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dextropropoxyphene and naloxone

dextropropoxyphene has been researched along with naloxone in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199044 (83.02)18.7374
1990's3 (5.66)18.2507
2000's2 (3.77)29.6817
2010's4 (7.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Nickander, R; Smits, SE; Steinberg, MI1
Maykut, MO1
Leander, JD1
Lehman, T; Peterson, GR1
Creese, I; Feinberg, AP; Snyder, SH2
Anggård, E1
Lawson, AA; Starkey, IR1
Crome, P; Goulding, R; Vale, JA; Volans, GN1
Chapman, S; Holdstock, GE; Loehry, CA; Wiseman, M1
Bae, EA; Johansson, JH1
Crome, P; Vale, JA; Volans, GN; Widdop, B1
Lunde, PK; Skjoto, J; Teisberg, P1
Gilbert, PE; Martin, WR1
Lovejoy, FH; Mitchell, AA1
Deacon, MA; Iorio, LC; Ryan, EA1
Chokroverty, S; Fahn, S; Hening, W; Walters, A1
Angelo, H; Häggmark, S; Madsen, PS; Ostman, M; Reiz, S; Strøm, J; Sørensen, MB1
Korpás, J; Nosál'ová, G; Strapková, A1
Ferreira, SH; Follenfant, RL; Smith, TW1
Côté, L; Fahn, S; Hening, W; Walters, A1
Bodd, E; Gulliksen, M; Mørland, J; Olsen, H1
Gorodetzky, CW1
Goldman, P; Lovejoy, FH; Mitchell, AA1
Colhoun, E; Dubas, T; Lundy, P; Parker, JM1
Gourley, DR1
Fraker, T; Vlasses, PM1
Daftery, AV1
Kersh, ES1
Pert, CB; Snyder, SH1
Forrest, JA; Tarala, R1
Granat, FR; Saelens, JK1
Neil, A; Terenius, L1
DiPalma, JR1
Young, RJ1
Angelo, HR; Bredgaard Sørensen, M; Reiz, S; Sloth Madsen, P; Strøm, J1
Proudfoot, AT1
Elonen, E; Neuvonen, PJ1
Waite, E; Wang, RI1
Barraclough, CJ; Lowe, RA1
Conner, CS; Moore, RA; Peterson, RG; Rumack, BH1
Planas, J; Torralba, A; Vinardell, P1
Evenepoel, M; Hantson, P; Hassoun, A; Mahieu, P; Ziade, D1
Marsden, AK; Mora, FM1
Daenens, P; Tytgat, J; Ulens, C1

Reviews

2 review(s) available for dextropropoxyphene and naloxone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Dextropropoxyphene overdosage. Pharmacological considerations and clinical management.
    Drugs, 1983, Volume: 26, Issue:1

    Topics: Dextropropoxyphene; Humans; Kinetics; Mortality; Naloxone; Tissue Distribution

1983

Trials

2 trial(s) available for dextropropoxyphene and naloxone

ArticleYear
Opioid responsiveness in patients with neuroleptic-induced akathisia.
    Movement disorders : official journal of the Movement Disorder Society, 1986, Volume: 1, Issue:2

    Topics: Acetaminophen; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Codeine; Dextropropoxyphene; Female; Humans; Male; Middle Aged; Naloxone; Psychomotor Agitation; Receptors, Opioid

1986
Crossover and parallel study of oral analgesics.
    Journal of clinical pharmacology, 1981, Volume: 21, Issue:4

    Topics: Administration, Oral; Adult; Aged; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene; Drug Combinations; Humans; Middle Aged; Naloxone; Oxycodone; Phenacetin

1981

Other Studies

49 other study(ies) available for dextropropoxyphene and naloxone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Propoxyphene and norpropoxyphene: pharmacologic and toxic effects in animals.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; In Vitro Techniques; Lethal Dose 50; Male; Mice; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Rats; Substance Withdrawal Syndrome; Time Factors

1977
Pharmacotherapy of narcotic dependence.
    Progress in neuro-psychopharmacology, 1977, Volume: 1, Issue:1-2

    Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Pregnancy; Pregnancy Complications; Prognosis; Substance-Related Disorders

1977
Effects of propoxyphene, ethoheptazine, and azabicyclane on schedule-controlled responding: attenuation by pentobarbital but not naloxone.
    Psychopharmacology, 1979, Volume: 66, Issue:1

    Topics: Analgesics, Opioid; Animals; Azepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Columbidae; Conditioning, Operant; Dextropropoxyphene; Male; Naloxone; Pentobarbital; Reinforcement Schedule

1979
Treatment of dextropropoxyphene poisoning.
    Lancet (London, England), 1977, Sep-10, Volume: 2, Issue:8037

    Topics: Dextropropoxyphene; Humans; Naloxone; Poisoning

1977
Naloxone-reversible analgesic action of SKF 525-A in mice.
    Psychopharmacology, 1978, Dec-08, Volume: 59, Issue:3

    Topics: Analgesics; Animals; Dextropropoxyphene; Male; Mice; Naloxone; Proadifen; Reflex

1978
The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.
    Proceedings of the National Academy of Sciences of the United States of America, 1976, Volume: 73, Issue:11

    Topics: Allosteric Regulation; Dextropropoxyphene; Fentanyl; Methadone; Models, Biological; Models, Molecular; Molecular Conformation; Morphine; Nalorphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship

1976
[Morphine intoxication and abstinence].
    Lakartidningen, 1977, Nov-30, Volume: 74, Issue:48

    Topics: Dextropropoxyphene; Drug Tolerance; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome

1977
Acute poisoning with Distalgesic.
    British medical journal, 1978, Nov-25, Volume: 2, Issue:6150

    Topics: Acetaminophen; Adolescent; Dextropropoxyphene; Drug Combinations; Electrocardiography; Female; Humans; Naloxone

1978
Dangers of dextropropoxyphene.
    British medical journal, 1977, Apr-09, Volume: 1, Issue:6066

    Topics: Dextropropoxyphene; Humans; Naloxone

1977
Dextropropoxyphene overdosage and naloxone.
    British medical journal, 1977, Apr-30, Volume: 1, Issue:6069

    Topics: Adolescent; Alcoholic Beverages; Dextropropoxyphene; Humans; Male; Naloxone; Respiratory Insufficiency

1977
[Severe dextro propoxyphene poisoning treated with naloxone].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Apr-30, Volume: 96, Issue:12

    Topics: Adult; Dextropropoxyphene; Humans; Male; Naloxone; Poisoning

1976
Letter: Dextropropoxyphene poisoning.
    British medical journal, 1976, Aug-14, Volume: 2, Issue:6032

    Topics: Acetaminophen; Dextropropoxyphene; Humans; Naloxone

1976
[Letter: Use of naloxone (Narcan) in poisoning by morphine, methadone and dextro propoxyphene].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Jun-20, Volume: 96, Issue:17-18

    Topics: Dextropropoxyphene; Humans; Methadone; Morphine; Naloxone; Poisoning; Suicide, Attempted

1976
Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:3

    Topics: Animals; Anticonvulsants; Dextropropoxyphene; Heroin; Male; Meperidine; Mice; Naloxone; Nipecotic Acids; Seizures; Thebaine

1975
Hemodialysis in an infant with propoxyphene intoxication.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:5

    Topics: Dextropropoxyphene; Humans; Infant; Naloxone; Poisoning; Renal Dialysis

1975
Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:1

    Topics: Administration, Oral; Animals; Apomorphine; Behavior, Animal; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Injections, Intraperitoneal; Male; Meperidine; Methadone; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotics; Pentazocine; Substance Withdrawal Syndrome

1975
Butyrophenone influences on the opiate receptor.
    European journal of pharmacology, 1976, Volume: 36, Issue:1

    Topics: Animals; Benperidol; Benzimidazoles; Brain; Butyrophenones; Dextropropoxyphene; In Vitro Techniques; Male; Meperidine; Naloxone; Phenothiazines; Pimozide; Rats; Receptors, Drug; Structure-Activity Relationship

1976
The effects of naloxone on central hemodynamics and myocardial metabolism in experimental propoxyphene-induced circulatory shock.
    Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:7

    Topics: Animals; Dextropropoxyphene; Heart; Hemodynamics; Myocardium; Naloxone; Pentobarbital; Receptors, Opioid; Shock; Swine

1985
[Relation between the antitussive and analgesic activity of substances].
    Bratislavske lekarske listy, 1987, Volume: 88, Issue:5

    Topics: Animals; Cats; Codeine; Cough; Dextropropoxyphene; Female; Male; Mice; Naloxone; Pain

1987
Antinociceptive models displaying peripheral opioid activity.
    International journal of tissue reactions, 1985, Volume: 7, Issue:1

    Topics: Analgesics; Animals; Carrageenan; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Epoprostenol; Female; Indomethacin; Mice; Morphine; Movement; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Dominantly inherited restless legs with myoclonus and periodic movements of sleep: a syndrome related to the endogenous opiates?
    Advances in neurology, 1986, Volume: 43

    Topics: Aged; Dextropropoxyphene; Electrocardiography; Electroencephalography; Electrooculography; Endorphins; Female; Humans; Male; Methadone; Middle Aged; Myoclonus; Naloxone; Narcotics; Restless Legs Syndrome; Sleep Wake Disorders

1986
Lack of evidence of increased lethality due to propoxyphene overdose in the presence of ethanol in male Wistar rats.
    Archives of toxicology, 1985, Volume: 56, Issue:3

    Topics: Animals; Brain; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Lethal Dose 50; Liver; Male; Myocardium; Naloxone; Organ Size; Rats; Rats, Inbred Strains

1985
Sensitivity of thin-layer chromatography for detection of 16 opioids, cocaine and quinine.
    Toxicology and applied pharmacology, 1972, Volume: 23, Issue:3

    Topics: Alphaprodine; Chromatography, Thin Layer; Cocaine; Codeine; Cyclazocine; Dextropropoxyphene; Humans; Hydromorphone; Levallorphan; Levorphanol; Meperidine; Methadone; Methods; Morphinans; Morphine; Nalorphine; Naloxone; Oxymorphone; Pentazocine; Quinine

1972
The management of propoxyphene poisoning.
    The Journal of pediatrics, 1974, Volume: 85, Issue:1

    Topics: Adult; Dextropropoxyphene; Female; Humans; Ipecac; Naloxone; Poisoning; Respiratory Insufficiency; Seizures; Vomiting

1974
Investigation of mechanisms involved in toxic effects of narcotic analgesics.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1972, Volume: 5, Issue:4

    Topics: Analgesics; Animals; Brain; Brain Chemistry; Catecholamines; Dextropropoxyphene; Drug Interactions; Female; Fenclonine; Heroin; Imipramine; Lethal Dose 50; Morphine; Naloxone; Narcotics; Norepinephrine; Pargyline; Rats; Reserpine; Tranylcypromine; Tyrosine

1972
Effects of opioid narcotic drugs on energy reserves of skeletal muscle. II. Further studies of the glycogenolytic action of methadone.
    Biochemical pharmacology, 1974, May-01, Volume: 23, Issue:11

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cyclic AMP; Dextropropoxyphene; Glycogen; In Vitro Techniques; Isomerism; Male; Methadone; Muscles; Naloxone; Phosphocreatine; Rats; Time Factors

1974
Letter: Naloxone for propoxyphene overdosage.
    JAMA, 1974, Aug-26, Volume: 229, Issue:9

    Topics: Adult; Dextropropoxyphene; Female; Humans; Male; Naloxone; Poisoning; Substance-Related Disorders

1974
Letter: Naloxone challenge in propoxyphene dependence.
    The New England journal of medicine, 1974, Oct-31, Volume: 291, Issue:18

    Topics: Adult; Dextropropoxyphene; Humans; Male; Naloxone; Substance Withdrawal Syndrome; Substance-Related Disorders

1974
Treatment of propoxyphene overdosage with naloxone.
    Chest, 1973, Volume: 63, Issue:1

    Topics: Adult; Coma; Dextropropoxyphene; Female; Humans; Infant; Methadone; Naloxone; Poisoning

1973
Opiate receptor: demonstration in nervous tissue.
    Science (New York, N.Y.), 1973, Mar-09, Volume: 179, Issue:4077

    Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium

1973
Treatment of dextropropoxyphene poisoning.
    British medical journal, 1973, Jun-02, Volume: 2, Issue:5865

    Topics: Adult; Dextropropoxyphene; Female; Humans; Injections, Intravenous; Naloxone; Poisoning

1973
Effect of stimulus intensity on the potency of some analgetic agents.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:1

    Topics: Analgesics; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Levorphanol; Male; Meperidine; Methadone; Mice; Mice, Inbred Strains; Naloxone; Pentazocine; Physical Stimulation; Reaction Time; Seizures; Time Factors; Tremor

1973
d-Propoxyphene acts differently from morphine on opioid receptor-effector mechanisms.
    European journal of pharmacology, 1981, Jan-05, Volume: 69, Issue:1

    Topics: Animals; Dextropropoxyphene; Dihydromorphine; Drug Tolerance; Female; Kinetics; Morphine; Naloxone; Nociceptors; Rats; Receptors, Opioid

1981
Opiate antagonists: naloxone.
    American family physician, 1984, Volume: 29, Issue:1

    Topics: Chemical Phenomena; Chemistry; Dextropropoxyphene; Female; Half-Life; Humans; Kinetics; Naloxone; Pregnancy; Receptors, Opioid; Tissue Distribution

1984
Dihydrocodeine overdose treated with naloxone infusion.
    British medical journal (Clinical research ed.), 1983, Nov-19, Volume: 287, Issue:6404

    Topics: Acetaminophen; Aged; Codeine; Dextropropoxyphene; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Rhabdomyolysis

1983
Haemodynamic, electrocardiographic and cardiometabolic changes after overdose of propoxyphene. An experimental study in pentobarbitone-anaesthetized pigs.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Anesthesia; Animals; Dextropropoxyphene; Dopamine; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Myocardium; Naloxone; Pentobarbital; Practolol; Prenalterol; Swine

1984
Clinical features and management of Distalgesic overdose.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Acetaminophen; Acetylcysteine; Dextropropoxyphene; Drug Combinations; Drug Interactions; Humans; Naloxone

1984
Mixed dextropropoxyphene poisoning: concentration-effect relationships and effect of naloxone.
    International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:1

    Topics: Adolescent; Dextropropoxyphene; Dose-Response Relationship, Drug; Female; Heart; Humans; Liver; Naloxone

1984
Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.
    Postgraduate medical journal, 1982, Volume: 58, Issue:684

    Topics: Acetaminophen; Adolescent; Dextropropoxyphene; Drug Combinations; Heart Diseases; Humans; Male; Naloxone

1982
Naloxone: underdosage after narcotic poisoning.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:2

    Topics: Child, Preschool; Dextropropoxyphene; Female; Humans; Naloxone

1980
Inhibition of erythromycin lactobionate-induced writhing by analgesic drugs.
    Il Farmaco; edizione pratica, 1980, Volume: 35, Issue:3

    Topics: Analgesics; Animals; Aspirin; Codeine; Dextropropoxyphene; Erythromycin; Indomethacin; Male; Mice; Morphine; Nalorphine; Naloxone; Pain; Phenylbutazone

1980
Adverse cardiac manifestations following dextropropoxyphene overdose: can naloxone be helpful?
    Annals of emergency medicine, 1995, Volume: 25, Issue:2

    Topics: Adult; Arrhythmias, Cardiac; Dextropropoxyphene; Drug Overdose; Female; Heart Block; Humans; Male; Middle Aged; Naloxone

1995
Case report--the successful use of naloxone in an asystolic pre-hospital arrest.
    Resuscitation, 1996, Volume: 32, Issue:2

    Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Emergencies; Female; Heart Arrest; Humans; Naloxone; Narcotic Antagonists; Resuscitation; Suicide, Attempted

1996
The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextropropoxyphene; DNA, Recombinant; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Ligands; Membrane Potentials; Methadone; Mice; Microinjections; Morphine; Naloxone; Oocytes; Patch-Clamp Techniques; Plasmids; Potassium Channels; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Complementary; Xenopus laevis

1999