deuterium has been researched along with nadp in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (51.75) | 18.7374 |
| 1990's | 28 (19.58) | 18.2507 |
| 2000's | 29 (20.28) | 29.6817 |
| 2010's | 10 (6.99) | 24.3611 |
| 2020's | 2 (1.40) | 2.80 |
| Authors | Studies |
|---|---|
| Curry, RA; Ting, IP | 1 |
| Corrall, RJ; Feldman, HB; Havre, P; Klein, PD; Landau, BR; Rodman, HM; Rosner, BA; Szczepanik, PA; Yu, LC | 1 |
| Kasama, T; Kawaguchi, A; Okuda, S; Seyama, Y; Yamakawa, T | 2 |
| Bodaness, RS; Chan, PC | 1 |
| Arai, K; Kasama, T; Kawaguchi, A; Okuda, S; Sasaki, K; Seyama, Y; Yamakawa, T | 1 |
| Davey, JF; Gibson, DT; Jeffrey, AM; Jerina, DM; Patel, TR; Yeh, HJ | 1 |
| Fukuyama, H; Nakano, M; Noguchi, T; Sato, M; Sugioka, K | 1 |
| Al-Gailany, KA; Bridges, JW; Netter, KJ | 1 |
| Engel, LL; Groman, EV; Schultz, RM | 1 |
| Colen, AH; Fisher, HF; Wilkinson, RR | 1 |
| Benkovic, SJ; Falzone, CJ; Li, L; Wright, PE | 1 |
| Blanchard, JS; Bradley, M; Leichus, BN; Nadeau, K; Walsh, CT | 1 |
| Bhatnagar, A; Das, B; Liu, SQ; Srivastava, SK | 1 |
| Podschun, B | 1 |
| Brown, KA; Farnum, MF; Howell, EE; Kraut, J; Warren, MS | 1 |
| Cleland, WW; Cook, PF; Gavva, SR; Harris, BG; Urbauer, JL; Weiss, PM | 1 |
| Ballou, DP; Blanchard, JS; Vanoni, MA; Wong, KK | 1 |
| Appleman, JR; Beard, WA; Blakley, RL; Delcamp, TJ; Freisheim, JH | 1 |
| Esaki, N; Nakajima, N; Nakamura, K; Soda, K; Tanaka, H | 1 |
| Buckmann, AF; Carrea, G; Danieli, B; Ottolina, G; Riva, S | 1 |
| Kurebayashi, H | 1 |
| Chandrasurin, P; Cichetti, JA; Nichol, CA; Smith, GK | 1 |
| Morrison, JF; Stone, SR | 2 |
| Lambeir, AM; Lindskog, S; Sahlman, L | 1 |
| Blanchard, JS; Stoll, VS | 1 |
| Chen, CY; Cleland, WW; Cook, PF; Weiss, PM | 1 |
| Benkovic, SJ; Chen, JT; Taira, K; Tu, CP | 1 |
| Bohren, KM; von Wartburg, JP; Wermuth, B | 1 |
| Saitoh, T; Takeshita, M; Yoshida, S | 1 |
| Fisher, RR; Kaplan, NO | 1 |
| Björkhem, I; Holmberg, I | 1 |
| Garattini, S; Guaitani, A; Marcucci, F; Martelli, P; Mussini, E | 1 |
| Hipps, PP; Holland, WH; Sehgal, RK; Sherman, WR | 1 |
| Björkhem, I; Gustafsson, J | 1 |
| Grisebach, H; Matern, U; Ortmann, R; Paulsen, H; Sinnwell, V; Stadler, P | 1 |
| Levy, HR; Nevaldine, BH | 1 |
| Bjur, R; Burgen, AS; Dann, JG; Feeney, J; Roberts, GC; Yuferov, V | 1 |
| Därr, W; Stoffel, W | 1 |
| Colman, RF; Durbano, M; Ramachandran, N | 1 |
| Engel, LL; Orr, JC; Sanyal, MK | 1 |
| Braselton, WE; Engel, LL; Orr, JC | 1 |
| Cronholm, T; Matern, H; Matern, S; Sjövall, J | 1 |
| Zakrzewski, S | 1 |
| Glaser, L; Melo, A | 1 |
| Chu, R; Colman, RF | 1 |
| Engel, LL; Karavolas, HJ; Orr, JC | 1 |
| Marver, HS; Schmid, R; Tenhunen, R | 1 |
| Ehrenberg, A; Eriksson, LE; Hyde, JS | 2 |
| Holtzman, JL | 2 |
| Bates, DJ; Frieden, C; Goldin, BR | 1 |
| Carr, ML; Holtzman, JL | 2 |
| Bard, JR; Fisher, HF; Prough, RA | 1 |
| Parker, FS; Stryker, MH | 1 |
| Chung, AE; Franzen, JS | 1 |
| Schulz, H; Wakil, SJ | 1 |
| Björkhem, I; Eriksson, H; Gustafsson, JA | 1 |
| Polito, AJ; Sweeley, CC | 1 |
| Bechara, EJ; Cilento, G | 1 |
| Edmond, J; Popják, G; Williams, VP; Wong, SM | 1 |
| Pastore, EJ | 2 |
| Cabrini, RL; Itoiz, ME; Klein-Szanto, AJ; Mayo, J; Smolko, EE | 1 |
| Cronholm, T; Makino, I; Sjövall, J | 1 |
| Clifford, KH; Cornforth, JW; Donninger, C; Mallaby, R | 1 |
| Dornand, J; Mani, JC; Mousseron-Canet, M; Vial-Reveillon, F | 1 |
| Björkhem, I | 1 |
| Cook, PF | 1 |
| Cleland, WW; Hermes, JD; Rendina, AR | 1 |
| Kawaguchi, A; Takeshita, M; Yoshida, S | 1 |
| Kawaguchi, A; Mizugaki, M; Nishimaki, T; Okuda, S; Shiraishi, T; Yamanaka, H | 1 |
| Kawaguchi, A; Okuda, S; Saito, K; Seyama, Y; Yamakawa, T | 1 |
| Ballou, DP; Ryerson, CC; Walsh, C | 1 |
| Damgaard, SE | 1 |
| Cleland, WW; Hermes, JD; O'Leary, MH; Roeske, CA | 1 |
| Barski, OA; Bohren, KM; Gabbay, KH; Grimshaw, CE | 1 |
| Chakraborty, S; Massey, V; Vaz, AD | 1 |
| Gready, JE; Jeong, SS | 2 |
| Bhatnagar, A; Chakrabarti, B; Liu, SQ; Srivastava, SK; Ueno, N | 1 |
| Perham, RN; Rescigno, M | 1 |
| Porter, DJ; Spector, T | 1 |
| Cook, PF; Jahnke, K; Podschun, B; Schnackerz, KD | 1 |
| Grimshaw, CE; Lai, CJ | 1 |
| Gelbaum, L; Howell, EE; Huang, FY; Huang, TH; Lin, TH; Yang, QX | 1 |
| Chiang, EW; Coon, MJ; Raner, GM; Vaz, AD | 1 |
| Constantine, KL; Farmer, BT; Friedrichs, MS; Goldfarb, V; Malley, MF; Metzler, WJ; Mueller, L; Robertson, JG; Wittekind, M; Yanchunas, J | 1 |
| Edo, K; Hishinuma, T; Kayaba-Nakazawa, M; Miura, K; Mizugaki, M; Tomioka, Y; Yamamoto, H | 1 |
| Angeletti, RH; Blanchard, JS; Scapin, G; Wang, F | 1 |
| Berdis, AJ; Cleland, WW; Cook, PF; Hwang, CC; Karsten, WE | 1 |
| Blanchard, JS; Marcinkeviciene, J; Wang, PF; Williams, CH | 1 |
| Bizouarn, T; Fjellström, O; Jackson, JB; Rydström, J; Venning, JD; Zhang, JW | 1 |
| Bradshaw, DE; Cleland, WW; Urbauer, JL | 1 |
| Castagnoli, K; Castagnoli, N; Franot, C; Kuttab, S; Mabic, S; Zhao, Z | 1 |
| Han, CH; Lambeth, JD; Motalebi, S; Nisimoto, Y | 1 |
| Kulbe, KD; Nidetzky, B; Slatner, M | 1 |
| Lei, B; Tu, SC; Wang, H | 1 |
| Buckman, J; Miller, SM | 2 |
| Guengerich, FP; Miller, GP; Yun, CH | 1 |
| Ishikawa, Y; Oda, S; Ohno, A; Yamazaki, N | 1 |
| Barber, MJ; Pollock, VV | 1 |
| Blanchard, JS; Patel, MP | 1 |
| Cane, DE; Gokhale, R; Khosla, C; Yin, Y | 1 |
| Anderson, VE; Fillgrove, KL | 1 |
| Hinck, AP; Miller, RT | 1 |
| Britton, G; Hornero-Méndez, D | 1 |
| Boitano, AE; Jones, JP; Rock, DA; Wahlstrom, JL | 1 |
| Brühlmann, F; Hauck, T; Landmann, C; Raab, T; Schwab, W | 1 |
| Farrés, J; Fita, I; Ochoa, WF; Parés, X; Rosell, A; Valencia, E | 1 |
| BLAKLEY, RL; RAMASASTRI, BV | 1 |
| ENGEL, LL; VELLE, W | 1 |
| Blanchard, JS; Zheng, R | 1 |
| Gao, J; Garcia-Viloca, M; Truhlar, DG | 1 |
| Dyson, HJ; Schnell, JR; Wright, PE | 1 |
| Dick, RA; Kensler, TW | 1 |
| van der Donk, WA; Woodyer, R; Zhao, H | 1 |
| Birdsall, B; Feeney, J; Polshakov, VI | 1 |
| Blakeley, MP; Hazemann, I; Meilleur, F; Mitschler, A; Myles, DA; Podjarny, A | 1 |
| Eisenreich, W; Fronza, G; Fuganti, C; Remaud, G; Robins, RJ; Schmidt, HL; Werner, RA | 1 |
| Basso, LA; de Souza, ON; Fernandes, CL; Fonseca, IO; Santos, DS; Silva, RG | 1 |
| Goto, Y; Hase, T; Hoshino, M; Ikegami, T; Lee, YH; Maeda, M; Sakurai, K; Takahashi, S; Tamura, K | 1 |
| Ahn, T; Chae, HZ; Guengerich, FP; Isin, EM; Kim, DH; Kim, KH; Yun, CH | 1 |
| Basso, LA; Rosado, LA; Santos, DS; Silva, RG | 1 |
| Case, DA; Romesberg, FE; Thielges, MC | 1 |
| Barski, OA; Bhatnagar, A; Srivastava, S; Tipparaju, SM | 1 |
| Gillespie, AL; Sessions, AL; Zhang, X | 1 |
| Calcutt, MW; Chowdhury, G; Guengerich, FP | 1 |
| Koketsu, K; Oguri, H; Oikawa, H; Suda, H; Watanabe, K | 1 |
| Blanchard, JS; Czekster, CM; Vandemeulebroucke, A | 1 |
| Dansette, PM; Defoy, D; Klarskov, K; Neugebauer, W; Wagner, JR | 1 |
| Chung, HW; Tu, SC | 1 |
| Dai, Z; Fang, W; Fu, H; He, Z; Huang, G; Li, B; Qin, D; Tian, L; Wang, H; Yang, H; Zhang, X; Zhu, B | 1 |
| Cane, DE; Garg, A; Keatinge-Clay, A; Khosla, C; Xie, X | 1 |
| Chivall, D; Damsté, JS; Heinzelmann, SM; M'Boule, D; Schouten, S; Sinke-Schoen, D; van der Meer, MT; Villanueva, L | 1 |
| Delrossi, M; Keul, ND; LaMattina, JW; Lanzilotta, WN; Neelam, AR; Nix, DB; Uy, KG | 1 |
| Chen, L; Liu, L; Rabinowitz, JD; Su, X; Zhang, Z | 1 |
| Lim, EW; Metallo, CM; Parker, SJ | 1 |
| Albekioni, E; Avellaneda Matteo, D; Caliger, D; Coleman, NJ; Komives, EA; Sabo, KA; Silletti, S; Sohl, CD; Thornberg, E | 1 |
143 other study(ies) available for deuterium and nadp
| Article | Year |
|---|---|
Purification, properties, and kinetic observations on the isoenzymes of NADP isocitrate dehydrogenase of maize.
Topics: Deuterium; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isoenzymes; Kinetics; Mitochondria; Molecular Weight; NADP; Plants; Zea mays | 1976 |
Stereospecificity of the hydrogen transfer catalyzed by human placental aldose reductase.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Deuterium; Female; Glucosephosphate Dehydrogenase; Humans; Isocitrate Dehydrogenase; Isotope Labeling; Mass Spectrometry; NADP; Placenta; Pregnancy; Sorbitol; Structure-Activity Relationship | 1977 |
Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes.
Topics: Acetyl Coenzyme A; Brevibacterium; Coenzyme A; Deuterium; Fatty Acid Synthases; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hydrogen; Malonates; NAD; NADP; Stereoisomerism; Water | 1977 |
Singlet oxygen as a mediator in the hematoporphyrin-catalyzed photooxidation of NADPH to NADP+ in deuterium oxide.
Topics: Aerobiosis; Anaerobiosis; Catalase; Chemical Phenomena; Chemistry; Deuterium; Hematoporphyrins; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; NADP; Oxidation-Reduction; Oxygen | 1977 |
Identification of sources of hydrogen atoms in fatty acids synthesized using deuterated water and stereospecifically deuterium labelled NADPH by gas chromatographic mass spectrometric analysis.
Topics: Alcohol Oxidoreductases; Animals; Chemical Phenomena; Chemistry; Chromatography, Gas; Cysteamine; Deuterium; Fatty Acid Desaturases; Fatty Acid Synthases; Fatty Acids; Hydrogen; In Vitro Techniques; Keto Acids; Liver; Mass Spectrometry; Molecular Conformation; NADP; Rats; Substrate Specificity | 1978 |
Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes.
Topics: Brevibacterium; Deuterium; Fatty Acid Synthases; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; NADP; Stereoisomerism | 1978 |
Initial reactions in the oxidation of naphthalene by Pseudomonas putida.
Topics: Culture Media; Deuterium; Kinetics; NAD; NADP; Naphthalenes; Oxidation-Reduction; Oxygen Consumption; Oxygenases; Pseudomonas; Stereoisomerism | 1975 |
Spectroscopic evidence for the generation of singlet oxygen in the reduced nicotinamide adenine dinucleotide phosphate-dependent microsomal lipid peroxidation system.
Topics: Adenosine Diphosphate; Animals; Deuterium; Iron; Lipid Metabolism; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Rats; Spectrum Analysis; Superoxide Dismutase | 1975 |
The dealkylation of some rho-nitrophenylalkylethers and their alpha-deuterated analogues by rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Deuterium; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Nitrobenzenes; Phenyl Ethers; Rats | 1975 |
Catalytic competence, a new criterion for affinity labeling. Demonstration of the reversible enzymatic interconversion of estrone and estradiol-17 beta covalently bound to human placental estradiol-17 beta dehydrogenase.
Topics: Affinity Labels; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Deuterium; Electrophoresis, Polyacrylamide Gel; Estradiol; Estradiol Dehydrogenases; Estrone; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Mercuribenzoates; NAD; NADP; Placenta; Stereoisomerism; Tritium | 1975 |
Location of deuterium oxide solvent isotope effects in the glutamate dehydrogenase reaction.
Topics: Deuterium; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; NADP | 1975 |
Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization.
Topics: Amino Acid Sequence; Base Sequence; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Mutagenesis, Insertional; NADP; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1992 |
Kinetic isotope effect analysis of the reaction catalyzed by Trypanosoma congolense trypanothione reductase.
Topics: Animals; Deuterium; Hydrogen-Ion Concentration; Kinetics; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Recombinant Proteins; Solvents; Tritium; Trypanosoma congolense | 1992 |
Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters.
Topics: Adenosine Diphosphate Ribose; Alcohol Dehydrogenase; Alcohols; Aldehydes; Binding, Competitive; Deuterium; Glucuronates; Glucuronic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; NADP; Oxidation-Reduction; Protons; Sugar Acids; Vitamin K | 1991 |
Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver.
Topics: Animals; Cytosol; Deuterium; Dihydrouracil Dehydrogenase (NADP); Kinetics; Liver; Magnetic Resonance Spectroscopy; Molecular Structure; NADP; Oxidation-Reduction; Oxidoreductases; Radioisotope Dilution Technique; Stereoisomerism; Swine; Uracil | 1992 |
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Coenzymes; Deuterium; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tryptophan | 1991 |
Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Topics: Animals; Ascaris; Carbon Isotopes; Chickens; Decarboxylation; Deuterium; Kinetics; Liver; Malate Dehydrogenase; Malates; NAD; NADP; Oxidation-Reduction; Substrate Specificity | 1991 |
Glutathione reductase: comparison of steady-state and rapid reaction primary kinetic isotope effects exhibited by the yeast, spinach, and Escherichia coli enzymes.
Topics: Deuterium; Escherichia coli; Glutathione Reductase; Kinetics; NAD; NADP; Plants; Substrate Specificity; Tritium; Yeasts | 1990 |
Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes.
Topics: Animals; Binding Sites; Catalysis; Cattle; Chickens; Deuterium; Electron Transport; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Mice; NADP; Tetrahydrofolate Dehydrogenase | 1989 |
Enzymatic in situ analysis by 1H-NMR of the hydrogen transfer stereospecificity of NAD(P)+-dependent dehydrogenases.
Topics: Amino Acid Isomerases; Deuterium; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Hydrogen; Magnetic Resonance Spectroscopy; NADH, NADPH Oxidoreductases; NADP; NADPH Dehydrogenase; Stereoisomerism | 1989 |
Enzymatic synthesis of [4R-2H]NAD (P)H and [4S-2H]NAD(P)H and determination of the stereospecificity of 7 alpha- and 12 alpha hydroxysteroid dehydrogenase.
Topics: Clostridium; Deuterium; Escherichia coli; Hydroxysteroid Dehydrogenases; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; NADP; Stereoisomerism; Substrate Specificity | 1989 |
Kinetic deuterium isotope effects on deamination and N-hydroxylation of cyclohexylamine by rabbit liver microsomes.
Topics: Animals; Carbon Monoxide; Chromatography, Gas; Cyclohexylamines; Deamination; Deuterium; Gas Chromatography-Mass Spectrometry; Hydroxylation; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Rabbits | 1989 |
The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.
Topics: Animals; Biopterins; Cattle; Deuterium; Gas Chromatography-Mass Spectrometry; Guanosine Triphosphate; Models, Chemical; NADP; Protons; Pteridines | 1985 |
Dihydrofolate reductase from Escherichia coli: the kinetic mechanism with NADPH and reduced acetylpyridine adenine dinucleotide phosphate as substrates.
Topics: Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NAD; NADP; Tetrahydrofolate Dehydrogenase; Viscosity | 1988 |
Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate.
Topics: Aspartic Acid; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NADP; Solvents; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1988 |
Rapid-scan stopped-flow studies of the pH dependence of the reaction between mercuric reductase and NADPH.
Topics: Anaerobiosis; Chromatography, Gel; Computers; Deuterium; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; NADP; Oxidoreductases; Pseudomonas aeruginosa; Spectrophotometry; Sulfhydryl Compounds | 1986 |
Kinetic mechanism and nucleotide specificity of NADH peroxidase.
Topics: Binding, Competitive; Deuterium; Enterococcus faecalis; Kinetics; Molecular Conformation; NAD; NADP; Nucleotides; Peroxidases; Substrate Specificity; Tritium | 1988 |
Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Topics: Alanine Dehydrogenase; Amino Acid Oxidoreductases; Animals; Bacillus subtilis; Cattle; Deuterium; Glutamate Dehydrogenase; Isotope Labeling; Kinetics; Liver; Mathematics; Models, Theoretical; NAD; NADP; Nitrogen Isotopes; Substrate Specificity; Tritium | 1988 |
Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Amino Acids; Binding Sites; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Mutation; NADP; Phenylalanine; Plasmids; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tyrosine; Valine | 1987 |
Kinetics of carbonyl reductase from human brain.
Topics: Alcohol Oxidoreductases; Brain; Deuterium; Humans; Kinetics; NADP; Oxidation-Reduction; Spectrometry, Fluorescence; Vitamin K | 1987 |
Hydrogen transfer by NADPH-dependent reductases in elongation of very-long-chain saturated and polyunsaturated fatty-acyl-CoA in swine cerebral microsomes.
Topics: Acyl Coenzyme A; Animals; Brain; Deuterium; Fatty Acid Desaturases; Gas Chromatography-Mass Spectrometry; Microsomes; NADP; Palmitoyl Coenzyme A; Sulfites; Swine | 1988 |
Studies on the mitochondrial energy-linked pyridine nucleotide transhydrogenase.
Topics: Aniline Compounds; Animals; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Magnesium Sulfate; Mitochondria, Muscle; Myocardium; NAD; NADH, NADPH Oxidoreductases; NADP; Naphthalenes; Niacinamide; Oxidoreductases; Spectrophotometry; Structure-Activity Relationship; Succinates; Sulfonic Acids; Tritium | 1973 |
Mechanism of enzymatic reduction of steroid double bonds.
Topics: Animals; Cholesterol; Deuterium; Ketosteroids; Kinetics; Male; Microsomes, Liver; NADP; Oxidoreductases; Progesterone; Rats; Subcellular Fractions; Tritium | 1973 |
Metabolism and anticonvulsant activity of deuterated N-demethyldiazepam.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dealkylation; Deuterium; Diazepam; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mice; Microsomes, Liver; NADP; Pentylenetetrazole; Structure-Activity Relationship; Time Factors | 1973 |
Identification and partial characterization of inositol: NAD+ epimerase and inosose: NAD(P)H reductase from the fat body of the American cockroach, Periplaneta americana L.
Topics: Adipose Tissue; Alcohol Oxidoreductases; Animals; Binding Sites; Chromatography, Gas; Cockroaches; Deuterium; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hemolymph; Hydrogen-Ion Concentration; Inositol; Isomerism; Ketones; Kinetics; NAD; NADP; Optical Rotation; Oxidation-Reduction; Protein Binding; Structure-Activity Relationship | 1973 |
Mitochondrial omega-hydroxylation of cholesterol side chain.
Topics: Animals; Calcium; Carbon Radioisotopes; Cholestenes; Cholesterol; Citrates; Deuterium; Hydroxylation; Hydroxymercuribenzoates; Hydroxysteroids; Isocitrates; Liver; Magnesium; Male; Metals; Mitochondria, Liver; NAD; NADP; Oxygen; Oxygen Isotopes; Rats; Steroid Hydroxylases | 1974 |
NADPH-dependent formation of thymidine diphosphodihydrostreptose from thymidine diphospho-D-glucose in a cell-free system from Streptomyces griseus and its correlation with streptomycin biosynthesis.
Topics: Amidinotransferases; Arginine; Carbon Radioisotopes; Cell-Free System; Chloromercuribenzoates; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Deoxy Sugars; Deuterium; Drug Stability; Electrophoresis, Paper; Glucose; Hexoses; Magnetic Resonance Spectroscopy; NADP; Nucleoside Diphosphate Sugars; Optical Rotation; Oxidation-Reduction; Rhamnose; Streptomyces griseus; Streptomycin; Thymine Nucleotides; Time Factors | 1974 |
The effects of 2H2O on mammary glucose-6-phosphate dehydrogenase.
Topics: Animals; Deuterium; Female; Glucosephosphate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Macromolecular Substances; Mammary Glands, Animal; Molecular Weight; NAD; NADP; Protein Conformation; Rats | 1974 |
Nuclear magnetic resonance studies of the binding of substrate analogs and coenzyme to dihydrofolate reductase from Lactobacillus casei.
Topics: Benzyl Compounds; Binding Sites; Deuterium; Glutamates; Hydrogen-Ion Concentration; Isomerism; Kinetics; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Mathematics; NADP; Nitro Compounds; Oxidation-Reduction; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
2-alkenal reductase isolation, properties and specificities.
Topics: Alcohol Oxidoreductases; Alkenes; Ammonium Sulfate; Animals; Brain; Chromatography, Gas; Cytosol; Deuterium; Dialysis; Kidney; Kinetics; Liver; Lung; Mass Spectrometry; Myocardium; NADP; Oxidoreductases; Rats; Spectrophotometry; Spleen; Stereoisomerism; Sulfhydryl Reagents | 1974 |
Kinetic isotope effects in the NAD- and NADP-specific isocitrate dehydrogenases of pig heart.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Deuterium; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Isoenzymes; Kinetics; Myocardium; NAD; NADP; Swine | 1974 |
The reversible reduction of testosterone to androst-4-ene-3alpha, 17beta-diol by a soluble enzyme of rat liver.
Topics: Androstanes; Androstenediols; Animals; Chromatography, Gas; Chromatography, Thin Layer; Cytosol; Deuterium; Hydroxysteroid Dehydrogenases; Liver; Male; Mass Spectrometry; NADP; Oxidation-Reduction; Rats; Testosterone | 1974 |
The flux of intermediates and products in aromatizaton of C19 steroids by human placental microsomes.
Topics: Androstenedione; Androstenols; Biotransformation; Carbon Radioisotopes; Deuterium; Estradiol; Estrone; Female; Humans; Hydroxysteroid Dehydrogenases; Microsomes; NADP; Placenta; Pregnancy; Temperature; Testosterone; Time Factors | 1974 |
Transfer of deuterium from (1-2H2) ethanol to Krebs cycle and related acids of rat liver in vivo.
Topics: Animals; Chromatography, Gas; Citrates; Citric Acid Cycle; Cytosol; Deuterium; Ethanol; Fumarates; Hydroxybutyrates; Isocitrates; Isotope Labeling; Lactates; Liver; Malates; Male; Mass Spectrometry; Mitochondria, Liver; NAD; NADP; Rats; Succinates | 1974 |
On the mechanism of chemical and enzymatic reduction of folate and dihydrofolate.
Topics: Chemical Phenomena; Chemistry; Deuterium; Folic Acid; NADP; Pteridines; Tetrahydrofolate Dehydrogenase; Tritium | 1966 |
The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose.
Topics: Chromatography, Gel; Deuterium; Hexoses; Hot Temperature; Hydrogen; NADP; Nucleotides; Pseudomonas aeruginosa; Rhamnose; Spectrum Analysis; Thymidine; Tritium | 1968 |
Deuterium solvent isotope effects in reactions catalyzed.
Topics: Animals; Chemical Phenomena; Chemistry; Deuterium; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Kinetics; Myocardium; NADP; Protons; Succinates; Swine; Water | 1969 |
Human placental 17 beta-estradiol dehydrogenase. IV. Differentiation of 17 beta-estradiol-activated transhydrogenase from the transhydrogenase function of 17 beta-estradiol dehydrogenase.
Topics: Chemical Phenomena; Chemistry; Chromatography; Countercurrent Distribution; Deuterium; Diethylstilbestrol; Drug Stability; Estradiol; Estranes; Estrone; Female; Humans; Hydroxyapatites; Hydroxysteroid Dehydrogenases; Methods; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Placenta; Pregnancy; Temperature; Tritium | 1969 |
Microsomal heme oxygenase. Characterization of the enzyme.
Topics: Animals; Azides; Benzoates; Bilirubin; Brain; Carbon Monoxide; Cyanides; Depression, Chemical; Detergents; Deuterium; Heme; Hemoglobins; In Vitro Techniques; Kidney; Kinetics; Lipase; Lung; Male; Mercury; Methods; Microsomes; Microsomes, Liver; Myoglobin; NADP; Oxygen Consumption; Oxygenases; Phospholipases; Porphyrins; Rats; Spleen; Time Factors; Trypsin | 1969 |
Electron-nuclear double resonance from flavin radicals in liquid and polycrystalline phase and conjugated to protein.
Topics: Binding Sites; Cadmium; Chelating Agents; Crystallization; Deuterium; Dimethylformamide; Electron Spin Resonance Spectroscopy; Flavin Mononucleotide; Flavins; Free Radicals; Methods; NADP; Oxidoreductases; Pigments, Biological; Proteins; Riboflavin; Saccharomyces; Temperature; Zinc | 1969 |
Effect of 4,4-dideuteration of reduced nicotinamide-adenine dinucleotide phosphate on the mixed function oxidases of hepatic microsomes.
Topics: Adenine Nucleotides; Aniline Compounds; Animals; Carbon Monoxide; Deuterium; Electron Transport; Electron Transport Complex IV; Glucosephosphate Dehydrogenase; Hexokinase; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidoreductases; Oxygen Consumption; Rats | 1970 |
A new reaction of glutamate dehydrogenase: the enzyme-catalyzed formation of trinitrobenzene from TNBS in the presence of reduced coenzyme.
Topics: Amino Acids; Animals; Cattle; Coenzymes; Deuterium; Glutamate Dehydrogenase; Ketoglutaric Acids; NAD; NADP; Nitrobenzenes; Solvents; Sulfites; Yeasts | 1970 |
Inhibition of hepatic microsomal mixed function oxidases by D2O.
Topics: Animals; Deuterium; Hydrogen-Ion Concentration; Hydrolases; In Vitro Techniques; Male; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Rats; Transferases | 1970 |
Transient-state intermediates involved in the hydride transfer step of the glutamate dehydrogenase reaction.
Topics: Chemical Phenomena; Chemistry; Deuterium; Glutamate Dehydrogenase; Glutamates; Hydrogen; Ketoglutaric Acids; NADP; Quaternary Ammonium Compounds; Spectrophotometry | 1970 |
A hydrogen--deuterium exchange study of the conformation of bovine liver glutamate dehydrogenase.
Topics: Adenine Nucleotides; Animals; Cattle; Chemical Phenomena; Chemistry; Deuterium; Diethylstilbestrol; Glutamate Dehydrogenase; Glutamates; Guanine Nucleotides; Hydrogen; Infrared Rays; Leucine; Liver; Methionine; NAD; NADP; Spectrophotometry | 1970 |
The effect of 4,4-dideuteration of nicotinamide adenine dinucleotide phosphate on steroid hydroxylation.
Topics: Deuterium; Electron Transport; Mixed Function Oxygenases; NADP; Steroids | 1970 |
Comparative electron-nuclear double resonance study of two flavoproteins.
Topics: Azotobacter; Bacterial Proteins; Chemical Phenomena; Chemistry; Deuterium; Flavin Mononucleotide; Flavins; Magnetic Resonance Spectroscopy; NADP; Oxidoreductases | 1970 |
Oxidized triphosphopyridine nucleotide specific isocitrate dehydrogenase from Azotobacter vinelandii. 3. The path of hydrogen in the enzymatic reaction.
Topics: Azotobacter; Chemical Phenomena; Chemistry; Citrates; Deuterium; Hydrogen; Isocitrate Dehydrogenase; Ketoglutaric Acids; Magnesium; NADP; Optical Rotatory Dispersion; Spectrophotometry; Spectrum Analysis; Tritium | 1970 |
Studies on the mechanism of fatty acid synthesis. XXV. On the mechanism of beta-ketoacylacyl carrier protein reductase from Escherichia coli.
Topics: Acetoacetates; Amides; Bacterial Proteins; Binding Sites; Chromatography, Gel; Cysteamine; Deuterium; Electrophoresis, Disc; Escherichia coli; Fatty Acids; Hydroxybutyrates; Keto Acids; Kinetics; NADP; Oxidoreductases; Phosphates; Potassium Chloride; Protein Binding | 1971 |
Microbial formation of 17-alpha-C21 steroids. Stereochemistry of saturation of the delta-16-double bond.
Topics: Animals; Bacteria; Catalysis; Cecum; Chromatography, Gas; Deuterium; Hydrogenation; Microsomes, Liver; NADP; Pregnanes; Rats; Spectrum Analysis | 1971 |
Stereochemistry of the hydroxylation in 4-hydroxysphinganine formation and the steric course of hydrogen elimination in sphing-4-enine biosynthesis.
Topics: Adenosine Triphosphate; Alcohols; Amino Alcohols; Ascomycota; Binding Sites; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Gas; Coenzyme A; Deuterium; Lipids; Mass Spectrometry; Models, Chemical; NADP; Palmitic Acids; Sphingolipids; Stereoisomerism | 1971 |
Phosphate catalysis in the autoxidation of 1-n-propyl-6-hydroxy-1,4,5,6-tetrahydronicotinamide. A model for adenosine triphosphate formation.
Topics: Adenosine Triphosphate; Aniline Compounds; Arsenic; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Deuterium; Kinetics; NAD; NADP; Niacinamide; Organophosphorus Compounds; Oxidation-Reduction; Oxygen Consumption; Phosphates; Phosphoric Acids; Potentiometry; Pyridinium Compounds; Spectrophotometry; Ultraviolet Rays | 1971 |
Presqualene alcohol. Further evidence on the structure of a C 30 precursor of squalene.
Topics: Acetates; Acylation; Alcohols; Alkenes; Aluminum; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Cyclopropanes; Deuterium; Diphosphates; Farnesol; Hydrolysis; Infrared Rays; Lithium; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes; Microsomes, Liver; Models, Structural; NADP; Optical Rotation; Ozone; Saccharomyces; Spectrophotometry; Squalene; Stereoisomerism; Terpenes; Tritium | 1971 |
Proton magnetic resonance studies of folate and folate antagonists.
Topics: Aminopterin; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Structure-Activity Relationship; Temperature | 1971 |
Microspectrophotometric study of histoenzymic reactions in rat epidermis subjected to 0-5 Mrads of deuteron radiation.
Topics: Animals; Deuterium; Dihydrolipoamide Dehydrogenase; Glucosephosphate Dehydrogenase; Head; Histocytochemistry; L-Lactate Dehydrogenase; Methods; NADP; Oxidoreductases; Radiation Effects; Rats; Rats, Inbred Strains; Skin; Spectrophotometry; Succinate Dehydrogenase | 1970 |
Steroid metabolism in rats given (1- 2 H 2 ) ethanol. Biosynthesis of bile acids and reduction of 3-keto-5 -cholanoic acid.
Topics: Alcohol Oxidoreductases; Animals; Bile Acids and Salts; Biliary Fistula; Cholesterol; Chromatography, Gas; Deuterium; Ethanol; Fasting; Female; Glucose; Hydroxysteroid Dehydrogenases; Injections; Isomerism; Male; Mass Spectrometry; Metabolism; NAD; NADP; Oxidation-Reduction; Pyrazoles; Rats | 1972 |
Stereochemical course of decarboxylation of S-malate on malic enzyme.
Topics: Acetates; Acyltransferases; Alcohol Oxidoreductases; Animals; Carbonic Anhydrases; Chickens; Decarboxylation; Deuterium; L-Lactate Dehydrogenase; Lactates; Liver; Lyases; Malate Dehydrogenase; Malates; Methods; NADP; Optical Rotation; Pyruvate Kinase; Stereoisomerism | 1972 |
[Comparative extinction of intrinsic fluorescence of horse liver alcohol dehydrogenase (HLADH) by its reduced coenzymes and TNS].
Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Deuterium; Energy Transfer; Fluorescence; Horses; Hydrogen-Ion Concentration; Liver; NAD; NADP; Naphthalenes; Spectrum Analysis; Sulfonic Acids; Toluene | 1971 |
On the rate-limiting step in microsomal hydroxylation of steroids.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chemical Phenomena; Chemistry; Deuterium; Hydroxylation; Hydroxysteroids; Kinetics; Male; Microsomes, Liver; NADP; Pregnenolone; Rats; Sterols; Testosterone; Tritium; Water | 1972 |
Inhibition by deuterated water of the mixed-function oxidases of hepatic microsomes of the male rat.
Topics: Aniline Compounds; Animals; Benzopyrenes; Chemical Phenomena; Chemistry, Physical; Cytochrome c Group; Cytochrome P-450 Enzyme System; Deuterium; Dihydrolipoamide Dehydrogenase; Hydrogen-Ion Concentration; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Oxidoreductases, N-Demethylating; Rats; Time Factors | 1972 |
Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Topics: Adenosine Diphosphate; Animals; Binding, Competitive; Cattle; Deuterium; Dose-Response Relationship, Drug; Enzyme Activation; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Liver; NADP | 1982 |
Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase.
Topics: Carbon Isotopes; Deuterium; Hydrogen-Ion Concentration; Kinetics; NADP; Phosphogluconate Dehydrogenase; Saccharomyces cerevisiae; Tritium | 1984 |
Stereospecific incorporation of hydrogens from NADPH in elongation of very long fatty acyl-CoA by swine cerebral microsomes.
Topics: Acyl Coenzyme A; Animals; Brain; Deuterium; Gas Chromatography-Mass Spectrometry; Malonyl Coenzyme A; Microsomes; NADP; Oxidation-Reduction; Swine | 1984 |
Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli.
Topics: Deuterium; Escherichia coli; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Kinetics; Mass Spectrometry; NADP; Stereoisomerism | 1982 |
N5-Formyltetrahydrofolate (citrovorum factor) labeled stereospecifically with deuterium or tritium at carbon-6.
Topics: Chromatography, DEAE-Cellulose; Deuterium; Isotope Labeling; Leucovorin; NADP; Tritium | 1980 |
Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system.
Topics: Deuterium; Escherichia coli; Fatty Acid Synthases; Gas Chromatography-Mass Spectrometry; Glutamates; NAD; NADP; Water | 1980 |
Kinetic isotope effects in the oxidation of isotopically labeled NAD(P)H by bacterial flavoprotein monooxygenases.
Topics: 4-Hydroxybenzoate-3-Monooxygenase; Deuterium; Flavoproteins; Kinetics; Mixed Function Oxygenases; Models, Chemical; NADP; Oxidation-Reduction; Pseudomonas; Resorcinols; Tritium | 1982 |
The D(V/K) isotope effect of the cytochrome P-450-mediated oxidation of ethanol and its biological applications.
Topics: Animals; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Deuterium; Ethanol; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Propionates; Rats; Rats, Inbred Strains; Tritium | 1982 |
Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase.
Topics: Carbon Isotopes; Deuterium; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Kinetics; Malate Dehydrogenase; Malates; Mathematics; NADP; Pyridines; Thermodynamics | 1982 |
Mechanism of human aldehyde reductase: characterization of the active site pocket.
Topics: Aldehyde Reductase; Amino Acid Sequence; Base Sequence; Binding Sites; Deuterium; DNA Primers; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Protons; Recombinant Proteins; Substrate Specificity | 1995 |
Old Yellow enzyme: aromatization of cyclic enones and the mechanism of a novel dismutation reaction.
Topics: Acrolein; Aldehydes; Chromatography, High Pressure Liquid; Cyclohexanones; Deuterium; Escherichia coli; Gas Chromatography-Mass Spectrometry; Ketones; Magnetic Resonance Spectroscopy; NADP; NADPH Dehydrogenase; Oxidation-Reduction; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Tetrahydronaphthalenes | 1995 |
A method of preparation and purification of (4R)-deuterated-reduced nicotinamide adenine dinucleotide phosphate.
Topics: 1-Propanol; Alcohol Dehydrogenase; Chromatography, High Pressure Liquid; Deuterium; Isotope Labeling; Magnetic Resonance Spectroscopy; NADP; Oxidation-Reduction | 1994 |
pH dependence of enzyme reaction rates and deuterium isotope effects on the reduction of a new mechanism-based substrate by dihydrofolate reductase DHFR.
Topics: Animals; Catalysis; Chickens; Deuterium; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; NADP; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1995 |
Human placental aldose reductase: role of Cys-298 in substrate and inhibitor binding.
Topics: Aldehyde Reductase; Aldehydes; Circular Dichroism; Cysteine; Deuterium; Female; Humans; Imidazoles; Imidazolidines; Iodoacetates; Iodoacetic Acid; Kinetics; NADP; Naphthalenes; Placenta; Pregnancy; Quercetin; Spectrophotometry, Ultraviolet | 1994 |
Structure of the NADPH-binding motif of glutathione reductase: efficiency determined by evolution.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Biological Evolution; Deuterium; Enzyme Stability; Escherichia coli; Glutathione; Glutathione Disulfide; Glutathione Reductase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Oligodeoxyribonucleotides | 1994 |
Dihydropyrimidine dehydrogenase. Kinetic mechanism for reduction of uracil by NADPH.
Topics: Animals; Cattle; Deuterium; Dihydrouracil Dehydrogenase (NADP); Hydrogen-Ion Concentration; Kinetics; Liver; Mathematics; Models, Theoretical; NADP; Oxidation-Reduction; Oxidoreductases; Protein Binding; Radioisotope Dilution Technique; Spectrometry, Fluorescence; Tritium; Uracil | 1993 |
Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.
Topics: Animals; Cytosol; Deuterium; Dihydrouracil Dehydrogenase (NADP); Hydrogen-Ion Concentration; Kinetics; Liver; Magnetic Resonance Spectroscopy; Mathematics; Models, Structural; NADP; Oxidation-Reduction; Oxidoreductases; Swine | 1993 |
Oxidized aldose reductase: in vivo factor not in vitro artifact.
Topics: Aldehyde Reductase; Animals; Artifacts; Cattle; Chromatography; Chromatography, Ion Exchange; Deuterium; Durapatite; Enzyme Inhibitors; Female; Humans; Imidazoles; Imidazolidines; Isoenzymes; Kinetics; Mathematics; NADP; Oxidation-Reduction; Placenta; Pregnancy; Radioisotope Dilution Technique; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity | 1996 |
Dynamics of trimethoprim bound to dihydrofolate reductase--a deuterium NMR study.
Topics: Deuterium; Escherichia coli; Folic Acid Antagonists; Magnetic Resonance Spectroscopy; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim | 1996 |
Mechanism-based inactivation of cytochrome P450 2B4 by aldehydes: relationship to aldehyde deformylation via a peroxyhemiacetal intermediate.
Topics: Aldehydes; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Catalase; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Inhibitors; Epoxide Hydrolases; Free Radicals; Glutathione; Models, Chemical; Mutation; NADP; Steroid Hydroxylases; Superoxide Dismutase | 1997 |
Characterization of NADP+ binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes.
Topics: Amino Acid Sequence; Bacterial Proteins; Carbohydrate Dehydrogenases; Carbon Isotopes; Deuterium; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; NADP; Nitrogen Isotopes; Protein Structure, Secondary; Recombinant Proteins | 1997 |
4 Pro-R hydrogen of NADPH was abstracted for enzymatic hydride transfer by N-ethylmaleimide-reductase of Yarrowia lipolytica.
Topics: Candida; Cyclopentanes; Deuterium; Enzyme Inhibitors; Ethylmaleimide; Hydrogen; Maleimides; NADP; Oxidation-Reduction; Oxidoreductases; Pyrazoles; Stereoisomerism; Substrate Specificity | 1997 |
Substrate binding and conformational changes of Clostridium glutamicum diaminopimelate dehydrogenase revealed by hydrogen/deuterium exchange and electrospray mass spectrometry.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Chromatography, Liquid; Clostridium; Deuterium; Hydrogen; Kinetics; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; NADP; Peptide Fragments; Recombinant Proteins; Substrate Specificity | 1998 |
Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Topics: Animals; Candida; Carbon Isotopes; Decarboxylation; Deuterium; Gluconates; Kinetics; Liver; NADP; Oxidants; Oxidation-Reduction; Phosphogluconate Dehydrogenase; Sheep; Substrate Specificity | 1998 |
Thioredoxin reductase-thioredoxin fusion enzyme from Mycobacterium leprae: comparison with the separately expressed thioredoxin reductase.
Topics: Adenine Nucleotides; Alkylation; Deuterium; Dithionite; Dithionitrobenzoic Acid; Escherichia coli; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Mycobacterium leprae; NADP; Naphthoquinones; Oxidation-Reduction; Protons; Recombinant Fusion Proteins; Solvents; Thioredoxin-Disulfide Reductase; Thioredoxins; Titrimetry | 1998 |
Catalytic properties of hybrid complexes of the NAD(H)-binding and NADP(H)-binding domains of the proton-translocating transhydrogenases from Escherichia coli and Rhodospirillum rubrum.
Topics: Binding Sites; Catalysis; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; NAD; NADH, NADPH Oxidoreductases; NADP; Peptide Fragments; Protein Structure, Tertiary; Recombinant Proteins; Rhodospirillum rubrum | 1999 |
Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate.
Topics: Animals; Carbon Isotopes; Catalysis; Cattle; Chickens; Coenzymes; Decarboxylation; Deuterium; Kinetics; Malate Dehydrogenase; Malates; NAD; NADP; Oxaloacetates; Rabbits; Substrate Specificity; Swine | 1998 |
Rat liver microsomal enzyme catalyzed oxidation of 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Deuterium; Kinetics; Male; Microsomes, Liver; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; NADP; Oxidation-Reduction; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1998 |
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558).
Topics: Cytochrome b Group; Deuterium; Electrons; Enzyme Reactivators; Flavins; Kinetics; NADP; NADPH Oxidases; Phosphoproteins; Pyridines; Superoxides | 1999 |
Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens.
Topics: Animals; Binding Sites; Catalysis; Deuterium; Hydrogen-Ion Concentration; Kinetics; L-Iditol 2-Dehydrogenase; Liver; Mannitol Dehydrogenases; Models, Chemical; NAD; NADP; Pseudomonas fluorescens; Recombinant Proteins; Sheep; Stereoisomerism | 1999 |
Vibrio harveyi NADPH-FMN oxidoreductase arg203 as a critical residue for NADPH recognition and binding.
Topics: Amino Acid Sequence; Arginine; Catalysis; Deuterium; Flavin Mononucleotide; FMN Reductase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity; Vibrio | 2000 |
Transient kinetics and intermediates formed during the electron transfer reaction catalyzed by Candida albicans estrogen binding protein.
Topics: Aldehydes; Binding Sites; Candida albicans; Carrier Proteins; Deuterium; Electron Transport; Fungal Proteins; Kinetics; Models, Molecular; NADP; Oxidation-Reduction; Receptors, Estrogen; Spectrophotometry | 2000 |
Stabilization of a novel enzyme.substrate intermediate in the Y206F mutant of Candida albicans EBP1: evidence for acid catalysis.
Topics: Base Sequence; Binding Sites; Candida albicans; Carrier Proteins; Deuterium; DNA Primers; Fungal Proteins; Hydrogen-Ion Concentration; Kinetics; Ligands; Mutagenesis, Site-Directed; NADP; Phenols; Receptors, Estrogen; Recombinant Proteins | 2000 |
Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.
Topics: Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Deuterium; Enzyme Activation; Ferric Compounds; Humans; Hydrogen Peroxide; Kinetics; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Phenacetin; Recombinant Proteins; tert-Butylhydroperoxide | 2000 |
NAD(P)+-NAD(P)H models. 90. Stereoselection controlled by electronic effect of a carbonyl group in oxidation of NAD(P)H analog.
Topics: Catalysis; Deuterium; Indicators and Reagents; Magnesium; NADP; Oxidation-Reduction; Stereoisomerism | 2000 |
Kinetic and mechanistic properties of biotin sulfoxide reductase.
Topics: Bacteriological Techniques; Binding, Competitive; Chromatography, High Pressure Liquid; Coenzymes; Deuterium; Diethyl Pyrocarbonate; Enzyme Activation; Guanine Nucleotides; Kinetics; Metalloproteins; Molybdenum Cofactors; NADP; Oxidoreductases; Potassium Cyanide; Pteridines; Pterins; Recombinant Proteins; Rhodobacter sphaeroides; Substrate Specificity; Tungsten | 2001 |
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
Topics: Deuterium; Disulfides; Hydrogen-Ion Concentration; Kinetics; Mycobacterium tuberculosis; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Protons; Solvents | 2001 |
Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase.
Topics: Bacteria; Catalytic Domain; Deuterium; Erythromycin; Gas Chromatography-Mass Spectrometry; Multienzyme Complexes; NADP; Oxidation-Reduction; Protein Structure, Tertiary; Substrate Specificity | 2001 |
The mechanism of dienoyl-CoA reduction by 2,4-dienoyl-CoA reductase is stepwise: observation of a dienolate intermediate.
Topics: Acyl Coenzyme A; Animals; Deuterium; Fatty Acid Desaturases; In Vitro Techniques; Kinetics; Models, Chemical; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protons; Rats; Recombinant Proteins; Solvents; Substrate Specificity | 2001 |
Characterization of hydride transfer to flavin adenine dinucleotide in neuronal nitric oxide synthase reductase domain: geometric relationship between the nicotinamide and isoalloxazine rings.
Topics: Animals; Catalysis; Deuterium; Flavin-Adenine Dinucleotide; Flavins; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; NADP; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Osmolar Concentration; Protein Structure, Tertiary; Rats; Substrate Specificity | 2001 |
Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis.
Topics: Allosteric Regulation; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Cyclization; Deuterium; Deuterium Oxide; Hydrogen; Intramolecular Lyases; Lycopene; Mass Spectrometry; NADP; Water | 2002 |
Use of kinetic isotope effects to delineate the role of phenylalanine 87 in P450(BM-3).
Topics: Amino Acid Substitution; Bacillus megaterium; Bacterial Proteins; Biphenyl Compounds; Catalytic Domain; Cytochrome P-450 Enzyme System; Deuterium; Kinetics; Mixed Function Oxygenases; NADP; NADPH-Ferrihemoprotein Reductase; Phenylalanine; Substrate Specificity; Xylenes | 2002 |
Chemical formation of 4-hydroxy-2,5-dimethyl-3[2H]-furanone from D-fructose 1,6-diphosphate.
Topics: Deuterium; Fructosediphosphates; Furans; Hydrogen-Ion Concentration; Molecular Structure; NADP; Temperature | 2002 |
Complete reversal of coenzyme specificity by concerted mutation of three consecutive residues in alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Animals; Binding Sites; Catalysis; Computer Simulation; Deuterium; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NADP; Protein Binding; Ranidae; Time Factors | 2003 |
5,10-METHYLENETETRAHYDROFOLIC DEHYDROGENASE FROM BAKERS' YEAST. III. STEREOSPECIFICITY OF HYDROGEN TRANSFER IN THE REACTION CATALYZED BY THE ENZYME.
Topics: Chromatography; Deuterium; Glutamates; Hydrogen; NADP; Oxidoreductases; Research; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Tritium | 1964 |
ENZYMES FROM BOVINE PLACENTA AND SEMINAL VESICLES THAT OXIDIZE D(-)-1,2-PROPANEDIOL AND OTHER POLYOLS: THEIR POSSIBLE RELATION TO FRUCTOSE FORMATION.
Topics: Animals; Carbohydrate Metabolism; Cattle; Deuterium; Enzyme Inhibitors; Female; Fructose; Galactose; Glucose; Glyceraldehyde; Glycerides; Humans; Lactose; Male; NAD; NADP; Oxidoreductases; Placenta; Polymers; Pregnancy; Pregnancy, Animal; Propylene Glycol; Propylene Glycols; Research; Seminal Vesicles; Sorbitol | 1964 |
Substrate specificity and kinetic isotope effect analysis of the Eschericia coli ketopantoate reductase.
Topics: Alcohol Oxidoreductases; Calorimetry; Catalysis; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Isotopes; Keto Acids; Kinetics; NADP; Oxidation-Reduction; Pantothenic Acid; Substrate Specificity; Thermodynamics | 2003 |
Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase.
Topics: Amino Acids; Binding Sites; Catalysis; Computer Simulation; Deuterium; Folic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; NADP; Quantum Theory; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2003 |
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.
Topics: Binding Sites; Deuterium; Escherichia coli Proteins; Folic Acid; Isoleucine; NADP; Nanotechnology; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thermodynamics; Threonine; Valine | 2004 |
The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Antioxidants; Carbon; Catalysis; Deuterium; Hydrogen; Hydrogen-Ion Concentration; Ketones; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; NADH, NADPH Oxidoreductases; NADP; Oxygen; Phylogeny; Progesterone; Protein Binding; Rats; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Stereoisomerism; Tryptophan; Zinc | 2004 |
Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.
Topics: Deuterium; Escherichia coli Proteins; Kinetics; Mutation; NAD; NADH, NADPH Oxidoreductases; NADP; Protein Structure, Tertiary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structural Homology, Protein; Time Factors; Tryptophan; Xylitol | 2005 |
Effects of co-operative ligand binding on protein amide NH hydrogen exchange.
Topics: Amides; Bacterial Proteins; Deuterium; Folic Acid; Hydrogen; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Ligands; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim | 2006 |
Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex.
Topics: Aldehyde Reductase; Binding Sites; Crystallization; Crystallography, X-Ray; Deuterium; Humans; Hydrogen; Hydrogen Bonding; Models, Molecular; Molecular Structure; NADP; Neutron Diffraction; Protein Conformation; Protons | 2006 |
The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: basis of the isotopic characteristics of natural aromatic compounds.
Topics: Benzaldehydes; Benzene Derivatives; Biological Factors; Carbon Isotopes; Cinnamates; Coumarins; Deuterium; Hydroxylation; Magnetic Resonance Spectroscopy; Models, Chemical; NADP; Phosphoenolpyruvate; Propanols; Salicylates; Shikimic Acid; Sugar Phosphates | 2006 |
Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Bacterial Proteins; Deuterium; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis; NADP; Protons; Sequence Homology, Amino Acid | 2007 |
Cores and pH-dependent dynamics of ferredoxin-NADP+ reductase revealed by hydrogen/deuterium exchange.
Topics: Chloroplasts; Deuterium; Ferredoxin-NADP Reductase; Ferredoxins; NADP; Nuclear Magnetic Resonance, Biomolecular; Plant Proteins; Protein Folding; Structure-Activity Relationship; Zea mays | 2007 |
Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.
Topics: Amino Acid Sequence; Base Sequence; Codon; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Deuterium; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen Peroxide; Hydroxylation; Kinetics; Molecular Sequence Data; Mutation; NADP; Oxidation-Reduction; Spectrophotometry; Substrate Specificity; Temperature | 2008 |
Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Acyl Coenzyme A; Alcohol Oxidoreductases; Bacterial Proteins; Catalysis; Deuterium; Dimerization; Hydrogen; Kinetics; Models, Chemical; Mycobacterium tuberculosis; Mycolic Acids; NADP; Protein Binding; Protons; Recombinant Proteins; Spectrometry, Fluorescence; Substrate Specificity | 2008 |
Carbon-deuterium bonds as probes of dihydrofolate reductase.
Topics: Crystallography, X-Ray; Deuterium; Ligands; Methionine; Models, Molecular; NADP; Spectroscopy, Fourier Transform Infrared; Static Electricity; Tetrahydrofolate Dehydrogenase | 2008 |
Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldehydes; Aldo-Keto Reductases; Animals; Binding Sites; Catalysis; Deuterium; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Ketones; Kinetics; Mutagenesis, Site-Directed; Mutation; NADP; Phospholipids; Potassium Channels, Voltage-Gated; Prostaglandins; Protein Subunits; Rats; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity | 2008 |
Large D/H variations in bacterial lipids reflect central metabolic pathways.
Topics: Deuterium; Fatty Acids; Hydrogen; Lipids; NADP; Proteobacteria | 2009 |
Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.
Topics: Aldehydes; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Carbon Radioisotopes; Carboxylic Acids; Cytochrome P-450 CYP2A6; Deuterium; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Mass Spectrometry; Methane; Models, Chemical; NADP; Oxidation-Reduction; Substrate Specificity | 2010 |
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
Topics: Antibiotics, Antineoplastic; Cloning, Molecular; Coenzyme A; Deuterium; Escherichia coli; Fatty Acids; Isoquinolines; Kinetics; Models, Molecular; NADP; Streptomyces | 2010 |
Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis.
Topics: Deuterium; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Mycobacterium tuberculosis; NADP; Tetrahydrofolate Dehydrogenase | 2011 |
Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites.
Topics: Acetaminophen; Animals; Carbamazepine; Chromatography, High Pressure Liquid; Deuterium; Deuterium Exchange Measurement; Esterification; Glutathione; Isotope Labeling; Male; Microsomes; NADP; Nanotechnology; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2011 |
Structure-function relationship of Vibrio harveyi NADPH-flavin oxidoreductase FRP: essential residues Lys167 and Arg15 for NADPH binding.
Topics: Amino Acid Sequence; Anaerobiosis; Arginine; Deuterium; FMN Reductase; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NADP; Oxidation-Reduction; Protein Binding; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Vibrio | 2012 |
Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro.
Topics: Animals; Carcinoma; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deuterium; G1 Phase; Humans; Matrix Metalloproteinase 9; Mice; NAD(P)H Dehydrogenase (Quinone); NADP; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; S Phase; Water | 2013 |
Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange.
Topics: Alcohol Oxidoreductases; Bacterial Proteins; Binding Sites; Biocatalysis; Deuterium; Macrolides; NADP; Oxidation-Reduction; Polyketide Synthases; Protein Structure, Tertiary; Racemases and Epimerases; Stereoisomerism; Substrate Specificity | 2014 |
Comparison of the effect of salinity on the D/H ratio of fatty acids of heterotrophic and photoautotrophic microorganisms.
Topics: Autotrophic Processes; Deuterium; Fatty Acids; Haptophyta; Heterotrophic Processes; Hydrogen; Light; Lipids; NADP; Pseudomonas; Salinity; Water | 2015 |
Anaerobic Heme Degradation: ChuY Is an Anaerobilin Reductase That Exhibits Kinetic Cooperativity.
Topics: Apoenzymes; Biocatalysis; Deuterium; Dimerization; Escherichia coli O157; Escherichia coli Proteins; Heme; Hydrolysis; Models, Molecular; Molecular Structure; Molecular Weight; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Protein Interaction Domains and Motifs; Recombinant Proteins; Structural Homology, Protein; Substrate Specificity; Tetrapyrroles | 2017 |
Chemical Basis for Deuterium Labeling of Fat and NADPH.
Topics: Adipose Tissue; Deuterium; Deuterium Exchange Measurement; Fatty Acids; HCT116 Cells; HEK293 Cells; Humans; NADP; Oxidation-Reduction; Water | 2017 |
Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells.
Topics: Animals; Cell Line; Cytosol; Deuterium; Electron Transport; HEK293 Cells; Humans; Mammals; Mitochondria; NAD; NADP; Oxidation-Reduction | 2020 |
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Topics: Deuterium; Deuterium Exchange Measurement; Humans; Hydrogen Deuterium Exchange-Mass Spectrometry; Isocitrate Dehydrogenase; Isocitrates; Ligands; NADP | 2023 |