Page last updated: 2024-08-22

deuterium and tamoxifen

deuterium has been researched along with tamoxifen in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grimshaw, RM; Horton, MN; Jarman, M; McCague, R; Poon, GK; Potter, GA; Rowlands, MG1
Crofton-Sleigh, C; Hewer, A; Horton, MN; Jarman, M; Phillips, DH; Potter, GA; Venitt, S1
Bridson, GW; Cheng, C; Gallegos, R; Graham, PB; Harbeson, SL; Liu, JF; Tung, R; Uttamsingh, V; Wells, DS; Zelle, R1

Trials

1 trial(s) available for deuterium and tamoxifen

ArticleYear
Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 354, Issue:1

    Topics: Animals; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Deuterium; Double-Blind Method; Drug Interactions; Female; Humans; Isotope Labeling; Microsomes, Liver; Paroxetine; Radioligand Assay; Rats; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Tamoxifen

2015

Other Studies

2 other study(ies) available for deuterium and tamoxifen

ArticleYear
The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.
    Carcinogenesis, 1995, Volume: 16, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Deuterium; Hydroxylation; Inactivation, Metabolic; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Sensitivity and Specificity; Tamoxifen

1995
Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.
    Carcinogenesis, 1994, Volume: 15, Issue:8

    Topics: Animals; Biotransformation; Carcinogens; Deuterium; DNA; Female; Hydroxylation; Liver; Liver Neoplasms; Micronucleus Tests; Rats; Rats, Inbred F344; Tamoxifen

1994