deuterium has been researched along with dimethylnitrosamine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kroeger-Koepke, MB; Michejda, CJ | 1 |
| Oshiro, Y; Sarma, DS; Zielinski, WL | 1 |
| Cottrell, RC; Gangolli, SD; Lake, BG; Phillips, JC | 1 |
| Heyns, K; Röper, H | 1 |
| Archer, MC; Dagani, D | 1 |
| Keefer, LK; Kleihues, P; Nims, RW; Reist, EJ; Schmerold, I; von Hofe, E | 1 |
| Bradley, MO; Kraynak, AR; Perry, RM; Sargent, EV; Storer, RD | 1 |
| Anderson, LM; Heur, YH; Keefer, LK; Kleihues, P; Mico, BA; Nelson, VC; Nims, RW; Streeter, AJ; von Hofe, E | 1 |
| Anjo, T; Hrabie, JA; Keefer, LK; Metral, CJ; Mico, BA; Riggs, CW; Roman, JM; Wade, D; Yang, CS | 1 |
| Anjo, T; Keefer, LK; Wade, D; Yang, CS | 1 |
| Garland, WA; Hu, HS; Keefer, LK; Mico, BA; Oldfield, NF; Swagzdis, JE | 1 |
| Angeles, RM; Keefer, LK; Mace, R; Swann, PF | 1 |
| Farrelly, JG; Lijinsky, W; Saavedra, JE; Stewart, ML | 1 |
| Lijinsky, W; Reuber, MD | 1 |
| Anderson, LW; Dickens, BF; Kusmierz, JJ; Mandel, HG | 1 |
| Calcutt, MW; Chowdhury, G; Guengerich, FP | 1 |
| Craft, S; Lu, K; Moeller, BC; Nakamura, J; Swenberg, JA | 1 |
| Calcutt, MW; Chowdhury, G; Guengerich, FP; Nagy, LD | 1 |
18 other study(ies) available for deuterium and dimethylnitrosamine
| Article | Year |
|---|---|
Evidence for several demethylase enzymes in the oxidation of dimethylnitrosamine and phenylmethylnitrosamine by rat liver fractions.
Topics: Animals; Deuterium; Dimethylnitrosamine; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Subcellular Fractions | 1979 |
Deuterium isotope effect on rat liver DNA damage in vivo by dimethylnitrosamine.
Topics: Animals; Deuterium; Dimethylnitrosamine; DNA; Liver; Nitrosamines; Rats | 1978 |
Metabolic degradation of stable-isotope-labelled dimethylnitrosamine by rat liver.
Topics: Animals; Deuterium; Dimethylnitrosamine; Liver; Nitrogen Isotopes; Nitrosamines; Rats | 1977 |
Mass spectrometry of nitrosamines: rearrangement of nitrosobenzylmethylamine molecular ions with loss of OH-radicals investigated by deuterated derivatives.
Topics: Chemical Phenomena; Chemistry; Deuterium; Dimethylnitrosamine; Free Radicals; Mass Spectrometry; Nitrosamines; Structure-Activity Relationship | 1976 |
Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.
Topics: Animals; Binding, Competitive; Carcinogens; Chemical Phenomena; Chemistry; Deuterium; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrosamines; Rats | 1976 |
Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Chromatography; Deuterium; Dimethylnitrosamine; DNA; Esophagus; Guanine; Kidney; Liver; Lung; Male; Methylation; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344 | 1991 |
The effect of deuterium labeling on the genotoxicity of N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate.
Topics: Animals; Cell Survival; Deuterium; Dimethylnitrosamine; DNA Damage; Epichlorohydrin; Liver; Male; Mutagens; Rats; Rats, Inbred Strains; Sulfuric Acid Esters | 1991 |
Single-dose toxicokinetics of N-nitrosomethylethylamine and N-nitrosomethyl (2,2,2-trideuterioethyl)amine in the rat.
Topics: Animals; Deuterium; Dimethylnitrosamine; Hydroxylation; Injections, Intravenous; Intubation, Gastrointestinal; Kidney; Male; Rats; Rats, Inbred F344 | 1990 |
Deuterium isotope effect on denitrosation and demethylation of N-nitrosodimethylamine by rat liver microsomes.
Topics: Animals; Cytochrome P-450 CYP2E1; Deuterium; Dimethylnitrosamine; In Vitro Techniques; Kinetics; Mass Spectrometry; Methylation; Microsomes, Liver; Nitrates; Oxidoreductases, N-Demethylating; Rats | 1987 |
Kinetic isotope effect on the demethylation and denitrosation of N-nitrosodimethylamine in vitro.
Topics: Acetone; Animals; Deuterium; Dimethylnitrosamine; In Vitro Techniques; Kinetics; Microsomes, Liver; Radiochemistry; Rats | 1987 |
Low-dose in vivo pharmacokinetic and deuterium isotope effect studies of N-nitrosodimethylamine in rats.
Topics: Animals; Deuterium; Dimethylnitrosamine; Kinetics; Male; Metabolic Clearance Rate; Rats; Structure-Activity Relationship | 1985 |
Deuterium isotope effect on metabolism of N-nitrosodimethylamine in vivo in rat.
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deuterium; Dimethylnitrosamine; Female; Kinetics; Rats; Rats, Inbred Strains; Respiration | 1983 |
Relationship between carcinogenicity and in vitro metabolism of nitrosomethylethylamine, nitrosomethyl-N-butylamine, and nitrosomethyl-(2-phenylethyl)amine labeled with deuterium in the methyl and alpha-methylene positions.
Topics: Animals; Biotransformation; Carcinogens; Deuterium; Dimethylnitrosamine; Kinetics; Male; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1982 |
Carcinogenicity in rats of nitrosomethylethylamines labeled with deuterium in several positions.
Topics: Animals; Deuterium; Dimethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Nose Neoplasms; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1980 |
Quantitation of urinary 7-methyladenine by gas chromatography-mass spectrometry using isotopically labeled internal standards.
Topics: Adenine; Animals; Deuterium; Dimethylnitrosamine; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Rats; Reference Standards; Reproducibility of Results; Tritium | 1994 |
Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.
Topics: Aldehydes; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Carbon Radioisotopes; Carboxylic Acids; Cytochrome P-450 CYP2A6; Deuterium; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Mass Spectrometry; Methane; Models, Chemical; NADP; Oxidation-Reduction; Substrate Specificity | 2010 |
Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine.
Topics: Carbon Isotopes; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deuterium; Dimethylnitrosamine; DNA Adducts; DNA Methylation; Formaldehyde; HeLa Cells; Humans; Tandem Mass Spectrometry | 2012 |
Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Deuterium; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2012 |