deuterium has been researched along with nad in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 125 (67.20) | 18.7374 |
| 1990's | 27 (14.52) | 18.2507 |
| 2000's | 22 (11.83) | 29.6817 |
| 2010's | 8 (4.30) | 24.3611 |
| 2020's | 4 (2.15) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, SL; Tuazon, PT | 1 |
| Kasama, T; Kawaguchi, A; Okuda, S; Seyama, Y; Yamakawa, T | 2 |
| Rogers, MJ; Strittmatter, P | 1 |
| Monder, C; Orr, JC | 1 |
| Arnold, LJ; Kaplan, NO; You, KS | 1 |
| Romslo, I; Ulvik, R | 1 |
| Apitz-Castro, R; Bull, HG; Cordes, EH; Ferraz, JP; Ribbi, A | 1 |
| Ryerson, CC; Walsh, C | 1 |
| Cronholm, T | 4 |
| Cleland, WW; Cook, PF; Viola, RE | 1 |
| Davey, JF; Gibson, DT; Jeffrey, AM; Jerina, DM; Patel, TR; Yeh, HJ | 1 |
| Winicov, I | 1 |
| Klinman, JP | 2 |
| Anderson, BM; Chan, JK | 1 |
| Engel, LL; Groman, EV; Schultz, RM | 1 |
| Bradshaw, CW; Lalonde, JJ; Wong, CH | 1 |
| Rys, P; Wang, J | 1 |
| Kotik, M; Zuber, H | 1 |
| Liu, HW; Liu, LD; Russell, RN; Thorson, JS; Yu, Y | 1 |
| Blanchard, JS; Stoll, VS | 2 |
| Cleland, WW; Cook, PF; Gavva, SR; Harris, BG; Urbauer, JL; Weiss, PM | 1 |
| Adolph, HW; Branlant, G; Corbier, C; Gerard, D; Mely, Y; Mougin, A; Wonacott, A; Zeppezauer, M | 1 |
| Ballou, DP; Blanchard, JS; Vanoni, MA; Wong, KK | 1 |
| Anderson, VE; LaReau, RD; Wan, W | 1 |
| Burgner, J; Callender, R; Deng, H; Zheng, J | 1 |
| Birktoft, JJ; Dalton, LR; Park, JH; Trommer, WE; Venkataramu, SD; Wilder, RT | 1 |
| Bender, SL; Knowles, JR; Widlanski, T | 1 |
| Anderson, VE; LaReau, RD | 1 |
| Buckmann, AF; Carrea, G; Danieli, B; Ottolina, G; Riva, S | 1 |
| Creighton, DJ; Pourmotabbed, T; Shih, MJ | 1 |
| Barrow, KD; Rogers, PL; Smith, GM | 1 |
| Morrison, JF; Stone, SR | 1 |
| Chen, CY; Cleland, WW; Cook, PF; Weiss, PM | 1 |
| Atkins, WM; Sligar, SG | 1 |
| De Weck, Z; Kägi, JH; Pande, J | 1 |
| Duggleby, RG; Northrop, DB | 1 |
| Cook, PF; Harris, BG; Kiick, DM | 1 |
| Tu, SC; Wang, LH; Yu, YM | 1 |
| Callender, R; Chen, D; Martin, C; Rhee, KW; Sloan, D; Yue, KT | 1 |
| Fisher, RR; Kaplan, NO | 1 |
| Hipps, PP; Holland, WH; Sehgal, RK; Sherman, WR | 1 |
| Björkhem, I; Gustafsson, J | 1 |
| Levy, HR; Nevaldine, BH | 1 |
| Colman, RF; Durbano, M; Ramachandran, N | 1 |
| Cronholm, T; Matern, H; Matern, S; Sjövall, J | 1 |
| Estabrook, RW; Tyler, DD | 1 |
| Kolesnikov, NA; Petrochenko, EI | 1 |
| Koritz, SB; Oleinick, NL | 1 |
| Dalziel, K; Dickinson, FM | 1 |
| Furfine, CS; White, A | 1 |
| Chaykin, S; Kim, CS | 1 |
| Henderson, RF; Henderson, TR | 1 |
| Blomquist, CH | 1 |
| Patel, DJ | 1 |
| Björkhem, I | 1 |
| Dolin, MI | 1 |
| Catterall, WA; Hollis, DP; Walter, CF | 1 |
| Brunner, A; Chagoya, V; Piña, E; Saldaña, Y | 1 |
| Sherman, WR; Stewart, MA; Zinbo, M | 1 |
| Cronholm, T; Sjövall, J | 2 |
| Admirand, WH; Cronholm, T; Sjövall, J | 1 |
| Gutfreund, H; Shore, JD | 1 |
| Warren, WA | 1 |
| Bush, K; Mahler, HR; Shiner, VJ | 2 |
| Apitz, R; Cordes, EH; Mickelson, K; Shriver, K | 1 |
| Bechara, EJ; Cilento, G | 2 |
| Davis, L; Glaser, L | 1 |
| Avruch, J; Wallach, DF | 1 |
| Arnold, LJ; Kaplan, NO; Oppenheimer, NJ | 1 |
| Kyogoku, Y; Yu, BS | 1 |
| Brooks, RL; Shore, JD | 1 |
| Jarman, M; Searle, F | 1 |
| Feldman, RI; Weiner, H | 1 |
| Bernhard, SA; McFarland, JT | 1 |
| Brown, B; Hollis, D; McDonald, G; Walter, C | 1 |
| Noel, JK; Schumaker, VN | 1 |
| Blattmann, P; Rétey, J | 1 |
| Oppenheimer, NJ | 1 |
| Abeles, RH; Gershman, H | 1 |
| Biller, F; Günther, H; Kellner, M; Simon, H | 1 |
| Meany, JE; Tienhaara, R | 1 |
| Everse, J; Lee, CY | 1 |
| Schachman, HK; Smith, GD | 1 |
| Dunn, MF; Hutchison, JS | 1 |
| Dornand, J; Mani, JC; Mousseron-Canet, M; Vial-Reveillon, F | 2 |
| Cassman, M; Vetterlein, D | 1 |
| Higuti, T; Horio, T; Hosoi, K; Kakuno, T | 1 |
| Gracheva, IN; Kustanovich, IM; Mishchenko, VV; Samokhvalov, GI | 1 |
| Leroi, GE; Patrick, DM; Wilson, JE | 1 |
| Andree, PJ; Zantema, A | 1 |
| Crastes de Paulet, A; Torreilles, J | 1 |
| Kaplan, NO; Lee, CY; Oppenheimer, NJ | 1 |
| Kaplan, NO; Oppenheimer, NJ | 2 |
| Cassman, M | 1 |
| Bignetti, E; Luisi, PL | 1 |
| Engel, LL; Karavolas, HJ; Orr, JC | 1 |
| Holtzman, JL | 1 |
| Bates, DJ; Frieden, C; Goldin, BR | 1 |
| Parker, FS; Stryker, MH | 1 |
| Cronholm, T; Makino, I; Sjövall, J | 1 |
| Egan, RM; Matherly, LH; Phillips, AT | 1 |
| Balasubramanian, K; Beth, A; Fritzsche, TM; Glöggler, KG; Park, JH; Pearson, DE; Trommer, WE; Venkastaramu, SD | 1 |
| Matsudaira, H; Tanaka, O; Ueno, AM | 1 |
| Yagi, T | 1 |
| Cleland, WW; Fisher, MA; Scharschmidt, M | 1 |
| Cleland, WW; Hermes, JD; Morrical, SW; O'Leary, MH | 1 |
| Cleland, WW; Fisher, MA; Hermes, JD; Morrison, JF; O'Leary, MH; Tipton, PA | 1 |
| Cronholm, T; Curstedt, T | 1 |
| Cleland, WW; Cook, PF; Grimshaw, CE | 1 |
| Knowles, JR; Sue, JM | 1 |
| Armarego, WL; Randles, D; Taguchi, H | 1 |
| Kawaguchi, A; Okuda, S; Saito, K; Seyama, Y; Yamakawa, T | 1 |
| Damgaard, SE | 1 |
| Gelb, MH; Heimbrook, DC; Mälkönen, P; Sligar, SG | 1 |
| Egerer, P; Günther, H; Simon, H | 1 |
| Claiborne, A; Crane, EJ; Parsonage, D; Poole, LB | 1 |
| Furumo, NC; Helton, M; Milbrandt, J; Rardin, J; Wright, SK; Zhao, FJ | 1 |
| Blanchard, JS; Marcinkeviciene, JA | 1 |
| Cook, PF; Gavva, SR; Karsten, WE; Park, SH | 1 |
| Cook, PF; Hara, S; McClure, GD; Yoon, MY | 1 |
| Ballou, DP; Gassner, GT; Johnson, DA; Liu, HW | 1 |
| Cook, PF; Peisach, J; Quinn, TP; Tipton, PA | 1 |
| Cronholm, T; Yu, BY | 1 |
| Blanchard, JS; Tang, XJ; Wang, F | 1 |
| Scheuring, J; Schramm, VL | 1 |
| Markham, GD; Xiang, B | 1 |
| Eisenbrand, G; Fuchs, A; Goelzer, P; Humberd, C; Janzowski, C; Loeppky, RN; Schneider, H | 1 |
| Bizouarn, T; Fjellström, O; Jackson, JB; Rydström, J; Venning, JD; Zhang, JW | 1 |
| Bradshaw, DE; Cleland, WW; Urbauer, JL | 1 |
| Digits, JA; Hedstrom, L | 1 |
| Cook, PF; Hwang, CC; Karsten, WE | 1 |
| Kulbe, KD; Nidetzky, B; Slatner, M | 1 |
| Moynihan, DP; Parikh, S; Tonge, PJ; Xiao, G | 1 |
| Copeland, RA; Marcinkeviciene, J; Rogers, MJ; Tinney, LM; Wang, KH | 1 |
| Bernhardt, FH; Sandfort, G; Twilfer, H | 1 |
| Blanchard, JS; Patel, MP | 1 |
| Argyrou, A; Blanchard, JS | 1 |
| Agarwal, PK; Billeter, SR; Hammes-Schiffer, S; Iordanov, T; Webb, SP | 1 |
| Bergquist, C; Koutcher, L; Parkin, G; Vaught, AL | 1 |
| Daiber, A; Hultschig, C; Kudo, T; Nauser, T; Shoun, H; Takaya, N; Ullrich, V; Weber, P | 1 |
| Fisher, HF; Maniscalco, SJ; Saha, SK; Tally, JF | 1 |
| Cook, PF; Karsten, WE; Tipton, PA | 1 |
| Bartlett, PN; Simon, E | 1 |
| Basran, J; Harris, RJ; Scrutton, NS; Sutcliffe, MJ | 1 |
| SAN PIETRO, A | 1 |
| HVIDT, A; KAEGI, JH; OTTESEN, M | 1 |
| HVIDT, A; KAEGI, JH | 1 |
| ENGEL, LL; VELLE, W | 1 |
| BORDNER, LF; DARLING, JJ; THOMSON, JF | 1 |
| DISABATO, G; OTTESEN, M | 1 |
| NANCE, SL; THOMSON, JF | 1 |
| Ferreira, AL; Krinsky, NI; Russell, RM; Tang, G; Yeum, KJ | 1 |
| Kavanagh, KL; Kratzer, R; Nidetzky, B; Wilson, DK | 1 |
| Kandrac, J; Leskovac, V; Pericin, D; Trivić, S | 1 |
| Kidman, G; Northrop, DB; Park, H | 1 |
| Alam, J; Beyer, N; Liu, HW | 1 |
| van der Donk, WA; Woodyer, R; Zhao, H | 1 |
| Carrea, G; Giordano, A; Raia, CA; Rossi, M; Russo, C; Secundo, F | 1 |
| Hay, S; Scrutton, NS; Sutcliffe, MJ | 1 |
| Hellmer, H; Klimacek, M; Nidetzky, B | 1 |
| Clarke, AR; Cliff, MJ; Sessions, RB; Shoemark, DK | 1 |
| Endicott, D; Kuester, W; Lu, Y; Moore, B; Qu, F | 1 |
| Bradshaw, J; Lu, Y; Moore, B; Qu, F; Small, AM; Zhao, Y | 1 |
| Esposito, L; Giordano, A; Langella, E; Pennacchio, A; Raia, CA; Rossi, M | 1 |
| Paneth, P; Świderek, K | 1 |
| Andi, B; Bobyk, KD; Cook, PF; Kumar, VP; Thomas, LM; West, AH | 1 |
| Brecker, L; Eixelsberger, T; Nidetzky, B | 1 |
| Malver, O; Oppenheimer, NJ; Sebastian, MJ | 1 |
| Chang, EP; Schramm, VL; Wang, Z | 1 |
| Palmer, DR; Vetter, ND | 1 |
| Carpick, B; Chen, T; Ettorre, L; James, DA; Liuni, P; Szeto, J; Wilson, DJ; Zhu, S | 1 |
| Lim, EW; Metallo, CM; Parker, SJ | 1 |
| Barger, C; Batsios, G; Costello, JF; Gillespie, AM; Ronen, SM; Stevers, N; Taglang, C; Tran, M; Viswanath, P | 1 |
| Elliott, MA; Nanga, RPR; Reddy, R; Soni, ND; Swago, S; Swain, A; Wilson, N; Witschey, WR | 1 |
| Beckett, D; Buddula, S; Carr, J; Deredge, D; Diantonio, A; Eisenmesser, E; Essuman, K; Glendening, G; Klontz, E; Milbrandt, J; Nallar, S; Obi, JO; Obiorah, T; Palm, C; Ray, K; Redzic, JS; Schmidt, K; Scudder, AH; Snyder, GA; Snyder, MLD; Soares, AS; Tsibouris, C; Wang, Y | 1 |
2 review(s) available for deuterium and nad
| Article | Year |
|---|---|
[Use of deuterium in the study of the enzyme reaction mechanism].
Topics: Acetates; Chemical Phenomena; Chemistry; Deuterium; Enzymes; Hydrogen; Hydrogenation; Indoles; Malate Synthase; Methionine; Molecular Conformation; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxidoreductases; Steroids; Tryptophan Synthase; Tyrosine Phenol-Lyase | 1983 |
Effects of pressure on deuterium isotope effects of yeast alcohol dehydrogenase using alternative substrates.
Topics: Alcohol Dehydrogenase; Computer Simulation; Deuterium; Ethanol; Hydrogen-Ion Concentration; Hydrostatic Pressure; Isotopes; Kinetics; Mathematics; Models, Chemical; NAD; Oxidation-Reduction; Protein Conformation; Reference Standards; Saccharomyces cerevisiae; Spectrophotometry; Substrate Specificity | 2005 |
184 other study(ies) available for deuterium and nad
| Article | Year |
|---|---|
Acid-catalyzed hydration of reduced nicotinamide adenine dinucleotide and its analogues.
Topics: Binding Sites; Deuterium; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Mathematics; NAD; Oxidation-Reduction; Water | 1977 |
Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes.
Topics: Acetyl Coenzyme A; Brevibacterium; Coenzyme A; Deuterium; Fatty Acid Synthases; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hydrogen; Malonates; NAD; NADP; Stereoisomerism; Water | 1977 |
Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes.
Topics: Brevibacterium; Deuterium; Fatty Acid Synthases; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; NADP; Stereoisomerism | 1978 |
The interaction of NADH-cytochrome b5 reductase and cytochrome b5 bound to egg lecithin liposomes.
Topics: Animals; Carbon Radioisotopes; Cattle; Chlorella; Cytochrome Reductases; Cytochromes; Deuterium; Eggs; Kinetics; Liposomes; Liver; Male; Microscopy, Electron; NAD; Phosphatidylcholines; Phospholipids; Protein Binding | 1975 |
The stereospecificity of the enzymic reduction of 21-dehydrocortisol by NADH.
Topics: Deuterium; Hydroxysteroid Dehydrogenases; Mass Spectrometry; NAD; Oxidation-Reduction; Prednisolone; Stereoisomerism | 1975 |
The stereospecificity of bacterial external flavoprotein monooxygenases for nicotinamide adenine dinucleotide.
Topics: Deuterium; Flavoproteins; Magnetic Resonance Spectroscopy; Mixed Function Oxygenases; NAD; Pseudomonas; Stereoisomerism; Structure-Activity Relationship | 1977 |
Studies on the utilization of ferritin iron in the ferrochelatase reaction of isolated rat liver mitochondria.
Topics: Animals; Cytosol; Deuterium; Ferritins; Ferrochelatase; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; In Vitro Techniques; Iron; Kinetics; Lyases; Lysosomes; Microsomes, Liver; Mitochondria, Liver; NAD; Rats; Succinates | 1978 |
Concerning the mechanism of the enzymatic and nonenzymatic hydrolysis of nicotinamide nucleotide coenzymes.
Topics: Animals; Brain; Deuterium; Kinetics; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Neurospora crassa; Nicotinamide Mononucleotide; Swine | 1978 |
The stereochemistry of NADH utilization by the flavoenzyme monooxygenase orcinol hydroxylase.
Topics: Deuterium; Kinetics; Mixed Function Oxygenases; Molecular Conformation; NAD; Protein Binding; Pseudomonas; Resorcinols; Tritium | 1979 |
Incorporation of the hydrogen atoms of ethanol into amino acids in rat liver in vivo.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Deuterium; Ethanol; Female; Glutamates; Hydrogen; Liver; NAD; Proline; Rats | 1979 |
Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis.
Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Deuterium; Ethanol; Glucosephosphate Dehydrogenase; Isotope Labeling; NAD; Oxidation-Reduction; Stereoisomerism | 1979 |
Initial reactions in the oxidation of naphthalene by Pseudomonas putida.
Topics: Culture Media; Deuterium; Kinetics; NAD; NADP; Naphthalenes; Oxidation-Reduction; Oxygen Consumption; Oxygenases; Pseudomonas; Stereoisomerism | 1975 |
The mechanism of end product inhibition of serine biosynthesis. V. Mechanism of serim inhibition of phosphoglycerate dehydrogenases.
Topics: Alcohol Oxidoreductases; Deuterium; Escherichia coli; Glyceric Acids; Hydrogen-Ion Concentration; NAD; Organophosphorus Compounds; Protein Binding; Serine; Thermodynamics | 1975 |
Acid-base catalysis in the yeast alcohol dehydrogenase reaction.
Topics: Alcohol Oxidoreductases; Benzyl Compounds; Deuterium; Hydrogen-Ion Concentration; Isotope Labeling; Kinetics; Mathematics; NAD; Saccharomyces cerevisiae | 1975 |
A novel diazonium-sulfhydryl reaction in the inactivation of yeast alcohol dehydrogenase by diazotized 3-aminopyridine adenine dinucleotide.
Topics: Alcohol Oxidoreductases; Amino Acids; Azo Compounds; Benzoates; Binding Sites; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Deuterium; Disulfides; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; NAD; Nitro Compounds; Protein Binding; Saccharomyces cerevisiae; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Time Factors | 1975 |
Catalytic competence, a new criterion for affinity labeling. Demonstration of the reversible enzymatic interconversion of estrone and estradiol-17 beta covalently bound to human placental estradiol-17 beta dehydrogenase.
Topics: Affinity Labels; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Deuterium; Electrophoresis, Polyacrylamide Gel; Estradiol; Estradiol Dehydrogenases; Estrone; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Mercuribenzoates; NAD; NADP; Placenta; Stereoisomerism; Tritium | 1975 |
Enzymatic synthesis of (R) and (S) 1-deuterohexanol.
Topics: Alcohol Dehydrogenase; Aldehydes; Deuterium; Heterocyclic Compounds; Hexanols; Molecular Structure; NAD; Oxidation-Reduction; Stereoisomerism | 1992 |
Hydrogen/deuterium isotope effect in the oscillating peroxidase-oxidase reaction.
Topics: Deuterium; Horseradish Peroxidase; Hydrogen; Isotope Labeling; Kinetics; NAD; Oxidation-Reduction; Spectrophotometry; Time Factors | 1992 |
Evidence for temperature-dependent conformational changes in the L-lactate dehydrogenase from Bacillus stearothermophilus.
Topics: Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Deuterium; Fluorescence Polarization; Fructosediphosphates; Geobacillus stearothermophilus; Hot Temperature; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; NAD; Protein Conformation; Thermodynamics | 1992 |
Mechanistic studies of the biosynthesis of 3,6-dideoxyhexoses in Yersinia pseudotuberculosis. Purification and stereochemical analysis of CDP-D-glucose oxidoreductase.
Topics: Amino Acids; Carbohydrate Dehydrogenases; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Deoxy Sugars; Deuterium; Glucose; Hexoses; Isomerism; Kinetics; Molecular Weight; NAD; Nucleoside Diphosphate Sugars; Tritium; Yersinia pseudotuberculosis | 1992 |
Chemical mechanism and rate-limiting steps in the reaction catalyzed by Streptococcus faecalis NADH peroxidase.
Topics: Deuterium; Enterococcus faecalis; Hydrogen-Ion Concentration; Kinetics; NAD; Oxidation-Reduction; Peroxidases; Solvents; Substrate Specificity | 1991 |
Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Topics: Animals; Ascaris; Carbon Isotopes; Chickens; Decarboxylation; Deuterium; Kinetics; Liver; Malate Dehydrogenase; Malates; NAD; NADP; Oxidation-Reduction; Substrate Specificity | 1991 |
The nicotinamide subsite of glyceraldehyde-3-phosphate dehydrogenase studied by site-directed mutagenesis.
Topics: Apoenzymes; Deuterium; Enzyme Activation; Geobacillus stearothermophilus; Glyceraldehyde-3-Phosphate Dehydrogenases; Hot Temperature; Kinetics; Mutagenesis, Site-Directed; NAD; Phosphorylation; Protein Conformation; Stereoisomerism; X-Ray Diffraction | 1990 |
Glutathione reductase: comparison of steady-state and rapid reaction primary kinetic isotope effects exhibited by the yeast, spinach, and Escherichia coli enzymes.
Topics: Deuterium; Escherichia coli; Glutathione Reductase; Kinetics; NAD; NADP; Plants; Substrate Specificity; Tritium; Yeasts | 1990 |
Isotope effects on binding of NAD+ to lactate dehydrogenase.
Topics: Animals; Binding Sites; Deuterium; In Vitro Techniques; L-Lactate Dehydrogenase; Mass Spectrometry; Molecular Structure; NAD; Niacinamide; Scintillation Counting; Tritium | 1989 |
Molecular properties of pyruvate bound to lactate dehydrogenase: a Raman spectroscopic study.
Topics: Binding Sites; Carbon Isotopes; Deuterium; Deuterium Oxide; L-Lactate Dehydrogenase; NAD; Protein Binding; Pyruvates; Spectrum Analysis, Raman; Water | 1989 |
Catalytic mechanism and interactions of NAD+ with glyceraldehyde-3-phosphate dehydrogenase: correlation of EPR data and enzymatic studies.
Topics: Allosteric Regulation; Animals; Catalysis; Deuterium; Electron Spin Resonance Spectroscopy; Glyceraldehyde-3-Phosphate Dehydrogenases; In Vitro Techniques; Mathematics; Models, Chemical; NAD; Protein Binding; Rabbits; Spin Labels | 1989 |
Dehydroquinate synthase: the use of substrate analogues to probe the early steps of the catalyzed reaction.
Topics: Catalysis; Deuterium; Kinetics; Lyases; Molecular Conformation; NAD; Oxidation-Reduction; Phosphorus-Oxygen Lyases; Substrate Specificity; Sugar Phosphates | 1989 |
Lactate dehydrogenase displays absolute stereospecificity in the transfer of the prochiral hydrogen of NADH.
Topics: Animals; Deuterium; Hydrogen; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Myocardium; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Radioisotope Dilution Technique; Stereoisomerism; Swine; Tritium | 1989 |
Enzymatic synthesis of [4R-2H]NAD (P)H and [4S-2H]NAD(P)H and determination of the stereospecificity of 7 alpha- and 12 alpha hydroxysteroid dehydrogenase.
Topics: Clostridium; Deuterium; Escherichia coli; Hydroxysteroid Dehydrogenases; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; NADP; Stereoisomerism; Substrate Specificity | 1989 |
Bovine liver formaldehyde dehydrogenase. Kinetic and molecular properties.
Topics: Aldehyde Oxidoreductases; Animals; Binding Sites; Catalysis; Cattle; Deuterium; Guanidine; Guanidines; Humans; Isoelectric Point; Isoenzymes; Kinetics; Liver; Molecular Weight; NAD; Protein Denaturation; Urea | 1989 |
NMR studies of [1-2H]glucose metabolism in Zymomonas mobilis.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Bacteria; Deuterium; Ethanol; Glucose; Magnetic Resonance Spectroscopy; Models, Chemical; NAD; Software; Stereoisomerism | 1986 |
Dihydrofolate reductase from Escherichia coli: the kinetic mechanism with NADPH and reduced acetylpyridine adenine dinucleotide phosphate as substrates.
Topics: Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NAD; NADP; Tetrahydrofolate Dehydrogenase; Viscosity | 1988 |
Kinetic mechanism and nucleotide specificity of NADH peroxidase.
Topics: Binding, Competitive; Deuterium; Enterococcus faecalis; Kinetics; Molecular Conformation; NAD; NADP; Nucleotides; Peroxidases; Substrate Specificity; Tritium | 1988 |
Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Topics: Alanine Dehydrogenase; Amino Acid Oxidoreductases; Animals; Bacillus subtilis; Cattle; Deuterium; Glutamate Dehydrogenase; Isotope Labeling; Kinetics; Liver; Mathematics; Models, Theoretical; NAD; NADP; Nitrogen Isotopes; Substrate Specificity; Tritium | 1988 |
Deuterium isotope effects in norcamphor metabolism by cytochrome P-450cam: kinetic evidence for the two-electron reduction of a high-valent iron-oxo intermediate.
Topics: Camphor 5-Monooxygenase; Cytochrome P-450 Enzyme System; Deuterium; Electron Transport; Kinetics; Mixed Function Oxygenases; NAD; Norbornanes; Oxidation-Reduction; Radioisotope Dilution Technique | 1988 |
Interdependence of coenzyme-induced conformational work and binding potential in yeast alcohol and porcine heart lactate dehydrogenases: a hydrogen-deuterium exchange study.
Topics: Alcohol Dehydrogenase; Animals; Deuterium; Hydrogen; Kinetics; L-Lactate Dehydrogenase; Ligands; Myocardium; NAD; Oxidation-Reduction; Protein Binding; Protein Conformation; Saccharomyces cerevisiae; Spectrophotometry, Infrared; Swine | 1987 |
Preparation and storage of isotopically labeled reduced nicotinamide adenine dinucleotide.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deuterium; Drug Stability; Isotope Labeling; NAD; Oxidation-Reduction | 1987 |
Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Topics: Animals; Ascaris; Deuterium; Hydrogen-Ion Concentration; Kinetics; Malate Dehydrogenase; Mathematics; Mitochondria; NAD; Oxidation-Reduction; Radioisotope Dilution Technique | 1986 |
Pseudomonas cepacia 3-hydroxybenzoate 6-hydroxylase: stereochemistry, isotope effects, and kinetic mechanism.
Topics: Anaerobiosis; Deuterium; Kinetics; Mixed Function Oxygenases; NAD; Pseudomonas; Radioisotope Dilution Technique; Tritium | 1987 |
Classical Raman spectroscopic studies of NADH and NAD+ bound to liver alcohol dehydrogenase by difference techniques.
Topics: Adenosine Diphosphate Ribose; Alcohol Dehydrogenase; Deuterium; Kinetics; Liver; NAD; Oxidation-Reduction; Protein Binding; Spectrum Analysis, Raman | 1987 |
Hydrogen transfer between ethanol molecules during oxidoreduction in vivo.
Topics: Acetaldehyde; Animals; Bile; Cyanamide; Deuterium; Ethanol; Female; Hydrogen; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1985 |
Studies on the mitochondrial energy-linked pyridine nucleotide transhydrogenase.
Topics: Aniline Compounds; Animals; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Magnesium Sulfate; Mitochondria, Muscle; Myocardium; NAD; NADH, NADPH Oxidoreductases; NADP; Naphthalenes; Niacinamide; Oxidoreductases; Spectrophotometry; Structure-Activity Relationship; Succinates; Sulfonic Acids; Tritium | 1973 |
Identification and partial characterization of inositol: NAD+ epimerase and inosose: NAD(P)H reductase from the fat body of the American cockroach, Periplaneta americana L.
Topics: Adipose Tissue; Alcohol Oxidoreductases; Animals; Binding Sites; Chromatography, Gas; Cockroaches; Deuterium; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hemolymph; Hydrogen-Ion Concentration; Inositol; Isomerism; Ketones; Kinetics; NAD; NADP; Optical Rotation; Oxidation-Reduction; Protein Binding; Structure-Activity Relationship | 1973 |
Mitochondrial omega-hydroxylation of cholesterol side chain.
Topics: Animals; Calcium; Carbon Radioisotopes; Cholestenes; Cholesterol; Citrates; Deuterium; Hydroxylation; Hydroxymercuribenzoates; Hydroxysteroids; Isocitrates; Liver; Magnesium; Male; Metals; Mitochondria, Liver; NAD; NADP; Oxygen; Oxygen Isotopes; Rats; Steroid Hydroxylases | 1974 |
The effects of 2H2O on mammary glucose-6-phosphate dehydrogenase.
Topics: Animals; Deuterium; Female; Glucosephosphate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Macromolecular Substances; Mammary Glands, Animal; Molecular Weight; NAD; NADP; Protein Conformation; Rats | 1974 |
Kinetic isotope effects in the NAD- and NADP-specific isocitrate dehydrogenases of pig heart.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Deuterium; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Isoenzymes; Kinetics; Myocardium; NAD; NADP; Swine | 1974 |
Transfer of deuterium from (1-2H2) ethanol to Krebs cycle and related acids of rat liver in vivo.
Topics: Animals; Chromatography, Gas; Citrates; Citric Acid Cycle; Cytosol; Deuterium; Ethanol; Fumarates; Hydroxybutyrates; Isocitrates; Isotope Labeling; Lactates; Liver; Malates; Male; Mass Spectrometry; Mitochondria, Liver; NAD; NADP; Rats; Succinates | 1974 |
The influence of deuterium oxide and organic solvents on the interaction of respiratory chain components.
Topics: Animals; Cattle; Cytochromes; Deuterium; Dimethyl Sulfoxide; Dimethylformamide; Glycerol; Glycols; In Vitro Techniques; Liver; Mitochondria; Myocardium; NAD; Oxidative Phosphorylation; Oxidoreductases; Polarography; Rats; Solvents; Succinates; Sucrose | 1966 |
[Participation of phenols in the fermentative oxidation of NAD-H2].
Topics: Chemical Phenomena; Chemistry; Deuterium; NAD; Peroxidases; Phenols | 1965 |
Studies on the mechanism of action of the delta5-3-ketosteroid isomerase from rat adrenal small particles.
Topics: Adrenal Glands; Androgens; Animals; Catalysis; Deuterium; In Vitro Techniques; Isomerases; Microsomes; NAD; Rats | 1966 |
Substrate specificity and stereospecificity of alcohol dehydrogenases.
Topics: 1-Propanol; Alcohol Oxidoreductases; Animals; Chemical Phenomena; Chemistry; Deuterium; Ethanol; Horses; Humans; Liver; NAD; Oxidation-Reduction; Yeasts | 1967 |
Purification and properties of a bovine adrenal 21-dehydrosteroid reductase.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Animals; Cattle; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, Ion Exchange; Deuterium; Hydrocortisone; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; NAD; Oxidoreductases; Periodic Acid; Pregnanes; Spectrum Analysis; Steroids; Tritium; Ultraviolet Rays | 1968 |
Mechanisms of the primary acid modification reaction of reduced diphosphopyridine nucleotide models.
Topics: Benzene Derivatives; Chemical Phenomena; Chemistry; Crystallography; Deuterium; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Oxidation-Reduction; Pyridines; Spectrophotometry; Tritium | 1968 |
Effects of D2O on the allosteric properties of bovine liver glutamic dehydrogenase.
Topics: Adenine Nucleotides; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Deuterium; Drug Stability; Glutamate Dehydrogenase; Guanine Nucleotides; Kinetics; Liver; Molecular Weight; NAD; Protein Denaturation; Water | 1969 |
The effect of deuterium oxide on the fluorescence of reduced nicotinamide adenine dinucleotide free in solution and in complexes with liver alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Deuterium; Fluorescence; Liver; NAD; Niacinamide; Phosphoric Monoester Hydrolases; Protein Binding; Pyridines; Spectrum Analysis; Water | 1969 |
220 MHz proton magnetic resonance spectrum of NADH.
Topics: Alcohol Oxidoreductases; Deuterium; Hydroxysteroid Dehydrogenases; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Oxidation-Reduction; Temperature | 1969 |
On the mechanism of the enzymatic conversn of cholest-5-ene-3-beta, 7-alpha-diol into 7-alpha-hydroxycholest-4-en-3-one.
Topics: Animals; Carbon Isotopes; Cholestanes; Cholesterol; Deuterium; In Vitro Techniques; Liver; Male; Microsomes; NAD; Rats; Time Factors; Tritium | 1969 |
Kinetics of malic-lactic transhydrogenase. Abortive complex formation with substrates and products.
Topics: Acetates; Bacteria; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorides; Deuterium; Drug Stability; Fluorescence; Fluorometry; Keto Acids; Kinetics; Lactates; Malates; NAD; Nucleotides; Oxaloacetates; Oxidoreductases; Pyruvates; Spectrophotometry; Time Factors; Urea | 1969 |
Nuclear magnetic resonance study of the conformation of nicotinamide--adenine dinucleotide and reduced nicotinamide--adenine dinucleotide in solution.
Topics: Deuterium; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methanol; NAD; Urea | 1969 |
Some characteristics of the d-glucose-6-phosphate: cycloaldolase (NAD+ dependent) from Neurospora crassa.
Topics: Aldehyde-Lyases; Amines; Ammonium Chloride; Centrifugation, Density Gradient; Deuterium; Diphosphates; Enzyme Activation; Flavin-Adenine Dinucleotide; Hexosephosphates; Inositol; Kinetics; Magnesium; Molecular Weight; NAD; Neurospora; Nucleotides; Temperature; Tritium | 1969 |
Mass spectrometric study on the mechanism of D-glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase.
Topics: Animals; Cattle; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gas; Deuterium; Hexosephosphates; Inositol; Isomerases; Male; Methods; NAD; Oxidoreductases; Phosphoric Acids; Quaternary Ammonium Compounds; Rats; Silicon; Spectrum Analysis; Testis | 1969 |
Effect of ethanol metabolism on redox state of steroid sulphates in man.
Topics: 17-Ketosteroids; Adult; Androstanes; Chromatography, Gas; Computers; Dehydroepiandrosterone; Depression, Chemical; Deuterium; Ethanol; Humans; Liver; Male; NAD; Oxidation-Reduction; Pregnanes; Pregnenolone; Silicon; Spectrum Analysis; Steroids; Stimulation, Chemical; Sulfuric Acids; Time Factors | 1970 |
Reduction of dehydroepiandrosterone sulfate in the liver during ethanol metabolism.
Topics: 17-Hydroxycorticosteroids; Alcohol Oxidoreductases; Androstanes; Animals; Dehydroepiandrosterone; Deuterium; Ethanol; Female; Guinea Pigs; Liver; NAD; Pyrazoles | 1970 |
Transients in the reactions of liver alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Animals; Chemical Phenomena; Chemistry; Deuterium; Ethanol; Horses; Hydrogen; Kinetics; Liver; NAD; Sodium Chloride | 1970 |
Preparation of deuteroglyoxylate and (A) DPND.
Topics: Deuterium; Glyoxylates; Infrared Rays; Kinetics; L-Lactate Dehydrogenase; Methods; NAD; Oxalates; Spectrum Analysis | 1970 |
Deuterium effects on binding of reduced coenzyme alcohol dehydrogenase isoenzyme EE.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Deuterium; Fluorometry; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; NAD | 1971 |
Some properties of reactions catalyzed by pig brain NAD glycohydrolase.
Topics: Acetone; Alcohols; Animals; Brain; Catalysis; Chemical Phenomena; Chemistry; Deuterium; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleosides; Osmolar Concentration; Sulfhydryl Reagents; Sulfur; Swine | 1971 |
Autoxidation of reduced pyridine coenzymes and of their models promoted by N,N,N',N'-tetramethyl-p-phenylenediamine.
Topics: Aniline Compounds; Benzyl Compounds; Catalysis; Deuterium; Free Radicals; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Manometry; Mathematics; Methanol; NAD; Niacinamide; Oxidation-Reduction; Oxygen; Oxygen Consumption; Potentiometry; Pyridinium Compounds; Spectrophotometry; Thermodynamics; Tromethamine | 1971 |
On the mechanism of the UDP-D-glucose-4'-epimerase. Evidence for a 3-keto-hexose intermediate.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Deuterium; Escherichia coli; Galactose; Glucose; Hexoses; Isomerases; Ketones; Models, Chemical; NAD; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Spectrophotometry; Thymine Nucleotides; Time Factors; Tritium; Ultraviolet Rays; Uracil Nucleotides | 1971 |
Spectroscopic evidence for beta structure in rat adipocyte plasma membrane protein.
Topics: Acetone; Adipose Tissue; Animals; Cell Membrane; Chlorine; Chloroform; Deuterium; Endoplasmic Reticulum; Erythrocytes; Ethanol; Humans; Infrared Rays; Methanol; NAD; Nucleotidases; Oxidoreductases; Phosphates; Protein Conformation; Rats; Sodium; Species Specificity; Spectrophotometry; Succinate Dehydrogenase | 1971 |
A structure of pyridine nucleotides in solution.
Topics: Chemical Phenomena; Chemistry; Deuterium; Isomerism; Magnetic Resonance Spectroscopy; NAD; Nucleic Acid Conformation; Oxidation-Reduction | 1971 |
Selective binding of barbital to the adenine moieties of FAD and NAD.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Barbiturates; Chemical Phenomena; Chemistry; Deuterium; Dimethyl Sulfoxide; Flavin-Adenine Dinucleotide; Fluorometry; Infrared Rays; Magnetic Resonance Spectroscopy; Methylation; Models, Chemical; NAD; Optical Rotatory Dispersion; Phenobarbital; Spectrophotometry; Ultraviolet Rays | 1970 |
Effect of substrate structure on the rate of the catalytic step in the liver alcohol dehydrogenase mechanism.
Topics: 1-Propanol; Alcohol Oxidoreductases; Animals; Catalysis; Deuterium; Ethanol; Fluorometry; Horses; Kinetics; Liver; Methanol; NAD; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 1971 |
Potential coenzyme inhibitors. V. The synthesis and some properties of 4-methylnicotinamide adenine dinucleotide.
Topics: Adenosine Monophosphate; Carbamates; Chemical Phenomena; Chemistry; Chromatography, Paper; Cyanides; Cyclohexanes; Deuterium; Electrophoresis, Paper; Glyceraldehyde-3-Phosphate Dehydrogenases; Imides; Kinetics; Magnetic Resonance Spectroscopy; Methylation; NAD; Oxidation-Reduction; Phosphoric Acids; Protein Binding; Pyridinium Compounds; Ribose; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Sulfites; Ultraviolet Rays | 1972 |
Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity.
Topics: Acetates; Aldehydes; Animals; Binding Sites; Deuterium; Esterases; Glyceraldehyde; Horses; Hot Temperature; Kinetics; Liver; NAD; Nitrophenols; Oxidoreductases; Protein Denaturation; Structure-Activity Relationship | 1972 |
Catalytic steps during the single-turnover reduction of aldehydes by alcohol dehydrogenase.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehydes; Animals; Azo Compounds; Binding Sites; Catalysis; Chlorine; Deuterium; Horses; Imidazoles; Kinetics; Liver; NAD; Oxidation-Reduction; Phenols; Protein Binding; Pyrazoles; Spectrophotometry; Ultraviolet Rays; Yeasts | 1972 |
Some effects of environment on the folding of nicotinamide-adenine dinucleotides in aqueous solutions.
Topics: Adenosine Monophosphate; Chemical Phenomena; Chemistry; Deuterium; Magnetic Resonance Spectroscopy; Mathematics; Methanol; NAD; Niacinamide; Oxidation-Reduction; Ribonucleotides; Silicon; Statistics as Topic; Sulfonic Acids; Temperature; Thermodynamics; Urea; Water | 1972 |
Sequential conformational changes with the binding of NAD to rabbit muscle glyceraldhyde-3-phosphate dehydrogenase.
Topics: Animals; Binding Sites; Buffers; Deuterium; Glyceraldehyde-3-Phosphate Dehydrogenases; Muscles; NAD; Protein Conformation; Rabbits; Spectrophotometry; Ultracentrifugation | 1972 |
Stereospecificity of the dihydroorotate-dehydrogenase reaction.
Topics: Asparagine; Aspartic Acid; Bacteria; Benzyl Compounds; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Deuterium; Esters; Ethanol; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; NAD; Orotic Acid; Oxidation-Reduction; Oxidoreductases; Structure-Activity Relationship | 1972 |
The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide-dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction.
Topics: Alcohol Oxidoreductases; Benzaldehydes; Bromine; Chemical Phenomena; Chemistry; Chlorine; Deuterium; Dialysis; Electron Transport; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mathematics; Methyl Ethers; Models, Chemical; Models, Structural; NAD; Oxidation-Reduction; Saccharomyces cerevisiae; Spectrophotometry; Structure-Activity Relationship; Thermodynamics | 1972 |
The primary acid product of DPNH.
Topics: Acids; Chemical Phenomena; Chemistry; Deuterium; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; NAD; Protons; Spectrophotometry; Stereoisomerism | 1973 |
Deuterium isotope effects in the oxidation of alcohols in vitro and in vivo.
Topics: 1-Propanol; Alcohol Oxidoreductases; Aldehydes; Animals; Chromatography, DEAE-Cellulose; Colorimetry; Deuterium; Drug Stability; Electrophoresis, Polyacrylamide Gel; Ethanol; Horses; In Vitro Techniques; Isotope Labeling; Kinetics; Lactates; Liver; Mice; NAD; Oxidation-Reduction; Propylene Glycols; Sodium Dodecyl Sulfate; Time Factors | 1973 |
Preparative-scale synthesis of (1R)-and (1S)-monodeuteriopropanol by enzymatic exchange reactions.
Topics: 1-Propanol; Alcohol Oxidoreductases; Deuterium; Dihydrolipoamide Dehydrogenase; NAD; Polarography | 1973 |
The lactate dehydrogenase catalyzed reduction of pyruvate. Active substrate and substrate inhibition.
Topics: Animals; Catalysis; Cattle; Deuterium; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Muscles; Myocardium; NAD; Oxidation-Reduction; Propionates; Protons; Pyruvates; Rabbits; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Swine | 1973 |
Studies on the properties of 1,N 6 -ethenoadenine derivatives of various coenzymes.
Topics: Adenine; Adenosine Monophosphate; Alcohol Oxidoreductases; Animals; Chickens; Chromatography, Ion Exchange; Chromatography, Paper; Cyclic AMP; Deuterium; Flavin-Adenine Dinucleotide; Imidazoles; Isoenzymes; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Molecular Conformation; Muscles; N-Glycosyl Hydrolases; NAD; Neurospora; Protein Kinases; Quantum Theory; Rabbits; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Effect of D2O and nicotinamide adenine dinucleotide on the sedimentation properties and structure of glyceraldehyde phosphate dehydrogenase.
Topics: Animals; Apoproteins; Binding Sites; Deuterium; Drug Stability; Glucosephosphate Dehydrogenase; Hydrogen-Ion Concentration; Mathematics; Molecular Weight; Muscles; NAD; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry, Ultraviolet; Time Factors; Ultracentrifugation | 1973 |
Roles of zinc ion and reduced coenzyme in the formation of a transient chemical intermediate during the equine liver alcohol dehydrogenase catalyzed reduction of an aromatic aldehyde.
Topics: Alcohol Oxidoreductases; Aldehydes; Animals; Binding Sites; Chemical Phenomena; Chemistry; Cinnamates; Deuterium; Dimethylamines; Horses; Hydrogen-Ion Concentration; Kinetics; Liver; Mathematics; Models, Chemical; NAD; Protein Binding; Spectrophotometry; Temperature; Thermodynamics; Zinc | 1973 |
[Study by fluorescence of the TNS complex with placental 17 beta-hydroxysteroid dehydrogenase].
Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Binding, Competitive; Chromatography, Gel; Deuterium; Electrophoresis, Polyacrylamide Gel; Female; Fluorescence; Horses; Hydrogen-Ion Concentration; Hydroxysteroid Dehydrogenases; Kinetics; Liver; Methods; NAD; Naphthalenesulfonates; Placenta; Pregnancy; Rabbits; Toluidines; Ultracentrifugation | 1973 |
Deuterium isotope effects on initial rates of the liver alcohol dehydrogenase reaction.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Chromatography, Gel; Chromatography, Ion Exchange; Deuterium; Electrophoresis, Starch Gel; Isotope Labeling; Kinetics; Liver; NAD; Oxidation-Reduction; Spectrophotometry, Ultraviolet | 1973 |
Allosteric and nonallosteric interactions with reduced nicotinamide adenine dinucleotide in two forms of cytoplasmic malic dehydrogenase.
Topics: Allosteric Regulation; Amino Acids; Animals; Binding Sites; Cattle; Cytoplasm; Deuterium; Drug Stability; Electrophoresis, Polyacrylamide Gel; Fructosephosphates; Hexosediphosphates; Kinetics; Macromolecular Substances; Malate Dehydrogenase; Molecular Weight; Myocardium; NAD; Phosphoric Diester Hydrolases; Protein Binding; Sodium Dodecyl Sulfate; Ultracentrifugation | 1974 |
Electron and proton transport in Rhodospirillum rubrum chromatophores.
Topics: Adenosine Triphosphate; Bacterial Chromatophores; Cytochrome c Group; Deuterium; Electron Transport; Hydrogen-Ion Concentration; NAD; Oxidation-Reduction; Protons; Rhodospirillum rubrum; Succinates | 1973 |
[Alcohol in the metabolism--transfer of hydrogen atoms].
Topics: Animals; Cholesterol; Deuterium; Ethanol; Glycerol; Humans; Liver; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Steroids; Time Factors | 1974 |
The use of synthetic inhibitors to study the interaction of nicotinamide adenine dinucleotide with yeast alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Binding, Competitive; Densitometry; Deuterium; Ethanol; Kinetics; Magnetic Resonance Spectroscopy; Models, Structural; Molecular Conformation; NAD; Oxidation-Reduction; Saccharomyces cerevisiae; Spectrophotometry; Structure-Activity Relationship; Temperature; Time Factors | 1974 |
Isotope effects and hydrogen transfer during simultaneous metabolism of ethanol and cyclohexanone in rats.
Topics: Alcohol Oxidoreductases; Animals; Bile; Binding Sites; Carbon Radioisotopes; Chromatography, Gas; Cyclohexanes; Deuterium; Ethanol; Glucuronates; Isotope Labeling; Ketones; Liver; Male; Mass Spectrometry; Mathematics; NAD; Oxidation-Reduction; Protein Binding; Rats; Time Factors; Tritium | 1974 |
A Raman and infrared spectroscopic study of the 3-carbonyl group of pyridine nucleotide coenzymes and related model compounds.
Topics: Acetates; Aldehydes; Chemical Phenomena; Chemistry; Coenzymes; Deuterium; Dioxins; Drug Stability; Models, Chemical; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Oxidation-Reduction; Pyridines; Ribonucleotides; Spectrophotometry, Infrared; Spectrum Analysis | 1974 |
Magnetic resonance studies on glutamate dehydrogenase.
Topics: Adenosine Diphosphate; Binding Sites; Deuterium; Electron Spin Resonance Spectroscopy; Glutamate Dehydrogenase; Guanine Nucleotides; Iodoacetates; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; Oxidation-Reduction; Piperidines; Protein Binding; Protein Conformation; Spin Labels | 1974 |
Studies of NAD(H) conformations in solution: a new method using the PMR spectra of cobalt ion-dinucleotide complexes.
Topics: Binding Sites; Cobalt; Deuterium; Dioxanes; Drug Stability; Energy Transfer; Evaluation Studies as Topic; Kinetics; Magnetic Resonance Spectroscopy; Methods; Molecular Conformation; NAD; Oxidation-Reduction; Probability; Solubility; Spectrometry, Fluorescence; Temperature; Water | 1974 |
Proton relaxation studies of diphosphopyridine coenzymes.
Topics: Animals; Binding Sites; Chickens; Deuterium; Fourier Analysis; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Mathematics; Models, Biological; Molecular Conformation; Muscles; NAD; Niacinamide; Oxidation-Reduction; Protein Binding; Structure-Activity Relationship; Time Factors | 1974 |
Structure of the primary acid rearrangement product of reduced nicotinamide adenine dinucleotide (NADH).
Topics: Circular Dichroism; Deuterium; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; Oxidation-Reduction; Pyridines; Ribose; Spectrophotometry, Ultraviolet; Stereoisomerism | 1974 |
Glyceraldehyde-3-phosphate dehydrogenase catalyzed hydration of the 5-6 double bond of reduced beta-nicotinamide adenine dinucleotide (betaNADH). Formation of beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide.
Topics: Binding Sites; Chromatography, DEAE-Cellulose; Circular Dichroism; Computers; Deuterium; Glyceraldehyde-3-Phosphate Dehydrogenases; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; Oxidation-Reduction; Protein Binding; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Stereoisomerism; Water; X-Ray Diffraction | 1974 |
D2O effects on association behavior and binding properties of phospho- and dephospho-cytoplasmic malic dehydrogenase.
Topics: Animals; Binding Sites; Cattle; Cytoplasm; Deuterium; Isotope Labeling; Kinetics; Malate Dehydrogenase; Molecular Weight; Myocardium; NAD; Oxidation-Reduction; Phosphoproteins; Protein Binding; Spectrometry, Fluorescence; Ultracentrifugation; Water | 1974 |
The half-of-the-sites reactivity of horse liver alcohol dehydrogenase in the presence of alcohol substrates.
Topics: Alcohol Oxidoreductases; Animals; Benzyl Compounds; Binding Sites; Deuterium; Horses; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; Protein Binding; Structure-Activity Relationship; Temperature; Time Factors | 1974 |
Human placental 17 beta-estradiol dehydrogenase. IV. Differentiation of 17 beta-estradiol-activated transhydrogenase from the transhydrogenase function of 17 beta-estradiol dehydrogenase.
Topics: Chemical Phenomena; Chemistry; Chromatography; Countercurrent Distribution; Deuterium; Diethylstilbestrol; Drug Stability; Estradiol; Estranes; Estrone; Female; Humans; Hydroxyapatites; Hydroxysteroid Dehydrogenases; Methods; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Placenta; Pregnancy; Temperature; Tritium | 1969 |
Effect of 4,4-dideuteration of reduced nicotinamide-adenine dinucleotide phosphate on the mixed function oxidases of hepatic microsomes.
Topics: Adenine Nucleotides; Aniline Compounds; Animals; Carbon Monoxide; Deuterium; Electron Transport; Electron Transport Complex IV; Glucosephosphate Dehydrogenase; Hexokinase; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidoreductases; Oxygen Consumption; Rats | 1970 |
A new reaction of glutamate dehydrogenase: the enzyme-catalyzed formation of trinitrobenzene from TNBS in the presence of reduced coenzyme.
Topics: Amino Acids; Animals; Cattle; Coenzymes; Deuterium; Glutamate Dehydrogenase; Ketoglutaric Acids; NAD; NADP; Nitrobenzenes; Solvents; Sulfites; Yeasts | 1970 |
A hydrogen--deuterium exchange study of the conformation of bovine liver glutamate dehydrogenase.
Topics: Adenine Nucleotides; Animals; Cattle; Chemical Phenomena; Chemistry; Deuterium; Diethylstilbestrol; Glutamate Dehydrogenase; Glutamates; Guanine Nucleotides; Hydrogen; Infrared Rays; Leucine; Liver; Methionine; NAD; NADP; Spectrophotometry | 1970 |
Phosphate catalysis in the autoxidation of 1-n-propyl-6-hydroxy-1,4,5,6-tetrahydronicotinamide. A model for adenosine triphosphate formation.
Topics: Adenosine Triphosphate; Aniline Compounds; Arsenic; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Deuterium; Kinetics; NAD; NADP; Niacinamide; Organophosphorus Compounds; Oxidation-Reduction; Oxygen Consumption; Phosphates; Phosphoric Acids; Potentiometry; Pyridinium Compounds; Spectrophotometry; Ultraviolet Rays | 1971 |
Steroid metabolism in rats given (1- 2 H 2 ) ethanol. Biosynthesis of bile acids and reduction of 3-keto-5 -cholanoic acid.
Topics: Alcohol Oxidoreductases; Animals; Bile Acids and Salts; Biliary Fistula; Cholesterol; Chromatography, Gas; Deuterium; Ethanol; Fasting; Female; Glucose; Hydroxysteroid Dehydrogenases; Injections; Isomerism; Male; Mass Spectrometry; Metabolism; NAD; NADP; Oxidation-Reduction; Pyrazoles; Rats | 1972 |
[Comparative extinction of intrinsic fluorescence of horse liver alcohol dehydrogenase (HLADH) by its reduced coenzymes and TNS].
Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Deuterium; Energy Transfer; Fluorescence; Horses; Hydrogen-Ion Concentration; Liver; NAD; NADP; Naphthalenes; Spectrum Analysis; Sulfonic Acids; Toluene | 1971 |
Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns.
Topics: Deuterium; Gas Chromatography-Mass Spectrometry; Hydro-Lyases; Kinetics; NAD; Pseudomonas; Radioisotope Dilution Technique; Urocanate Hydratase | 1981 |
The synthesis of deuterium-substituted, spin-labeled analogues of AMP and NAD+ and their use in ESR studies of lactate dehydrogenase.
Topics: Adenosine Monophosphate; Cyclic N-Oxides; Deuterium; Electron Spin Resonance Spectroscopy; L-Lactate Dehydrogenase; NAD; Spin Labels | 1982 |
Inhibition of gamma-ray dose-rate effects by D2O and inhibitors of poly(ADP-ribose) synthetase in cultured mammalian L5178Y cells.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cobalt Radioisotopes; Deuterium; Deuterium Oxide; Dose-Response Relationship, Radiation; Gamma Rays; Leukemia L5178; Leukemia, Experimental; Mice; NAD; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerase Inhibitors; Theobromine; Theophylline; Water | 1984 |
Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 1. Liver alcohol dehydrogenase with benzyl alcohol and yeast aldehyde dehydrogenase with benzaldehyde.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Aldehyde Dehydrogenase; Animals; Benzaldehydes; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Horses; Kinetics; Liver; NAD; Oxidation-Reduction; Saccharomyces cerevisiae | 1984 |
Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase.
Topics: Aldehyde Oxidoreductases; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Formate Dehydrogenases; Formates; Kinetics; NAD; Nitrogen Isotopes; Oxidation-Reduction; Oxygen Isotopes; Saccharomyces cerevisiae | 1984 |
Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate.
Topics: Carbon Isotopes; Chorismate Mutase; Cyclohexanecarboxylic Acids; Cyclohexenes; Decarboxylation; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Isomerases; Kinetics; Magnetic Resonance Spectroscopy; NAD; Oxidation-Reduction; Oxidoreductases; Prephenate Dehydrogenase; Spectrophotometry, Ultraviolet | 1984 |
Heterogeneity of the sn-glycerol 3-phosphate pool in isolated hepatocytes, demonstrated by the use of deuterated glycerols and ethanol.
Topics: Animals; Deuterium; Female; Glycerol; Glycerophosphates; Half-Life; In Vitro Techniques; Liver; Methanol; NAD; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1984 |
NAD+-dependent ethanol oxidation: redox effects and rate limitation.
Topics: Animals; Cyclohexanols; Cyclohexanones; Cytosol; Deuterium; Ethanol; Female; Kinetics; Liver; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1983 |
Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Bacillus subtilis; Chemical Phenomena; Chemistry, Physical; Deuterium; Hydrogen-Ion Concentration; Mathematics; NAD; Serine | 1981 |
Ribulose-1,5-bisphosphate carboxylase: primary deuterium kinetic isotope effect using [3-2H]ribulose 1,5-bisphosphate.
Topics: Carbon Dioxide; Carboxy-Lyases; Deuterium; Kinetics; NAD; Pentosephosphates; Ribulose-Bisphosphate Carboxylase; Ribulosephosphates | 1982 |
Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one with dihydropteridine reductase.
Topics: Animals; Deuterium; Dihydropteridine Reductase; Humans; Kinetics; Liver; NAD; NADH, NADPH Oxidoreductases; Pteridines; Pterins; Pyrimidines; Pyrimidinones; Sheep | 1983 |
Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system.
Topics: Deuterium; Escherichia coli; Fatty Acid Synthases; Gas Chromatography-Mass Spectrometry; Glutamates; NAD; NADP; Water | 1980 |
Primary deuterium and tritium isotope effects upon V/K in the liver alcohol dehydrogenase reaction with ethanol.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Deuterium; Ethanol; Hydrogen-Ion Concentration; Kinetics; Liver; Mathematics; NAD; Tritium | 1981 |
Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system.
Topics: Camphor; Camphor 5-Monooxygenase; Cytochrome P-450 Enzyme System; Deuterium; Kinetics; Mixed Function Oxygenases; NAD; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1982 |
On the hydrogen-deuterium exchange reaction catalyzed by the soluble hydrogenase from Alcaligenes eutrophus H16 in the free and immobilized state.
Topics: Alcaligenes; Deuterium; Enzyme Activation; Enzymes, Immobilized; Hydrogen; NAD; Oxidoreductases; Time Factors | 1982 |
Analysis of the kinetic mechanism of enterococcal NADH peroxidase reveals catalytic roles for NADH complexes with both oxidized and two-electron-reduced enzyme forms.
Topics: Catalysis; Coenzymes; Deuterium; Electrons; Enterococcus; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; NAD; Oxidation-Reduction; Peroxidases | 1995 |
Mechanistic studies on malate dehydrogenase from Escherichia coli.
Topics: Binding Sites; Deuterium; Diethyl Pyrocarbonate; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Iodoacetates; Iodoacetic Acid; Kinetics; Malate Dehydrogenase; NAD | 1995 |
Quinone reductase reaction catalyzed by Streptococcus faecalis NADH peroxidase.
Topics: Binding Sites; Catalysis; Deuterium; Electron Transport; Enterococcus faecalis; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Kinetics; NAD; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Oxidation-Reduction; Peroxidases; Quinones | 1995 |
Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Topics: Animals; Ascaris suum; Carbon Isotopes; Cations, Divalent; Decarboxylation; Deuterium; Enzyme Activation; Kinetics; Malate Dehydrogenase; Malates; Metals; NAD; Oxaloacetates; Oxidation-Reduction; Substrate Specificity; Tritium | 1995 |
Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Topics: Alcohol Dehydrogenase; Animals; Catalysis; Deuterium; Ethanol; Kinetics; L-Lactate Dehydrogenase; Mathematics; NAD; Rabbits; Saccharomyces cerevisiae | 1993 |
Kinetics of the reductive half-reaction of the iron-sulfur flavoenzyme CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase.
Topics: Cloning, Molecular; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Iron-Sulfur Proteins; Kinetics; NAD; Oxidation-Reduction; Oxidoreductases; Photolysis; Recombinant Proteins; Spectrophotometry; Time Factors; Yersinia pseudotuberculosis | 1996 |
Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex.
Topics: Animals; Ascaris suum; Binding Sites; Cations, Divalent; Deuterium; Electron Spin Resonance Spectroscopy; Malate Dehydrogenase; Malates; Manganese; NAD; Protein Binding; Protein Conformation; Spin Labels; Stereoisomerism; Structure-Activity Relationship | 1996 |
Coupling of ethanol metabolism to lipid biosynthesis: labelling of the glycerol moieties of sn-glycerol-3-phosphate, a phosphatidic acid and a phosphatidylcholine in liver of rats given [1,1-2H2]ethanol.
Topics: Animals; Deuterium; Ethanol; Fatty Liver, Alcoholic; Glycerol; Glycerophosphates; Lipids; Liver; Male; NAD; Phosphatidic Acids; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Triglycerides | 1997 |
Hydrogen exchange/electrospray ionization mass spectrometry studies of substrate and inhibitor binding and conformational changes of Escherichia coli dihydrodipicolinate reductase.
Topics: Amino Acid Sequence; Chromatography, Liquid; Deuterium; Dihydrodipicolinate Reductase; Enzyme Inhibitors; Escherichia coli; Hydrogen; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; NAD; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pepsin A; Peptide Fragments; Picolinic Acids; Protein Binding; Protein Conformation | 1997 |
Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Catalysis; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Deuterium; GTP-Binding Proteins; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; NAD; Pertussis Toxin; Protein Structure, Secondary; Ribose; Virulence Factors, Bordetella | 1997 |
Probing the mechanism of inosine monophosphate dehydrogenase with kinetic isotope effects and NMR determination of the hydride transfer stereospecificity.
Topics: Cations, Monovalent; Deuterium; Enzyme Activation; Humans; Hydrogen; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; Protein Conformation; Recombinant Proteins; Water | 1997 |
Probing the mechanism of the carcinogenic activation of N-nitrosodiethanolamine with deuterium isotope effects: in vivo induction of DNA single-strand breaks and related in vitro assays.
Topics: Animals; Biotransformation; Carcinogens; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Deuterium; Diethylnitrosamine; DNA, Single-Stranded; Kinetics; Liver; Male; NAD; Oxidation-Reduction; Rats; Rats, Wistar; Sulfates; Transfection | 1998 |
Catalytic properties of hybrid complexes of the NAD(H)-binding and NADP(H)-binding domains of the proton-translocating transhydrogenases from Escherichia coli and Rhodospirillum rubrum.
Topics: Binding Sites; Catalysis; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; NAD; NADH, NADPH Oxidoreductases; NADP; Peptide Fragments; Protein Structure, Tertiary; Recombinant Proteins; Rhodospirillum rubrum | 1999 |
Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate.
Topics: Animals; Carbon Isotopes; Catalysis; Cattle; Chickens; Coenzymes; Decarboxylation; Deuterium; Kinetics; Malate Dehydrogenase; Malates; NAD; NADP; Oxaloacetates; Rabbits; Substrate Specificity; Swine | 1998 |
Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cysteine; Deuterium; Humans; IMP Dehydrogenase; Kinetics; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Protein Binding; Serine; Spectrometry, Fluorescence; Thermodynamics; Tritrichomonas foetus | 1999 |
Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Topics: Animals; Ascaris suum; Cattle; Deuterium; Kinetics; Malate Dehydrogenase; Malates; NAD; Oxidation-Reduction; Protons; Substrate Specificity; Tritium | 1999 |
Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens.
Topics: Animals; Binding Sites; Catalysis; Deuterium; Hydrogen-Ion Concentration; Kinetics; L-Iditol 2-Dehydrogenase; Liver; Mannitol Dehydrogenases; Models, Chemical; NAD; NADP; Pseudomonas fluorescens; Recombinant Proteins; Sheep; Stereoisomerism | 1999 |
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Catalysis; Circular Dichroism; Deuterium; Histidine; Kinetics; Lysine; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; Oxidoreductases; Peptide Fragments; Recombinant Proteins; Solvents; Tyrosine | 1999 |
Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.
Topics: Amino Acid Sequence; Bacterial Proteins; Catalysis; Deuterium; Dihydroorotate Dehydrogenase; Enterococcus faecalis; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; NAD; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Solvents; Spectrophotometry; Substrate Specificity | 1999 |
Substrate and solvent isotope effects on the fate of the active oxygen species in substrate-modulated reactions of putidamonooxin.
Topics: Bacterial Proteins; Benzoates; Deuterium; Deuterium Oxide; Hydrogen Peroxide; Hydroxybenzoate Ethers; Hydroxybenzoates; Kinetics; Molecular Weight; NAD; Oxidation-Reduction; Oxidoreductases, O-Demethylating; Oxygenases; Pseudomonas putida; Reactive Oxygen Species; Solvents; Uncoupling Agents | 2000 |
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
Topics: Deuterium; Disulfides; Hydrogen-Ion Concentration; Kinetics; Mycobacterium tuberculosis; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Protons; Solvents | 2001 |
Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes.
Topics: Amino Acid Sequence; Bacterial Outer Membrane Proteins; Cloning, Molecular; Deuterium; Dihydrolipoamide Dehydrogenase; Escherichia coli; Flavin-Adenine Dinucleotide; Genes, Bacterial; Kinetics; Models, Chemical; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Protein Conformation; Pseudomonas putida; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Solvents; Spectrophotometry | 2001 |
Hydride transfer in liver alcohol dehydrogenase: quantum dynamics, kinetic isotope effects, and role of enzyme motion.
Topics: Alcohol Dehydrogenase; Binding Sites; Deuterium; Hydrogen; Kinetics; Liver; Models, Molecular; NAD; Protein Conformation; Quantum Theory; Thermodynamics; Tritium | 2001 |
Reactivity of the B-H Bond in tris(pyrazolyl)hydroborato zinc complexes: unexpected example of zinc hydride formation in a protic solvent and its relevance towards hydrogen transfer to NAD(+) mimics by tris(pyrazolyl)hydroborato zinc complexes in alcoholi
Topics: Acridines; Alcohol Dehydrogenase; Alkanes; Boron Compounds; Catalysis; Cations; Deuterium; Electrochemistry; Hydroxides; Liver; Models, Molecular; Molecular Structure; NAD; Niacinamide; Organometallic Compounds; Zinc; Zinc Compounds | 2002 |
Isotope effects and intermediates in the reduction of NO by P450(NOR).
Topics: Cytochrome P-450 Enzyme System; Deuterium; Electron Spin Resonance Spectroscopy; Fusarium; Kinetics; NAD; Nitric Oxide; Oxidation-Reduction; Oxidoreductases | 2002 |
Detection of multiple active site domain motions in transient-state component time courses of the Clostridium symbiosum L-glutamate dehydrogenase-catalyzed oxidative deamination reaction.
Topics: Amination; Animals; Binding Sites; Calorimetry; Catalysis; Cattle; Clostridium; Deuterium; Glutamate Dehydrogenase; Kinetics; Liver; Models, Chemical; NAD; Oxidation-Reduction; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Thermodynamics | 2002 |
Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Topics: Alcohol Oxidoreductases; Carbon Isotopes; Catalysis; Deuterium; Hydrogen-Ion Concentration; Kinetics; Malates; NAD; Oxaloacetic Acid; Pseudomonas putida | 2002 |
Measurement of the kinetic isotope effect for the oxidation of NADH at a poly(aniline)-modified electrode.
Topics: Aniline Compounds; Deuterium; Electrochemistry; Electrodes; Kinetics; NAD; Oxidation-Reduction | 2003 |
H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.
Topics: Bacterial Proteins; Catalysis; Chemical Phenomena; Chemistry, Physical; Cyclohexanones; Deuterium; Escherichia coli; Flavin Mononucleotide; Flavins; Hydrogen; Hydrogen-Ion Concentration; Kinetics; NAD; Oxidation-Reduction; Oxidoreductases; Spectrophotometry; Temperature; Thermodynamics | 2003 |
Base-catalyzed deuterium exchange with diphosphopyridine nucleotide.
Topics: Alkalies; Coenzymes; Deuterium; NAD | 1955 |
EFFECT OF OXIDIZED NICOTINAMIDE-ADENINE DINUCLEOTIDE ON HYDROGEN-DEUTERIUM EXCHANGE OF YEAST ALCOHOL DEHYDROGENASE AS MEASURED BY INFRARED SPECTROPHOTOMETRY.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Deuterium; Deuterium Exchange Measurement; Hydrogen; Infrared Rays; NAD; Oxidation-Reduction; Research; Spectrophotometry; Spectrophotometry, Infrared; Yeasts | 1963 |
EFFECT OF COENZYMES ON HYDROGEN-DEUTERIUM EXCHANGE OF YEAST ALCOHOL DEHYDROGENASE AS DETERMINED BY INFRARED SPECTROPHOTOMETRY.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Coenzymes; Deuterium; Deuterium Exchange Measurement; Hydrogen; NAD; Oxidation-Reduction; Research; Saccharomyces; Spectrophotometry; Spectrophotometry, Infrared | 1963 |
ENZYMES FROM BOVINE PLACENTA AND SEMINAL VESICLES THAT OXIDIZE D(-)-1,2-PROPANEDIOL AND OTHER POLYOLS: THEIR POSSIBLE RELATION TO FRUCTOSE FORMATION.
Topics: Animals; Carbohydrate Metabolism; Cattle; Deuterium; Enzyme Inhibitors; Female; Fructose; Galactose; Glucose; Glyceraldehyde; Glycerides; Humans; Lactose; Male; NAD; NADP; Oxidoreductases; Placenta; Polymers; Pregnancy; Pregnancy, Animal; Propylene Glycol; Propylene Glycols; Research; Seminal Vesicles; Sorbitol | 1964 |
ISOTOPE AND SOLVENT EFFECTS OF DEUTERIUM ON RABBIT-MUSCLE LACTATE DEHYDROGENASE.
Topics: Alcohol Oxidoreductases; Animals; Deuterium; Hydrogen-Ion Concentration; Isotopes; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Muscles; NAD; Pyruvates; Rabbits; Research; Solvents; Yeasts | 1964 |
EFFECT OF COENZYMES ON THE HYDROGEN-DEUTERIUM EXCHANGE OF CHICKEN HEART LACTIC DEHYDROGENASE AS MEASURED BY INFRARED SPECTROPHOTOMETRY.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Coenzymes; Deuterium; Deuterium Exchange Measurement; Heart; Hydrogen; Infrared Rays; L-Lactate Dehydrogenase; Myocardium; NAD; Oxidoreductases; Poultry; Pyridines; Research; Spectrophotometry; Spectrophotometry, Infrared; Surface-Active Agents | 1965 |
DEUTERIUM ISOTOPE EFFECTS ON BEEF-HEART LACTATE DEHYDROGENASE.
Topics: Animals; Biochemical Phenomena; Biochemistry; Cattle; Deuterium; Isotopes; Kinetics; L-Lactate Dehydrogenase; Muscles; Myocardium; NAD; Research | 1965 |
Enzymatic and oxidative metabolites of lycopene.
Topics: Animals; Carotenoids; Chromatography, High Pressure Liquid; Deuterium; Dithiothreitol; Glycine max; Intestinal Mucosa; Lipoxygenase; Lycopene; Male; Mass Spectrometry; NAD; Oxidation-Reduction; Potassium Chloride; Rats; Rats, Sprague-Dawley; Spectrophotometry | 2003 |
Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant.
Topics: Alanine; Aldehyde Reductase; Amino Acid Substitution; Binding Sites; Candida; Catalysis; Crystallography, X-Ray; Deuterium; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; NAD; Quantitative Structure-Activity Relationship | 2004 |
A general method for the analysis of random bisubstrate enzyme mechanisms.
Topics: 2-Propanol; Alcohol Dehydrogenase; Deuterium; Kinetics; NAD; Nonlinear Dynamics; Substrate Specificity; Yeasts | 2004 |
Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).
Topics: Bacterial Proteins; Cloning, Molecular; Deoxy Sugars; Deuterium; Electrophoresis, Polyacrylamide Gel; Guanosine Diphosphate Sugars; Hexosyltransferases; Hydrogen; Ketone Oxidoreductases; Kinetics; NAD; Yersinia pseudotuberculosis | 2004 |
Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.
Topics: Deuterium; Escherichia coli Proteins; Kinetics; Mutation; NAD; NADH, NADPH Oxidoreductases; NADP; Protein Structure, Tertiary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structural Homology, Protein; Time Factors; Tryptophan; Xylitol | 2005 |
Temperature-induced conformational change at the catalytic site of Sulfolobus solfataricus alcohol dehydrogenase highlighted by Asn249Tyr substitution. A hydrogen/deuterium exchange, kinetic, and fluorescence quenching study.
Topics: Alcohol Dehydrogenase; Amino Acid Substitution; Binding Sites; Deuterium; Hot Temperature; Kinetics; NAD; Point Mutation; Protein Binding; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Sulfolobus solfataricus | 2005 |
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects.
Topics: Bacterial Proteins; Biophysical Phenomena; Biophysics; Catalysis; Deuterium; Enzyme Activation; Enzymes; Hydrostatic Pressure; Isotopes; Kinetics; Models, Chemical; Motion; NAD; Oxidoreductases; Pseudomonas putida; Thermodynamics | 2007 |
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Topics: Animals; Cysteine; D-Xylulose Reductase; Deuterium; Enzyme Inhibitors; Fungal Proteins; Glutamic Acid; Humans; Hydrogen-Ion Concentration; L-Iditol 2-Dehydrogenase; Liver; Molecular Structure; NAD; Oxidation-Reduction; Point Mutation; Sheep; Solvents; Sorbitol; Zinc | 2007 |
Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum.
Topics: Animals; Deuterium; Drug Design; Fluorescence Resonance Energy Transfer; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; NAD; Plasmodium falciparum; Substrate Specificity | 2007 |
Hydride reduction of NAD+ analogues by isopropyl alcohol: kinetics, deuterium isotope effects and mechanism.
Topics: 2-Propanol; Boranes; Deuterium; Kinetics; Molecular Structure; NAD; Oxidation-Reduction; Solvents | 2008 |
Kinetics of the hydride reduction of an NAD(+) analogue by isopropyl alcohol in aqueous and acetonitrile solutions: solvent effects, deuterium isotope effects, and mechanism.
Topics: 2-Propanol; Acetonitriles; Alcohol Dehydrogenase; Alcohols; Catalytic Domain; Deuterium; Hydroxyl Radical; Isotopes; Kinetics; Models, Chemical; NAD; Solvents; Temperature | 2009 |
Insight into the stereospecificity of short-chain thermus thermophilus alcohol dehydrogenase showing pro-S hydride transfer and prelog enantioselectivity.
Topics: 2-Propanol; Alcohol Dehydrogenase; Bacterial Proteins; Deuterium; Models, Molecular; NAD; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Stereoisomerism; Thermus thermophilus | 2010 |
Binding ligands and cofactor to L-lactate dehydrogenase from human skeletal and heart muscles.
Topics: Deuterium; Humans; L-Lactate Dehydrogenase; Ligands; Molecular Dynamics Simulation; Muscle, Skeletal; Myocardium; NAD; Protein Binding; Protein Isoforms; Quantum Theory; Water | 2011 |
Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Topics: Amino Acid Substitution; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Deuterium; Enzyme Stability; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; NAD; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases; Viscosity | 2012 |
Catalytic mechanism of human UDP-glucose 6-dehydrogenase: in situ proton NMR studies reveal that the C-5 hydrogen of UDP-glucose is not exchanged with bulk water during the enzymatic reaction.
Topics: Biocatalysis; Deuterium; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation; NAD; Nuclear Magnetic Resonance, Biomolecular; Protons; Recombinant Proteins; Stereoisomerism; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid; Water | 2012 |
Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+).
Topics: 2-Propanol; Alcohol Dehydrogenase; Alcohols; Animals; Catalytic Domain; Chemistry Techniques, Synthetic; Deuterium; Enzyme Inhibitors; Horses; NAD; Niacinamide; Oligopeptides; Spectrophotometry, Ultraviolet; Substrate Specificity | 2014 |
Triple Isotope Effects Support Concerted Hydride and Proton Transfer and Promoting Vibrations in Human Heart Lactate Dehydrogenase.
Topics: Deuterium; Heart; Humans; Hydrogen; Kinetics; Lactate Dehydrogenases; NAD; Protons; Vibration | 2016 |
Simultaneous Measurement of Glucose-6-phosphate 3-Dehydrogenase (NtdC) Catalysis and the Nonenzymatic Reaction of Its Product: Kinetics and Isotope Effects on the First Step in Kanosamine Biosynthesis.
Topics: Bacillus subtilis; Bacterial Proteins; Biocatalysis; Deuterium; Escherichia coli; Gene Expression Regulation, Bacterial; Glucosamine; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; NAD; Operon; Oxidation-Reduction; Protons; Recombinant Proteins; Thermodynamics | 2017 |
Hydrogen-Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin.
Topics: Antibodies, Monoclonal; Antibodies, Neutralizing; Corynebacterium diphtheriae; Deuterium; Deuterium Exchange Measurement; Diphtheria Toxin; Epitope Mapping; Epitopes; Kinetics; NAD; Protein Binding; Protein Conformation; Protein Domains | 2019 |
Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells.
Topics: Animals; Cell Line; Cytosol; Deuterium; Electron Transport; HEK293 Cells; Humans; Mammals; Mitochondria; NAD; NADP; Oxidation-Reduction | 2020 |
Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.
Topics: Animals; Deuterium; Glioblastoma; Lactic Acid; Mice; NAD; Pyruvic Acid; Telomerase | 2022 |
Identification of l-Tryptophan by down-field
Topics: Brain; Deuterium; Humans; Magnetic Resonance Spectroscopy; NAD; Protons; Serotonin; Tryptophan | 2022 |
The structure of NAD
Topics: Acinetobacter baumannii; Bacteria; Bacterial Proteins; Deuterium; Hydrolases; Mammals; NAD; Protein Domains | 2023 |