Page last updated: 2024-08-24

dexmedetomidine and atipamezole

dexmedetomidine has been researched along with atipamezole in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.56)	18.2507
2000's	19 (29.69)	29.6817
2010's	31 (48.44)	24.3611
2020's	13 (20.31)	2.80

Authors

Authors	Studies
Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J	1
Virag, L; Vulliemoz, Y; Whittington, RA	1
Lassila, R; Mustonen, P; Savola, J	1
Kalmari, J; Onttonen, T; Pertovaara, A	1
Audinot, V; Boutin, JA; Cordi, A; Cussac, D; Dekeyne, A; Duqueyroix, D; Girardon, S; Lacoste, JM; Millan, MJ; Milligan, G; Mullot, J; Newman-Tancredi, A; Nicolas, JP; Renouard-Try, A	1
Auclair, A; Bosc, C; Brocco, M; Cordi, A; Dekeyne, A; Gobert, A; Lacoste, JM; Lejeune, F; Millan, MJ; Rivet, JM	1
Clarke, RW; Eves, S; Harris, J; Peachey, JE; Stuart, E	1
Donovan, DM; Mansikka, H; Pertovaara, A; Raja, SN; Zhou, L	1
Björklund, M; Holmberg, M; Ihalainen, JA; Puoliväli, J; Scheinin, M; Tanila, H	1
Franks, NP; Guo, T; Lu, J; Maze, M; Nelson, LE; Saper, CB	1
Lähdesmäki, J; MacDonald, E; Sallinen, J; Scheinin, M; Sirviö, J	1
Fotopoulos, A; Johnson, EO; Konstandi, M; Kostakis, D; Lang, MA; Marselos, M	1
Lähdesmäki, J; MacDonald, E; Sallinen, J; Scheinin, M	1
Ihalainen, JA; Tanila, H	1
Fagerholm, V; Grönroos, T; Haaparanta, M; Marjamäki, P; Scheinin, M; Viljanen, T	1
Ahsan, MR; Lin, Y; Quartermain, D; Stone, EA	1
Agová, V; Hess, L; Krsiak, M; Slíva, J; Votava, M	1
Agmo, A; Haapalinna, A; Viitamaa, T	1
Aspegrén, JC; Granholm, M; McKusick, BC; Westerholm, FC	2
Johnson, EO; Konstandi, M; Kostakis, D; Lang, MA; Marselos, M	1
Laarakker, MC; Ohl, F; Raai, JR; van Lith, HA	1
Andersson, KE; Santti, R; Streng, T	1
Berry, K; Bouts, T; Gasthuys, F; Harrison, N; Routh, A; Taylor, P	1
Austin, BR; Barletta, M; Inoue, T; Ko, JC; Payton, ME; Weil, AB	1
Kanai, T; Maruta, T; Nemoto, T; Satoh, S; Tsuneyoshi, I; Wada, A; Yanagita, T	1
Chen, J; Gu, J; Ma, D; Tao, G; Xia, P; Zhao, H	1
Barletta, M; Constable, P; Ko, JC; Krimins, RA; Payton, ME; Sen, I; Weil, AB	1
Freeman, KS; Good, KL; Kass, PH; Nestorowicz, N; Ofri, R; Park, SA	1
Mikaelian, I; Singer, L; Wellington, D	1
Brunetti, A; Gargiulo, S; Gramanzini, M; Greco, A; Liuzzi, R; Vesce, G	1
Andersson, KE; Aro, E; Bastman, S; Streng, T	1
Bilek, J; Hornak, S; Hromada, R; Ledecky, V; Liptak, T; Mazensky, D; Petrovic, V	1
Ide, R; Saiki, C; Takahashi, M; Tamiya, J	1
Izer, JM; Whitcomb, TL; Wilson, RP	1
Brown, D; Cooney, C; Gunn, M; Hasiuk, MM; Pang, DS	1
Cui, J; Lu, K; Ma, D; Sun, JJ; Wang, C; Zhao, H	1
Bennett, SL; Cohen, AE	1
Lei, J; Niu, N; Sun, ZH; Xiao, Y; Yang, L; Ye, G; You, HJ	1
Chen, Q; Gu, J; Lu, K; Ma, D; Ma, J; Ning, J; Wu, L; Yi, B	1
Jiang, L; Li, ZJ; Ran, K; Wang, D; Zhang, SB; Zhang, Y	1
Buisman, M; Gunn, M; Hasiuk, MMM; Pang, DSJ	1
Hayek, LC; Marker, L; Murray, S; Sanchez, CR; Woc Colburn, AM	1
Aoyama, B; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M	1
Arnemo, JM; Atickem, A; Bekele, A; Farstad, WK; Gutema, TM; Lemma, A; Sillero-Zubiri, C; Stenseth, NC; Zinner, D	1
Gao, X; Hei, Z; Huang, P; Ji, H; Qiu, R; Sha, W; Wang, F; Yao, W; Yuan, D	1
Fang, ZX; Gao, H; Luo, ZY; Wang, WT; Xiang, BQ	1
Chen, Q; Chen, Y; Gu, J; Li, J; Lu, K; Ma, D; Ma, J; Mi, E; Ning, J; Yi, B; Zhao, H	1
Ambrosini, F; Carvalho, ER; Champion, T; D'Otaviano de Castro Vilani, RG; da Silva, GA; Freitas, GC	1
Campoy, L; Martin-Flores, M; Parry, S; Sakai, DM; Zatroch, KK	1
Bueno, MG; Cortopassi, SRG; Ferraro, MAR; Gris, VN; Kierulff, MCM; Molina, CV	1
Adam, M; Hautajärvi, HJ; Honkavaara, JM; Kallio-Kujala, IJ; Larenza Menzies, P; Männikkö, SK; Nevanperä, K; Raekallio, MR; Restitutti, F; Scheinin, M; Turunen, H; Vainio, OM	1
Cevidanes, A; Chirife, AD; Millán, J	1
Hikasa, Y; Matsukawa, T	1
Cui, D; Gao, Y; Han, H; Li, Y; Sun, M; Yang, J; Zhao, G; Zou, J	1
Dupont, WD; Finnie, KR; Jones, CP; Salleng, KJ; Shuster, KA	1
Applegate, J; Cannedy, A; Deresienski, D; Lewbart, G; Mozzachio, K; Posner, LP; Serrano, M	1
Ballesteros, JJ; Briscoe, JB; Ishizawa, Y	1
Cui, RS; Li, XW; Liu, LY; Ruan, H	1
Eguchi, R; Kitano, T; Okamatsu-Ogura, Y; Otsuguro, KI; Yamaguchi, S	1
Coelho, CM; EdosSL Fernandes, M; FAda Silva, M; Gomes, VH; Oliveira, LC; Peixoto, AJ	1
Andersen, E; Anderson, EL; Côté, E; Stryhn, H; Yu, J; Zwicker, LA	1
Cappelli, N; da Silva, MFA; de Carvalho, WTS; Gomes, VH; Mignani, BTG; Pimentel, VC	1
Cheng, AJ; Garbin, M; Lutevele, N; Malo, A; Marangoni, S; Monteiro, BP; Ruel, HL; Steagall, PV; Watanabe, R	1

Trials

11 trial(s) available for dexmedetomidine and atipamezole

Article	Year
Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole. Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Cats; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Prospective Studies; Respiration; Treatment Outcome	2006
Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. The Veterinary record, 2007, Jun-30, Volume: 160, Issue:26 Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Body Temperature; Dexmedetomidine; Dogs; Drug Administration Routes; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Respiration; Time Factors	2007
Evaluation of dexmedetomidine and ketamine in combination with opioids as injectable anesthesia for castration in dogs. Journal of the American Veterinary Medical Association, 2011, May-01, Volume: 238, Issue:9 Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Animals; Dexmedetomidine; Dogs; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Orchiectomy	2011
Influence of ketamine on the cardiopulmonary effects of intramuscular administration of dexmedetomidine-buprenorphine with subsequent reversal with atipamezole in dogs. Journal of the American Veterinary Medical Association, 2013, Feb-01, Volume: 242, Issue:3 Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Buprenorphine; Cardiac Output; Cross-Over Studies; Dexmedetomidine; Dogs; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Oxygen; Respiration; Stroke Volume	2013
CARDIORESPIRATORY EFFECTS OF DEXMEDETOMIDINE-BUTORPHANOL-MIDAZOLAM (DBM): A FULLY REVERSIBLE ANESTHETIC PROTOCOL IN CAPTIVE AND SEMI-FREE-RANGING CHEETAHS (ACINONYX JUBATUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2017, Volume: 48, Issue:1 Topics: Acinonyx; Analgesics, Opioid; Anesthesia; Animals; Animals, Zoo; Butorphanol; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Midazolam; Naltrexone; Respiration	2017
Evaluation of atipamezole as a treatment for dexmedetomidine-induced cardiovascular depression in anesthetized cats. American journal of veterinary research, 2019, Volume: 80, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cardiac Output; Cats; Cross-Over Studies; Dexmedetomidine; Female; Heart Rate; Hemodynamics; Imidazoles; Isoflurane; Male; Random Allocation; Vascular Resistance	2019
Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α American journal of veterinary research, 2019, Volume: 80, Issue:10 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cardiac Output; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Quinolizines; Random Allocation; Single-Blind Method	2019
Effective Field Immobilization of Andean Fox ( Journal of wildlife diseases, 2020, Volume: 56, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Dissociative; Animals; Dexmedetomidine; Foxes; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine	2020
A Comparison of the Efficacy and Cardiopulmonary Effects of 3 Different Sedation Protocols in Journal of the American Association for Laboratory Animal Science : JAALAS, 2020, 09-01, Volume: 59, Issue:5 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Anesthetics; Animals; Blood Pressure; Dexmedetomidine; Female; Galagidae; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Pregnanediones	2020
Effects of dissociative anesthesia opioid-free protocols combined with local anesthesia, with or without flumazenil or atipamezole postoperatively, for orchiectomy in cats. Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:1 Topics: Analgesics, Opioid; Anesthesia, Local; Animals; Cats; Dexmedetomidine; Flumazenil; Imidazoles; Male; Orchiectomy; Prospective Studies	2022
Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy. Journal of feline medicine and surgery, 2023, Volume: 25, Issue:3 Topics: Analgesics, Opioid; Anesthesia; Animals; Bupivacaine; Cats; Dexmedetomidine; Eating; Female; Hysterectomy; Injections, Intramuscular; Ketamine; Meloxicam; Midazolam; Ovariectomy; Pain Measurement; Pain, Postoperative; Single-Blind Method	2023

Other Studies

53 other study(ies) available for dexmedetomidine and atipamezole

Article	Year
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. Bioorganic & medicinal chemistry, 2016, 07-15, Volume: 24, Issue:14 Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine	2016
The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists. Brain research, 1999, Dec-04, Volume: 849, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cyclic GMP; Dexmedetomidine; Functional Laterality; Hypnotics and Sedatives; Imidazoles; Locus Coeruleus; Male; Microinjections; Motor Activity; Nitric Oxide; Posture; Rats; Rats, Sprague-Dawley; Reflex; Tyrosine 3-Monooxygenase	1999
Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thrombosis research, 2000, Aug-01, Volume: 99, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Binding Sites; Binding, Competitive; Blood Platelets; Dexmedetomidine; Drug Evaluation, Preclinical; Epinephrine; Humans; Imidazoles; Phenylephrine; Platelet Aggregation Inhibitors; Prazosin; Receptors, Adrenergic, alpha-2; Yohimbine	2000
Selective and segmentally restricted antinociception induced by MPV-2426, a novel alpha-2-adrenoceptor agonist, following intrathecal administration in the rat. Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:9 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dexmedetomidine; Electrophysiology; H-Reflex; Hot Temperature; Imidazoles; Immersion; Indans; Injections, Spinal; Male; Pain Measurement; Rats; Rats, Wistar	2000
S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Body Temperature; CHO Cells; Clonidine; Cricetinae; Dexmedetomidine; Humans; Imidazoles; Imidazoline Receptors; Male; Mice; Oxazoles; Rats; Rats, Wistar; Receptors, Drug	2000
S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Biogenic Monoamines; Clonidine; Dexmedetomidine; Imidazoles; Locus Coeruleus; Male; Mice; Motor Activity; Oxazoles; Raphe Nuclei; Rats; Rats, Wistar; Ventral Tegmental Area; Vocalization, Animal	2000
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems. Neuroscience, 2002, Volume: 112, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Decerebrate State; Dexmedetomidine; Dizocilpine Maleate; Drug Synergism; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Antagonists; Idazoxan; Imidazoles; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Rabbits; Reflex; Skin; Sural Nerve; Tarsus, Animal	2002
The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia. Neuroscience, 2002, Volume: 113, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carrageenan; Decerebrate State; Dexmedetomidine; Foot; Hindlimb; Hot Temperature; Hyperalgesia; Imidazoles; Inflammation; Mice; Mice, Knockout; Nociceptors; Physical Stimulation; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Reference Values	2002
Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology, 2002, Volume: 43, Issue:8 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Arousal; Brain; Dexmedetomidine; Dose-Response Relationship, Drug; Electroencephalography; Female; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Adrenergic, alpha-2	2002
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology, 2003, Volume: 98, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cell Count; Dexmedetomidine; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-A Receptor Agonists; Gene Expression Regulation; Genes, fos; Hypnotics and Sedatives; Ibotenic Acid; Imidazoles; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred C57BL; Neural Pathways; Postural Balance; Pyridazines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha-2; Sleep; Sleep, REM	2003
Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. Neuropharmacology, 2003, Volume: 44, Issue:7 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Dexmedetomidine; Imidazoles; Male; Mice; Mice, Knockout; Motor Activity; Receptors, Adrenergic, alpha-2	2003
Stress-mediated modulation of B(alpha)P-induced hepatic CYP1A1: role of catecholamines. Chemico-biological interactions, 2004, Jan-15, Volume: 147, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Benzo(a)pyrene; Catecholamines; Corticosterone; Cytochrome P-450 CYP1A1; Dexmedetomidine; Enzyme Induction; Imidazoles; Liver; Male; Prazosin; Propranolol; Rats; Rats, Wistar; Reserpine; Restraint, Physical; RNA, Messenger; Stress, Physiological	2004
Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:7 Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Brain Chemistry; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Electric Stimulation; Female; Imidazoles; Inhibition, Psychological; Male; Mice; Mice, Knockout; Receptors, Adrenergic, alpha-2; Reflex, Startle	2004
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens. Journal of neurochemistry, 2004, Volume: 91, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Dexmedetomidine; Dopamine; Dose-Response Relationship, Drug; Female; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Norepinephrine; Nucleus Accumbens; Receptors, Adrenergic, alpha-2	2004
Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice. European journal of pharmacology, 2004, Nov-28, Volume: 505, Issue:1-3 Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Binding, Competitive; Blood Glucose; Dexmedetomidine; Fluorodeoxyglucose F18; Genotype; Glucose; Homeostasis; Imidazoles; Injections, Intravenous; Insulin; Islets of Langerhans; Isoquinolines; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscles; Myocardium; Naphthyridines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Tissue Distribution; Tritium	2004
Alpha(1)-adrenergic and alpha(2)-adrenergic balance in the dorsal pons and gross behavioral activity of mice in a novel environment. Psychopharmacology, 2005, Volume: 183, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Behavior, Animal; Dexmedetomidine; Dose-Response Relationship, Drug; Environment; Imidazoles; Male; Mice; Motor Activity; Pons; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2	2005
Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice. European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aggression; Analysis of Variance; Animals; Behavior, Animal; Conflict, Psychological; Dexmedetomidine; Dose-Response Relationship, Drug; Imidazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, Adrenergic, alpha-2; Social Behavior	2005
The adrenergic alpha2 receptor and sexual incentive motivation in male rats. Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Copulation; Dexmedetomidine; Female; Imidazoles; Male; Motivation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sexual Behavior, Animal; Yohimbine	2006
Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Benzo(a)pyrene; Catecholamines; Cytochrome P-450 CYP1A2; Dexmedetomidine; Drug Therapy, Combination; Environmental Pollutants; Enzyme Induction; Gene Expression Regulation, Enzymologic; Guanethidine; Imidazoles; Injections, Intraperitoneal; Male; Microsomes, Liver; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reserpine; Restraint, Physical; Stress, Physiological	2008
The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour. Psychoneuroendocrinology, 2010, Volume: 35, Issue:4 Topics: Adaptation, Psychological; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anxiety; Arousal; Behavior, Animal; Dexmedetomidine; Exploratory Behavior; Imidazoles; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Adrenergic, alpha-2; Stress, Psychological; Swimming	2010
Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat. BJU international, 2010, Volume: 106, Issue:10 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Dexmedetomidine; Imidazoles; Male; Rats; Urinary Tract; Urination; Urodynamics	2010
Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus). Veterinary anaesthesia and analgesia, 2010, Volume: 37, Issue:3 Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Animals; Blood Gas Analysis; Body Temperature; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Imidazoles; Injections, Intramuscular; Ketamine; Macropodidae; Male; Medetomidine; Respiratory Rate; Xylazine	2010
Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells. Journal of anesthesia, 2011, Volume: 25, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding Sites; Cattle; Cells, Cultured; Chromaffin Cells; Clonidine; Cyclopentanes; Dexmedetomidine; Imidazoles; Lidocaine; Organophosphorus Compounds; Ouabain; Pain; Receptors, Adrenergic, alpha-2; Scorpion Venoms; Sodium; Sodium Channels; Tetrodotoxin; Veratridine; Yohimbine	2011
Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:10 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Depression, Chemical; Dexmedetomidine; Imidazoles; Immunohistochemistry; Intercellular Adhesion Molecule-1; Kidney Diseases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Organ Size; Paraffin Embedding; Peroxidase; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Tumor Necrosis Factor-alpha	2011
Effects of chemical restraint on electroretinograms recorded sequentially in awake, sedated, and anesthetized dogs. American journal of veterinary research, 2013, Volume: 74, Issue:7 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Intravenous; Animals; Butorphanol; Dexmedetomidine; Dogs; Drug Therapy, Combination; Electroretinography; Female; Imidazoles	2013
Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats. Journal of the American Association for Laboratory Animal Science : JAALAS, 2013, Volume: 52, Issue:4 Topics: Anesthesia; Anesthetics; Animals; Dexmedetomidine; Drug Therapy, Combination; Heart Rate; Imidazoles; Injections, Intraperitoneal; Ketamine; Male; Rats; Rats, Wistar; Xylazine	2013
Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice. BMC veterinary research, 2013, Dec-17, Volume: 9 Topics: Acepromazine; Anesthetics; Anesthetics, Inhalation; Animals; Dexmedetomidine; Female; Hypnotics and Sedatives; Imidazoles; Isoflurane; Male; Mice; Microcirculation; Microvessels; Skin; Ultrasonography, Doppler	2013
Is there a peripheral site of action contributing to the voiding effects of α₂-adrenoceptor agonists and antagonists? World journal of urology, 2015, Volume: 33, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dexmedetomidine; Imidazoles; Male; Mice; Mice, Inbred C57BL; Models, Animal; Peripheral Nerves; Quinolizines; Urethra; Urinary Bladder; Urination; Urodynamics	2015
A preliminary trial of the sedation induced by intranasal administration of midazolam alone or in combination with dexmedetomidine and reversal by atipamezole for a short-term immobilization in pigeons. Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:2 Topics: Administration, Intranasal; Anesthetics, Combined; Animals; Body Temperature; Columbidae; Deep Sedation; Dexmedetomidine; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Midazolam	2015
Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Animals, Newborn; Dexmedetomidine; Electrocardiography; Female; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Isoflurane; Pregnancy; Rats; Rats, Wistar; Respiratory Mechanics; Tidal Volume	2014
Atipamezole reverses ketamine-dexmedetomidine anesthesia without altering the antinociceptive effects of butorphanol and buprenorphine in female C57BL/6J mice. Journal of the American Association for Laboratory Animal Science : JAALAS, 2014, Volume: 53, Issue:6 Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Anesthesia; Anesthetics; Animals; Buprenorphine; Butorphanol; Dexmedetomidine; Female; Imidazoles; Ketamine; Mice; Mice, Inbred C57BL	2014
Application of fast-track surgery principles to evaluate effects of atipamezole on recovery and analgesia following ovariohysterectomy in cats anesthetized with dexmedetomidine-ketamine-hydromorphone. Journal of the American Veterinary Medical Association, 2015, Mar-15, Volume: 246, Issue:6 Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Cats; Dexmedetomidine; Hydromorphone; Hypnotics and Sedatives; Hysterectomy; Imidazoles; Ketamine; Ovariectomy; Pain, Postoperative	2015
Dexmedetomidine attenuates oxidative stress induced lung alveolar epithelial cell apoptosis in vitro. Oxidative medicine and cellular longevity, 2015, Volume: 2015 Topics: Apoptosis; bcl-2-Associated X Protein; Cadherins; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cytochromes c; Dexmedetomidine; Down-Regulation; Epithelial Cells; Humans; Hydrogen Peroxide; Imidazoles; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Up-Regulation	2015
Oral transmucosal administration of dexmedetomidine for sedation in 4 dogs. The Canadian veterinary journal = La revue veterinaire canadienne, 2015, Volume: 56, Issue:11 Topics: Administration, Mucosal; Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Aggression; Animals; Conscious Sedation; Dexmedetomidine; Dogs; Hypnotics and Sedatives; Imidazoles; Male	2015
Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine. The Journal of physiology, 2016, Apr-01, Volume: 594, Issue:7 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dexmedetomidine; Fentanyl; Hyperalgesia; Imidazoles; Male; Neural Inhibition; Nociception; Pain Threshold; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Thalamic Nuclei	2016
α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury. Oncotarget, 2016, Aug-30, Volume: 7, Issue:35 Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Endothelium; Focal Adhesion Kinase 1; Humans; Imidazoles; Kidney; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction	2016
Dexmedetomidine may upregulate the expression of caveolin‑1 in lung tissues of rats with sepsis and improve the short‑term outcome. Molecular medicine reports, 2017, Volume: 15, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Gas Analysis; Body Temperature; Caveolin 1; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Imidazoles; Lung; Male; Rats; Rats, Sprague-Dawley; Sepsis; Toll-Like Receptor 4; Up-Regulation	2017
The influence of demeanor on scores from two validated feline pain assessment scales during the perioperative period. Veterinary anaesthesia and analgesia, 2017, Volume: 44, Issue:3 Topics: Anesthesia; Animals; Cats; Dexmedetomidine; Hydromorphone; Imidazoles; Ketamine; Lidocaine; Male; Meloxicam; Orchiectomy; Pain Measurement; Pain, Postoperative; Perioperative Period; Prospective Studies; Thiazines; Thiazoles	2017
The preventive effects of dexmedetomidine on endotoxin-induced exacerbated post-incisional pain in rats. Journal of anesthesia, 2017, Volume: 31, Issue:5 Topics: Animals; Dexmedetomidine; Endotoxins; Hyperalgesia; Imidazoles; Lipopolysaccharides; Male; Pain, Postoperative; Rats; Rats, Wistar; Signal Transduction	2017
CAPTURE AND IMMOBILIZATION OF AFRICAN WOLVES ( CANIS LUPASTER) IN THE ETHIOPIAN HIGHLANDS. Journal of wildlife diseases, 2018, Volume: 54, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Wild; Dexmedetomidine; Ethiopia; Female; Imidazoles; Ketamine; Male; Restraint, Physical; Wolves	2018
Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model. Life sciences, 2018, Jul-01, Volume: 204 Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cecal Diseases; Cecum; Cytokines; Dexmedetomidine; Imidazoles; Inflammation; Kidney; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sepsis; Toll-Like Receptor 4	2018
[Effect of dexmedetomidine on renal injury induced by lung ischemia/reperfusion in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2017, Apr-08, Volume: 33, Issue:4 Topics: Animals; Dexmedetomidine; Imidazoles; Interleukin-1beta; Kidney; Lung Injury; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Tumor Necrosis Factor-alpha	2017
Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms. Anesthesia and analgesia, 2020, Volume: 130, Issue:4 Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Catecholamines; Dexmedetomidine; Imidazoles; Inflammation Mediators; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Parasympathetic Nervous System; Reperfusion Injury; Vagus Nerve	2020
Dexmedetomidine low dose followed by constant rate infusion and antagonism by atipamezole in isoflurane-anesthetized cats: an echocardiographic study. Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:1 Topics: Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cats; Cohort Studies; Dexmedetomidine; Echocardiography; Heart Rate; Hypnotics and Sedatives; Imidazoles; Infusions, Intravenous; Isoflurane; Male; Orchiectomy; Prospective Studies	2019
Early reversal of ketamine/dexmedetomidine chemical immobilization by atipamezole in golden-headed lion tamarins (Leontopithecus chrysomelas). Journal of medical primatology, 2019, Volume: 48, Issue:6 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Imidazoles; Ketamine; Leontopithecus; Male; Random Allocation; Vasectomy	2019
Effects of imidazoline and nonimidazoline α-adrenoceptor agonists and antagonists, including xylazine, medetomidine, dexmedetomidine, yohimbine, and atipamezole, on aggregation of feline platelets. American journal of veterinary research, 2020, Volume: 81, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Blood Platelets; Cats; Dexmedetomidine; Imidazoles; Imidazolines; Medetomidine; Xylazine; Yohimbine	2020
Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium. Science China. Life sciences, 2020, Volume: 63, Issue:9 Topics: Administration, Inhalation; Administration, Intravenous; Anesthetics, Inhalation; Animals; Biological Transport; Brain; Caudate Nucleus; Dexmedetomidine; Drainage; Extracellular Fluid; Extracellular Space; Humans; Hypnotics and Sedatives; Imidazoles; Isoflurane; Male; Norepinephrine; Pentobarbital; Prazosin; Propranolol; Rats, Sprague-Dawley; Thalamus	2020
Total injectable anesthesia of dogs and cats for remote location veterinary sterilization clinic. BMC veterinary research, 2020, Aug-24, Volume: 16, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Intravenous; Anesthetics, Combined; Animals; Cats; Dexmedetomidine; Dogs; Ecuador; Female; Hydromorphone; Imidazoles; Ketamine; Male; Meloxicam; Orchiectomy; Ovariectomy; Pregnanediones	2020
Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist. eLife, 2020, 08-28, Volume: 9 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Consciousness; Dexmedetomidine; Electroencephalography; Humans; Hypnotics and Sedatives; Imidazoles; Macaca; Male; Unconsciousness; Wakefulness	2020
Involvement of noradrenergic and serotonergic systems in risk-based decisions between options of equivalent expected value in rats. Neurobiology of learning and memory, 2020, Volume: 175 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Amphetamines; Animals; Decision Making; Dexmedetomidine; Imidazoles; Rats; Reward; Risk Assessment; Risk-Taking; Serotonin 5-HT2 Receptor Agonists	2020
Opposing functions of α- and β-adrenoceptors in the formation of processes by cultured astrocytes. Journal of pharmacological sciences, 2021, Volume: 145, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Dexmedetomidine; Imidazoles; Isoproterenol; Norepinephrine; Prazosin; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Signal Transduction	2021
Effects of dexmedetomidine and its reversal with atipamezole on echocardiographic measurements and circulating cardiac biomarker concentrations in normal cats. Journal of the American Veterinary Medical Association, 2022, 02-16, Volume: 260, Issue:8 Topics: Animals; Biomarkers; Cats; Dexmedetomidine; Echocardiography; Imidazoles; Natriuretic Peptide, Brain; Peptide Fragments; Stroke Volume	2022
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats. Journal of the American Veterinary Medical Association, 2022, 12-01, Volume: 261, Issue:2 Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine; Male; Orchiectomy; Postoperative Period	2022