Page last updated: 2024-08-24

dexfenfluramine and phentermine

dexfenfluramine has been researched along with phentermine in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	14 (34.15)	18.2507
2000's	24 (58.54)	29.6817
2010's	3 (7.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cherin, P; Godeau, P; Tellier, P	1
Eligulashvili, V; McCann, UD; Ricaurte, GA	1
Shapiro, S	1
Bratter, J; Gessner, IH; Rowland, NE	1
Derby, LE; Jick, H; Myers, MW	1
Roth, JD; Rowland, NE	1
Bray, GA; Glancy, DL; Greenway, F; Helmcke, F; Ryan, DH; Sander, G; Subramaniam, P; Volaufova, J	1
Pi-Sunyer, FX	1
Pallasch, TJ	1
Adams, C; Cohen, A	1
Bonow, RO; Kancherla, MK; Mehlman, DJ; Mulderink, TA; Parker, M; Salti, HI	1
Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D	1
Jick, H	1
Marshall, M; Roth, JD; Rowland, NE	1
Gross, SB	1
Aronne, LJ; Hirsch, J; Mackintosh, RM	1
Alexander, RE	1
Ballmer, PE; Imoberdorf, R	1
Weissman, NJ	1
Carpenter, W; Rudin, R	1
Caccitolo, JA; Connolly, HM; Orszulak, TA; Rubenson, DS; Schaff, HV	1
Lo, J; Robertson, K; Rowland, NE	1
Aspley, S; Heal, DJ; Kilpatrick, IC; Lancashire, B; Prow, MR	1
Arnett, DK; Bella, JN; de Simone, G; Devereux, RB; Hopkins, PN; Kitzman, DW; Liu, JE; Morgan, D; Oberman, A; Palmieri, V; Roman, MJ	1
Derry, S; Loke, YK; Pritchard-Copley, A	1
Rigolin, VH; Seghatol, FF	1
Decker, P; Gelgand, EA; Prasad, A; Roldan, CA; Shively, BK	1
Gross, SB; Lepor, NE	1
Jollis, JG; Miller, WC; Ryan, T; Sachdev, M	1
Brennan, TA; Mello, MM; Studdert, DM	1
Gross, SB; Naqvi, TZ	1
Hess, MA	1
Glowa, JR; LeSage, MG; Stafford, D	1
Alemany, M; Cabot, C; Fernández-López, JA; Ferrer-Lorente, R; Remesar, X	1
Wellman, PJ	1
Behan, DP; Grottick, AJ; Morgan, M; Sage, C; Sanabria, EK; Whelan, K	1
Ceulemans, B; Gammaitoni, A; Keane, MG; Lagae, L; Marchau, F; Paelinck, BP; Pringsheim, M; Schoonjans, AS	1

Reviews

10 review(s) available for dexfenfluramine and phentermine

Article	Year
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy. Journal of the California Dental Association, 1999, Volume: 27, Issue:5 Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug Combinations; Endocarditis, Bacterial; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Phentermine; Practice Guidelines as Topic; Prevalence	1999
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives. Advance for nurse practitioners, 1999, Volume: 7, Issue:10 Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Nurse Practitioners; Obesity; Phentermine; Practice Guidelines as Topic; Predictive Value of Tests; Prevalence; Risk Factors; Selective Serotonin Reuptake Inhibitors; United States	1999
[Obesity: principles of drug therapy]. Therapeutische Umschau. Revue therapeutique, 2000, Volume: 57, Issue:8 Topics: Aminorex; Anti-Obesity Agents; Appetite Depressants; Chronic Disease; Combined Modality Therapy; Cyclobutanes; Dexfenfluramine; Diet, Reducing; Drug and Narcotic Control; Germany; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Lactones; Obesity; Orlistat; Phentermine	2000
Appetite suppressants and valvular heart disease. The American journal of the medical sciences, 2001, Volume: 321, Issue:4 Topics: Age Factors; Appetite Depressants; Dexfenfluramine; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Multicenter Studies as Topic; Obesity; Phentermine; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration	2001
Appetite suppressants and valvular heart disease - a systematic review. BMC clinical pharmacology, 2002, Aug-23, Volume: 2 Topics: Appetite Depressants; Clinical Trials as Topic; Cohort Studies; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine	2002
Appetite suppressants and valvular heart disease. Current opinion in cardiology, 2002, Volume: 17, Issue:5 Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Ultrasonography	2002
Anorexigen-related cardiopulmonary toxicity. Reviews in cardiovascular medicine, 2000,Fall, Volume: 1, Issue:2 Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine	2000
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies. American heart journal, 2002, Volume: 144, Issue:6 Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Mitral Valve Insufficiency; Phentermine; Serotonin Agents	2002
Anorexigen-induced cardiac valvulopathy and female gender. Current women's health reports, 2003, Volume: 3, Issue:2 Topics: Adult; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Obesity; Phentermine; Serotonin Receptor Agonists	2003
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population. Current medical research and opinion, 2017, Volume: 33, Issue:10 Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Incidence; Obesity; Phentermine	2017

Trials

2 trial(s) available for dexfenfluramine and phentermine

Article	Year
Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine. The American journal of cardiology, 1999, Dec-01, Volume: 84, Issue:11 Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dexfenfluramine; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Northwestern United States; Obesity; Phentermine; Prevalence; Pulmonary Wedge Pressure; Reproducibility of Results; Retrospective Studies; Surveys and Questionnaires	1999
The effects of drugs used to treat obesity on the autonomic nervous system. Obesity research, 2000, Volume: 8, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Appetite Depressants; Atropine; Autonomic Nervous System; Basal Metabolism; Calorimetry; Creatinine; Cyclobutanes; Dexfenfluramine; Dopamine; Epinephrine; Heart Rate; Humans; Male; Norepinephrine; Obesity; Parasympatholytics; Phentermine; Propanolamines; Serotonin Receptor Agonists; Single-Blind Method	2000

Article

Year

Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine.

The American journal of cardiology, 1999, Dec-01, Volume: 84, Issue:11

Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dexfenfluramine; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Northwestern United States; Obesity; Phentermine; Prevalence; Pulmonary Wedge Pressure; Reproducibility of Results; Retrospective Studies; Surveys and Questionnaires

1999

The effects of drugs used to treat obesity on the autonomic nervous system.

Obesity research, 2000, Volume: 8, Issue:3

Topics: Adrenergic beta-Antagonists; Adult; Appetite Depressants; Atropine; Autonomic Nervous System; Basal Metabolism; Calorimetry; Creatinine; Cyclobutanes; Dexfenfluramine; Dopamine; Epinephrine; Heart Rate; Humans; Male; Norepinephrine; Obesity; Parasympatholytics; Phentermine; Propanolamines; Serotonin Receptor Agonists; Single-Blind Method

2000

Other Studies

29 other study(ies) available for dexfenfluramine and phentermine

Article	Year
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?]. La Revue de medecine interne, 1998, Volume: 19, Issue:10 Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Middle Aged; Mitral Valve Insufficiency; Phentermine; Risk Factors	1998
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine. Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:7 Topics: Adolescent; Adult; Affect; Aged; Anxiety; Appetite Depressants; Cognition Disorders; Dexfenfluramine; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Memory Disorders; Mental Disorders; Middle Aged; Phentermine; Serotonin Receptor Agonists	1998
Studies confirm link between fen-phen and heart-valve disease. Harvard heart letter : from Harvard Medical School, 1998, Volume: 9, Issue:4 Topics: Appetite Depressants; Cyclobutanes; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine	1998
Appetite-suppressant drugs and valvular heart disease. The New England journal of medicine, 1999, Feb-11, Volume: 340, Issue:6 Topics: Appetite Depressants; Bias; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Odds Ratio; Phentermine; Prevalence	1999
Effects of prenatal co-administration of phentermine and dexfenfluramine in rats. European journal of pharmacology, 1999, Mar-26, Volume: 369, Issue:3 Topics: Animals; Appetite Depressants; Axons; Dexfenfluramine; Drug Combinations; Female; Fetus; Hippocampus; Infusion Pumps; Mitral Valve; Motor Activity; Phentermine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Serotonin	1999
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. British journal of clinical pharmacology, 1999, Volume: 47, Issue:5 Topics: Aged; Appetite Depressants; Body Mass Index; Case-Control Studies; Cerebrovascular Disorders; Cohort Studies; Dexfenfluramine; Diabetes Complications; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fenfluramine; Humans; Hypercholesterolemia; Hypertension; Male; Obesity; Phentermine; Risk Factors; Smoking	1999
Anorectic efficacy of the fenfluramine/phentermine combination in rats: additivity or synergy? European journal of pharmacology, 1999, Jun-04, Volume: 373, Issue:2-3 Topics: Animals; Anorexia; Appetite Depressants; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Fenfluramine; Food Deprivation; Milk; Phentermine; Rats; Rats, Sprague-Dawley; Regression Analysis; Treatment Outcome	1999
Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine. Obesity research, 1999, Volume: 7, Issue:4 Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Counseling; Dexfenfluramine; Drug Therapy, Combination; Echocardiography; Female; Fenfluramine; Humans; Incidence; Male; Mazindol; Middle Aged; Mitral Valve Insufficiency; Obesity; Observer Variation; Phentermine; Prevalence; Weight Loss	1999
Heart valve lesions in patients treated with appetite suppressants. Obesity research, 1999, Volume: 7, Issue:4 Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Humans; Mitral Valve Insufficiency; Obesity; Phentermine	1999
[Appetite suppressants and heart valve disorders]. Archives des maladies du coeur et des vaisseaux, 1999, Volume: 92, Issue:9 Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Middle Aged; Mitral Valve Insufficiency; Phentermine; Pulmonary Valve Insufficiency; Serotonin Agents; Serotonin Receptor Agonists	1999
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. JAMA, 2000, Apr-05, Volume: 283, Issue:13 Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Logistic Models; Male; Matched-Pair Analysis; Middle Aged; Mitral Valve Insufficiency; Obesity; Phentermine; Prevalence; Risk; Serotonin Agents; Statistics, Nonparametric	2000
Heart valve disorders and appetite-suppressant drugs. JAMA, 2000, Apr-05, Volume: 283, Issue:13 Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin Agents	2000
Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats. Psychopharmacology, 2000, Volume: 149, Issue:1 Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Desipramine; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Fluoxetine; Norepinephrine; Phentermine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Receptor Agonists; Time Factors	2000
Cardiac valvulopathy. Journal of the American Dental Association (1939), 2000, Volume: 131, Issue:7 Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Practice Guidelines as Topic; Risk Factors	2000
Diet drugs and cardiac valvulopathy: a survey of dental patients. Journal of the California Dental Association, 2000, Volume: 28, Issue:12 Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bacterial; Fenfluramine; Follow-Up Studies; Heart Valve Diseases; Humans; Phentermine; Prevalence; Serotonin Agents; Serotonin Receptor Agonists; Surveys and Questionnaires	2000
Valve disease due to appetite suppressants (cont'd). Prescrire international, 1999, Volume: 8, Issue:42 Topics: Aortic Valve; Appetite Depressants; Clinical Trials as Topic; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine; Selective Serotonin Reuptake Inhibitors; Treatment Outcome	1999
Operation for anorexigen-associated valvular heart disease. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:4 Topics: Adult; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Phentermine; Serotonin Agents; Serotonin Receptor Agonists; Ultrasonography	2001
Acute anorectic effect of single and combined drugs in mice using a non-deprivation protocol. Psychopharmacology, 2001, Volume: 157, Issue:2 Topics: Animals; Appetite Depressants; Dexfenfluramine; Drug Combinations; Eating; Female; Fluoxetine; Food Deprivation; Mice; Mice, Inbred C57BL; Phentermine; Serotonin Receptor Agonists	2001
Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:10 Topics: Animals; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Synergism; Hypothalamus, Anterior; Male; Microdialysis; Phentermine; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists	2001
Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study. The American journal of medicine, 2002, Jun-15, Volume: 112, Issue:9 Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Drug Combinations; Female; Fenfluramine; Humans; Hypertension; Male; Middle Aged; Phentermine	2002
Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography. The American journal of cardiology, 2002, Dec-01, Volume: 90, Issue:11 Topics: Adult; Aortic Valve; Appetite Depressants; Body Mass Index; Dexfenfluramine; Drug Combinations; Echocardiography, Transesophageal; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Mitral Valve; Obesity; Phentermine	2002
Medical monitoring for pharmaceutical injuries: tort law for the public's health? JAMA, 2003, Feb-19, Volume: 289, Issue:7 Topics: Appetite Depressants; Chromans; Dexfenfluramine; Drug Industry; Drug Monitoring; Fenfluramine; Health Policy; Humans; Hypoglycemic Agents; Liability, Legal; Phentermine; Product Surveillance, Postmarketing; Public Health; Thiazoles; Thiazolidinediones; Troglitazone; United States	2003
Taking things to heart. Journal of the American Dietetic Association, 2004, Volume: 104, Issue:7 Topics: Appetite Depressants; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine	2004
Effects of anorectic drugs on food intake under progressive-ratio and free-access conditions in rats. Journal of the experimental analysis of behavior, 2004, Volume: 82, Issue:3 Topics: Animals; Appetite Depressants; Behavior, Animal; Conditioning, Psychological; Dexfenfluramine; Dose-Response Relationship, Drug; Energy Intake; Male; Phentermine; Rats	2004
Effects of oleoyl-estrone with dexfenfluramine, sibutramine or phentermine on overweight rats. European journal of pharmacology, 2005, Apr-25, Volume: 513, Issue:3 Topics: Animals; Anti-Obesity Agents; Body Weight; Cyclobutanes; Dexfenfluramine; Drug Interactions; Drug Therapy, Combination; Energy Metabolism; Estrone; Insulin; Lipids; Male; Obesity; Oleic Acids; Phentermine; Rats; Rats, Wistar	2005
Effects of acute administration of phentermine, alone or in combination with dexfenfluramine, on pain reactivity in the adult rat. Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:3 Topics: Animals; Behavior, Animal; Data Interpretation, Statistical; Dexfenfluramine; Dopamine Uptake Inhibitors; Male; Pain; Pain Measurement; Phentermine; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin Receptor Agonists	2008
Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat. Psychopharmacology, 2015, Volume: 232, Issue:11 Topics: Animals; Appetite Depressants; Dexfenfluramine; Drug Synergism; Eating; Fenfluramine; Male; Phentermine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists	2015