Page last updated: 2024-08-22

deuterium and cobamamide

deuterium has been researched along with cobamamide in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's4 (17.39)18.2507
2000's13 (56.52)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bachovchin, WW; Gunter, JB; Moore, KW; Richards, JH1
Bachovchin, WW; Moore, KW; Richards, JH1
Hull, WE; König, A; Michenfelder, M; Rétey, J; Wölfle, K1
Abeles, RH; Toraya, T1
Babior, BM; Diziol, P; Graves, SW; Haas, H; Rétey, J1
Leadlay, PF; Meier, TW; Thomä, NH1
Chen, HP; Marsh, EN1
Albracht, SP; Bothe, H; Buckel, W; Darley, DJ; Gerfen, GJ; Golding, BT1
Evans, PR; Leadlay, PF; Meier, TW; Thomä, NH1
Evans, PR; Leadlay, PF; Thomä, NH1
Bandarian, V; Reed, GH1
Banerjee, R; Chowdhury, S; Escalante-Semerena, JC; Thomas, MG1
Bandarian, V; Chen, X; LoBrutto, R; Magnusson, OT; Reed, GH; Schramm, VL1
Frey, PA; Magnusson, OT1
O'Hagan, D; Patterson, S1
Ballou, DP; Madhavapeddi, P; Marsh, EN1
Darbre, T; Sun, F1
Ballou, DP; Marsh, EN; Xia, L1
Banerjee, R; Vlasie, MD1
Cheng, MC; Marsh, EN1
Banerjee, R; Fazliddinova, N; Mansoorabadi, SO; Padmakumar, R; Reed, GH; Vlasie, M1
Banerjee, R; Dybala-Defratyka, A; Paneth, P; Truhlar, DG1
Håkansson, K; Marsh, EN; Song, H; Yoon, M1

Other Studies

23 other study(ies) available for deuterium and cobamamide

ArticleYear
Hydrogen transfer in catalysis by adenosylcobalamin-dependent diol dehydratase.
    Biochemistry, 1979, Jun-26, Volume: 18, Issue:13

    Topics: Cobamides; Deuterium; Hydro-Lyases; Kinetics; Klebsiella pneumoniae; Mathematics; Propanediol Dehydratase

1979
Mechanism of action of adenosylcobalamin: hydrogen transfer in the inactivation of diol dehydratase by glycerol.
    Biochemistry, 1978, May-30, Volume: 17, Issue:11

    Topics: Cobamides; Deuterium; Glycerol; Hydro-Lyases; Isotope Labeling; Kinetics; Mathematics; Propanediol Dehydratase

1978
On the mechanism of action of methylmalonyl-CoA mutase. Change of the steric course on isotope substitution.
    European journal of biochemistry, 1986, May-02, Volume: 156, Issue:3

    Topics: Acyl Coenzyme A; Catalysis; Cobamides; Deuterium; Isomerases; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Malonyl Coenzyme A; Methylmalonyl-CoA Mutase; Stereoisomerism; Substrate Specificity; Tritium

1986
Inactivation of dioldehydrase in the presence of a coenzyme-B12 analog.
    Archives of biochemistry and biophysics, 1980, Volume: 203, Issue:1

    Topics: Cobamides; Deuterium; Hydro-Lyases; Klebsiella pneumoniae; Propanediol Dehydratase; Propylene Glycols; Protein Binding; Spectrophotometry

1980
The substrate-dependent steric course of the ethanolamine ammonia-lyase reaction.
    European journal of biochemistry, 1980, Volume: 106, Issue:1

    Topics: Aldehydes; Ammonia-Lyases; Carbon Radioisotopes; Cobamides; Deuterium; Ethanolamine Ammonia-Lyase; Isotope Labeling; Models, Chemical; Propanolamines; Stereoisomerism; Substrate Specificity; Tritium

1980
Tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-CoA mutase.
    Biochemistry, 1996, Sep-10, Volume: 35, Issue:36

    Topics: Acyl Coenzyme A; Cobamides; Deuterium; Kinetics; Methylmalonyl-CoA Mutase; Molecular Structure; Propionibacterium; Protein Binding; Tritium

1996
Adenosylcobalamin-dependent glutamate mutase: examination of substrate and coenzyme binding in an engineered fusion protein possessing simplified subunit structure and kinetic properties.
    Biochemistry, 1997, Dec-02, Volume: 36, Issue:48

    Topics: Apoenzymes; Clostridium; Cobamides; Deuterium; Escherichia coli; Intramolecular Transferases; Kinetics; Peptide Fragments; Protein Engineering; Recombinant Fusion Proteins

1997
Identification of the 4-glutamyl radical as an intermediate in the carbon skeleton rearrangement catalyzed by coenzyme B12-dependent glutamate mutase from Clostridium cochlearium.
    Biochemistry, 1998, Mar-24, Volume: 37, Issue:12

    Topics: Carbon; Carbon Isotopes; Catalysis; Clostridium; Cobamides; Deuterium; Electron Spin Resonance Spectroscopy; Glutamates; Glutamine; Intramolecular Transferases; Substrate Specificity

1998
Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase.
    Biochemistry, 1998, Oct-13, Volume: 37, Issue:41

    Topics: Amino Acid Substitution; Binding Sites; Cobamides; Crystallization; Crystallography, X-Ray; Deuterium; Enzyme Stability; Free Radicals; Kinetics; Methylmalonyl-CoA Mutase; Mutagenesis, Site-Directed; Phenylalanine; Propionibacterium; Tritium; Tyrosine

1998
Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase.
    Biochemistry, 2000, Aug-08, Volume: 39, Issue:31

    Topics: Aerobiosis; Alanine; Binding Sites; Cobamides; Crystallization; Crystallography, X-Ray; Deuterium; Free Radicals; Glutamine; Histidine; Kinetics; Methylmalonyl-CoA Mutase; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Propionibacterium; Spectrophotometry, Ultraviolet; Spectrum Analysis; Tritium

2000
Isotope effects in the transient phases of the reaction catalyzed by ethanolamine ammonia-lyase: determination of the number of exchangeable hydrogens in the enzyme-cofactor complex.
    Biochemistry, 2000, Oct-03, Volume: 39, Issue:39

    Topics: Catalysis; Cobamides; Coenzymes; Deuterium; Electron Transport; Ethanolamine Ammonia-Lyase; Hydrogen; Kinetics; Models, Chemical; Spectrophotometry; Substrate Specificity; Tritium

2000
The coenzyme b12 analog 5'-deoxyadenosylcobinamide-gdp supports catalysis by methylmalonyl-coa mutase in the absence of trans-ligand coordination.
    The Journal of biological chemistry, 2001, Jan-12, Volume: 276, Issue:2

    Topics: Binding Sites; Catalysis; Cobamides; Deuterium; Electron Spin Resonance Spectroscopy; Guanosine Diphosphate; Histidine; Kinetics; Ligands; Methylmalonyl-CoA Mutase; Models, Molecular; Molecular Conformation; Propionibacterium; Recombinant Proteins; Spectrophotometry

2001
5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies.
    Biochemistry, 2001, Jan-09, Volume: 40, Issue:1

    Topics: Binding Sites; Carbon Isotopes; Cobamides; Deoxyadenosines; Deuterium; Electron Spin Resonance Spectroscopy; Ethanolamine Ammonia-Lyase; Free Radicals; Propanolamines; Substrate Specificity

2001
Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer.
    Biochemistry, 2002, Feb-05, Volume: 41, Issue:5

    Topics: Carbon; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cobalt; Cobamides; Deuterium; Dideoxyadenosine; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Propanediol Dehydratase; Salmonella typhimurium; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Vitamin B 12

2002
Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process.
    Phytochemistry, 2002, Volume: 61, Issue:3

    Topics: Atropine; Atropine Derivatives; Carbon Isotopes; Cell Extracts; Cells, Cultured; Cobamides; Datura stramonium; Deuterium; Gas Chromatography-Mass Spectrometry; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Plant Roots; S-Adenosylmethionine

2002
Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase.
    Biochemistry, 2002, Dec-31, Volume: 41, Issue:52

    Topics: Amino Acid Substitution; Binding Sites; Cobamides; Deuterium; Escherichia coli Proteins; Glutamic Acid; Glutamine; Intramolecular Transferases; Kinetics; Mutagenesis, Site-Directed; N-Methylaspartate; Recombinant Proteins; Spectrophotometry, Ultraviolet; Substrate Specificity

2002
The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase.
    Organic & biomolecular chemistry, 2003, Sep-21, Volume: 1, Issue:18

    Topics: Chemistry, Organic; Cobamides; Deuterium; Electrochemistry; Malonates; Methylmalonyl-CoA Mutase; Models, Chemical; Succinic Acid

2003
Role of Arg100 in the active site of adenosylcobalamin-dependent glutamate mutase.
    Biochemistry, 2004, Mar-23, Volume: 43, Issue:11

    Topics: Arginine; Bacterial Proteins; Binding Sites; Catalysis; Cobamides; Deuterium; Glutamic Acid; Hydrogen Bonding; Intramolecular Transferases; Kinetics; Lysine; Mutagenesis, Site-Directed; N-Methylaspartate; Spectrophotometry; Substrate Specificity; Vitamin B 12

2004
When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase.
    Biochemistry, 2004, Jul-06, Volume: 43, Issue:26

    Topics: Acyl Coenzyme A; Binding Sites; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Cobamides; Deuterium; Electron Transport; Electrons; Hydrogen Bonding; Kinetics; Methylmalonyl-CoA Mutase; Models, Chemical; Models, Molecular; Mutation; Spectrometry, Mass, Electrospray Ionization; Time Factors; Ultraviolet Rays; Vitamin B 12

2004
Isotope effects for deuterium transfer between substrate and coenzyme in adenosylcobalamin-dependent glutamate mutase.
    Biochemistry, 2005, Feb-22, Volume: 44, Issue:7

    Topics: Catalysis; Chromatography, High Pressure Liquid; Cobamides; Deoxyadenosines; Deuterium; Deuterium Exchange Measurement; Energy Transfer; Escherichia coli Proteins; Free Radicals; Glutamic Acid; Holoenzymes; Hydrogen; Intramolecular Transferases; Kinetics; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity

2005
Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase.
    Biochemistry, 2005, Mar-08, Volume: 44, Issue:9

    Topics: Acyl Coenzyme A; Bacterial Proteins; Binding Sites; Carbon Isotopes; Catalysis; Cobalt; Cobamides; Coenzyme A Ligases; Deuterium; Electron Spin Resonance Spectroscopy; Free Radicals; Methylmalonyl-CoA Mutase; Models, Molecular; Spin Labels; Substrate Specificity; Vitamin B 12

2005
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jun-26, Volume: 104, Issue:26

    Topics: Binding Sites; Catalysis; Cobamides; Deuterium; Free Radicals; Hydrogen; Intramolecular Transferases; Kinetics; Models, Chemical; Models, Molecular; Motion; Quantum Theory; Vitamin B 12

2007
Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition.
    Biochemistry, 2010, Apr-13, Volume: 49, Issue:14

    Topics: Aspartic Acid; Cobamides; Deoxyadenosines; Deuterium; Hydrogen; Intramolecular Transferases; Kinetics; Models, Molecular; Temperature; Thermodynamics

2010