deuterium has been researched along with pyrimidinones in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brewer, CF; Santi, DV | 1 |
| Longfield, TH; Theriault, RJ; Zaugg, HE | 1 |
| Czochralska, B; Shugar, D | 1 |
| Bardos, TJ; Kalman, TI; Szabo, L | 1 |
| Armarego, WL; Randles, D; Taguchi, H | 1 |
| Caccamo, F; Caruso, A; Cutuli, VM; Santagati, NA | 1 |
| Almo, SC; Fedorov, A; Fedorov, E; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, G; Larese, JZ; Schramm, VL; Shi, W; Tyler, PC | 1 |
| Angeletti, RH; Grubmeyer, C; Nieves, E; Schramm, VL; Shi, W; Wang, F | 1 |
| Schramm, VL | 1 |
| Dankers, PY; Meijer, EW; Sijbesma, RP; ten Cate, AT | 1 |
| Benmohamed, R; Kirsch, DR; Morimoto, RI; Silverman, RB; Xia, G | 1 |
1 review(s) available for deuterium and pyrimidinones
| Article | Year |
|---|---|
Enzymatic transition states: thermodynamics, dynamics and analogue design.
Topics: Animals; Catalysis; Crystallography, X-Ray; Deuterium; Drug Design; Enzyme Inhibitors; Enzymes; Humans; Hydrogen; Hydrogen Bonding; Inosine; Kinetics; Models, Molecular; Motion; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity; Thermodynamics | 2005 |
10 other study(ies) available for deuterium and pyrimidinones
| Article | Year |
|---|---|
Model studies of thymidylate synthetase. Intramolecular catalysis of 5-hydrogen exchange and 5-hydroxymethylation of 1-substituted uracils.
Topics: Acetals; Carbon Isotopes; Catalysis; Chromatography, Paper; Chromatography, Thin Layer; Deoxyuridine; Deuterium; Ethers, Cyclic; Folic Acid; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Methyltransferases; Models, Chemical; Protons; Pyrimidinones; Ribonucleosides; Spectrophotometry, Ultraviolet; Tetrahydrofolates; Thymidylate Synthase; Tritium; Uracil; Uridine | 1973 |
Microbial conversion of 2,2-diphenyl-3-(1-pyrrolidino) propionitrile.
Topics: Amides; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Thin Layer; Deuterium; Infrared Rays; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitriles; Penicillium; Propionates; Pyrimidinones; Pyrrolidines; Spectrophotometry; Ultraviolet Rays | 1972 |
Photochemically reversible pyrimidine dimer product of electrochemical reduction of pyrimidone-2.
Topics: Chromatography, Paper; Cytosine; Deuterium; Electrochemistry; Electrolysis; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Oxidation-Reduction; Polarography; Pyrimidinones; Quaternary Ammonium Compounds; Radiation Effects; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Ultraviolet Rays | 1972 |
The reaction of 5-bromouracil derivatives with sulfur nucleophiles, and a novel synthetic route to 5-sulfur-substituted uracils and nucleotides.
Topics: Bromine; Deuterium; Methylthiouracil; Models, Chemical; Nucleotides; Pyrimidinones; Sulfur; Uracil; Uracil Nucleotides | 1970 |
Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one with dihydropteridine reductase.
Topics: Animals; Deuterium; Dihydropteridine Reductase; Humans; Kinetics; Liver; NAD; NADH, NADPH Oxidoreductases; Pteridines; Pterins; Pyrimidines; Pyrimidinones; Sheep | 1983 |
Synthesis and pharmacological evaluation of thieno[2,3-d]pyrimidin-2,4-dione and 5H-pyrimido [5,4-b]indol-2,4-dione derivatives.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Behavior, Animal; Carrageenan; Deuterium; Fungi; Indoles; Inflammation; Magnetic Resonance Spectroscopy; Male; Mice; Microbial Sensitivity Tests; Pain Measurement; Peritonitis; Pyrimidinones; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiophenes | 1995 |
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
Topics: Animals; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Deuterium; Electron Transport; Enzyme Inhibitors; Hydrolysis; Inosine; Macromolecular Substances; Motion; Phosphates; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles | 2001 |
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase.
Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Chromatography, High Pressure Liquid; Deuterium; Diphosphates; Enzyme Inhibitors; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Leucine; Macromolecular Substances; Magnesium; Magnesium Compounds; Mass Spectrometry; Molecular Sequence Data; Pepsin A; Peptide Fragments; Phenylalanine; Protons; Pyrimidinones; Pyrroles | 2001 |
Disulfide exchange in hydrogen-bonded cyclic assemblies: stereochemical self-selection by double dynamic chemistry.
Topics: Catalysis; Cyclization; Cystine; Deuterium; Disulfides; Hydrogen; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Pyrimidinones; Stereoisomerism; Sulfhydryl Compounds; Time Factors | 2005 |
Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties.
Topics: Animals; Caco-2 Cells; Deuterium; Half-Life; Halogenation; Humans; Mice; Microsomes; Pyrimidinones; Solubility | 2014 |