deuterium has been researched along with warfarin in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garland, WA; Nelson, SD; Pohl, LR; Trager, WF | 1 |
| Harada, N; Lu, AY; Miwa, GT | 1 |
| Bush, ED; Trager, WF | 2 |
| Chan, KK; Lewis, RJ; Trager, WF | 1 |
| Fukami, H; Kumagai, H; Ohkishi, H; Ueno, T; Yamada, H | 1 |
| Garland, WA; Lewis, RJ; Trager, WF | 1 |
| Shipchandler, M; Soine, TO | 1 |
| Lu, AY; Miwa, GT; Walsh, JS | 1 |
| Harada, N; Lu, AY; Miwa, GT; Walsh, JS | 1 |
| Bush, ED; Howald, WN; Motley, CH; O"Reilly, RA; Trager, WF | 1 |
| Darbyshire, JF; Grogan, J; Iyer, KR; Korzekwa, KR; Trager, WF | 1 |
| Fuller, RS; Rockwell, NC | 1 |
| DeCicco, C; Nelson, D; Stein, RL; Thomas, B | 1 |
| Bintoma, HM; Laurent, S; Muller, RN; Vander Elst, L | 1 |
| RITTENBERG, D; SADANA, JC | 1 |
| Brenna, E; Fronza, G; Fuganti, C; Gatti, FG; Grande, V; Guillou, C; Reniero, F; Serra, F; Serra, S | 1 |
| Eisenreich, W; Fronza, G; Fuganti, C; Remaud, G; Robins, RJ; Schmidt, HL; Werner, RA | 1 |
| Bhattacharyya, K; Das, DK; Mandal, U; Mondal, T | 1 |
| Ahn, T; Jang, HH; Kang, JY; Kim, SY; Park, SH; Ryu, SH; Yun, CH | 1 |
| Bagai, I; Becker, DF; Ragsdale, SW; Spencer, AL; Zuiderweg, ER | 1 |
| McGlacken, GP; Nolan, MT; Pardo, LM; Prendergast, AM | 1 |
| Cheng, W; Ding, Y; Sun, Y; Xie, Y; Yang, Z; Zhang, MZ; Zhang, W | 1 |
23 other study(ies) available for deuterium and warfarin
| Article | Year |
|---|---|
The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique.
Topics: Animals; Carbon Isotopes; Carbon Radioisotopes; Deuterium; Humans; Hydroxylation; Male; Mass Spectrometry; Microsomes, Liver; Rats; Stereoisomerism; Warfarin | 1975 |
Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters.
Topics: Animals; Chromatography, High Pressure Liquid; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Microsomes, Liver; Models, Biological; Oxidation-Reduction; Rats; Substrate Specificity | 1985 |
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
Topics: Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity; Warfarin | 1985 |
Absolute configurations of the four warfarin alcohols.
Topics: Administration, Oral; Alcohols; Blood Coagulation; Blood Coagulation Factors; Chromatography, Gas; Chromatography, Thin Layer; Deuterium; Humans; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Optical Rotation; Prothrombin Time; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin | 1972 |
[Synthesis of 3,4-dihydro-3-amino-7-hydroxycoumarin from S-methyl-l-cysteine and resorcinol by crystalline-beta-tyrosinase].
Topics: Catechol Oxidase; Coumarins; Cysteine; Deuterium; Escherichia; Kinetics; Magnetic Resonance Spectroscopy; Resorcinols | 1970 |
Mass spectral analysis in the identification of human metabolites of warfarin.
Topics: Carbon Isotopes; Chromatography, Thin Layer; Deuterium; Spectrum Analysis; Stereoisomerism; Ultraviolet Rays; Warfarin | 1970 |
Coumarins. 8. Mass spectra of lomatin and some of its derivatives.
Topics: Chemistry, Organic; Coumarins; Deuterium; Ions; Organic Chemistry Phenomena; Spectrum Analysis | 1968 |
Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Deuterium; Isotope Labeling; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Oxygenases; Rats; Tritium | 1984 |
Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Deuterium; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats | 1984 |
Evidence against an abstraction or direct insertion mechanism for cytochrome P-450 catalysed meta hydroxylations.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Warfarin | 1982 |
A stable isotope assay for pseudoracemic warfarin from human plasma samples.
Topics: Carbon Isotopes; Chromatography, High Pressure Liquid; Deuterium; Half-Life; Humans; Mass Spectrometry; Stereoisomerism; Warfarin | 1980 |
Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Warfarin | 1996 |
Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2.
Topics: Acylation; Amides; Chromogenic Compounds; Coumarins; Deuterium; Hydrolysis; Kinetics; Mass Spectrometry; Oligopeptides; Proprotein Convertases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Solvents; Spectrometry, Fluorescence; Substrate Specificity; Subtilisins; Temperature | 2001 |
Slow-binding inhibition of gamma-glutamyl transpeptidase by gamma-boroGlu.
Topics: Acylation; Amides; Binding, Competitive; Boron Compounds; Boronic Acids; Catalysis; Coumarins; Deuterium; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutamic Acid; Glycine; Hydrolysis; Kinetics; Solvents | 2001 |
Albumin-bound MRI contrast agents: the dilemma of the rotational correlation time.
Topics: 4-Hydroxycoumarins; Contrast Media; Deuterium; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Warfarin | 2001 |
IRON REQUIREMENT FOR THE HYDROGENASE OF DESULFOVIBRIO DESULFURICANS.
Topics: Coumarins; Cysteine; Desulfovibrio; Desulfovibrio desulfuricans; Deuterium; Hydrogenase; Iron; Metabolism; Oxidoreductases | 1964 |
Stable isotope characterization of the ortho-oxygenated phenylpropanoids: coumarin and melilotol.
Topics: Coumarins; Deuterium; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction | 2005 |
The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: basis of the isotopic characteristics of natural aromatic compounds.
Topics: Benzaldehydes; Benzene Derivatives; Biological Factors; Carbon Isotopes; Cinnamates; Coumarins; Deuterium; Hydroxylation; Magnetic Resonance Spectroscopy; Models, Chemical; NADP; Phosphoenolpyruvate; Propanols; Salicylates; Shikimic Acid; Sugar Phosphates | 2006 |
Probing deuterium isotope effect on structure and solvation dynamics of human serum albumin.
Topics: Circular Dichroism; Coumarins; Deuterium; Deuterium Exchange Measurement; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Serum Albumin; Solvents | 2011 |
Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation.
Topics: Aryl Hydrocarbon Hydroxylases; Biocatalysis; Coumarins; Cytochrome P-450 CYP1B1; Deuterium; Estradiol; Humans; Kinetics; Oxidation-Reduction; Phospholipids; Substrate Specificity | 2012 |
Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.
Topics: Apoproteins; Chromatography, Gel; Coumarins; Cross-Linking Reagents; Crystallography, X-Ray; Deuterium; Fluorescence; Heme; Heme Oxygenase (Decyclizing); Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Weight; Mutagenesis; Mutant Proteins; NADPH-Ferrihemoprotein Reductase; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Surface Plasmon Resonance; Ultracentrifugation | 2014 |
Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins.
Topics: Catalysis; Coumarins; Deuterium; Halogenation; Molecular Structure; Protons; Pyrones; Stereoisomerism | 2015 |
General Strategy for in Situ Generation of a Coumarin-Cu
Topics: Copper; Coumarins; Deuterium; Fluorescent Dyes; Spectrometry, Fluorescence; Water | 2019 |