diacetolol has been researched along with acebutolol in 40 studies
*Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action. [MeSH]
*Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (70.00) | 18.7374 |
| 1990's | 6 (15.00) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Basil, B; Clark, JR; Coffee, EC; Jordon, R; Loveless, AH; Pain, DL; Wooldridge, KR | 1 |
| Jamali, F; Piquette-Miller, M | 1 |
| Foster, RT; Jamali, F; Kappagoda, CT; Piquette-Miller, M | 2 |
| Foster, RT; Piquette-Miller, M | 1 |
| Blanchot, G; Desmonts, JM; Farinotti, R; Hazebroucq, J; Mantz, J; Marty, J; Trouvin, JH | 1 |
| Abernethy, DR; Arendt, RM; Greenblatt, DJ | 1 |
| Ryan, JR | 1 |
| De Bono, G; Kaye, CM; Roland, E; Summers, AJ | 1 |
| Borchard, U; Hafner, D; Hirth, C | 1 |
| Tattersfield, AE; Thomas, MS | 1 |
| Bianchetti, G; Boutroy, MJ; Dubruc, C; Morselli, PL; Vert, P | 1 |
| Dalgleish, JG; Fergusson, NV; Saunders, DA | 1 |
| Boobis, AR; Gulaid, AA; Houghton, GW | 1 |
| Gabriel, R; Kaye, CM; Sankey, MG | 1 |
| Flabeau, C; Flouvat, B; Menard, J; Pasquier, P; Roux, A; Thibonnier, M; Thouvenin, M | 1 |
| Basil, B; Jordan, R | 1 |
| Delhotal, B; Flouvat, B; Lemaigre, D; Leroy, M; Liot, F; Roux, A | 1 |
| Pong, SF; Tinkham, CL | 1 |
| Gulaid, A; Kaye, CM; Sankey, MG | 1 |
| Kaye, CM | 1 |
| Costello, RB; DiBianco, R; Fletcher, RD; Gottdiener, JS; Laddu, AR; Miller, RR; Nahormek, P; Newton, GC; Shah, PM; Singh, SN | 1 |
| Bourdarias, JP; Chau, NP; Flouvat, B; Forette, F; Fouache, Y; Henry, JF; Hervy, MP; Roux, A | 1 |
| Bailey, RR; Begg, E; Ebert, R; Ferry, DG; Munn, S | 1 |
| Kaye, CM; Odom, NJ; Reece, IJ; Sankey, MG; Thoms, GM | 1 |
| Berggren, G; Braun, W; Kirch, W; Köhler, H | 1 |
| Collins, RF; Dreux, C; Fiet, J; Gourmel, B; Passa, P; Villette, JM | 1 |
| Andre-Fouet, X; Chau, NP; Flouvat, B; Gregoire, J; Roux, A; Viallet, M; Woehrle, R | 1 |
| Jack, DB; Kendall, MJ; Zaman, R | 1 |
| Dennis, M; Houghton, GW; Kaye, CM; Ohashi, K; Templeton, R; Turner, P; Warrington, SJ | 1 |
| Coombs, TJ; Coulson, CJ; Smith, VJ | 1 |
| Bowker, MJ; Gladwin, RP; Mills, DJ; Stubbles, JA | 1 |
| Schieffer, GW | 1 |
| Aboul-Enein, HY; Bojarski, J; Szymura-Oleksiak, J; Walczak, M | 1 |
| Burm, JP; Choi, JS | 1 |
| Foster, RT; Mostafavi, SA | 1 |
| Lilja, JJ; Neuvonen, PJ; Raaska, K | 1 |
| Ji, QC; Jiang, H; Jiang, X; Junga, H; Randlett, C | 1 |
| Chen, FM; Cheng, JQ; Liu, T; Nie, XM; Wang, CS; Zhang, F | 1 |
| Allard, PM; Allard, S; Baert, A; Bouvet, R; Gicquel, T; Le Daré, B; Morel, I | 1 |
1 review(s) available for diacetolol and acebutolol
| Article | Year |
|---|---|
Acebutolol: ten years of experience.
Topics: Acebutolol; Adrenergic beta-Antagonists; Age Factors; Animals; Arrhythmias, Cardiac; Blood Circulation; Bronchi; Chemical Phenomena; Chemistry; Drug Interactions; Humans; Hypertension; Kidney Diseases; Kinetics; Liver Diseases; Sympathomimetics | 1985 |
8 trial(s) available for diacetolol and acebutolol
| Article | Year |
|---|---|
Comparison of beta-adrenoceptor selectivity of acebutolol and its metabolite diacetolol with metoprolol and propranolol in normal man.
Topics: Acebutolol; Adrenergic beta-Antagonists; Airway Resistance; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Metoprolol; Physical Exertion; Propranolol; Receptors, Adrenergic, beta | 1986 |
Acebutolol and oral surgery: plasma levels following a single oral dose.
Topics: Acebutolol; Administration, Oral; Adult; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Intraoperative Complications; Male; Middle Aged; Premedication; Random Allocation; Tooth Extraction | 1985 |
Antihypertensive effect of diacetolol in essential hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Patient Compliance; Time Factors | 1982 |
The beta-blocking effect of diacetolol in humans and its relationship to plasma levels.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Male; Physical Exertion | 1982 |
Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo-controlled study.
Topics: Acebutolol; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Physical Exertion; Propranolol; Random Allocation | 1982 |
Pharmacokinetics and bioavailability of diacetolol, the main metabolite of acebutolol.
Topics: Acebutolol; Administration, Oral; Adult; Biological Availability; Half-Life; Humans; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate | 1981 |
Observations on the clinical pharmacology and plasma concentrations of diacetolol, the major human metabolite of acebutolol.
Topics: Acebutolol; Adult; Depression, Chemical; Forced Expiratory Volume; Heart Rate; Humans; Male; Peak Expiratory Flow Rate; Physical Exertion; Respiration | 1981 |
Effects of grapefruit juice on the pharmacokinetics of acebutolol.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Beverages; Citrus paradisi; Cross-Over Studies; Female; Food-Drug Interactions; Hemodynamics; Humans; Male | 2005 |
31 other study(ies) available for diacetolol and acebutolol
| Article | Year |
|---|---|
A new series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols.
Topics: Adrenergic beta-Antagonists; Anilides; Animals; Arrhythmias, Cardiac; Cats; Dogs; Heart Rate; Isoproterenol; Molecular Conformation; Organ Specificity; Ouabain; Propanolamines; Receptors, Adrenergic; Structure-Activity Relationship | 1976 |
Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats.
Topics: Acebutolol; Animals; Arthritis, Experimental; Female; Liver; Mycobacterium; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1992 |
Effect of aging on the pharmacokinetics of acebutolol enantiomers.
Topics: Acebutolol; Aged; Aging; Blood Proteins; Female; Humans; Isomerism; Kidney; Male; Middle Aged; Protein Binding | 1992 |
Pharmacokinetics of acebutolol enantiomers in humans.
Topics: Acebutolol; Administration, Oral; Adult; Female; Humans; Male; Stereoisomerism | 1991 |
High-performance liquid chromatographic determination of diacetolol enantiomers.
Topics: Acebutolol; Chromatography, High Pressure Liquid; Fluorescence; Humans | 1990 |
Acebutolol and diacetolol plasma levels in patients undergoing myocardial revascularization with hypothermic cardiopulmonary bypass.
Topics: Acebutolol; Administration, Oral; Aged; Cardiopulmonary Bypass; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Myocardial Revascularization | 1990 |
Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Cats; Cell Membrane; Dogs; Guinea Pigs; Hypertension; Lipid Metabolism; Propranolol; Solubility; Sotalol | 1985 |
Clinical pharmacology of acebutolol.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Digoxin; Drug Interactions; Female; Humans; Hypertension; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Prothrombin Time; Tolbutamide; Warfarin | 1985 |
In vitro studies on the pharmacological properties of diacetolol, the major metabolite of acebutolol in man.
Topics: Acebutolol; Action Potentials; Adrenergic beta-Antagonists; Animals; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Myocardial Contraction; Papillary Muscles; Rats; Sympathomimetics; Trachea | 1985 |
To nurse when receiving acebutolol: is it dangerous for the neonate?
Topics: Acebutolol; Breast Feeding; Female; Humans; Hypertension; Infant, Newborn; Milk, Human; Postpartum Period; Pregnancy; Prospective Studies | 1986 |
Separation of acebutolol and diacetolol diastereomers by reversed-phase high-performance liquid chromatography.
Topics: Acebutolol; Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Stereoisomerism | 1985 |
Preliminary observations on the excretion of acebutolol and its acetyl metabolite in the urine and faeces of man.
Topics: Acebutolol; Feces; Humans; Time Factors | 1981 |
Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Bronchi; Cats; Dogs; Guinea Pigs; Heart; In Vitro Techniques; Male; Rabbits; Refractory Period, Electrophysiological; Sympathomimetics; Trachea; Vasodilation | 1982 |
Displacement of [3H]dihydroalprenolol binding from rat heart and lung by acebutolol, diacetolol and D-diacetolol.
Topics: Acebutolol; Alprenolol; Animals; Binding, Competitive; Dihydroalprenolol; In Vitro Techniques; Isomerism; Lung; Myocardium; Rats; Rats, Inbred Strains; Tritium | 1983 |
Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.
Topics: Acebutolol; Chromatography, High Pressure Liquid; Half-Life; Humans; Stereoisomerism | 1984 |
New drugs: beta blockers and sympathomimetics.
Topics: Acebutolol; Humans | 1983 |
A pharmacokinetic study of acebutolol in aged subjects as compared to young subjects.
Topics: Acebutolol; Administration, Oral; Adult; Aged; Female; Half-Life; Humans; Hypertension; Injections, Intravenous; Male | 1983 |
Plasma and urine concentrations of acebutolol and its acetyl metabolite in patients with renal functional impairment.
Topics: Acebutolol; Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Kidney Diseases; Kinetics; Male; Middle Aged | 1980 |
Acebutolol and coronary artery surgery. Plasma levels following oral pre-operative treatment.
Topics: Acebutolol; Adult; Coronary Artery Bypass; Humans; Intraoperative Period; Male; Middle Aged; Postoperative Period; Premedication; Time Factors | 1982 |
The influence of renal function on plasma levels and urinary excretion of acebutolol and its main N-acetyl metabolite.
Topics: Acebutolol; Administration, Oral; Adolescent; Adult; Aged; Female; Glomerular Filtration Rate; Half-Life; Humans; Injections, Intravenous; Kidney; Kidney Diseases; Kinetics; Male; Middle Aged | 1982 |
Plasma diacetolol assessment by radioimmunoassay.
Topics: Acebutolol; Antibody Specificity; Humans; Radioimmunoassay | 1981 |
The penetration of acebutolol and its major metabolite, diacetolol, into human cerebrospinal fluid and saliva.
Topics: Acebutolol; Adult; Female; Humans; Male; Middle Aged; Saliva | 1981 |
Blood plasma binding of acebutolol and diacetolol in man.
Topics: Acebutolol; Blood Proteins; Humans; In Vitro Techniques; Protein Binding; Solubility | 1980 |
Semi-automated high-performance liquid chromatographic method for the determination of diacetolol hydrochloride in medicated animal diets.
Topics: Acebutolol; Animal Feed; Animals; Chromatography, High Pressure Liquid; Diet; Mice | 1980 |
Reversed-phase high-performance liquid chromatography with differential pulse polarographic detection for assaying drugs in feed: stability-indicating assay of diacetolol.
Topics: Acebutolol; Animal Feed; Animals; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Technology, Pharmaceutical | 1980 |
Enantioselective high performance liquid chromatographic assay of acebutolol and its active metabolite diacetolol in human serum.
Topics: Acebutolol; Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Hypertension; Indicators and Reagents; Regression Analysis; Stereoisomerism | 1999 |
Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.
Topics: Acebutolol; Administration, Oral; Adrenergic beta-Antagonists; Animals; Area Under Curve; Biotransformation; Carbon Tetrachloride Poisoning; Chromatography, High Pressure Liquid; Liver Failure; Male; Rabbits | 2002 |
Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Gastric Acidity Determination; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2003 |
Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plas
Topics: Acebutolol; Adrenergic beta-Antagonists; Cellulose 1,4-beta-Cellobiosidase; Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry | 2009 |
Analysis of 27 β-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Ethanolamines; Limit of Detection; Milk; Molecular Structure; Principal Component Analysis; Propanolamines; Propranolol; Solid Phase Extraction; Tandem Mass Spectrometry | 2019 |
A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.
Topics: Acebutolol; Aged; Autopsy; Chromatography, Liquid; Female; Humans; Molecular Imaging; Suicide; Tandem Mass Spectrometry | 2020 |