deuterium has been researched along with methotrexate in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufman, S; Milstien, S | 1 |
| Kalman, TI | 1 |
| Brown, KA; Farnum, MF; Howell, EE; Kraut, J; Warren, MS | 1 |
| Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE; Warren, MS | 1 |
| Deits, T; Jerkunica, I; Whiteley, JM | 1 |
| Pastore, EJ | 1 |
| Poe, M | 1 |
| Berchtold, W; Bürki, H; Laissue, JA | 1 |
| de Jonge, R; den Boer, E; Lindemans, J; Luider, TM; Mathot, RA; Meesters, RJ; van Klaveren, RJ | 1 |
| Becker, ML; Leeder, JS; Stobaugh, JF; van Haandel, L; Williams, TD | 1 |
10 other study(ies) available for deuterium and methotrexate
| Article | Year |
|---|---|
Studies on the phenylalanine hydroxylase system in vivo. An in vivo assay based on the liberation of deuterium or tritium into the body water from ring-labeled L-phenylalanine.
Topics: Animals; Body Water; Deuterium; Fenclonine; Isotope Labeling; Kinetics; Methotrexate; Molecular Conformation; Phenylalanine; Phenylalanine Hydroxylase; Rats; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1975 |
Molecular aspects of the mechanism of action of 5-fluorodeoxyuridine.
Topics: Deuterium; Floxuridine; Isotope Labeling; Kinetics; Lacticaseibacillus casei; Mathematics; Methotrexate; Methyltransferases; Molecular Conformation; Thymidylate Synthase | 1975 |
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Coenzymes; Deuterium; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tryptophan | 1991 |
Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis.
Topics: Aspartic Acid; Crystallography; Deuterium; Escherichia coli; Kinetics; Methotrexate; Mutation; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1986 |
Affinity chromatography of thymidylate synthetases using 5-fluoro-2'-deoxyuridine 5'-phosphate derivatives of sepharose.
Topics: Binding Sites; Chromatography, Affinity; Coliphages; Deuterium; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Evaluation Studies as Topic; Floxuridine; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Methyltransferases; Organophosphorus Compounds; Protein Binding; Structure-Activity Relationship; Thymidylate Synthase; Uracil Nucleotides | 1974 |
Proton magnetic resonance studies of folate and folate antagonists.
Topics: Aminopterin; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Structure-Activity Relationship; Temperature | 1971 |
Proton magnetic resonance studies of folate, dihydrofolate, and methotrexate. Evidence from pH and concentration studies for dimerization.
Topics: Aminopterin; Carboxylic Acids; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Hydrogen-Ion Concentration; Macromolecular Substances; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; Models, Structural; Osmolar Concentration; Protons; Pterins; Spectrophotometry, Ultraviolet | 1973 |
Survival of tumor-bearing mice exposed to heavy water or heavy water plus methotrexate.
Topics: Animals; Cell Line; Deuterium; Female; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasm Transplantation; Probability; Sarcoma, Experimental; Time Factors | 1982 |
Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry.
Topics: Deuterium; Drug Stability; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2011 |
Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Deuterium; Erythrocytes; Humans; Ions; Isotope Labeling; Methotrexate; Phenethylamines; Polyglutamic Acid; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |