrology : JASN, 1996, Volume: 7, Issue:8

    Topics: Anesthesia; Animals; Blood Pressure; Bosentan; Cyclooxygenase Inhibitors; Dinucleoside Phosphates; Diuresis; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Wistar; Sulfonamides; Vasoconstrictor Agents

1996
Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors.
    British journal of pharmacology, 1996, Volume: 119, Issue:5

    Topics: Animals; Dinucleoside Phosphates; Humans; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Recombinant Proteins; Xenopus laevis

1996
Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein.
    Immunology, 1997, Volume: 90, Issue:1

    Topics: Adenosine Triphosphate; Calcium; Cell Culture Techniques; Dinucleoside Phosphates; GTP-Binding Proteins; Humans; Neutrophils; Pertussis Toxin; Receptors, Purinergic P2; Virulence Factors, Bordetella

1997
Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ.
    The Biochemical journal, 1997, May-01, Volume: 323 ( Pt 3)

    Topics: Acid Anhydride Hydrolases; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cations, Divalent; Diethyl Pyrocarbonate; Dinucleoside Phosphates; Electric Organ; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Nerve Tissue Proteins; Presynaptic Terminals; Pyridoxal Phosphate; Torpedo

1997
Ap3A and Ap4A are primers for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase.
    FEBS letters, 1997, May-19, Volume: 408, Issue:2

    Topics: 2',5'-Oligoadenylate Synthetase; Adenine Nucleotides; Adenosine Triphosphate; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dinucleoside Phosphates; Humans; Interferons; Kinetics; Oligoribonucleotides; Tryptophan-tRNA Ligase

1997
Human seminal plasma soluble 5'-nucleotidase: regulatory aspects of the dephosphorylation of nucleoside 5'-monophosphates.
    Biochemical and molecular medicine, 1997, Volume: 61, Issue:1

    Topics: 5'-Nucleotidase; Adenosine Monophosphate; Cytidine Monophosphate; Dinucleoside Phosphates; Energy Metabolism; Guanosine Monophosphate; Humans; Inosine Monophosphate; Male; Phosphorylation; Purine Nucleotides; Semen; Solubility; Uridine Monophosphate; Vanadates

1997
Ecto-enzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cells.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Adrenal Medulla; Animals; Cattle; Cell Membrane; Cells, Cultured; Dextrans; Dinucleoside Phosphates; Endothelium, Vascular; Exocytosis; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Microspheres; Models, Biological

1997
Opposite effects of cell differentiation and apoptosis on Ap3A/Ap4A ratio in human cell cultures.
    FEBS letters, 1997, Sep-29, Volume: 415, Issue:2

    Topics: Apoptosis; Cell Differentiation; Chromatography, Thin Layer; Dinucleoside Phosphates; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Immunohistochemistry; Interferons; Podophyllotoxin; Signal Transduction; Tetradecanoylphorbol Acetate; Topoisomerase II Inhibitors

1997
Effect of diadenosine polyphosphates on Ca2+ ATPase activity.
    Journal of molecular medicine (Berlin, Germany), 1997, Volume: 75, Issue:9

    Topics: Adenosine Triphosphate; Calcium-Transporting ATPases; Dinucleoside Phosphates; Humans; Structure-Activity Relationship

1997
Potent inhibition of specific diadenosine polyphosphate hydrolases by suramin.
    FEBS letters, 1998, Jun-12, Volume: 429, Issue:2

    Topics: Acid Anhydride Hydrolases; Animals; Brain; Dinucleoside Phosphates; Enzyme Inhibitors; Hydrolysis; Male; Neoplasm Proteins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Suramin; Tissue Extracts

1998
Effects of diadenosine polyphosphates on the intracellular Ca2+ concentration in endothelial cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1998, Volume: 8, Issue:4

    Topics: Adenosine Triphosphate; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cell Line; Cells, Cultured; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Rats; Rats, Inbred WKY

1998
Effects of adenosine 5'-triphosphate, uridine 5'-triphosphate, adenosine 5'-tetraphosphate and diadenosine polyphosphates in guinea-pig taenia caeci and rat colon muscularis mucosae.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:4

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Colon; Dinucleoside Phosphates; Guinea Pigs; Male; Rats; Rats, Wistar; Suramin; Uridine Triphosphate

1998
Selectivity of diadenosine polyphosphates for rat P2X receptor subunits.
    European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Binding, Competitive; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Membrane Potentials; Oocytes; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X3; Receptors, Purinergic P2X4; RNA, Messenger; Xenopus

1999
High-performance liquid chromatographic assay of the diadenosine polyphosphates in human platelets.
    Analytical biochemistry, 1999, Apr-10, Volume: 269, Issue:1

    Topics: Blood Platelets; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans

1999
Ap4A induces apoptosis in human cultured cells.
    FEBS letters, 1999, Jul-30, Volume: 456, Issue:1

    Topics: 3T3 Cells; Animals; Apoptosis; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Ceramides; Dinucleoside Phosphates; DNA; Humans; Leukemia, Myeloid; Mice; Phorbol Esters; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases.
    Archives of biochemistry and biophysics, 2000, Jan-01, Volume: 373, Issue:1

    Topics: Acid Anhydride Hydrolases; Dinucleoside Phosphates; Humans; Hydrolysis; In Vitro Techniques; Neoplasm Proteins; Proteins; Recombinant Proteins; Substrate Specificity

2000
Possible role of diadenosine polyphosphates in glucose-stimulated insulin release: effects of NaF upon metabolic and functional variables in rat isolated islets.
    International journal of molecular medicine, 2000, Volume: 5, Issue:5

    Topics: Animals; Calcium; Calcium Radioisotopes; Dinucleoside Phosphates; Female; Glucose; In Vitro Techniques; Inorganic Pyrophosphatase; Insulin; Islets of Langerhans; Peptides; Perfusion; Pyrophosphatases; Rats; Rats, Wistar; Sodium Fluoride

2000
The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate.
    Cancer research, 2000, May-01, Volume: 60, Issue:9

    Topics: Acid Anhydride Hydrolases; Blotting, Western; Dinucleoside Phosphates; Humans; Immunoblotting; Neoplasm Proteins; Proteins; Signal Transduction; Tumor Cells, Cultured

2000
Separation of diadenosine polyphosphates by capillary electrophoresis.
    Electrophoresis, 2000, Volume: 21, Issue:12

    Topics: Borates; Buffers; Carbonates; Dinucleoside Phosphates; Electrophoresis, Capillary

2000
A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension.
    Journal of hypertension, 2001, Volume: 19, Issue:2

    Topics: Adult; Blood Platelets; Dinucleoside Phosphates; Female; Humans; Hypertension; Male; Reproducibility of Results

2001
Coronary vasomotor and cardiac electrophysiologic effects of diadenosine polyphosphates and nonhydrolyzable analogs in the guinea pig.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:5

    Topics: Action Potentials; Animals; Coronary Vessels; Dinucleoside Phosphates; Guinea Pigs; Heart; Heart Rate; Hydrolysis; Male; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Structure-Activity Relationship; Vasoconstrictor Agents; Vasomotor System

2001
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Division; Dinucleoside Phosphates; Enzyme Activation; Glioma; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Purinergic P2 Receptor Agonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Thionucleotides; Time Factors; Triazines; Tumor Cells, Cultured

2001
Activity of diadenosine polyphosphates at P2Y receptors stably expressed in 1321N1 cells.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Adenosine Diphosphate; Calcium; Carbachol; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Gene Expression; Humans; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Tumor Cells, Cultured; Uridine Triphosphate

2001
Presence of diadenosine polyphosphates in human tears.
    Pflugers Archiv : European journal of physiology, 2002, Volume: 443, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Epithelium, Corneal; Humans; Rabbits; Tears

2002
Potent desensitization of human P2X3 receptors by diadenosine polyphosphates.
    European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Carbachol; Cholinergic Agonists; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electrophysiology; Humans; Oocytes; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Recombinant Proteins; Xenopus laevis

2002
Vasoactivity of diadenosine polyphosphates in human small mesenteric resistance arteries.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2

    Topics: Animals; Dinucleoside Phosphates; Humans; In Vitro Techniques; Kinetics; Mesenteric Arteries; Muscle Contraction; Rats; Vascular Resistance

2002
Identification and quantification of diadenosine polyphosphate concentrations in human plasma.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Jul-01, Volume: 23, Issue:7

    Topics: Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Female; Humans; Male; Middle Aged; Polyphosphates; Probability; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2003
Effects of diadenosine polyphosphates and seminal fluid vesicles on rabbit sperm cells.
    Reproduction (Cambridge, England), 2003, Volume: 125, Issue:6

    Topics: 5'-Nucleotidase; Acrosome Reaction; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Male; Microscopy, Electron; Polyphosphates; Rabbits; Seminal Vesicles; Sperm Capacitation; Spermatozoa; Type C Phospholipases

2003
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.
    Biochemistry, 2006, Jan-17, Volume: 45, Issue:2

    Topics: Adenosine Triphosphate; Adenylate Kinase; Binding Sites; Crystallography, X-Ray; Dinucleoside Phosphates; Eosinophil-Derived Neurotoxin; Humans; Protein Structure, Tertiary

2006
The duality of LysU, a catalyst for both Ap4A and Ap3A formation.
    The FEBS journal, 2006, Volume: 273, Issue:15

    Topics: Blotting, Western; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dinucleoside Phosphates; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Lysine-tRNA Ligase; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation

2006
Dual roles of diadenosine polyphosphates in corneal epithelial cell migration.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:10

    Topics: Animals; Cell Movement; Cells, Cultured; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Epithelium, Corneal; Fluorescent Antibody Technique, Indirect; Keratins; Microscopy, Confocal; Nucleotides; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Wound Healing

2006
[A molecular marker for dry eye].
    Archivos de la Sociedad Espanola de Oftalmologia, 2007, Volume: 82, Issue:3

    Topics: Animals; Biomarkers; Dinucleoside Phosphates; Disease Models, Animal; Dry Eye Syndromes; Humans; Intraocular Pressure; Ophthalmic Solutions; Polyphosphates; Tears; Uracil Nucleotides

2007
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells.
    Cancer letters, 2008, Feb-08, Volume: 259, Issue:2

    Topics: Acetates; Acid Anhydride Hydrolases; Antibodies; Antineoplastic Agents, Phytogenic; Apoptosis; Cadmium; Cell Line; Cold Temperature; Dinucleoside Phosphates; Epithelial Cells; Etoposide; fas Receptor; Humans; Ligands; Neoplasm Proteins; Osmotic Pressure; Signal Transduction; Sorbitol; Up-Regulation

2008
Specific phosphorylase from Euglena gracilis splits diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and diadenosine 5',5'''-P(1),P(3)-triphosphate (Ap(3)A).
    The International journal of biochemistry, 1988, Volume: 20, Issue:4

    Topics: Acanthamoeba castellanii; Dinucleoside Phosphates; Euglena gracilis; Hydrogen-Ion Concentration; Molecular Weight; Nucleotidyltransferases; Substrate Specificity

1988
NPP4 is a procoagulant enzyme on the surface of vascular endothelium.
    Blood, 2012, Nov-22, Volume: 120, Issue:22

    Topics: Adenosine Diphosphate; Adult; Animals; Blood Coagulation; Coagulants; Cyclic Nucleotide Phosphodiesterases, Type 4; Dinucleoside Phosphates; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Hydrolysis; In Vitro Techniques; Insecta; Phosphoric Diester Hydrolases; Platelet Aggregation; Pyrophosphatases; Tissue Distribution

2012
Highly sensitive, selective and rapid LC-MS method for simultaneous quantification of diadenosine polyphosphates in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jun-15, Volume: 961

    Topics: Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2014
Cystathionine β-Synthase (CBS) Domain-containing Pyrophosphatase as a Target for Diadenosine Polyphosphates in Bacteria.
    The Journal of biological chemistry, 2015, Nov-13, Volume: 290, Issue:46

    Topics: Adenine Nucleotides; Amino Acid Sequence; Bacteria; Bacterial Proteins; Clostridium perfringens; Cystathionine beta-Synthase; Dinucleoside Phosphates; Kinetics; Molecular Sequence Data; Moorella; Protein Binding; Protein Structure, Tertiary; Pyrophosphatases

2015
Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes.
    Cell chemical biology, 2019, Nov-21, Volume: 26, Issue:11

    Topics: Biocatalysis; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans; Mass Spectrometry; Mutagenesis; Recombinant Proteins; Small Ubiquitin-Related Modifier Proteins; Ubiquitin; Ubiquitin-Activating Enzymes

2019
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate.
    Nature communications, 2021, 10-04, Volume: 12, Issue:1

    Topics: Adenosine Triphosphate; Dinucleoside Phosphates; Endoribonucleases; Escherichia coli; Escherichia coli Proteins; HEK293 Cells; Humans; L-Lactate Dehydrogenase; Phosphoglycerate Kinase; Photoaffinity Labels; Protein Binding; Proteomics; Ubiquitin-Activating Enzymes

2021