Compounds > deuterium
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deuterium and selegiline

deuterium has been researched along with selegiline in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.26)18.7374
1990's5 (26.32)18.2507
2000's6 (31.58)29.6817
2010's6 (31.58)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
McCallister, JD; Nguyen, BL; Patrick, KS1
Dewey, SL; Fowler, JS; Langstrom, B; Logan, J; MacGregor, RR; Schlyer, DJ; Wolf, AP1
Andersson, J; Antoni, G; Bergström, M; Kumlien, E; Långström, B; Lilja, A; Szekeres, V; Westerberg, CE; Westerberg, G1
Alexoff, DL; Fowler, JS; Logan, J; MacGregor, RR; Pappas, N; Patlak, C; Schlyer, DJ; Volkow, ND; Wang, GJ; Xie, S1
Alexoff, D; Cilento, R; Fowler, JS; Logan, J; MacGregor, R; Pappas, N; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Zezulkova, I1
Bergström, M; Kumlien, E; Långström, B; Lilja, A; Tyrefors, N; Westerberg, G1
Fowler, JS; Logan, J; MacGregor, RR; Shea, C; Volkow, ND; Wang, GJ1
Bergström, M; Hagberg, G; Kumlien, E; Långström, B; Nilsson, A1
Alexoff, D; Ding, YS; Ferrieri, R; Fowler, JS; Garza, V; John Gatley, S; Li, Z; Logan, J; Schlyer, D; Shea, C; Telang, F; Vaska, P; Volkow, ND; Wang, GJ; Xu, Y; Zhu, W1
Fowler, JS; Logan, J1
Axelsson, J; Bengtsson, E; Bergström, M; Långström, B; Razifar, P; Schneider, H1
Aquilonius, SM; Askmark, H; Blomquist, G; Engler, H; Johansson, A; Långström, B; Scott, B; Wall, A1
Engler, H; Gambini, JP; Kilander, L; Långström, B; Lannfelt, L; Santillo, AF; Ulla-Marja, L1
Almkvist, O; Carter, SF; Engler, H; Långström, B; Nordberg, A; Schöll, M; Wall, A1
Alken, RG; Feltmann, K; Konradsson-Geuken, Å; Malmlöf, T; Schilström, B; Schneider, F; Svensson, TH1
Aschner, M; Bornhorst, J; Chakraborty, S; Gulbins, E; Kleuser, B; Schumacher, F; Schwerdtle, T1
Almkvist, O; Carter, SF; Chiotis, K; Långström, B; Leuzy, A; Nordberg, A; Rodriguez-Vieitez, E; Saint-Aubert, L; Schöll, M; Wall, A1
Engler, H; Kreimerman, I; Olivera, S; Savio, E; Vasilskis, E1
Almkvist, O; Ferreira, D; Fortea, J; Graff, C; Lleó, A; Montal, V; Nordberg, A; Rodriguez-Vieitez, E; Vilaplana, E; Wall, A; Westman, E1

Trials

2 trial(s) available for deuterium and selegiline

ArticleYear
Temporal lobe epilepsy visualized with PET with 11C-L-deuterium-deprenyl--analysis of kinetic data.
    Acta neurologica Scandinavica, 1998, Volume: 98, Issue:4

    Topics: Adult; Carbon Radioisotopes; Caudate Nucleus; Cerebellum; Cerebral Cortex; Deuterium; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Monoamine Oxidase; Neuroprotective Agents; Predictive Value of Tests; Selegiline; Temporal Lobe; Tomography, Emission-Computed

1998
Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans.
    Nuclear medicine and biology, 2004, Volume: 31, Issue:3

    Topics: Adult; Brain; Carbon Radioisotopes; Clorgyline; Deuterium; Enzyme Activation; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organ Specificity; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Selegiline; Tissue Distribution

2004

Other Studies

17 other study(ies) available for deuterium and selegiline

ArticleYear
Gas chromatographic-mass spectrometric determination of plasma selegiline using a deuterated internal standard.
    Journal of chromatography, 1992, Dec-02, Volume: 583, Issue:2

    Topics: Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Selegiline

1992
Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain.
    Journal of neurochemistry, 1988, Volume: 51, Issue:5

    Topics: Animals; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deuterium; Electrophoresis, Polyacrylamide Gel; Kinetics; Mice; Molecular Structure; Monoamine Oxidase; Papio; Phenethylamines; Selegiline; Tissue Distribution; Tomography, Emission-Computed

1988
Positron emission tomography with [11C]deuterium-deprenyl in temporal lobe epilepsy.
    Epilepsia, 1995, Volume: 36, Issue:7

    Topics: Adult; Analysis of Variance; Animals; Cerebellar Cortex; Deuterium; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Kinetics; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Monoamine Oxidase Inhibitors; Selegiline; Temporal Lobe; Tomography, Emission-Computed

1995
Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1995, Volume: 36, Issue:7

    Topics: Adult; Brain; Carbon Radioisotopes; Deuterium; Female; Humans; Male; Middle Aged; Monoamine Oxidase; Selegiline; Sensitivity and Specificity; Tomography, Emission-Computed

1995
Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition.
    Journal of addictive diseases, 1998, Volume: 17, Issue:1

    Topics: Adult; Basal Ganglia; Brain; Carbon Radioisotopes; Deuterium; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Selegiline; Smoke; Smoking; Tomography, Emission-Computed

1998
Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain.
    Nuclear medicine and biology, 2000, Volume: 27, Issue:1

    Topics: Adult; Aged; Algorithms; Brain; Deuterium; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Models, Biological; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Reproducibility of Results; Selegiline; Tomography, Emission-Computed

2000
PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy.
    Acta neurologica Scandinavica, 2001, Volume: 103, Issue:6

    Topics: Adolescent; Adult; Brain; Deuterium; Drug Combinations; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Monoamine Oxidase Inhibitors; Multivariate Analysis; Radiopharmaceuticals; Selegiline; Tomography, Emission-Computed

2001
Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers.
    Nuclear medicine and biology, 2005, Volume: 32, Issue:5

    Topics: Arteries; Carbon Radioisotopes; Clorgyline; Deuterium; Humans; Lung; Monoamine Oxidase; Positron-Emission Tomography; Selegiline; Smoking

2005
A new application of pre-normalized principal component analysis for improvement of image quality and clinical diagnosis in human brain PET studies--clinical brain studies using [11C]-GR205171, [11C]-L-deuterium-deprenyl, [11C]-5-Hydroxy-L-Tryptophan, [11
    NeuroImage, 2006, Nov-01, Volume: 33, Issue:2

    Topics: Antiemetics; Brain; Brain Mapping; Carbon Radioisotopes; Deuterium; Humans; Image Processing, Computer-Assisted; Levodopa; Piperidines; Positron-Emission Tomography; Selegiline; Tetrazoles

2006
Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET.
    Journal of the neurological sciences, 2007, Apr-15, Volume: 255, Issue:1-2

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Astrocytes; Brain; Brain Mapping; Carbon Radioisotopes; Deuterium; Female; Gliosis; Humans; Male; Middle Aged; Monoamine Oxidase; Nerve Fibers, Myelinated; Positron-Emission Tomography; Predictive Value of Tests; Selegiline

2007
In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study.
    European journal of nuclear medicine and molecular imaging, 2011, Volume: 38, Issue:12

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Deuterium; Female; Gliosis; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Selegiline; Thiazoles; Tissue Distribution

2011
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Cognitive Dysfunction; Deuterium; Female; Fluorodeoxyglucose F18; Gliosis; Humans; Male; Middle Aged; Monoamine Oxidase; Neuropsychological Tests; Positron-Emission Tomography; Radioactive Tracers; Retrospective Studies; Selegiline; Thiazoles

2012
Deuterium-substituted L-DOPA displays increased behavioral potency and dopamine output in an animal model of Parkinson's disease: comparison with the effects produced by L-DOPA and an MAO-B inhibitor.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:2

    Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Brain; Deuterium; Disease Models, Animal; Dopamine; Forelimb; Levodopa; Male; Microdialysis; Monoamine Oxidase Inhibitors; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Tyrosine 3-Monooxygenase

2015
Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans.
    Talanta, 2015, Nov-01, Volume: 144

    Topics: Animals; Benzophenones; Caenorhabditis elegans; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Deuterium; Dopamine; Limit of Detection; Monoamine Oxidase Inhibitors; Nitrophenols; Selegiline; Serotonin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors; Tolcapone

2015
Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7

    Topics: Aged; Alzheimer Disease; Aniline Compounds; Cerebellum; Cerebrovascular Circulation; Cognitive Dysfunction; Deuterium; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Gliosis; Gray Matter; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Perfusion; Pons; Positron-Emission Tomography; Radiopharmaceuticals; Selegiline; Thiazoles

2016
Comparative In Vitro Study of
    Cancer biotherapy & radiopharmaceuticals, 2017, Volume: 32, Issue:9

    Topics: Astrocytes; Astrocytoma; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Deuterium; Glial Fibrillary Acidic Protein; Gliosis; Humans; Methionine; Monoamine Oxidase; Positron-Emission Tomography; Radiopharmaceuticals; Selegiline

2017
Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease.
    Neurology, 2020, 05-12, Volume: 94, Issue:19

    Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Brain; Carbon Radioisotopes; Cerebral Cortex; Deuterium; Female; Heterozygote; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neuroimaging; Neuropsychological Tests; Positron-Emission Tomography; Presenilin-1; Prodromal Symptoms; Selegiline

2020