dexmedetomidine has been researched along with l 659066 in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 20 (74.07) | 24.3611 |
| 2020's | 5 (18.52) | 2.80 |
| Authors | Studies |
|---|---|
| Honkavaara, JM; Hyvärinen, EA; Kuusela, EK; Raekallio, MR; Vainio, OM | 1 |
| Bilge, SS; Bostanci, MO; Bozkurt, A; Ciftcioglu, E; Dilek, A; Güldogus, F; Ilkaya, F; Ulger, F | 1 |
| Honkavaara, JM; Raekallio, MR; Vainio, OM | 1 |
| Honkavaara, JM; Kuusela, EK; Raekallio, MR; Restitutti, F; Vainio, OM | 2 |
| Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E | 1 |
| Honkavaara, J; Kuusela, E; Raekallio, M; Ranta-Panula, V; Restitutti, F; Rinne, V; Salla, K; Scheinin, M; Vainio, O | 1 |
| Kuusela, E; Raekallio, M; Restitutti, F; Vainio, O; Vainionpää, M | 1 |
| Kuusela, E; Laitinen, MR; O'Brien, RT; Raekallio, MR; Restitutti, F; Vainio, OM; Vainionpää, M | 1 |
| Andersson, KE; Aro, E; Bastman, S; Streng, T | 1 |
| Honkavaara, J; Ilkiw, JE; Pypendop, BH | 2 |
| Honkavaara, J; Ilkiw, J; Pypendop, B | 1 |
| Hector, RC; Hess, AM; Honkavaara, JM; Knych, HK; Mama, KR; Raekallio, MR; Rezende, ML; Steffey, EP; Vainio, OM | 1 |
| Honkavaara, J; Ilkiw, JE; Pypendop, BH; Siao, KT | 1 |
| Bennett, RC; Kuusela, E; Raekallio, MR; Salla, KM; Scheinin, M; Tuns, CI; Vainio, OM | 1 |
| Hopster, K; Kästner, SB; Raekallio, M; Rohn, K; Vainio, OM; Wittenberg-Voges, L | 1 |
| Campoy, L; Gleed, RD; Honkavaara, J; Martin-Flores, M; Portela, DA; Sakai, DM | 1 |
| Bennett, RC; Kallio-Kujala, IJ; Meierjohann, A; Raekallio, MR; Savontaus, E; Scheinin, M; Spillmann, T; Vainio, OM; Yatkin, E | 1 |
| Ahokoivu, H; Honkavaara, J; Pypendop, BH | 2 |
| Ahokoivu, H; Honkavaara, J; Jaeger, AT; Pypendop, BH | 1 |
| Adam, M; Hautajärvi, HJ; Honkavaara, JM; Kallio-Kujala, IJ; Larenza Menzies, P; Männikkö, SK; Nevanperä, K; Raekallio, MR; Restitutti, F; Scheinin, M; Turunen, H; Vainio, OM | 1 |
| Hector, RC; Mama, KR; Raekallio, MR; Rezende, ML; Steffey, EP; Vainio, OM | 1 |
| Kästner, S; Kopp, V; Neudeck, S; Twele, L | 1 |
| Kobluk, K; Pypendop, BH | 1 |
| Honkavaara, J; Huuskonen, V; Pesonen, T; Raekallio, M; Restitutti, F; Vainio, O | 1 |
16 trial(s) available for dexmedetomidine and l 659066
| Article | Year |
|---|---|
The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.
Topics: Adrenergic Antagonists; Anesthesia; Animals; Bradycardia; Cross-Over Studies; Dexmedetomidine; Dog Diseases; Dogs; Hypnotics and Sedatives; Quinolizines | 2008 |
The effects of L-659,066, a peripheral α2-adrenoceptor antagonist, and verapamil on the cardiovascular influences of dexmedetomidine in conscious sheep.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cross-Over Studies; Dexmedetomidine; Female; Heart Rate; Hypnotics and Sedatives; Quinolizines; Sheep; Vascular Resistance; Verapamil | 2010 |
The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Consciousness; Cross-Over Studies; Dexmedetomidine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Injections, Intravenous; Male; Quinolizines; Vascular Resistance | 2011 |
Plasma glucose, insulin, free fatty acids, lactate and cortisol concentrations in dexmedetomidine-sedated dogs with or without MK-467: a peripheral α-2 adrenoceptor antagonist.
Topics: Administration, Intravenous; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Anesthetics, Intravenous; Animals; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Colorimetry; Cross-Over Studies; Dexmedetomidine; Dogs; Drug Combinations; Female; Hydrocortisone; Insulin; Male; Models, Biological; Quinolizines; Radioimmunoassay | 2012 |
The impact of MK-467 on sedation, heart rate and arterial blood pressure after intramuscular coadministration with dexmedetomidine in conscious cats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Combined; Animals; Arterial Pressure; Cats; Conscious Sedation; Cross-Over Studies; Dexmedetomidine; Heart Rate; Hypnotics and Sedatives; Injections, Intramuscular; Male; Quinolizines | 2017 |
Hemodynamic effects of dexmedetomidine, with and without MK-467, following intramuscular administration in cats anesthetized with isoflurane.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Cats; Cross-Over Studies; Deep Sedation; Dexmedetomidine; Hemodynamics; Hypnotics and Sedatives; Injections, Intramuscular; Isoflurane; Male; Quinolizines; Vascular Resistance | 2017 |
Cardiovascular effects of premedication with medetomidine alone and in combination with MK-467 or glycopyrrolate in dogs subsequently anesthetized with isoflurane.
Topics: Adjuvants, Anesthesia; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Female; Glycopyrrolate; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Isoflurane; Ketamine; Male; Medetomidine; Premedication; Quinolizines | 2017 |
Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Combined; Animals; Dexmedetomidine; Female; Gastrointestinal Tract; Horses; Isoflurane; Male; Microcirculation; Oxygen; Prospective Studies; Quinolizines; Xylazine | 2018 |
Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Intravenous; Animals; Blood Glucose; Cross-Over Studies; Dexmedetomidine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucagon; Glyburide; Hypnotics and Sedatives; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Quinolizines; Random Allocation; Treatment Outcome | 2018 |
Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cats; Cross-Over Studies; Dexmedetomidine; Drug Interactions; Drug Therapy, Combination; Hypnotics and Sedatives; Isoflurane; Male; Pulmonary Alveoli; Quinolizines | 2019 |
Pharmacokinetics of dexmedetomidine during administration of vatinoxan in male neutered cats anesthetized with isoflurane.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cats; Dexmedetomidine; Drug Interactions; Hypnotics and Sedatives; Isoflurane; Male; Quinolizines | 2020 |
Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Inhalation; Animals; Blood Pressure; Cats; Cross-Over Studies; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hypnotics and Sedatives; Hypotension; Isoflurane; Male; Quinolizines; Vascular Resistance | 2019 |
Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cardiac Output; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Quinolizines; Random Allocation; Single-Blind Method | 2019 |
Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study.
Topics: Anesthetics, Inhalation; Animals; Dexmedetomidine; Horses; Isoflurane; Pilot Projects; Prospective Studies; Quinolizines | 2021 |
Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Dexmedetomidine; Dopamine; Heart Rate; Hypotension; Isoflurane; Male; Norepinephrine; Phenylephrine; Quinolizines | 2022 |
Cardiovascular effects of dobutamine, norepinephrine and phenylephrine in isoflurane-anaesthetized dogs administered dexmedetomidine-vatinoxan.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Dexmedetomidine; Dobutamine; Dog Diseases; Dogs; Hypotension; Isoflurane; Norepinephrine; Phenylephrine; Saline Solution | 2022 |
11 other study(ies) available for dexmedetomidine and l 659066
| Article | Year |
|---|---|
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Catheterization; Clonidine; Colon; Data Interpretation, Statistical; Dexmedetomidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Rectum; Yohimbine | 2009 |
Effects of different doses of L-659'066 on the bispectral index and clinical sedation in dogs treated with dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Conscious Sedation; Consciousness Monitors; Dexmedetomidine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electromyography; Hypnotics and Sedatives; Male; Quinolizines | 2011 |
Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Dexmedetomidine; Drug Tolerance; Guanfacine; Male; Morphine; Quinolizines; Rats; Rats, Wistar | 2011 |
Influence of MK-467, a peripherally acting α2-adrenoceptor antagonist on the disposition of intravenous dexmedetomidine in dogs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Intravenous; Animals; Dexmedetomidine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Hemodynamics; Hypnotics and Sedatives; Male; Quinolizines | 2012 |
Effect of MK-467 on organ blood flow parameters detected by contrast-enhanced ultrasound in dogs treated with dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Inhalation; Animals; Contrast Media; Dexmedetomidine; Dogs; Female; Hypnotics and Sedatives; Intestine, Small; Iohexol; Kidney; Liver; Male; Quinolizines; Regional Blood Flow; Spleen; Ultrasonography | 2013 |
Is there a peripheral site of action contributing to the voiding effects of α₂-adrenoceptor agonists and antagonists?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dexmedetomidine; Imidazoles; Male; Mice; Mice, Inbred C57BL; Models, Animal; Peripheral Nerves; Quinolizines; Urethra; Urinary Bladder; Urination; Urodynamics | 2015 |
Pharmacokinetics of dexmedetomidine, MK-467, and their combination following intravenous administration in male cats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Cats; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intravenous; Male; Quinolizines | 2016 |
Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Intravenous; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Cats; Desflurane; Dexmedetomidine; Female; Heart Rate; Isoflurane; Prospective Studies; Quinolizines; Vasoconstriction | 2017 |
Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs.
Topics: Anesthesia, Inhalation; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dexmedetomidine; Dogs; Dose-Response Relationship, Drug; Female; Male; Methyl Ethers; Pulmonary Alveoli; Quinolizines; Sevoflurane | 2017 |
Hemodynamic effects of MK-467 following intravenous administration to isoflurane-anesthetized cats concurrently receiving dexmedetomidine.
Topics: Anesthetics, Inhalation; Animals; Arteries; Blood Pressure; Cats; Dexmedetomidine; Female; Heart Rate; Hemodynamics; Infusions, Intravenous; Isoflurane; Quinolizines; Vascular Resistance | 2018 |
Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs.
Topics: Anesthetics, Inhalation; Animals; Dexmedetomidine; Dogs; Prospective Studies; Quinolizines; Sevoflurane | 2021 |