diacerein has been researched along with rhein in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 5 (18.52) | 2.80 |
| Authors | Studies |
|---|---|
| Kam, CM; Powers, JC; Zalkow, LH; Zembower, DE | 1 |
| Cai, J; Chao, M; Chen, J; Duan, Y; Ji, M; Yu, J | 1 |
| Inui, K; Kanamitsu, K; Katayama, W; Kitakami, R; Mizuguchi, M; Nakagawa, S; Nakagawa, Y; Okada, T; Sawai, Y; Toyooka, N; Yokoyama, T | 1 |
| Belli, B; Fascetti, P; Gentilini, P; La Villa, G; Laffi, G; Marra, F; Meacci, E | 1 |
| Coppi, G; Springolo, V | 1 |
| Berdah, L; Louchahi, K; Magnard, O; Molinier, P; Perret, G; Petitjean, O; Tod, M | 1 |
| Berdah, L; Debord, P; Louchahi, K; Molinier, P; Perret, G; Petitjean, O; Tod, M | 1 |
| Brun, PH | 1 |
| Shirazi, I; Yaron, I; Yaron, M | 2 |
| Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Mineau, F; Pelletier, JP | 1 |
| Duval, N; Fernandes, JC; Martel-Pelletier, J; Mineau, F; Pelletier, JP | 1 |
| Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Moldovan, F; Pelletier, JP | 1 |
| Ohmori, K; Tamura, T | 1 |
| Ishiwa, J; Ito, A; Kosaka, N; Nagase, H; Sato, T; Tamura, T | 1 |
| Fernandes, JC; Lajeunesse, D; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P; Sabouret, P | 1 |
| Ohmori, K; Tamura, T; Yokoyama, T | 1 |
| Caramona, MM; de Carvalho, AP; Lopes, MC; Mendes, AF | 1 |
| Baati, R; Mioskowski, C; Nicolas, M; Tisserand, S | 1 |
| Abdelkawy, M; Abdelwahab, NS; Ali, NW; Emam, AA | 1 |
| Abhay, H; Dhaneshwar, S; Dipmala, P; Prashant, B | 1 |
| Adel, MM; Basalious, EB; El-Hoseiny, BM; El-Laithy, HM | 1 |
| Kulkarni, S; Mandawgade, SD; Padhi, BK; Pal, A; Raghuvanshi, RS; Srivastava, S | 1 |
| Patel, RD; Pethani, TM; Raval, MK | 1 |
| Husain, SM; Mondal, A; Pandey, SK; Rajput, A | 1 |
| Huang, SY; Hung, CC; Kao, MC; Kuo, CY; Lee, TE; Teng, YN; Wu, TS | 1 |
| Jain, M; Joharapurkar, A; Patel, V | 1 |
1 review(s) available for diacerein and rhein
| Article | Year |
|---|---|
Therapeutic Potential of Diacerein in Management of Pain.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histamine; Humans; Matrix Metalloproteinases; Nitric Oxide; Osteoarthritis; Pain; Prostaglandins; Substance P; Transient Receptor Potential Channels | 2022 |
3 trial(s) available for diacerein and rhein
| Article | Year |
|---|---|
Effects of rhein on renal arachidonic acid metabolism and renal function in patients with congestive heart failure.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Aldosterone; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprostone; Double-Blind Method; Female; Heart Failure; Humans; Kidney; Kidney Function Tests; Renin | 1989 |
Influence of renal function on the pharmacokinetics of diacerein after a single oral dose.
Topics: Administration, Oral; Adult; Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Female; Humans; Male; Middle Aged; Renal Insufficiency | 1993 |
Development and Pharmacokinetic Evaluation of New Oral Formulations of Diacerein.
Topics: Administration, Oral; Anthraquinones; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Liberation; Gastrointestinal Absorption; Gastrointestinal Tract; Humans; Solubility | 2016 |
23 other study(ies) available for diacerein and rhein
| Article | Year |
|---|---|
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Topics: Anthraquinones; Cathepsin G; Cathepsins; Humans; Leukocyte Elastase; Pancreatic Elastase; Serine Endopeptidases; Structure-Activity Relationship | 1992 |
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Chemistry Techniques, Synthetic; Drug Stability; Durapatite; Esters; Female; Glycols; Male; Mice; Prodrugs; Rats; Ulcer | 2012 |
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Topics: Amyloid Neuropathies, Familial; Anthraquinones; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Xanthones | 2021 |
Simple method for the determination of rhein in biological fluids by high-performance liquid chromatography.
Topics: Administration, Oral; Animals; Anthraquinones; Biological Availability; Chromatography, High Pressure Liquid; Indicators and Reagents; Male; NADH, NADPH Oxidoreductases; Rats; Rats, Inbred Strains | 1988 |
Pharmacokinetics of diacerein in patients with liver cirrhosis.
Topics: Adult; Anthraquinones; Capsules; Drug Administration Schedule; Female; Humans; Liver Cirrhosis; Male; Middle Aged | 1993 |
Effect of diacetylrhein on the development of experimental osteoarthritis. A biochemical investigation.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Osteoarthritis | 1997 |
[Anti-interleukin-1 effects of diacerhein in vitro].
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Culture Techniques; Humans; Interleukin-1; Lipopolysaccharides; NADH, NADPH Oxidoreductases; Osteoarthritis; Proteoglycans; Synovial Membrane | 1997 |
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
Topics: Aged; Anthraquinones; Blotting, Northern; Cells, Cultured; Chondrocytes; Culture Techniques; Enzyme Inhibitors; Female; Humans; Interleukin-1; Lipopolysaccharides; Male; Matrix Metalloproteinase 3; Middle Aged; Osteoarthritis; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 1998 |
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases | 1998 |
Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Female; Humans; Interleukin-1; Male; Nitric Oxide; Osteoarthritis; Receptors, Interleukin-1 | 1999 |
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Cartilage, Articular; Caspase 1; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Situ Hybridization; Interleukin-1; Interleukin-18; Male; Osteoarthritis; RNA, Messenger | 2000 |
Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Female; Interleukin-1; Joints; Knee; Matrix Metalloproteinases; Naproxen; Proteoglycans; Rabbits; Shoulder | 2001 |
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Hindlimb; Joints; Matrix Metalloproteinases; Osteoarthritis; Protease Inhibitors; Rabbits; Tissue Inhibitor of Metalloproteinases | 2001 |
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
Topics: Aged; Aged, 80 and over; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Bone Remodeling; Cells, Cultured; Female; Humans; Male; Middle Aged; Osteoarthritis; Osteoblasts | 2001 |
Effects of diacerein on indomethacin-induced gastric ulceration.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Neutrophils; Rats; Reactive Oxygen Species; Stomach Ulcer | 2001 |
Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Blotting, Western; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Depression, Chemical; I-kappa B Proteins; Interleukin-1; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nuclear Matrix | 2002 |
Expedient total syntheses of rhein and diacerhein via Fries rearrangement.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Molecular Structure | 2004 |
Validated stability indicating TLC-densitometric method for the determination of diacerein.
Topics: Anthraquinones; Chromatography, Thin Layer; Densitometry; Drug Contamination; Drug Stability; Emodin; Reproducibility of Results; Sensitivity and Specificity | 2014 |
Disease-modifying effect of anthraquinone prodrug with boswellic acid on collagenase-induced osteoarthritis in Wistar rats.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Anti-Ulcer Agents; Body Weight; Collagenases; Edema; Male; Osteoarthritis; Prodrugs; Rats; Rats, Wistar; Triterpenes | 2013 |
Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: Simultaneous portal blood absorption and lymphatic delivery.
Topics: Administration, Oral; Animals; Anthraquinones; Biological Availability; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Emulsions; Male; Nanoparticles; Particle Size; Rats; Rats, Wistar; Solubility; Surface-Active Agents; Suspensions | 2015 |
Application of a Validated RP-HPLC Method in Solubility and Dissolution Testing for Simultaneous Estimation of Diacerein and Its Active Metabolite Rhein in Presence of Coformers in the Eutectic Tablet Formulation.
Topics: Anthraquinones; Chromatography, High Pressure Liquid; Reproducibility of Results; Solubility; Tablets | 2021 |
Synthesis of rhein and diacerein: a chemoenzymatic approach using anthrol reductase of
Topics: Anthraquinones; Anti-Inflammatory Agents; Molecular Structure; Oxidoreductases; Talaromyces | 2022 |
Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression.
Topics: Anthraquinones; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Neoplasms; Prodrugs; STAT3 Transcription Factor | 2022 |