dextromethorphan has been researched along with 4-methyl-alpha-ethyl-m-tyramine* in 1 studies
1 other study(ies) available for dextromethorphan and 4-methyl-alpha-ethyl-m-tyramine
| Article | Year |
|---|---|
Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats.
A role for calcium in p-chloroamphetamine-induced neurotoxicity has been inferred previously from protective effects of dextromethorphan. We found that dextromethorphan reduces rat brain concentrations of 5-hydroxyindoleacetic acid and blocks the acute, non-neurotoxic depletion of brain serotonin by p-chloroamphetamine and by H75/12. Inhibition of the membrane transporter on brain serotonin neurons by dextromethorphan in vivo might explain its protective effect against p-chloroamphetamine neurotoxicity. Topics: Amphetamines; Animals; Brain; Dextromethorphan; Hydroxyindoleacetic Acid; Male; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin | 1992 |