diadenosine 5',5''''-p1,p6-hexaphosphate and p(1),p(5)-di(adenosine-5'-)pentaphosphate

diadenosine 5',5''''-p1,p6-hexaphosphate has been researched along with p(1),p(5)-di(adenosine-5'-)pentaphosphate in 37 studies

Compound Research Comparison

Studies (diadenosine 5',5''''-p1,p6-hexaphosphate)	Trials (diadenosine 5',5''''-p1,p6-hexaphosphate)	Recent Studies (post-2010) (diadenosine 5',5''''-p1,p6-hexaphosphate)	Studies (p(1),p(5)-di(adenosine-5'-)pentaphosphate)	Trials (p(1),p(5)-di(adenosine-5'-)pentaphosphate)	Recent Studies (post-2010) (p(1),p(5)-di(adenosine-5'-)pentaphosphate)
52	0	5	215	2	26

Protein Interaction Comparison

Protein	Taxonomy	diadenosine 5',5''''-p1,p6-hexaphosphate (IC50)	p(1),p(5)-di(adenosine-5'-)pentaphosphate (IC50)
Chain A, Adenosine kinase, putative	Trypanosoma brucei		29.4

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	24 (64.86)	18.2507
2000's	8 (21.62)	29.6817
2010's	5 (13.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Günther Sillero, MA; Sillero, A; Wasternack, C	1
Ankorina, I; Haxelmans, S; Kleta, R; Schlatter, E	1
Miras-Portugal, MT; Pintor, J	1
Harrach, B; Heidenreich, S; Schlüter, H; Tepel, M; Zidek, W	1
Brüggemann, G; Karas, M; Nordhoff, E; Offers, E; Schlüter, H; Spieker, C; Tepel, M; van der Giet, M; Witzel, H; Zidek, W	1
Dimmick, MA; Hilderman, RH; Jones, GB; Lilien, JE; Tate, DH; Zimmerman, JK	1
Bogle, RG; Davies, G; MacAllister, RJ; Vallance, P	1
Assmann, G; Löwe, S; Nofer, JR; Schlüter, H; Tepel, M; Zidek, W	1
Borucki, U; Enck, G; Hohage, H; Reinhardt, C; Schlatter, E; Schlüter, H; Zidek, W	1
Edwards, SW; Gasmi, L; McLennan, AG	1
Assmann, G; Beinlich, A; Heidenreich, S; Nofer, JR; Schlüter, H; Tepel, M; Walter, M; Zidek, W	1
Bläsius, R; Ogilvie, A; Schulze-Lohoff, E; Sterzel, RB	1
Alekseev, AE; Jovanovic, A; Terzic, A	1
Jankowski, J; Schlüter, H; Spieker, C; Tepel, M; Zidek, W	1
Bachmann, J; Jankowski, J; Ruess, C; Schlüter, H; Tepel, M; Terliesner, J; van der Giet, M; Zidek, W	1
Hohage, H; Hollah, P; Khattab, M; Rahn, KH; Schlatter, E	1
Hohage, H; Rahn, KH; Schlatter, E; Stachon, A; Stegemann, H	1
Brown, SG; Burnstock, G; King, BF; Wildman, SS	1
Barnes, LD; Ingram, SW; Stratemann, SA	1
Jankowski, J; Potthoff, W; Schlüter, H; Tepel, M; van der Giet, M; Zidek, W	1
Flores, NA; Sheridan, DJ; Stavrou, BM	1
Henning, L; Jankowski, J; Junker, R; Schlüter, H; Tente, IM; Tepel, M; van der Giet, M; Zidek, W	1
Cinkilic, O; Jankowski, J; Schlüter, H; Tepel, M; van der Giet, M; Zidek, W	1
Edgecombe, M; Fisher, MJ; McLennan, AG	1
Breittmayer, JP; Frelin, C; Vigne, P	1
Barenbrock, M; Hausberg, M; Hollah, P; Kosch, M; Letzel, M; Rahn, KH; Schlatter, E	1
Blackburn, GM; Cohen, T; Flores, NA; Lawrence, C; Sheridan, DJ; Stavrou, BM	1
Abowath, A; Miller, AD; Tanner, JA	1
Barnes, A; Boughtflower, R; Camacho, J; Cousens, D; Marshall, F; Patel, K; Paterson, C	1
Janssen, AK; Pelster, F; Rahn, KH; Schlatter, E; Steinmetz, M	1
Güngär, N; Jankowski, J; Jankowski, V; Luo, J; Neumann, J; Schlüter, H; Schmitz, W; Zidek, W	1
Herget-Rosenthal, S; Jankowski, J; Jankowski, V; Karadogan, S; Nofer, JR; Tölle, M; Tran, TN; van der Giet, M; Vanholder, R; Zidek, W	1
Chen, FY; Chu, HM; Ko, TP; Wang, AH	1
Jankowski, J; Jankowski, V; Schulz, A; Zidek, W	1
Anashkin, VA; Baykov, AA; Lahti, R; Orlov, VN; Salminen, A; Tuominen, HK	1
Kimura, Y; Oka, M; Takegawa, K	1
Arif, SM; Varshney, U; Vijayan, M	1

Reviews

4 review(s) available for diadenosine 5',5''''-p1,p6-hexaphosphate and p(1),p(5)-di(adenosine-5'-)pentaphosphate

Article	Year
P2 purinergic receptors for diadenosine polyphosphates in the nervous system. General pharmacology, 1995, Volume: 26, Issue:2 Topics: Animals; Dinucleoside Phosphates; Male; Nervous System; Receptors, Purinergic P2	1995
Adenine dinucleotides: a novel class of signalling molecules. Journal of autonomic pharmacology, 1996, Volume: 16, Issue:6 Topics: Animals; Cell Division; Dinucleoside Phosphates; DNA; Humans; Muscle, Smooth, Vascular; Platelet Activation; Rats; Signal Transduction	1996
Intracellular diadenosine polyphosphates: a novel family of inhibitory ligands of the ATP-sensitive K+ channel. Biochemical pharmacology, 1997, Jul-15, Volume: 54, Issue:2 Topics: Adenosine Triphosphate; Animals; Cell Membrane; Dinucleoside Phosphates; Ion Channel Gating; Islets of Langerhans; Ligands; Myocardium; Polyphosphates; Potassium Channel Blockers; Potassium Channels	1997
The effects of diadenosine polyphosphates on the cardiovascular system. Cardiovascular research, 1999, Volume: 42, Issue:1 Topics: Action Potentials; Animals; Cardiovascular System; Dinucleoside Phosphates; Endothelium, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Potassium Channels; Receptors, Purinergic; Second Messenger Systems; Vascular Resistance; Vasodilation	1999

Other Studies

33 other study(ies) available for diadenosine 5',5''''-p1,p6-hexaphosphate and p(1),p(5)-di(adenosine-5'-)pentaphosphate

Article	Year
Diadenosine polyphosphates inhibit the action of ribonucleotide reductase on ADP. Biochemistry international, 1991, Volume: 23, Issue:1 Topics: Adenosine Diphosphate; Cell Membrane Permeability; Chromatography, Gel; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Enzyme Inhibitors; Oxidation-Reduction; Ribonucleotide Reductases; Yeasts	1991
Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells. Pflugers Archiv : European journal of physiology, 1995, Volume: 430, Issue:5 Topics: Adenosine Triphosphate; Angiotensin II; Animals; Calcium; Cell Line; Cytosol; Dinucleoside Phosphates; Fura-2; Glomerular Mesangium; Hypertension; Muscle Contraction; Patch-Clamp Techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY	1995
Regulation of rat mesangial cell growth by diadenosine phosphates. The Journal of clinical investigation, 1995, Volume: 95, Issue:6 Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium; Cell Division; Cells, Cultured; Dinucleoside Phosphates; DNA; Drug Synergism; Glomerular Mesangium; In Vitro Techniques; Male; Platelet-Derived Growth Factor; Rats; Rats, Inbred WKY; Uridine Triphosphate	1995
Diadenosine phosphates and the physiological control of blood pressure. Nature, 1994, Jan-13, Volume: 367, Issue:6459 Topics: 5'-Nucleotidase; Alkaline Phosphatase; Animals; Aorta; Blood Platelets; Blood Pressure; Chromatography, Liquid; Dinucleoside Phosphates; Exonucleases; In Vitro Techniques; Kidney; Mass Spectrometry; Nucleotidases; Phosphodiesterase I; Phosphoric Diester Hydrolases; Rats; Spectrophotometry, Ultraviolet; Vasoconstriction	1994
Adenylated dinucleotide binding to the adenosine 5',5'''-P1,P4-tetraphosphate mouse heart receptor. Biochemical and biophysical research communications, 1994, Apr-29, Volume: 200, Issue:2 Topics: Animals; Antibodies, Monoclonal; Cell Membrane; Dinucleoside Phosphates; Female; In Vitro Techniques; Kinetics; Mice; Models, Molecular; Myocardium; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thermodynamics	1994
Effect of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors. British journal of clinical pharmacology, 1995, Volume: 40, Issue:2 Topics: Arginine; Blood Platelets; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; omega-N-Methylarginine; Theophylline; Umbilical Arteries; Vasoconstrictor Agents	1995
Diadenosine polyphosphates regulate cytosolic calcium in human fibroblast cells by interaction with P2x purinoceptors coupled to phospholipase C. Biochimica et biophysica acta, 1996, Jun-13, Volume: 1312, Issue:2 Topics: Bridged-Ring Compounds; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Dinucleoside Phosphates; Fibroblasts; Fura-2; Humans; Manganese; Nickel; Norbornanes; Phosphodiesterase Inhibitors; Purinergic Antagonists; Receptors, Purinergic; Suramin; Theobromine; Thiocarbamates; Thiones; Type C Phospholipases; Vasoconstrictor Agents; Verapamil; Xanthines	1996
Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats. Journal of the American Society of Nephrology : JASN, 1996, Volume: 7, Issue:8 Topics: Anesthesia; Animals; Blood Pressure; Bosentan; Cyclooxygenase Inhibitors; Dinucleoside Phosphates; Diuresis; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Wistar; Sulfonamides; Vasoconstrictor Agents	1996
Neutrophil apoptosis is delayed by the diadenosine polyphosphates, Ap5A and Ap6A: synergism with granulocyte-macrophage colony-stimulating factor. British journal of haematology, 1996, Volume: 95, Issue:4 Topics: Apoptosis; Dinucleoside Phosphates; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Neutrophils; Vasoconstrictor Agents	1996
Diadenosine polyphosphates induce transplasma membrane calcium influx in cultured glomerular mesangial cells. European journal of clinical investigation, 1996, Volume: 26, Issue:12 Topics: Adenosine Triphosphate; Affinity Labels; Angiotensin II; Animals; Calcium; Cell Membrane; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Glomerular Mesangium; Male; Phospholipase D; Rats; Rats, Inbred WKY; Second Messenger Systems; Suramin; Type C Phospholipases; Vasoconstrictor Agents	1996
Effect of diadenosine polyphosphates on Ca2+ ATPase activity. Journal of molecular medicine (Berlin, Germany), 1997, Volume: 75, Issue:9 Topics: Adenosine Triphosphate; Calcium-Transporting ATPases; Dinucleoside Phosphates; Humans; Structure-Activity Relationship	1997
Diadenosine polyphosphates' action on calcium and vessel contraction. American journal of hypertension, 1997, Volume: 10, Issue:12 Pt 1 Topics: Animals; Calcium; Dinucleoside Phosphates; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; Vasoconstriction	1997
Effects of diadenosine polyphosphates on systemic and regional hemodynamics in anesthetized rats. Kidney & blood pressure research, 1998, Volume: 21, Issue:1 Topics: Animals; Blood Pressure; Cardiac Output; Dinucleoside Phosphates; Femoral Artery; Hemodynamics; Kidney; Male; Nitroprusside; Norepinephrine; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Regional Blood Flow; Second Messenger Systems; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents	1998
Effects of diadenosine polyphosphates on the intracellular Ca2+ concentration in endothelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1998, Volume: 8, Issue:4 Topics: Adenosine Triphosphate; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cell Line; Cells, Cultured; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Rats; Rats, Inbred WKY	1998
Selectivity of diadenosine polyphosphates for rat P2X receptor subunits. European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1 Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Binding, Competitive; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Membrane Potentials; Oocytes; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X3; Receptors, Purinergic P2X4; RNA, Messenger; Xenopus	1999
Schizosaccharomyces pombe Aps1, a diadenosine 5',5' "-P1, P6-hexaphosphate hydrolase that is a member of the nudix (MutT) family of hydrolases: cloning of the gene and characterization of the purified enzyme. Biochemistry, 1999, Mar-23, Volume: 38, Issue:12 Topics: Bacterial Proteins; Cloning, Molecular; Dinucleoside Phosphates; Escherichia coli; Escherichia coli Proteins; Hydrolysis; Kinetics; Molecular Sequence Data; Phosphoric Monoester Hydrolases; Pyrophosphatases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Analysis; Substrate Specificity	1999
High-performance liquid chromatographic assay of the diadenosine polyphosphates in human platelets. Analytical biochemistry, 1999, Apr-10, Volume: 269, Issue:1 Topics: Blood Platelets; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans	1999
Identification and characterization of P(1), P(7)-Di(adenosine-5')-heptaphosphate from human platelets. The Journal of biological chemistry, 1999, Aug-20, Volume: 274, Issue:34 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Dinucleoside Phosphates; Humans; Platelet Aggregation; Rats; Suramin; Thrombin; Vasoconstriction; Vasoconstrictor Agents	1999
Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney. British journal of pharmacology, 1999, Volume: 127, Issue:6 Topics: Adenosine Triphosphate; Animals; Dinucleoside Phosphates; Dose-Response Relationship, Drug; In Vitro Techniques; Kidney; Male; Perfusion; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Inbred WKY; Receptors, Purinergic P2; Renal Artery; Renal Circulation; Suramin; Vasoconstriction; Vasoconstrictor Agents	1999
Diadenosine polyphosphates and the control of cyclic AMP concentrations in isolated rat liver cells. FEBS letters, 1999, Sep-03, Volume: 457, Issue:3 Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Dinucleoside Phosphates; Glucagon; In Vitro Techniques; Liver; Male; Rats; Rats, Wistar; Receptors, Purinergic P2; Signal Transduction; Thionucleotides	1999
Diadenosine polyphosphates as antagonists of the endogenous P2Y(1) receptor in rat brain capillary endothelial cells of the B7 and B10 clones. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Brain; Calcium; Cells, Cultured; Clone Cells; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Endothelium, Vascular; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1	2000
A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension. Journal of hypertension, 2001, Volume: 19, Issue:2 Topics: Adult; Blood Platelets; Dinucleoside Phosphates; Female; Humans; Hypertension; Male; Reproducibility of Results	2001
Coronary vasomotor and cardiac electrophysiologic effects of diadenosine polyphosphates and nonhydrolyzable analogs in the guinea pig. Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:5 Topics: Action Potentials; Animals; Coronary Vessels; Dinucleoside Phosphates; Guinea Pigs; Heart; Heart Rate; Hydrolysis; Male; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Structure-Activity Relationship; Vasoconstrictor Agents; Vasomotor System	2001
Isothermal titration calorimetry reveals a zinc ion as an atomic switch in the diadenosine polyphosphates. The Journal of biological chemistry, 2002, Feb-01, Volume: 277, Issue:5 Topics: Adenosine Triphosphate; Binding Sites; Calorimetry; Cations, Divalent; Circular Dichroism; Dinucleoside Phosphates; Manganese; Molecular Conformation; Zinc	2002
Activity of diadenosine polyphosphates at P2Y receptors stably expressed in 1321N1 cells. European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3 Topics: Adenosine Diphosphate; Calcium; Carbachol; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Gene Expression; Humans; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Tumor Cells, Cultured; Uridine Triphosphate	2001
Vasoactivity of diadenosine polyphosphates in human small mesenteric resistance arteries. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Dinucleoside Phosphates; Humans; In Vitro Techniques; Kinetics; Mesenteric Arteries; Muscle Contraction; Rats; Vascular Resistance	2002
Endogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: Cholinergic Agents; Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cytoplasmic Granules; Dinucleoside Phosphates; Heart; Humans; Myocardium; Potassium Channels; Receptors, Purinergic P2; Receptors, Purinergic P2X; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Vasoconstriction	2004
Paracrine stimulation of vascular smooth muscle proliferation by diadenosine polyphosphates released from proximal tubule epithelial cells. Kidney international, 2007, Volume: 71, Issue:10 Topics: Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; Dinucleoside Phosphates; Drug Synergism; Epithelial Cells; Kidney Tubules, Proximal; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paracrine Communication; Platelet-Derived Growth Factor; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine	2007
Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates. FEBS letters, 2010, Sep-24, Volume: 584, Issue:18 Topics: Alkyl and Aryl Transferases; Catalysis; Dinucleoside Phosphates; Humulus; Mutation; Protein Conformation	2010
Highly sensitive, selective and rapid LC-MS method for simultaneous quantification of diadenosine polyphosphates in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jun-15, Volume: 961 Topics: Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2014
Cystathionine β-Synthase (CBS) Domain-containing Pyrophosphatase as a Target for Diadenosine Polyphosphates in Bacteria. The Journal of biological chemistry, 2015, Nov-13, Volume: 290, Issue:46 Topics: Adenine Nucleotides; Amino Acid Sequence; Bacteria; Bacterial Proteins; Clostridium perfringens; Cystathionine beta-Synthase; Dinucleoside Phosphates; Kinetics; Molecular Sequence Data; Moorella; Protein Binding; Protein Structure, Tertiary; Pyrophosphatases	2015
Lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate. Archives of biochemistry and biophysics, 2016, 08-15, Volume: 604 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Bacterial Proteins; Catalysis; Dinucleoside Phosphates; DNA Mutational Analysis; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine-tRNA Ligase; Manganese; Myxococcus xanthus; Phosphates; Pyrophosphatases; Ribonucleotides	2016
Hydrolysis of diadenosine polyphosphates. Exploration of an additional role of Mycobacterium smegmatis MutT1. Journal of structural biology, 2017, Volume: 199, Issue:3 Topics: Acid Anhydride Hydrolases; Adenosine Diphosphate; Adenosine Triphosphate; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Dinucleoside Phosphates; Hydrolysis; Models, Molecular; Mycobacterium smegmatis; Polyphosphates; Protein Conformation	2017