deuterium has been researched along with phenobarbital in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (96.30) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamond, BI; Sabelli, HC; Vázquez, AJ | 1 |
| Kroeger-Koepke, MB; Michejda, CJ | 1 |
| Bridges, JW; Cox, PJ; Farmer, PB; Foster, AB; Jarman, M; McKillop, D | 1 |
| Krishna, G; Pohl, LR | 1 |
| Baty, JD; Robinson, PR | 1 |
| Abdel-Monem, MM | 1 |
| Daly, JW; Jerina, DM; Tomaszewski, JE | 1 |
| Alvin, JD; Bush, MT | 1 |
| Hansen, LL; Lundquist, F | 1 |
| Benchekroun, Y; Brazier, JL; Cherrah, Y; Falconnet, JB; Ribon, B | 1 |
| Huang, MT; Lundquist, F; Quistorff, B | 1 |
| Baillie, TA; Boberg, M; Rettenmeier, AW; Rettie, AE | 1 |
| Brazier, JL; Cherrah, Y; Desage, M; Falconnet, JB; Tillement, JP; Zini, R | 2 |
| Benchekroun, Y; Brazier, JL; Desage, M; Ribon, B | 1 |
| Kyogoku, Y; Yu, BS | 1 |
| Toft, P | 1 |
| Connors, TA; Cox, PJ; Farmer, PB; Foster, AB; Jarman, M; Macleod, JK | 1 |
| Daly, JW; Jerina, DM; Reed, DJ; Vimmerstedt, J | 1 |
| Dehn, RL; Mitoma, C; Tanabe, M | 1 |
| Daly, J; Farnsworth, J; Guroff, G; Jerina, D | 1 |
| Baden, JM; Mazze, RI; Rice, SA | 1 |
| Bush, ED; Trager, WF | 1 |
| Anders, MW; Stevens, JL | 1 |
| Burke, TR; George, JW; Martin, JL; Pohl, LR | 1 |
| Anders, MW; Kubic, VL | 1 |
| Kishimoto, D; Kurihara, N; Masuda, M | 1 |
27 other study(ies) available for deuterium and phenobarbital
| Article | Year |
|---|---|
Differential effects of phenobarbital and pentobarbital on isolated nervous tissue.
Topics: Animals; Anura; Axons; Cats; Cerebral Cortex; Depression, Chemical; Deuterium; Dose-Response Relationship, Drug; Evoked Potentials; Hydrogen-Ion Concentration; Pentobarbital; Peripheral Nerves; Phenobarbital; Synaptic Membranes | 1975 |
Evidence for several demethylase enzymes in the oxidation of dimethylnitrosamine and phenylmethylnitrosamine by rat liver fractions.
Topics: Animals; Deuterium; Dimethylnitrosamine; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Subcellular Fractions | 1979 |
Microsomal biophenyl hydroxylation: the effect of selective deuterium substitution on the rate of formation of the monohydroxybiphenyls [proceedings].
Topics: Animals; Biphenyl Compounds; Deuterium; Hydroxylation; Isotope Labeling; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity | 1979 |
Deuterium isotope effect in bioactivation and hepatotoxicity of chloroform.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cysteine; Cytochrome P-450 Enzyme System; Deuterium; Male; Microsomes, Liver; Phenobarbital; Rats; Thiazoles | 1978 |
Production in vitro of paracetamol from phenacetin and [2H]acetanilide: a study with stable isotopes [proceedings].
Topics: Acetaminophen; Acetanilides; Animals; Deuterium; Isotope Labeling; Liver; Male; Phenacetin; Phenobarbital; Rats | 1977 |
Isotope effects in enzymatic N-demethylation of tertiary amines.
Topics: Amines; Animals; Dealkylation; Deuterium; Isomerism; Kinetics; Liver; Male; Mass Spectrometry; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Structure-Activity Relationship | 1975 |
Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to arene oxide pathway.
Topics: Animals; Deuterium; Enzyme Induction; Isotope Labeling; Kinetics; Liver; Mass Spectrometry; Methylcholanthrene; Oxygenases; Phenobarbital; Phenols; Rats; Structure-Activity Relationship | 1975 |
Synthesis of millimole amounts of 14C- and 2D-labelled primidone, phenylethylmalonamide and phenobarbital for high-sensitivity detection in biological materials.
Topics: Biodegradation, Environmental; Body Fluids; Carbon Radioisotopes; Chromatography, Thin Layer; Countercurrent Distribution; Deuterium; Humans; Isotope Labeling; Malonates; Mass Spectrometry; Microchemistry; Phenobarbital; Phenylethylmalonamide; Primidone | 1975 |
Deuterium isotope effects as a tool in the study of ethanol oxidation in rat liver microsomes.
Topics: Acetone; Amides; Animals; Azides; Carbon Radioisotopes; Deuterium; Ethanol; Female; Hydrogen Peroxide; Kinetics; Microsomes, Liver; Oxidation-Reduction; Pentetic Acid; Phenobarbital; Rats; Rats, Inbred Strains; Superoxides; Thiourea | 1989 |
Pharmacokinetic equivalence of 5(ethyl(2H)5)- and unlabelled phenobarbitone.
Topics: Adult; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Indicators and Reagents; Male; Phenobarbital; Protein Binding; Serum Albumin | 1989 |
Deuterium isotope effects on ethanol oxidation in perfused rat liver and in rats and rabbits in vivo: application to determine the contribution of various pathways.
Topics: Acetaldehyde; Acetone; Amides; Anesthesia; Animals; Deuterium; Ethanol; Female; Kinetics; Liver; Microsomes, Liver; Oxidation-Reduction; Oxygen; Perfusion; Phenobarbital; Rabbits; Rats | 1989 |
Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
Topics: Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Fatty Acids, Monounsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Phenytoin; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Valproic Acid | 1988 |
Study of isotope effects on protein binding by gas chromatography/mass spectrometry of theophylline-phenobarbitone and 2H, 13C, 15N isotopomers.
Topics: Carbon Isotopes; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Isotopes; Nitrogen Isotopes; Phenobarbital; Protein Binding; Serum Albumin; Theophylline | 1988 |
Study of deutero-isotopomer-induced inhibition of caffeine and phenobarbitone binding to human serum albumin.
Topics: Binding Sites; Caffeine; Deuterium; Humans; Phenobarbital; Protein Binding; Serum Albumin | 1988 |
Simultaneous quantitation of phenobarbitone and p-hydroxyphenobarbitone and their perdeuteroethyl analogues in biological fluids by combined gas chromatography-mass spectrometry.
Topics: Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Phenobarbital | 1987 |
Selective binding of barbital to the adenine moieties of FAD and NAD.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Barbiturates; Chemical Phenomena; Chemistry; Deuterium; Dimethyl Sulfoxide; Flavin-Adenine Dinucleotide; Fluorometry; Infrared Rays; Magnetic Resonance Spectroscopy; Methylation; Models, Chemical; NAD; Optical Rotatory Dispersion; Phenobarbital; Spectrophotometry; Ultraviolet Rays | 1970 |
Studies on the metabolism of steroid hormones. Part II. Reversible steroid-protein interactions via enol intermediates.
Topics: Animals; Binding Sites; Deuterium; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Receptors, Cell Surface; Steroid Hydroxylases; Testosterone | 1974 |
Observations on the mechanism of hydroxylation of cyclophosphamide by rat liver microsomes: the metabolism of cyclophosphamide-4-d2.
Topics: Animals; Chromatography, Thin Layer; Cyclophosphamide; Deuterium; Female; Hydroxylation; Male; Mass Spectrometry; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Neoplasms, Experimental; Phenobarbital; Phosphorus Radioisotopes; Rats; Time Factors | 1974 |
Formation of phenols from aromatic substrates by plant and animal mono-oxygenases: the effect of adjacent deuteriums on the magnitude of the NIH shift of tritium.
Topics: Acetanilides; Animals; Anisoles; Carbon Isotopes; Cinnamates; Deuterium; Hydroxylation; In Vitro Techniques; Male; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Phenols; Phenylalanine; Plant Cells; Plants; Proteins; Rats; Tritium | 1973 |
In vitro metabolic studies on propyl p-nitrophenyl ether.
Topics: 1-Propanol; Animals; Carbon Isotopes; Deuterium; Enzyme Induction; Ethers; Guinea Pigs; In Vitro Techniques; Male; Metabolism; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Propionates; Rats | 1971 |
The migration of deuterium during aryl hydroxylation. II. Effect of induction of microsomal hydroxylases with phenobarbital or polycyclic aromatic hydrocarbons.
Topics: Acetanilides; Acetone; Animals; Benzopyrenes; Cats; Cricetinae; Depression, Chemical; Deuterium; Enzyme Induction; Female; Genetics; Guinea Pigs; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Mice; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Tritium | 1969 |
Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats.
Topics: Anesthesia; Animals; Deuterium; Enzyme Induction; Fluorides; Kidney; Kidney Diseases; Male; Methoxyflurane; Phenobarbital; Rats; Rats, Inbred F344 | 1982 |
Evidence against an abstraction or direct insertion mechanism for cytochrome P-450 catalysed meta hydroxylations.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Warfarin | 1982 |
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.
Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes | 1981 |
Investigation of the mechanism of defluorination of enflurane in rat liver microsomes with specifically deuterated derivatives.
Topics: Animals; Biotransformation; Deuterium; Enflurane; In Vitro Techniques; Isoniazid; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1980 |
Mechanism of the microsomal reduction of carbon tetrachloride and halothane.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Tetrachloride; Chloroform; Deuterium; Gas Chromatography-Mass Spectrometry; Halothane; Hydrogen; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Rate parameter changes by added albumin in the microsomal oxidative demethylation of deuteriated and non-deuteriated 4-methoxyanisole.
Topics: Animals; Anisoles; Cytochrome P-450 Enzyme System; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Male; Methylation; Microsomes, Liver; Models, Chemical; Oxidation-Reduction; Phenobarbital; Rats; Rats, Wistar; Serum Albumin, Bovine; Substrate Specificity | 1996 |