deuterium has been researched along with phenytoin in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalier, R; Toussaint, A | 1 |
| Baty, JD; Robinson, PR | 1 |
| Browne, TR; Perchalski, RJ; Pylilo, RJ; Szabo, GK | 1 |
| el-Din, MK; el-Emam, AA; Moustafa, MA; Subbagh, HI | 1 |
| Brams, A; Crutzen-Fayt, MC; Dumont, P; Duverger-Van Bogaert, M; Lambotte-Vandepaer, M; Léonard, A | 1 |
| Abramson, FP; Chace, DH | 1 |
| Baillie, TA; Boberg, M; Rettenmeier, AW; Rettie, AE | 1 |
| Dayton, PG; Perel, JM | 1 |
| Daly, JW; Jerina, DM; Witkop, B | 1 |
| Gregg, CT | 1 |
| Gerber, N; Seibert, RA; Thompson, RM | 1 |
| Borgå, O; Garle, M; Rane, A; Sjöqvist, F | 1 |
| Baba, S; Goromaru, T; Kasuya, Y; Yamazaki, K | 1 |
| Browne, TR; Davoudi, H; Josephs, EG; Szabo, GK | 1 |
| Ajami, A; Browne, HK; Josephs, EG; Szabo, GK | 1 |
| Abdelal, AM; el-Emam, AA; Metwally, ME; Moustafa, MA | 1 |
| Annesley, TM; Buchanan, N; Kurzyniec, S; Nordblom, GD; Pool, W; Reily, M; Roberts, WL; Talaat, R | 1 |
2 review(s) available for deuterium and phenytoin
| Article | Year |
|---|---|
Physiological and physicochemical bases of drug interactions in man.
Topics: Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, Thin Layer; Deuterium; Dextrans; Dicumarol; Dogs; Drug Antagonism; Drug Synergism; Humans; Kinetics; Male; Metabolism; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Probenecid; Protein Binding; Receptors, Drug; Salicylates; Stereoisomerism; Sulfinpyrazone; Sulfoxides; Thiopental | 1971 |
Some application of stable isotopes in clinical pharmacology.
Topics: Animals; Carbon Isotopes; Carbon Radioisotopes; Chromatography, Gas; Deuterium; Humans; Isotopes; Mass Spectrometry; Metabolism, Inborn Errors; Methods; Mice; Nitrogen Isotopes; Oxygen Isotopes; Pharmaceutical Preparations; Pharmacology; Phenytoin; Radioisotope Dilution Technique; Sulfur Isotopes | 1974 |
1 trial(s) available for deuterium and phenytoin
| Article | Year |
|---|---|
Determination of pharmacokinetic drug interactions with carbamazepine and phenytoin using stable isotope labeling and simple high-performance liquid chromatography/ultraviolet detection technique.
Topics: Administration, Oral; Analysis of Variance; Carbamazepine; Chromatography, High Pressure Liquid; Deuterium; Drug Interactions; Humans; Isotope Labeling; Metabolic Clearance Rate; Phenytoin; Spectrophotometry, Ultraviolet | 1994 |
14 other study(ies) available for deuterium and phenytoin
| Article | Year |
|---|---|
Study in vivo of the stereoselective aromatic hydroxylation of diphenylhydantoin by man, rat and dog by the use of a specifically deuterated substrate [proceedings].
Topics: Animals; Deuterium; Dogs; Humans; Hydroxylation; Male; Mass Spectrometry; Molecular Conformation; Phenytoin; Rats; Species Specificity | 1978 |
Single and multiple ion recording techniques for the analysis of diphenylhydantoin and its major metabolite in plasma.
Topics: Chromatography, Gas; Deuterium; Humans; Mass Spectrometry; Methods; Phenytoin | 1977 |
Simultaneous separation and determination (in serum) of phenytoin and carbamazepine and their deuterated analogues by high-performance liquid chromatography--ultraviolet detection for tracer studies.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Deuterium; Humans; Phenytoin; Ultraviolet Rays | 1990 |
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin.
Topics: Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Hydroxylation; Male; Oxidation-Reduction; Phenytoin; Rats | 1990 |
[Comparison of the teratogenic properties manifested in BALB c mice, by diphenylhydantoin and deuterated diphenylhydantoin].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Deuterium; Female; Mice; Mice, Inbred BALB C; Phenytoin; Pregnancy; Teratogens | 1989 |
Selective detection of carbon-13, nitrogen-15, and deuterium labeled metabolites by capillary gas chromatography-chemical reaction interface/mass spectrometry.
Topics: Animals; Carbon Isotopes; Deuterium; Dogs; Gas Chromatography-Mass Spectrometry; Male; Nitrogen Isotopes; Phenytoin | 1989 |
Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
Topics: Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Fatty Acids, Monounsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Phenytoin; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Valproic Acid | 1988 |
Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.
Topics: Animals; Benz(a)Anthracenes; Benzene; Carcinogens; Chemical Phenomena; Chemistry; Deuterium; Ethers, Cyclic; Hydro-Lyases; Hydrocarbons; Hydrocarbons, Halogenated; Hydroxylation; Iodobenzenes; Microsomes, Liver; Mixed Function Oxygenases; Naphthalenes; Nitrobenzenes; Oxides; Oxygenases; Phenanthrenes; Phenols; Phenytoin; Polycyclic Compounds; Rats; Tritium | 1972 |
Identification of a catechol glucuronide metabolite of 5,5-diphenylhydantoin (DPH) in rat bile by gas chromatography (GC) and mass spectrometry (MS).
Topics: Animals; Bile; Catechols; Chromatography, Gas; Deuterium; Glucuronates; Hydrolysis; In Vitro Techniques; Liver; Mass Spectrometry; Methods; Methylation; Perfusion; Phenytoin; Rats | 1973 |
Plasma disappearance of transplacentally transferred diphenylhydantoin in the newborn studied by mass fragmentography.
Topics: Adult; Deuterium; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Male; Mass Spectrometry; Maternal-Fetal Exchange; Milk, Human; Phenytoin; Pregnancy | 1974 |
Use of stable isotopes in the study of pharmacokinetics of drugs by mass fragmentography II: Detailed examination of pharmacokinetics of a single oral dose of phenytoin in humans.
Topics: Administration, Oral; Adult; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Male; Phenytoin; Regression Analysis; Saliva | 1980 |
Alternatives to least squares linear regression analysis for computation of standard curves for quantitation by high performance liquid chromatography: applications to clinical pharmacology.
Topics: Analysis of Variance; Carbamazepine; Chromatography, High Pressure Liquid; Deuterium; Humans; Least-Squares Analysis; Pharmacology, Clinical; Phenytoin; Reference Values; Regression Analysis | 1994 |
Percentages of the deuterium retained after para-hydroxylation of (R)(+)4-2H-phenytoin and (S)(-) 4-2H-phenytoin in rat.
Topics: Animals; Anticonvulsants; Deuterium; Gas Chromatography-Mass Spectrometry; Hydroxylation; Phenytoin; Rats; Stereoisomerism | 1991 |
Glucuronidation of prodrug reactive site: isolation and characterization of oxymethylglucuronide metabolite of fosphenytoin.
Topics: Chromatography, High Pressure Liquid; Deuterium; Fluorescence Polarization Immunoassay; Glucuronides; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenytoin; Prodrugs; Uremia | 2001 |