Page last updated: 2024-08-24

dexelvucitabine and zalcitabine

dexelvucitabine has been researched along with zalcitabine in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (21.05)	18.2507
2000's	28 (73.68)	29.6817
2010's	2 (5.26)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cheng, YC; Dutschman, GE; Gullen, E; Lin, TS; Liu, MC; Luo, MZ; Zhu, YL	1
Bridges, EG; Cheng, YC; Dutschman, GE; Gullen, E; Guo, X; Kukhanova, M; Liu, SH	1
Bridges, EG; Cheng, YC; Dutschman, DE; Liu, SH; Zhu, YL	1
Carmichael, E; Chen, SH; Doyle, TW; Feng, M; King, I; Li, X	1
Chen, SH; Cheng, YC; Doyle, TW; Dutschman, GE; Gullen, EA; King, I; Lin, S; Spinka, T	1
Hurwitz, SJ; Liotta, DC; Ma, L; Mcatee, JJ; McClure, HM; Schinazi, RF; Shi, J	1
Juodawlkis, A; Liotta, DC; McAtee, JJ; Schinazi, RF; Schlueter Wirtz, S; Shi, J; Tharnish, P	1
Cheng, YC; Fu, L; Liu, SH	1
Chen, SH; Cheng, YC; Chevallier, M; Guerret, S; Hantz, O; Jamard, C; King, I; Le Guerhier, F; Li, XY; Pichoud, C; Trépo, C; Zoulim, F	1
Cheng, YC; Chou, KM; Kukhanova, M	1
Cheng, YC	1
Cheng, YC; Chevallier, M; Guerret, S; Hantz, O; Jamard, C; King, I; Le Guerhier, F; Peyrol, S; Pichoud, C; Trépo, C; Zoulim, F	1
Bacheler, L; Bazmi, H; Diamond, S; Erickson-Viitanen, S; Gallagher, K; Garber, S; Geleziunas, R; Hammond, J; Klabe, R; Liotta, DC; Manion, DJ; Mellors, J; Otto, MJ; Pierce, M; Rayner, M; Schinazi, RF; Stuyver, L; Trainor, G; Wu, JT; Zhang, H	1
Emm, T; Gallagher, K; Geleziunas, R; Li, Y; Olah, T; Shi, G; Unger, S; Wu, JT	1
Anderson, KS; Murakami, E; Peterson, CN; Ray, AS; Schinazi, RF; Shi, J	1
Mitra, AK; Patel, J	1
Berthillon, P; Cheng, YC; Germon, S; Guerhier, FL; Pichoud, C; Seigneres, B; Trepo, C; Zoulim, F	1
Erickson-Viitanen, S; Fish, B; Gallagher, K; Geleziunas, R; King, RW; Klabe, R; Otto, MJ; Schinazi, RF; Shi, G; Unger, S; Wu, JT	1
Bacheler, L; Erickson-Viitanen, S; Gallagher, K; Garber, S; Geleziunas, R; Otto, MJ; Schinazi, RF; Shi, G; Wu, JT; Zhang, H	1
Adams, M; Erickson-Viitanen, S; Gallagher, K; Geleziunas, R; Grier, JP; Mathew, JS; Otto, MJ; Pai, SB; Rachakonda, S; Schinazi, RF; Shi, G; Shi, J; Stuyver, L; Tharnish, PM; Watanabe, KA; Wu, JT; Zhang, H	1
Anderson, KS; Murakami, E; Ray, AS; Schinazi, RF	1
James, JS	1
Avci, A; Erhardt, A; Häussinger, D; Heintges, T; Lörke, J; Sagir, A	1
Almond, MR; Liotta, DC; Mao, S; Painter, GR	1
Otto, MJ	1
Beard, A; Cartee, L; De La Rosa, A; Kravec, I; McBrayer, TR; Murphy, RL; Otto, MJ; Schinazi, RF; Schürmann, D; Stuyver, LJ	1
Sax, PE	1
Nelson, MR; Waters, L	1
Bazmi, HZ; Chu, CK; Hammond, JL; Koontz, DL; Mellors, JW; Parikh, UM; Schinazi, RF; Schlueter-Wirtz, S	1
Susman, E	1
Feinberg, J	1
Grier, JP; Hernandez-Santiago, BI; Mathew, JS; Rapp, KL; Schinazi, RF	1
Colucci, P; Ducharme, MP; Hoepelman, IM; Pottage, JC; Robison, H; Schürmann, D; Turgeon, J	1
Colucci, P; Ducharme, MP; Pottage, JC; Robison, H; Turgeon, J	1
Meusinger, R	1

Reviews

5 review(s) available for dexelvucitabine and zalcitabine

Article	Year
ACH-126443 Achillion/Yale University. Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:11 Topics: Animals; Clinical Trials as Topic; Hepatitis B; HIV Infections; Humans; Reverse Transcriptase Inhibitors; Technology, Pharmaceutical; Zalcitabine	2002
[New approaches in the treatment of hepatitis B]. Deutsche medizinische Wochenschrift (1946), 2004, May-21, Volume: 129, Issue:21 Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine	2004
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10 Topics: Adenine; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonucleotides; Dioxolanes; DNA, Viral; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; Humans; Kinetics; Molecular Structure; Nucleosides; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Protein Binding; Protein Conformation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir; Zalcitabine	2004
New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections. Current opinion in pharmacology, 2004, Volume: 4, Issue:5 Topics: Animals; Anti-HIV Agents; Clinical Trials as Topic; Cytidine Triphosphate; Deoxycytidine; Dideoxynucleosides; Dioxolanes; Emtricitabine; HIV Infections; Humans; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thionucleosides; Zalcitabine	2004
New drugs. HIV medicine, 2005, Volume: 6, Issue:4 Topics: Anti-HIV Agents; Benzophenones; Cytidine Triphosphate; Darunavir; Deoxycytidine; Emtricitabine; HIV; HIV Fusion Inhibitors; HIV Reverse Transcriptase; Humans; Imidazoles; Nitriles; Protease Inhibitors; Pyridazines; Pyridines; Pyrimidines; Pyrones; Reverse Transcriptase Inhibitors; Sulfonamides; Sulfur Compounds; Zalcitabine	2005

Trials

3 trial(s) available for dexelvucitabine and zalcitabine

Article	Year
Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose. Antiviral therapy, 2004, Volume: 9, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Cytidine Triphosphate; Dose-Response Relationship, Drug; Drug Administration Schedule; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Middle Aged; Reverse Transcriptase Inhibitors; Sequence Analysis, RNA; Viral Load; Zalcitabine	2004
Meeting notes from the 3rd IAS Conference. New drugs. AIDS clinical care, 2005, Volume: 17, Issue:10 Topics: Brazil; CCR5 Receptor Antagonists; Congresses as Topic; Cytidine Triphosphate; Darunavir; HIV Infections; Reverse Transcriptase Inhibitors; Sulfonamides; Zalcitabine	2005
Effect of a single dose of ritonavir on the pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered in healthy volunteers. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Adult; Anti-HIV Agents; Area Under Curve; Binding, Competitive; Biological Availability; Cross-Over Studies; Drug Interactions; Female; Humans; Intestinal Absorption; Linear Models; Male; Middle Aged; Population; Reverse Transcriptase Inhibitors; Ritonavir; Tandem Mass Spectrometry; Young Adult; Zalcitabine	2009

Other Studies

30 other study(ies) available for dexelvucitabine and zalcitabine

Article	Year
Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human Journal of medicinal chemistry, 1996, Apr-26, Volume: 39, Issue:9 Topics: Antiviral Agents; Drug Design; Hepatitis B virus; HIV; Humans; Zalcitabine	1996
Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7 Topics: Anti-HIV Agents; Cell Line; Deamination; Deoxycytidine Kinase; Didanosine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; DNA, Viral; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Phosphorylation; Stavudine; Virus Replication; Zalcitabine; Zidovudine	1998
Anti-hepatitis B virus activity and metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7 Topics: Antiviral Agents; Biological Products; Deoxycytidine; Deoxycytidine Kinase; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Hepatitis B virus; Humans; Lamivudine; Phosphorylation; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured; Zalcitabine	1998
Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of beta-L-FD4C as potent anti-HBV agent. Bioorganic & medicinal chemistry letters, 1998, Jan-06, Volume: 8, Issue:1 Topics: Antiviral Agents; Cell Survival; Hepatitis B virus; Humans; Organophosphorus Compounds; Prodrugs; Tumor Cells, Cultured; Zalcitabine	1998
Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C. Bioorganic & medicinal chemistry letters, 1998, Nov-17, Volume: 8, Issue:22 Topics: Animals; Antiviral Agents; Hepatitis B virus; HIV; Mice; Rats; Stereoisomerism; Zalcitabine	1998
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Animals; Antiviral Agents; Biological Availability; Injections, Intravenous; Macaca mulatta; Metabolic Clearance Rate; Zalcitabine	1999
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase. Journal of medicinal chemistry, 1999, Mar-11, Volume: 42, Issue:5 Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; HIV Reverse Transcriptase; Humans; Organophosphates; Rats; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Zalcitabine	1999
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. Biochemical pharmacology, 1999, Jun-15, Volume: 57, Issue:12 Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Drug Resistance, Multiple; Guanine; Hepatitis B virus; Lamivudine; Microbial Sensitivity Tests; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Zalcitabine	1999
Characterization of the antiviral effect of 2',3'-dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:1 Topics: Animals; Antiviral Agents; DNA, Circular; DNA, Viral; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Liver; Reverse Transcriptase Inhibitors; Viral Proteins; Virus Replication; Zalcitabine	2000
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA. The Journal of biological chemistry, 2000, Oct-06, Volume: 275, Issue:40 Topics: Anions; Antineoplastic Agents; Antiviral Agents; Blotting, Western; Carbon-Oxygen Lyases; Cations; Chromatography, Agarose; Chromatography, Ion Exchange; Cytarabine; Cytosine; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonuclease IV (Phage T4-Induced); Dioxolanes; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Electrophoresis, Polyacrylamide Gel; Endonucleases; Humans; Oligonucleotides; Recombinant Proteins; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thionucleosides; Tumor Cells, Cultured; Zalcitabine	2000
Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers. Cancer letters, 2001, Volume: 162 Suppl Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Dioxolanes; Hepatitis B virus; Herpesvirus 4, Human; Humans; Neoplasms; Nucleosides; Stereoisomerism; Structure-Activity Relationship; Uracil; Virus Diseases; Zalcitabine	2001
Antiviral activity of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:4 Topics: Animals; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Circular; DNA, Viral; Drug Administration Schedule; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Lamivudine; Liver; Marmota; Skin Pigmentation; Viremia; Virus Replication; Zalcitabine	2001
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:5 Topics: Animals; Anti-HIV Agents; Cytidine; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Macaca mulatta; Nucleosides; Reverse Transcriptase Inhibitors; Zalcitabine; Zidovudine	2002
ViroLogic announces agreement with Achillion. Pharmacogenomics, 2002, Volume: 3, Issue:2 Topics: Clinical Trials, Phase II as Topic; Cooperative Behavior; Drug Industry; Drug Resistance, Viral; Female; Hepatitis B; HIV Infections; Humans; Zalcitabine	2002
Novel direct detection method for quantitative determination of intracellular nucleoside triphosphates using weak anion exchange liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:11 Topics: Chromatography, Liquid; Cytidine Triphosphate; Deoxycytidine; Mass Spectrometry; Monocytes; Reverse Transcriptase Inhibitors; Zalcitabine	2002
Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase. Antiviral research, 2002, Volume: 56, Issue:3 Topics: Base Sequence; Binding Sites; Cytidine Triphosphate; Deoxycytosine Nucleotides; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Sequence Data; Point Mutation; Reverse Transcriptase Inhibitors; Stereoisomerism; Zalcitabine	2002
Animal models for the study of HBV infection and the evaluation of new anti-HBV strategies. Journal of gastroenterology and hepatology, 2002, Volume: 17 Suppl Topics: Animals; Disease Models, Animal; Ducks; Hepadnaviridae Infections; Hepatitis; Hepatitis B Virus, Duck; Hepatitis B Virus, Woodchuck; Hepatitis, Viral, Animal; Humans; In Vitro Techniques; Marmota; Reverse Transcriptase Inhibitors; RNA, Viral; Virus Replication; Zalcitabine	2002
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV. Antiviral chemistry & chemotherapy, 2003, Volume: 14, Issue:1 Topics: Anti-HIV Agents; Cells, Cultured; Cytidine Triphosphate; Drug Interactions; Drug Resistance, Viral; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Intracellular Membranes; Leukocytes, Mononuclear; Nucleosides; Phosphorylation; Phytohemagglutinins; Reverse Transcriptase Inhibitors; Zalcitabine	2003
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset). Antiviral chemistry & chemotherapy, 2003, Volume: 14, Issue:1 Topics: Adenine; Anti-HIV Agents; Cell Line; Cytidine Triphosphate; Didanosine; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Species Specificity; Tenofovir; Transfection; Zalcitabine; Zidovudine	2003
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity. Antiviral chemistry & chemotherapy, 2003, Volume: 14, Issue:2 Topics: Animals; Anti-HIV Agents; Antiviral Agents; Cell Division; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Dose-Response Relationship, Drug; Hepatitis B virus; HIV-1; Humans; Inhibitory Concentration 50; Models, Chemical; Vero Cells; Zalcitabine	2003
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Antiviral research, 2004, Volume: 62, Issue:1 Topics: Anti-HIV Agents; DNA; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Kinetics; Molecular Structure; Reverse Transcriptase Inhibitors; Stereoisomerism; Zalcitabine	2004
Antiretroviral pipeline: new-drug reports from retroviruses conference. AIDS treatment news, 2004, Feb-27, Issue:398 Topics: Anti-HIV Agents; CCR5 Receptor Antagonists; Cytidine Triphosphate; Drug Resistance, Viral; HIV; HIV Fusion Inhibitors; Membrane Fusion; Zalcitabine	2004
Meeting notes from ICAAC. D-D4FC (Reverset): further data on treatment-experienced patients. AIDS clinical care, 2005, Volume: 17, Issue:1 Topics: Anti-HIV Agents; Cytidine Triphosphate; HIV Infections; Humans; Mutation; Viral Load; Zalcitabine	2005
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:9 Topics: Amino Acid Substitution; Anti-HIV Agents; Cell Line; Cytidine Triphosphate; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Mutagenesis, Site-Directed; Mutation; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Zalcitabine	2005
HIV Pathogenesis and Treatment - Third International AIDS Society Conference. IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:10 Topics: Adenine; Antiretroviral Therapy, Highly Active; Chemistry, Pharmaceutical; Clinical Trials as Topic; Congresses as Topic; Darunavir; Drugs, Investigational; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Peptide Fragments; Pyrimidines; Receptors, CCR5; Reverse Transcriptase Inhibitors; Rilpivirine; Societies, Scientific; Sulfonamides; Tenofovir; Zalcitabine	2005
dD4FC development discontinued. AIDS clinical care, 2006, Volume: 18, Issue:5 Topics: Cytidine Triphosphate; Drug Industry; HIV Infections; Humans; Hyperlipidemias; Reverse Transcriptase Inhibitors; Zalcitabine	2006
Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Anti-HIV Agents; Cell Line, Tumor; Cells, Cultured; Drug Interactions; Drug Synergism; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Reverse Transcriptase Inhibitors; Zalcitabine	2007
Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Anti-HIV Agents; Area Under Curve; Biological Availability; Cohort Studies; Drug Combinations; Half-Life; HIV Infections; HIV-1; Humans; Lopinavir; Models, Statistical; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Zalcitabine	2009
Elvucitabine data released at CROI. AIDS patient care and STDs, 2010, Volume: 24, Issue:3 Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials, Phase II as Topic; Cyclopropanes; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load; Zalcitabine	2010
Doubling spectroscopy challenge. Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:27 Topics: Anti-HIV Agents; Magnetic Resonance Spectroscopy; Protons; Thermodynamics; Zalcitabine	2015