deuterium has been researched along with tamoxifen in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grimshaw, RM; Horton, MN; Jarman, M; McCague, R; Poon, GK; Potter, GA; Rowlands, MG | 1 |
| Crofton-Sleigh, C; Hewer, A; Horton, MN; Jarman, M; Phillips, DH; Potter, GA; Venitt, S | 1 |
| Bridson, GW; Cheng, C; Gallegos, R; Graham, PB; Harbeson, SL; Liu, JF; Tung, R; Uttamsingh, V; Wells, DS; Zelle, R | 1 |
1 trial(s) available for deuterium and tamoxifen
| Article | Year |
|---|---|
Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine.
Topics: Animals; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Deuterium; Double-Blind Method; Drug Interactions; Female; Humans; Isotope Labeling; Microsomes, Liver; Paroxetine; Radioligand Assay; Rats; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Tamoxifen | 2015 |
2 other study(ies) available for deuterium and tamoxifen
| Article | Year |
|---|---|
The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.
Topics: Animals; Chromatography, High Pressure Liquid; Deuterium; Hydroxylation; Inactivation, Metabolic; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Sensitivity and Specificity; Tamoxifen | 1995 |
Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.
Topics: Animals; Biotransformation; Carcinogens; Deuterium; DNA; Female; Hydroxylation; Liver; Liver Neoplasms; Micronucleus Tests; Rats; Rats, Inbred F344; Tamoxifen | 1994 |