desoxycorticosterone has been researched along with spironolactone in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 118 (71.52) | 18.7374 |
| 1990's | 15 (9.09) | 18.2507 |
| 2000's | 22 (13.33) | 29.6817 |
| 2010's | 9 (5.45) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Haga, N; Ishibashi, M; Itoh, T; Kamata, S; Matsui, T; Nakamura, M; Odaguchi, K; Shimizu, T; Suzuki, T; Yamada, F | 1 |
| Bellavance, E; Luu-The, V; Poirier, D | 1 |
| Dean, HG; Lee, MR; Rylett, P | 1 |
| Kishikawa, T; Kugai, N; Nishiki, K; Ogata, E | 1 |
| Lafuma, J; Schorn, H; Walter, C | 1 |
| Gregorová, I; Horký, K; Silinková-Málková, E; Tomsová, Z; Vancura, J | 1 |
| Aguilera, G; Catt, KJ | 1 |
| Wexler, BC | 1 |
| Bucher, H; Furrer, J; Keller, HP; Rampini, S; Zachmann, M | 1 |
| Jones, W; Wong, R | 1 |
| Brown, EA; Chinn, LJ; Karim, A; Mizuba, SS | 1 |
| Abshagen, U; Oelkers, W; Schöneshöfer, M; Spörl, S | 1 |
| Hofmann, LM; Weier, RM | 1 |
| Chinn, LJ; Hofmann, LM; Krupnick, MI; Pedrera, HA; Suleymanov, OD | 1 |
| Mulrow, PJ; Tan, SY | 1 |
| Cummings, JR; Gussin, RZ; Ronsberg, MA; Stokey, EH | 1 |
| Epstein, M; Levinson, R; Pins, DS; Schneider, N | 1 |
| Bader, M; Djavidani, B; Ganten, D; Maser-Gluth, C; Mullins, J; Peters, J; Sander, M; Vecsei, P | 1 |
| Christ, M; Eisen, C; Wehling, M | 1 |
| Morris, DJ; Souness, GW | 1 |
| Ichikawa, S; Murata, K; Nakamura, T; Ono, Z; Sakamaki, T; Sakamoto, H; Takayama, Y | 1 |
| Biglieri, EG; Irony, I; Kater, CE; Shackleton, CH | 1 |
| Capek, K; Pácha, J; Popp, M | 1 |
| Fregly, MJ; Sumners, C | 1 |
| Ichikawa, S; Kato, T; Kogure, M; Murata, K; Nakamura, T; Sakamaki, T; Sato, K; Tajima, Y | 1 |
| Churchill, MC; Churchill, PC; Malvin, RL | 1 |
| Alexander, EA; Bengele, HH; Perrone, RD | 1 |
| Brown, RS; Sugarman, A | 1 |
| Beaumont, K | 1 |
| Kaissling, B | 1 |
| Brown, JJ; Ferriss, JB; Fraser, R; Lever, AF; Love, DR; Robertson, JI; Wilson, A | 1 |
| Beevers, DG; Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lebel, M; Lever, AF; Morton, JJ; Robertson, JI; Schalekamp, MA; Tree, M; Wilson, A | 1 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Kourounakis, P; Selye, H; Szabo, S | 2 |
| Richards, P | 1 |
| Melby, JC | 1 |
| Hoffmeister, AW; Hoffmeister, W | 1 |
| Besarab, A; Charney, AN; Epstein, FH; Silva, P | 1 |
| Fachet, J; Hajtman, B; Palkovits, M; Stark, E | 1 |
| Weille, FL | 1 |
| Mundi, B; Nuding, J; Perner, F; Vallent, K | 1 |
| Palkovits, M | 2 |
| Selye, H | 12 |
| Spark, RF | 1 |
| Forte, LR | 1 |
| Horton, R | 1 |
| Genard, P; Matagne, D; Palem-Vliers, M; Reuter, A | 1 |
| Speller, PJ; Streeten, DH | 1 |
| Mécs, I; Savoie, L; Selye, H | 1 |
| Krajny, M; Solymoss, B; Varga, S | 1 |
| Selye, H; Solymoss, B | 1 |
| Mécs, I; Selye, H; Yeghiayan, E | 1 |
| Beevers, DG; Brown, JJ; Ferriss, JB; Fraser, R; Lever, AF; Robertson, JI | 1 |
| Ripa, R | 1 |
| Mills, IH | 1 |
| Regal, EM; Schrier, RW | 1 |
| Chinn, LJ; Hofmann, LM | 1 |
| Ausiello, DA; Sharp, GW | 1 |
| Kaplan, NM | 1 |
| Linèt, O | 1 |
| Bartter, FC; Delea, CS; Gill, JR | 1 |
| Garcia, HA; Hofmann, LM | 1 |
| Baer, L; Fieve, RR; Kassir, S; Platman, SR | 1 |
| Skadhauge, E | 1 |
| Jelinek, J; Krajny, M; Selye, H | 1 |
| Bartter, FC; Gill, JR; Wills, MR | 1 |
| Alberti, KG; Sharp, GW | 1 |
| Vogel, HG | 1 |
| Gibiński, K; Giec, L; Kokot, F; Nowak, S | 1 |
| Kovacs, K; Somogyi, A | 1 |
| Gardell, C; Hatakeyama, S; Kovacs, K; Tuchweber, B | 1 |
| Garg, BD; Hatakeyama, S; Tuchweber, B | 1 |
| Kimsey, J; Porter, GA | 1 |
| Kovacs, K; Tuchweber, B | 1 |
| Ito, H; Rikimaru, S; Shioji, R | 1 |
| Beckhelm, GA; Willard, PW | 1 |
| Handler, JS; Orloff, J; Preston, AS | 1 |
| Delarue, NC; Laidlaw, JC; Ruse, JL; Salti, IS; Stiefel, M | 1 |
| Laidlaw, JC; Ruse, JL; Salti, IS; Stiefel, M | 1 |
| Glitzer, MS; Steelman, SL | 2 |
| Hammer, C; Radó, JP; Szilágyi, L; Takó, J | 1 |
| Komack, CL; Leaf, A; Sharp, GW | 1 |
| Fregly, MJ; Waters, IW | 1 |
| Hofmann, LM | 1 |
| Bacciarelli, C | 1 |
| Boedeker, EC; Charney, AN; Decker, RA; Donowitz, M; Marnane, WG; Tai, YH | 1 |
| Asp, ND; Berg, GJ; Fisher, JS; Fittingoff, DB; Mayes, DM; Sowers, JR; Tuck, ML | 1 |
| Chatterjee, TK; Das, S; Ganguly, A; Ghosh, JJ | 1 |
| Sekihara, H | 1 |
| Campen, TJ; Fanestil, DD; Vaughn, DA | 1 |
| Alexander, EA; Bengele, HH; Dale, SL; Melby, JC; Perrone, RD; Schwartz, JH | 1 |
| Sokolova, MM | 1 |
| Man in 't Veld, AJ; Schalekamp, MA; Wenting, GJ | 1 |
| Buse, M; Casals-Stenzel, J; Losert, W | 1 |
| Arrieta, J; Cabarcos, A; Damiano, A; Esteban, L; Quiroga, J; Yagüe, S | 1 |
| Hopfer, U; Lebowitz, JL; Will, PC | 1 |
| Funder, J; Head, G; Young, M | 1 |
| Cosen-Binker, L; de Kloet, ER; De Nicola, AF; Gonzalez, S; Grillo, CA; McEwen, BS; Vallee, SM | 1 |
| Ebihara, A; Fujimura, A; Shiga, T | 1 |
| de Jong, W; de Kloet, ER; Van den Berg, DT | 1 |
| Kageyama, Y; Saruta, T; Suzuki, H | 1 |
| Funder, JW; Liu, JP; Sato, A | 1 |
| Pácha, J; Zemanová, Z | 1 |
| Brown, L; Duce, B; Miric, G; Sernia, C | 1 |
| Fadzilah, S; Hamid, A; Khalid, BA; Morat, PB; Nwe, KH | 1 |
| Grafte-Faure, S; Leveque, C; Norris, V; Soria, C; Vannier, JP; Vasse, M | 1 |
| Fluharty, SJ; Ma, LY; McEwen, BS; Sakai, RR | 1 |
| Copolov, D; Huang, W; Lee, D; Lim, AT; Wang, L | 1 |
| Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ | 1 |
| Barthelmebs, M; De Jong, W; De Kloet, ER; Grima, M; Imbs, JL; Rahmouni, K; Sibug, RM | 1 |
| Breyer, MD; Hao, CM; Harris, RC; McKanna, JA; Zhang, MZ | 1 |
| Funder, JW | 1 |
| Dilley, R; Funder, JW; Moussa, L; Young, MJ | 1 |
| Fujisawa, G; Fujita, N; Ishibashi, S; Itabashi, N; Kusano, E; Muto, S; Okada, K | 1 |
| BAQUICHE, M; DUCOMMUN, P; DUCOMMUN, S | 1 |
| UETE, T; VENNING, EH | 1 |
| DIXON, JP; MCNEILL, IF; MOORE, FD | 1 |
| CONN, JW; LOUIS, LH; ROVNER, DR; STEVENSON, CT; STREETEN, DH | 1 |
| AOKI, K | 1 |
| ANDERSON, ML; BOUSKA, DJ; KAGAWA, CM | 2 |
| ABE, S; DEMURA, H; FUKUCHI, S; HANATA, M; SHIOJI, R | 1 |
| KAGAWA, CM | 1 |
| KAGAWA, CM; PAPPO, R | 1 |
| BIGLIERI, EG; SLATON, PE | 1 |
| LEAF, A; SHARP, GW | 1 |
| GILLENWATER, JY | 1 |
| IMAI, S; KATORI, M; MURASE, H; OKADA, M; SHIGEI, T | 1 |
| Beltz, T; Felder, RB; Francis, J; Johnson, AK | 1 |
| Funder, JW; Young, M | 1 |
| Burnham, WM; Edwards, HE; Vimal, S | 1 |
| Belaiba, RS; Berchtold, S; Dalton, ND; Daut, J; Flögel, U; Friedrich, B; Görlach, A; Grahammer, F; Huang, DY; Hussain, A; Kandolf, R; Klingel, K; Kuhl, D; Lang, F; Osswald, H; Ross, J; Schrader, J; Vallon, V; Wulff, P; Wyatt, AW | 1 |
| Shibata, H | 1 |
| Artunc, F; Avram, D; Boehmer, C; Boini, KM; Friedrich, B; Grahammer, F; Häring, HU; Hennige, AM; Huang, DY; Kuhl, D; Lang, F; Osswald, H; Palmada, M; Ullrich, S; Vallon, V; Wulff, P | 1 |
| Chaffin, CL; Fru, KN; VandeVoort, CA | 1 |
| Fuller, PJ; Funder, JW; Morgan, J; Rickard, AJ; Young, MJ | 1 |
| Fujisawa, G; Ishibashi, S; Iwazu, Y; Kusano, E; Muto, S; Nakazawa, E; Okada, K | 1 |
| Klein, M; Krahn, T; Kramer, F; Sandner, P | 1 |
| Amann, K; Hartner, A; Hilgers, KF; Klanke, B; Melk, A; Steinbach, MP; Westhoff, JH | 1 |
| Cordasic, N; Hartner, A; Hilgers, KF; Klanke, B; Schmieder, RE; Veelken, R | 1 |
| Brands, MW; Cannon, JG; Schreihofer, DA; Sturgis, LC | 1 |
| Johnson, AK; Morris, MJ; Na, ES | 1 |
| Brennan, FE; Cheung, CM; Fuller, PJ; Pippal, JB; Yao, YZ | 1 |
| Gärtner, S; Hartmann, E; Kolkhof, P; Kretschmer, A; Oli, RG; Queisser, N; Schäfer, S; Schmid, U; Schupp, N; Stopper, H | 1 |
| Chasiotis, H; Kelly, SP | 1 |
| Fujisawa, G; Hirahara, I; Iwazu, Y; Kusano, E; Muto, S; Takeda, S | 1 |
| Cassis, LA; Daugherty, A; Gong, MC; Guo, Z; Liu, S; Pearson, KJ; Xie, Z | 1 |
| Carreño, JE; Contreras, F; Irarrazabal, CE; Marusic, E; Montellano, FA; Sandoval, M; Schalper, KA; Veloso, S; Verdugo, FJ; Villanueva, S | 1 |
| Bernhardt, R; Brixius-Anderko, S; Hannemann, F; Hobler, A; Müller, AR; Schiffer, L; Zapp, J | 1 |
| Adachi, S; Baker, ME; Katsu, Y; Oka, K; Sato, R; Sugimoto, A | 1 |
| Baker, ME; Hyodo, S; Katsu, Y; Lin, X; Oana, S | 1 |
16 review(s) available for desoxycorticosterone and spironolactone
| Article | Year |
|---|---|
Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids.
Topics: Aldosterone; Animals; Biological Transport; Carrier Proteins; Cell Size; Desoxycorticosterone; Dogs; Humans; Hydrocortisone; Hypertension; Kidney Tubules; Leukocytes, Mononuclear; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Muscle, Smooth; Potassium; Rats; Receptors, Mineralocorticoid; Second Messenger Systems; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Spironolactone; Swine; Time Factors | 1992 |
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adult; Aldosterone; Child; Desoxycorticosterone; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Renin; Spironolactone | 1990 |
Sodium retention after adrenal enucleation.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Biological Assay; Bufo marinus; Corticosterone; Desoxycorticosterone; Female; Homeostasis; Kidney; Male; Natriuresis; Nephrons; Pro-Opiomelanocortin; Rats; Regeneration; Sodium; Spironolactone; Time Factors; Urinary Bladder | 1986 |
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldosterone; Androgens; Child; Cushing Syndrome; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Infant; Male; Pituitary-Adrenal Function Tests; Renin; Spironolactone; Virilism | 1971 |
Aldosterone: review of its physiology and diagnostic aspects of primary aldosteronism.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Hypokalemia; Potassium; Radiography; Renin; Sodium; Spironolactone | 1973 |
Protection by catatoxic steroids against cyclophosphamide-induced organ lesions.
Topics: Adrenal Glands; Animals; Body Weight; Bone Marrow; Cyclophosphamide; Desoxycorticosterone; Enzyme Induction; Estradiol; Ethylestrenol; Female; Ketones; Microsomes, Liver; Mortality; Oxandrolone; Phenobarbital; Prednisolone; Pregnancy; Pregnanediones; Pregnanes; Pregnenolone; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1970 |
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carcinoma; Desoxycorticosterone; Female; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney Failure, Chronic; Mineralocorticoids; Pregnancy; Pregnancy Complications, Cardiovascular; Renal Artery Obstruction; Renin; Spironolactone | 1973 |
[Present trends in the diagnosis of primary hyperaldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Desoxycorticosterone; Humans; Hyperaldosteronism; Potassium; Renin; Sodium; Spironolactone | 1974 |
Primary hyperaldosteronism.
Topics: Adrenal Gland Neoplasms; Aldosterone; Corticosterone; Desoxycorticosterone; Electrocardiography; Humans; Hyperaldosteronism; Hypokalemia; Kidney Diseases; Renal Artery Obstruction; Renin; Sodium; Spironolactone; Time Factors; Urea | 1974 |
Commentary on incidence of primary aldosteronism: current estimations based on objective data.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Blood Pressure; Desoxycorticosterone; Electrolytes; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Renin; Sodium; Spironolactone; Thiazines | 1969 |
[Steroid spirolactones--antagonists of mineralocorticoids].
Topics: Adrenalectomy; Animals; Ascites; Chemistry Techniques, Analytical; Desoxycorticosterone; Dogs; Feces; Female; Heart Failure; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Liver Cirrhosis; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Nephrotic Syndrome; Potassium; Rats; Sodium; Spironolactone; Steroids; Water-Electrolyte Balance | 1969 |
Pathogenesis of mineralocorticoid hypertension.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Aldosterone; Animals; Blood Volume; Body Fluids; Body Weight; Cardiac Output; Desoxycorticosterone; Disease Models, Animal; Female; Humans; Hyperaldosteronism; Hypertension; Kidney; Male; Mineralocorticoids; Natriuresis; Posture; Potassium; Sodium; Spironolactone; Sympathetic Nervous System; Vascular Resistance | 1981 |
New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone.
Topics: Aldosterone; Animals; Cardiomegaly; Clinical Trials as Topic; Desoxycorticosterone; Eplerenone; Fibrosis; Heart; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Spironolactone | 2002 |
ALDOSTERONE IN CLINICAL MEDICINE.
Topics: Aldosterone; Blood Volume; Body Weight; Desoxycorticosterone; Dexamethasone; Diuretics; Drug Therapy; Edema; Erythrocyte Count; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Liver Cirrhosis; Natriuresis; Organomercury Compounds; Pressoreceptors; Spironolactone; Water-Electrolyte Balance | 1964 |
[Deoxycorticosterone-producing adrenal tumor].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagnosis, Differential; Humans; Hypertension; Hyponatremia; Mineralocorticoid Receptor Antagonists; Mitotane; Prognosis; Renin; Spironolactone | 2006 |
1 trial(s) available for desoxycorticosterone and spironolactone
| Article | Year |
|---|---|
A role for sodium-retaining steroids in the regulation of proximal tubular sodium reabsorption in man.
Topics: Blood Pressure; Desoxycorticosterone; Diuresis; Female; Fructose; Glomerular Filtration Rate; Humans; Inulin; Kidney Tubules; Natriuresis; Sodium; Spironolactone | 1972 |
148 other study(ies) available for desoxycorticosterone and spironolactone
| Article | Year |
|---|---|
Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives.
Topics: Adrenalectomy; Animals; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Mineralocorticoid; Receptors, Progesterone; Receptors, Steroid; Structure-Activity Relationship | 1987 |
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity | 2009 |
Brain tyrosine hydroxylase activity and systolic blood pressure in rats treated with either deoxycorticosterone and salt or angiotensin.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Desoxycorticosterone; Male; Rats; Sodium Chloride; Spironolactone; Time Factors; Tyrosine 3-Monooxygenase | 1976 |
Oxidative response to aldosterone of pyridine nucleotide in rat kidney in situ.
Topics: Adenine Nucleotides; Aldosterone; Animals; Calcitonin; Cycloheximide; Dactinomycin; Desoxycorticosterone; Dexamethasone; Dinitrophenols; Dose-Response Relationship, Drug; Energy Metabolism; Glycyrrhetinic Acid; Hemorrhage; Kidney; Male; Malonates; NAD; Ouabain; Oxidation-Reduction; Pyruvates; Rats; Rotenone; Spironolactone; Water | 1977 |
The effect of corticosteroids on alveolar macrophage activity.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aerosols; Aldosterone; Animals; Biological Transport; Desoxycorticosterone; Hydrocortisone; Iron; Macrophages; Male; Metyrapone; Pulmonary Alveoli; Rats; Spironolactone; Triamcinolone Acetonide | 1977 |
Plasma concentration of aldosterone, 18-hydroxy-deoxycorticosterone and cortisol in adrenal veins of patients with low-renin hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Renin; Spironolactone; Veins | 1977 |
Loci of action of regulators of aldosterone biosynthesis in isolated glomerulosa cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Corticosterone; Desoxycorticosterone; Dogs; In Vitro Techniques; Potassium; Progesterone; Rats; Spironolactone | 1979 |
Opposing effects of deoxycorticosterone and spironolactone on isoprenaline-induced myocardial infarction.
Topics: Animals; Body Weight; Corticosterone; Desoxycorticosterone; Isoproterenol; Lipids; Male; Myocardial Infarction; Organ Size; Rats; Spironolactone; Water-Electrolyte Balance | 1979 |
Congenital pseudohypoaldosteronism: case report and review. Effect of indomethacin during sodium chloride depletion.
Topics: Adrenal Insufficiency; Aldosterone; Body Weight; Chlorides; Desoxycorticosterone; Diagnosis, Differential; Diet; Humans; Indomethacin; Infant, Newborn; Male; Potassium; Renin; Sodium; Sodium Chloride; Spironolactone | 1978 |
Effects of Aldactazide and DOCA injections on saline preference in Gerbils (Meriones unguiculatus).
Topics: Animals; Choice Behavior; Desoxycorticosterone; Drinking; Drug Combinations; Gerbillinae; Hydrochlorothiazide; Male; Saline Solution, Hypertonic; Spironolactone | 1978 |
Ring D oxygenated Spirolactones. Characterization of human metabolic product of spironolactone.
Topics: Animals; Canrenone; Chemical Phenomena; Chemistry; Desoxycorticosterone; Humans; Penicillium; Pregnadienes; Rats; Spironolactone; Structure-Activity Relationship | 1977 |
Increased plasma 11-deoxycorticosterone during spironolactone medication.
Topics: Addison Disease; Desoxycorticosterone; False Positive Reactions; Humans; Male; Radioimmunoassay; Spironolactone | 1977 |
Synthesis and antimineralocorticoid activities of some 6-substituted 7 alpha-carboalkoxy steroidal spirolactones.
Topics: Adrenalectomy; Animals; Desoxycorticosterone; Deuterium; Male; Rats; Spironolactone | 1977 |
Potassium prorenoate: a new steroidal aldosterone antagonist.
Topics: Adrenal Glands; Adrenalectomy; Animals; Canrenoic Acid; Desoxycorticosterone; Diuretics; Dogs; Female; Kidney; Kidney Function Tests; Male; Mineralocorticoid Receptor Antagonists; Potassium; Pregnadienes; Rats; Sodium; Spironolactone | 1975 |
Interference of spironolactone in 11-doexycorticosterone radioassays.
Topics: Desoxycorticosterone; Evaluation Studies as Topic; False Positive Reactions; Humans; Hypertension; Male; Radioimmunoassay; Radioligand Assay; Spironolactone | 1975 |
Azolimine: a nonsteroidal antagonist of the effects of mineralocorticoids on renal electrolyte excretion.
Topics: Adrenal Glands; Adrenalectomy; Amiloride; Animals; Desoxycorticosterone; Dogs; Hydrochlorothiazide; Imidazoles; Imines; Kidney; Male; Mineralocorticoids; Potassium; Rats; Sodium; Spironolactone; Sulfonamides | 1975 |
Determinants of deranged sodium and water homeostasis in decompensated cirrhosis.
Topics: Adult; Aldosterone; Body Weight; Creatinine; Desoxycorticosterone; Diet; Homeostasis; Humans; Immersion; Liver Cirrhosis; Middle Aged; Natriuresis; Osmolar Concentration; Potassium; Sodium; Spironolactone; Water-Electrolyte Imbalance | 1976 |
The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27.
Topics: 18-Hydroxycorticosterone; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Animals, Genetically Modified; Corticosterone; Desoxycorticosterone; Enzyme Precursors; Gene Expression; Hypertension; Rats; Rats, Inbred Strains; Renin; Spironolactone | 1992 |
The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type I) antagonist RU28318.
Topics: Adrenalectomy; Aldosterone; Animals; Carbenoxolone; Corticosterone; Creatinine; Desoxycorticosterone; Male; Mineralocorticoids; Natriuresis; Potassium; Rats; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1991 |
Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism.
Topics: Adenoma; Administration, Oral; Adrenal Gland Neoplasms; Adult; Aldosterone; Corticosterone; Desoxycorticosterone; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoids; Monitoring, Physiologic; Potassium; Renin; Sodium; Spironolactone; Time Factors | 1990 |
Effects of deoxycorticosterone acetate on the electrical properties of rat large intestine: segmental differences.
Topics: Amiloride; Animals; Cecum; Colon; Desoxycorticosterone; Electrophysiology; Epithelium; Intestine, Large; Ion Channels; Male; Rats; Rats, Inbred Strains; Rectum; Sodium; Spironolactone | 1987 |
Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids.
Topics: Aldosterone; Angiotensin II; Animals; Astrocytes; Brain Stem; Cells, Cultured; Corticosterone; Cycloheximide; Desoxycorticosterone; Dexamethasone; Dose-Response Relationship, Drug; Estradiol; Hypothalamus; Mineralocorticoids; Neurons; Progesterone; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Spironolactone; Testosterone | 1989 |
Role of atrial natriuretic peptide in mineralocorticoid escape phenomenon in patients with primary aldosteronism.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Middle Aged; Mineralocorticoids; Natriuresis; Potassium; Renin; Spironolactone | 1987 |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias.
Topics: Adrenocorticotropic Hormone; Angiotensin II; Animals; Desoxycorticosterone; Diuresis; Dogfish; Female; Glomerular Filtration Rate; Sharks; Spironolactone; Water-Electrolyte Balance | 1985 |
The role of aldosterone in potassium tolerance: studies in anephric humans.
Topics: Adult; Aldosterone; Desoxycorticosterone; Female; Humans; Kidney; Male; Middle Aged; Nephrectomy; Potassium; Potassium Chloride; Renal Dialysis; Spironolactone | 1988 |
Rat C6 glioma cells contain type I as well as type II corticosteroid receptors.
Topics: Adrenal Cortex Hormones; Aldosterone; Androstanols; Animals; Cell Line; Corticosterone; Desoxycorticosterone; Dexamethasone; Glioma; Progesterone; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Spironolactone; Triamcinolone | 1985 |
Cellular heterogeneity of the distal nephron and its relation to function.
Topics: Animals; Desoxycorticosterone; Diuresis; Epithelial Cells; Furosemide; Kidney Tubules; Kidney Tubules, Collecting; Kidney Tubules, Distal; Microscopy, Electron; Potassium; Rats; Sodium; Spironolactone; Water-Electrolyte Balance | 1985 |
Apparently isolated excess deoxycorticosterone in hypertension. A variant of the mineralocorticoid-excess syndrome.
Topics: 17-Ketosteroids; Adult; Aged; Aldosterone; Chromatography, Gas; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydroxycorticosteroids; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Radioimmunoassay; Renin; Spironolactone; Syndrome | 1972 |
Sodium and the renin-angiotensin system in essential hypertension and mineralocorticoid excess.
Topics: Adolescent; Adult; Angiotensin II; Blood Pressure; Desoxycorticosterone; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoids; Renin; Sodium; Spironolactone | 1974 |
Letter: Effect of various steroids and ACTH on methyprylon plasma levels and sleeping time in rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Desoxycorticosterone; Female; Fludrocortisone; Piperidones; Pregnenolone Carbonitrile; Rats; Sleep; Spironolactone; Triamcinolone | 1973 |
Effect of pharmacologic conditioning on sulfadiazine toxicity and concentrations in plasma.
Topics: Adrenocorticotropic Hormone; Androstenols; Animals; Depression, Chemical; Desoxycorticosterone; Estradiol; Female; Ketosteroids; Kidney; Organ Size; Phenobarbital; Prednisolone; Pregnanediones; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Stimulation, Chemical; Sulfadiazine; Thyroxine; Triamcinolone | 1974 |
Clinical investigation of the effects of adrenal corticosteroid excess on the colon.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adult; Aldosterone; Colon; Corticosterone; Desoxycorticosterone; Dialysis; Feces; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Magnesium; Magnesium Sulfate; Male; Middle Aged; Potassium; Sodium; Spironolactone; Urea | 1969 |
[Experimental study on the prevention of steroid-induced gastric ulcer].
Topics: Aldosterone; Animals; Antacids; Cellulose; Desoxycorticosterone; Female; Gastric Juice; Gastrointestinal Hormones; Glycosaminoglycans; Mucins; Peptic Ulcer; Prednisolone; Rats; Spironolactone; Stomach | 1971 |
Separate effects of aldosterone, DOCA, and methylprednisolone on renal Na-K-ATPase,.
Topics: Adenosine Triphosphatases; Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Diet, Sodium-Restricted; Kidney; Kidney Cortex; Kidney Medulla; Male; Methylprednisolone; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Sodium Chloride; Spironolactone | 1974 |
Adrenocortical nuclear volume and adrenocortical function.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Desoxycorticosterone; Heparin; Hydrocortisone; Injections, Intramuscular; Injections, Intraperitoneal; Pituitary-Adrenal Function Tests; Rats; Spironolactone | 1965 |
Hypoglycemia in Meniere's disease.
Topics: Adrenocorticotropic Hormone; Aldosterone; Desoxycorticosterone; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Glucocorticoids; Glucose; Glucose Tolerance Test; Humans; Hydrocortisone; Hypoglycemia; Insulin; Meniere Disease; Potassium; Spironolactone | 1968 |
[On the effect of heparin and corticoid therapy on the number of circulating eosinophils].
Topics: Adrenocorticotropic Hormone; Aldosterone; Cortisone; Depression, Chemical; Desoxycorticosterone; Eosinophils; Fractures, Bone; Heparin; Hernia; Humans; Injections, Intramuscular; Injections, Intravenous; Spironolactone; Stimulation, Chemical | 1966 |
[Karyometric studies of the clarification of the osmo-or volume regulatgry role of the subcommissural organ and its functional connection with the adrenal cortex].
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Dehydration; Desoxycorticosterone; Diencephalon; Hydrocortisone; Injections, Intraperitoneal; Karyometry; Male; Rats; Spironolactone; Thalamus; Water-Electrolyte Balance | 1968 |
Prevention of various forms of metabolic myocardial necrosis by catatoxic steroids.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Digitoxin; Disease Models, Animal; Ethylestrenol; Female; Fludrocortisone; Myocardial Infarction; Necrosis; Norsteroids; Oxandrolone; Perchlorates; Prednisolone; Progesterone; Rats; Sodium; Spironolactone; Steroids; Triamcinolone | 1970 |
Low renin hypertension and the adrenal cortex.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Blood Pressure; Corticosterone; Desoxycorticosterone; Diuresis; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypertension; Hypokalemia; Indoles; Male; Pyridines; Renin; Secretory Rate; Spironolactone; Sulfonic Acids | 1972 |
Effect of mineralocorticoid agonists and antagonists on binding of 3 H-aldosterone to adrenalectomized rat kidney plasma membranes.
Topics: Adrenalectomy; Aldosterone; Animals; Binding, Competitive; Cell Membrane; Desoxycorticosterone; Estradiol; Fludrocortisone; In Vitro Techniques; Kidney; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Progesterone; Protein Binding; Rats; Receptors, Cell Surface; Spironolactone; Subcellular Fractions; Testosterone; Tritium | 1972 |
An in vitro study of mineralocorticoid binding proteins from rat kidney.
Topics: Aldosterone; Animals; Binding Sites; Binding, Competitive; Cell Nucleus; Chromatin; Chromatography, Gel; Cytosol; Desoxycorticosterone; Estradiol; Fludrocortisone; In Vitro Techniques; Kidney; Male; Nucleoproteins; Protein Binding; Proteins; Rats; Receptors, Cell Surface; Solubility; Spironolactone; Tritium; Ultracentrifugation | 1974 |
The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.
Topics: Adult; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hypokalemia; Male; Metyrapone; Mineralocorticoids; Paralysis; Periodicity; Sodium; Spironolactone | 1974 |
Spironolactone actions, independent of mineralocorticoid blockade.
Topics: Anesthetics; Animals; Depression, Chemical; Desoxycorticosterone; Digitoxin; Electrolytes; Female; Kidney; Nephrectomy; Pregnanediones; Progesterone; Rats; Spironolactone | 1969 |
Inhibition of anesthetics and sedative actions by spironolactone.
Topics: Anesthetics; Animals; Bromides; Chloral Hydrate; Chlorides; Chlorpromazine; Dehydroepiandrosterone; Desoxycorticosterone; Diazepam; Diethylstilbestrol; Ethanol; Female; Hypnotics and Sedatives; Magnesium; Morphine; Pentobarbital; Phenoxybenzamine; Potassium; Pregnanediones; Pregnanes; Progesterone; Rats; Reserpine; Sodium; Spironolactone; Testosterone | 1969 |
Protection against methyprylon overdosage by catatoxic steroids.
Topics: Anabolic Agents; Anesthesia; Animals; Desoxycorticosterone; Ethylestrenol; Female; Hypnotics and Sedatives; Ketones; Oxandrolone; Prednisolone; Pregnanediol; Pregnanediones; Pregnanes; Progesterone; Rats; Spironolactone; Steroids; Triamcinolone | 1970 |
Independence of antimineralocorticoid and catatoxic effects of various steroids.
Topics: Anabolic Agents; Animals; Biotransformation; Desoxycorticosterone; Ethylestrenol; Female; Male; Mineralocorticoids; Natriuresis; Norsteroids; Potassium; Prednisolone; Pregnanediol; Pregnanediones; Progesterone; Rats; Sex Factors; Spironolactone; Triamcinolone | 1970 |
Protection by catatoxic steroids against phenindione overdosage.
Topics: Androstanes; Animals; Desoxycorticosterone; Dimethyl Sulfoxide; Estradiol; Ethylestrenol; Hemorrhagic Disorders; Oxandrolone; Phenindione; Prednisolone; Pregnanediones; Pregnanes; Premedication; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1970 |
Protection by catatoxic steroids against meprobamate.
Topics: Anabolic Agents; Animals; Desoxycorticosterone; Estradiol; Ethylestrenol; Female; Meprobamate; Norsteroids; Oxandrolone; Poisoning; Prednisolone; Pregnanediol; Pregnanediones; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1970 |
Prevention of nicotine intoxication by catatoxic steroids.
Topics: Animals; Desoxycorticosterone; Ethylestrenol; Ketones; Nicotine; Oxandrolone; Prednisolone; Pregnanediones; Pregnanes; Progesterone; Rats; Spironolactone; Steroids; Triamcinolone | 1970 |
Protection by catatoxic steroids against cycloheximide intoxication.
Topics: Anabolic Agents; Animals; Cycloheximide; Desoxycorticosterone; Estradiol; Ethylestrenol; Female; Norsteroids; Oxandrolone; Poisoning; Prednisolone; Pregnanediol; Pregnanediones; Progesterone; Rats; Spironolactone; Steroids; Thyroxine; Triamcinolone | 1970 |
Steroids influencing the toxicity of L-tyrosine.
Topics: Adrenal Cortex Hormones; Animals; Cholesterol; Desoxycorticosterone; Diet; Edema; Ethylestrenol; Eye; Eyelids; Female; Oxandrolone; Pancreas; Poisoning; Prednisolone; Pregnanediones; Pregnenolone; Rats; Spironolactone; Thyroxine; Triamcinolone; Tyrosine | 1971 |
Prevention of colchicine intoxication by catatoxic steroids.
Topics: Anabolic Agents; Animals; Colchicine; Desoxycorticosterone; Drug Antagonism; Enzyme Induction; Estradiol; Ethylestrenol; Female; Ketones; Microsomes, Liver; Oxandrolone; Prednisolone; Pregnanediones; Pregnanes; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1970 |
Resistance to picrotoxin poisoning induced by catatoxic steroids.
Topics: Anabolic Agents; Androstanes; Animals; Cholesterol; Desoxycorticosterone; Ethylestrenol; Female; Fluorine; Ketosteroids; Oxandrolone; Picrotoxin; Poisoning; Prednisolone; Pregnanediones; Pregnanes; Progesterone; Rats; Seizures; Spironolactone; Steroids; Triamcinolone | 1970 |
Protection by glucocorticoids against allopurinol nephropathy.
Topics: Allopurinol; Animals; Desoxycorticosterone; Estradiol; Ethylestrenol; Female; Kidney; Kidney Diseases; Oxandrolone; Prednisolone; Pregnanediones; Progesterone; Rats; Spironolactone; Triamcinolone | 1972 |
[Anticatatoxic hormones].
Topics: Animals; Desoxycorticosterone; Digitoxin; Drug Antagonism; Drug Synergism; Estradiol; Female; Glucocorticoids; Indomethacin; Mineralocorticoids; Nitriles; Pregnanediones; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Spironolactone; Thyroxine; Triamcinolone | 1972 |
Influence of aldosterone on sodium, water and potassium metabolism in chronic renal disease.
Topics: Aldosterone; Blood; Blood Urea Nitrogen; Body Water; Creatinine; Desoxycorticosterone; Diet, Sodium-Restricted; Extracellular Space; Feces; Glomerular Filtration Rate; Humans; Hydrocortisone; Kidney Concentrating Ability; Kidney Failure, Chronic; Mannitol; Osmolar Concentration; Plasma Volume; Potassium; Sodium; Spironolactone; Urea; Urine; Vasopressins | 1972 |
3- (16Beta,17beta-dihydroxy-3-oxoandrost-4-en-17alpha-yl) propionic acid gamma-lactone, its preparation and antimineralocorticoid activity.
Topics: Adrenalectomy; Androstanes; Androstenes; Animals; Desoxycorticosterone; Diuresis; Ketosteroids; Lactones; Magnetic Resonance Spectroscopy; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Potassium; Rats; Sodium; Spironolactone | 1973 |
Localization of physiological receptor sites for aldosteone in the bladder of the toad, Bufo marinus.
Topics: Aldosterone; Animals; Anura; Binding Sites; Cell Nucleus; Citrates; Desoxycorticosterone; DNA; Glucocorticoids; Hydrocortisone; In Vitro Techniques; Microscopy, Phase-Contrast; Mucous Membrane; Receptors, Drug; Spironolactone; Sucrose; Surface-Active Agents; Urinary Bladder | 1968 |
Interaction of spironolactone and indomethacin at the renal level.
Topics: Adrenal Glands; Adrenalectomy; Animals; Depression, Chemical; Desoxycorticosterone; Indomethacin; Male; Potassium; Rats; Sodium; Spironolactone; Stimulation, Chemical; Urination | 1972 |
Mechanisms of renal lithium handling and their relationship to mineralocorticoids: a dissociation between sodium and lithium ions.
Topics: Absorption; Adult; Aged; Animals; Biological Transport, Active; Bipolar Disorder; Chlorothiazide; Creatinine; Desoxycorticosterone; Diet; Diuresis; Female; Humans; Kidney; Kidney Tubules; Lithium; Male; Metabolic Clearance Rate; Middle Aged; Natriuresis; Potassium; Rats; Sodium; Spironolactone | 1971 |
Studies of the antidiuresis induced by natrichloriuretic drugs in rats with diabetes insipidus.
Topics: Aldosterone; Animals; Bendroflumethiazide; Desoxycorticosterone; Diabetes Insipidus; Diuresis; Female; Hypothalamus; Ketones; Natriuresis; Pyrimidines; Rats; Spironolactone; Triamterene; Water-Electrolyte Balance | 1966 |
Prevention of digitoxin poisoning by various steroids.
Topics: Anabolic Agents; Androstanes; Animals; Body Weight; Desoxycorticosterone; Digitoxin; Diuretics; Estradiol; Ethisterone; Ethylestrenol; Female; Fluoxymesterone; Hydrocortisone; Ketones; Methyltestosterone; Nandrolone; Norethandrolone; Norethynodrel; Organ Size; Oxandrolone; Oxymetholone; Poisoning; Pregnanes; Pregnenolone; Progesterone; Pyrazines; Rats; Spironolactone; Testosterone; Triamterene | 1969 |
The interrelationships of calcium and sodium excretions.
Topics: Biological Transport, Active; Calcium; Creatinine; Desoxycorticosterone; Humans; Kidney Tubules; Parathyroid Hormone; Sodium; Spironolactone; Time Factors | 1969 |
Macromolecular binding of aldosterone in the toad bladder.
Topics: Alcohols; Aldosterone; Animals; Anura; Binding Sites; Cell Nucleus; Chromatography, Gel; Cytoplasm; Deoxyribonucleases; Depression, Chemical; Desoxycorticosterone; DNA; Glycerol; Hydrocortisone; In Vitro Techniques; Macromolecular Substances; Methods; Mineralocorticoid Receptor Antagonists; Molecular Weight; Mucous Membrane; Polysaccharides; Protein Binding; Proteins; Ribonucleases; Solubility; Spironolactone; Stimulation, Chemical; Sulfur; Temperature; Testosterone; Tritium; Urinary Bladder; Vibration | 1969 |
[Effect of hormones on physical and chemical properties of connective- and supporting tissue. 1].
Topics: Acetates; Adrenalectomy; Age Factors; Aldosterone; Animals; Body Weight; Connective Tissue; Corticosterone; Depression, Chemical; Desoxycorticosterone; Dihydrotachysterol; Epiphyses; Estradiol; Female; Femur; Guinea Pigs; Hormones; Hydrocortisone; Male; Mice; Prednisolone; Progesterone; Rabbits; Rats; Sex Factors; Spironolactone; Stimulation, Chemical; Stress, Physiological; Succinates; Tail; Tendons; Testosterone | 1969 |
Resistance to various pesticides induced by catatoxic steroids.
Topics: Administration, Oral; Anabolic Agents; Animals; DDT; Desoxycorticosterone; Estradiol; Ethylestrenol; Female; Insecticides; Oxandrolone; Parathion; Phosphoric Acids; Physostigmine; Pralidoxime Compounds; Prednisolone; Pregnanediol; Pregnanes; Progesterone; Rats; Spironolactone; Steroids; Thyroxine; Triamcinolone | 1970 |
Mineralocorticoids and sweat gland function.
Topics: Adrenal Glands; Adult; Aldosterone; Desoxycorticosterone; Diuresis; Fasting; Hot Temperature; Humans; Kidney; Male; Mineralocorticoids; Potassium; Sodium; Spironolactone; Sweat; Sweat Glands; Sweating; Water-Electrolyte Balance | 1970 |
Effect of various steroids on the adrenal necrosis induced by 7,12-dimethylbenz(a)anthracene in rats.
Topics: Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Benz(a)Anthracenes; Desoxycorticosterone; Estradiol; Ethylestrenol; Female; Hydrocortisone; Necrosis; Progesterone; Rats; Spironolactone; Steroids; Testosterone; Triamcinolone | 1970 |
[Steroids and nephrectomy cardiopathy].
Topics: Animals; Calcinosis; Cardiovascular Diseases; Desoxycorticosterone; Estradiol; Ethylestrenol; Heart Diseases; Nephrectomy; Oxandrolone; Parathyroid Hormone; Prednisolone; Progesterone; Rats; Spironolactone; Steroids; Triamcinolone | 1970 |
Prevention of hypervitaminosis A by spironolactone and anabolic steroids.
Topics: Absorption; Anabolic Agents; Animals; Bone and Bones; Bone Diseases; Desoxycorticosterone; Drug Antagonism; Enzyme Induction; Estradiol; Female; Progesterone; Rats; Spironolactone; Triamcinolone; Vitamin A | 1970 |
Assessment of the mineralocorticoid activity of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in the isolated toad bladder.
Topics: Animals; Anura; Biological Assay; Biological Transport, Active; Desoxycorticosterone; Fludrocortisone; In Vitro Techniques; Mineralocorticoids; Pregnanes; Sodium; Spironolactone; Stimulation, Chemical; Urinary Bladder | 1971 |
Influence of phenobarbital and various steroids on CCl4 hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Desoxycorticosterone; Drug Synergism; Estradiol; Ethylestrenol; Female; Liver; Microsomes, Liver; Oxandrolone; Phenobarbital; Pregnanes; Progesterone; Rats; Spironolactone; Triamcinolone | 1971 |
Urinary citrate excretion in primary aldosteronism.
Topics: Addison Disease; Adult; Aldosterone; Carbon Dioxide; Citrates; Desoxycorticosterone; Dexamethasone; Female; Humans; Hyperaldosteronism; Hypokalemia; Male; Middle Aged; Potassium; Potassium Chloride; Spironolactone | 1967 |
Differential effect of hypotensive drugs on renal and steroid hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Bretylium Compounds; Desoxycorticosterone; Guanethidine; Hypertension; Hypertension, Renal; Mecamylamine; Methyldopa; Rats; Spironolactone | 1968 |
Effect of adrenal steroid hormones on the response of the toad's urinary bladder to vasopressin.
Topics: Aldosterone; Animals; Anura; Biological Transport; Carbon Isotopes; Chlorides; Corticosterone; Desoxycorticosterone; Dexamethasone; Glucose; Potassium; Sodium; Spironolactone; Urinary Bladder; Vasopressins; Water | 1969 |
Non-tumorous "primary" aldosteronism: II. Type not relieved by glucocorticoid.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Blood Pressure; Corticosterone; Desoxycorticosterone; Dexamethasone; Diet; Glucocorticoids; Humans; Hyperaldosteronism; Kidney Function Tests; Male; Middle Aged; Potassium; Secretory Rate; Spironolactone; Water-Electrolyte Balance | 1969 |
Non-tumorous "primary" aldosteronism. I. Type relieved by glucocorticoid (glucocorticoid-remediable aldosteronism).
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenalectomy; Adult; Aldosterone; Androgens; Child; Desoxycorticosterone; Dexamethasone; Diet; Estrogens; Female; Follow-Up Studies; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Prednisone; Renin; Secretory Rate; Sodium; Spironolactone | 1969 |
N-amidino-3-amino-6-chloropyrazinecarboxamide: a new diuretic which antagonizes the renal actions of aldosterone.
Topics: Aldosterone; Animals; Desoxycorticosterone; Diuretics; Hydrocortisone; Kidney; Natriuresis; Potassium; Rats; Spironolactone; Triamterene; Urine | 1965 |
[On the effect of aldosterone and aldactone A on various segments of kidney tubules in Cushing's syndrome with polyuria].
Topics: Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Kidney Tubules; Polyuria; Potassium; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1965 |
Studies on the binding of aldosterone in the toad bladder.
Topics: Aldosterone; Animals; Anura; Biological Transport, Active; Cholesterol; Desoxycorticosterone; Hydrocortisone; In Vitro Techniques; Progesterone; Radiometry; Sodium; Spironolactone; Tritium; Urinary Bladder | 1966 |
Effect of spironolactone on spontaneous NaCl intake of adrenalectomized rats.
Topics: Adrenalectomy; Animals; Desoxycorticosterone; Rats; Sodium Chloride; Spironolactone | 1966 |
N-Amidino-3,5-diamino-6-chloropyrazine-carboxamide: an active diuretic in the carboxamide series.
Topics: Adrenalectomy; Aldosterone; Amides; Amidines; Animals; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Hydrocortisone; Male; Potassium; Pyrazines; Rats; Sodium; Spironolactone; Sulfhydryl Compounds | 1966 |
The role of the subfornical organ in the salt and water balance.
Topics: Animals; Blood Volume; Cell Nucleus; Desoxycorticosterone; Hypertonic Solutions; Karyometry; Rats; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1966 |
An azido pyrimidine diuretic (SC-16102): reversal of the Na retention induced by aldosterone.
Topics: Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Male; Natriuresis; Potassium; Pyrimidines; Rats; Spironolactone | 1967 |
[The effects of digoxin, desoxycorticosterone and spironolactone on the myocardium of the mammal].
Topics: Animals; Calcium; Desoxycorticosterone; Digoxin; Drug Synergism; Guinea Pigs; Heart; Heart Atria; Potassium; Sodium; Spironolactone | 1967 |
Methylprednisolone stimulation of guanylate cyclase activity in rat small intestinal mucosa: possible role in electrolyte transport.
Topics: Animals; Biological Transport; Colon; Cyclic AMP; Cyclic GMP; Desoxycorticosterone; Electrolytes; Guanylate Cyclase; Ileum; Intestinal Mucosa; Male; Methylprednisolone; Rats; Spironolactone | 1981 |
Plasma corticosteroid concentrations during spironolactone administration: evidence for adrenal biosynthetic blockade in man.
Topics: 18-Hydroxycorticosterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldosterone; Desoxycorticosterone; Female; Humans; Kinetics; Male; Potassium; Progesterone; Renin; Sodium; Spironolactone | 1981 |
Role of adrenal steroids on electroacupuncture analgesia and on antagonising potency of naloxone.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Angiotensin II; Animals; Captopril; Desoxycorticosterone; Dexamethasone; Electric Stimulation Therapy; Male; Mineralocorticoids; Naloxone; Rats; Spironolactone; Time Factors; Transcutaneous Electric Nerve Stimulation | 1984 |
19-Hydroxyandrostenedione: evidence for a new class of sodium-retaining and hypertensinogenic steroids.
Topics: Aldosterone; Androstenedione; Animals; Blood Pressure; Corticosterone; Desoxycorticosterone; Drug Interactions; Potassium; Rats; Renin; Sodium; Spironolactone | 1983 |
Mineralo- and glucocorticoid effects on renal excretion of electrolytes.
Topics: Adrenalectomy; Aldosterone; Animals; Creatinine; Desoxycorticosterone; Dexamethasone; Fludrocortisone; Glomerular Filtration Rate; Glucocorticoids; Kidney; Mineralocorticoids; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone; Sulfates | 1983 |
Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in toad bladder.
Topics: Aldosterone; Animals; Biological Transport, Active; Bufo marinus; Desoxycorticosterone; Kinetics; Sodium; Spironolactone; Urinary Bladder | 1981 |
[Role of tissue depots and the kaliuretic effect of aldosterone in potassium homeostasis].
Topics: Aldosterone; Animals; Desoxycorticosterone; Olivomycins; Potassium; Potassium Chloride; Puromycin; Rana temporaria; Rats; Spironolactone; Tissue Distribution; Water-Electrolyte Balance | 1981 |
Detection and comparative evaluation of aldosterone antagonists in glucocorticoid-treated, adrenalectomized rats.
Topics: Adrenalectomy; Animals; Canrenoic Acid; Desoxycorticosterone; Dose-Response Relationship, Drug; Glucocorticoids; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone | 1982 |
[Apropos of a case of Conn's disease. Use of computerized axial tomography in the differential diagnosis from hyperaldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Desoxycorticosterone; Dexamethasone; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Spironolactone; Tomography, X-Ray Computed | 1981 |
Induction of amiloride-sensitive sodium transport in the rat colon by mineralocorticoids.
Topics: Action Potentials; Aldosterone; Amiloride; Animals; Colon; Desoxycorticosterone; Drug Therapy, Combination; Furosemide; Male; Membrane Potentials; Rats; Sodium; Spironolactone | 1980 |
Determinants of cardiac fibrosis in experimental hypermineralocorticoid states.
Topics: Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Drug Combinations; Fibrosis; Fludrocortisone; Heart; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Potassium; Rats; Rats, Sprague-Dawley; Spironolactone | 1995 |
Further studies in deoxycorticosterone acetate treated rats: brain content of mineralocorticoid and glucocorticoid receptors and effect of steroid antagonists on salt intake.
Topics: Amygdala; Animals; Appetite; Brain; Desoxycorticosterone; Hippocampus; Hypothalamus; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Ornithine Decarboxylase; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone | 1995 |
Administration time-dependent change in the effect of spironolactone in rats.
Topics: Administration, Oral; Adrenalectomy; Aldosterone; Analysis of Variance; Animals; Circadian Rhythm; Desoxycorticosterone; Injections, Intraperitoneal; Male; Natriuresis; Potassium; Random Allocation; Rats; Rats, Wistar; Sodium; Specific Pathogen-Free Organisms; Spironolactone | 1994 |
Central effects of mineralocorticoid antagonist RU-28318 on blood pressure of DOCA-salt hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Desoxycorticosterone; Heart Rate; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium Chloride; Spironolactone | 1994 |
Role of glucocorticoid in the development of glycyrrhizin-induced hypertension.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Blood Pressure; Corticosterone; Desoxycorticosterone; Dexamethasone; Glucocorticoids; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hydroxysteroid Dehydrogenases; Hypertension; Male; Mineralocorticoids; Potassium; Rats; Rats, Wistar; Renin; Spironolactone | 1994 |
Aldosterone rapidly represses protein kinase C activity in neonatal rat cardiomyocytes in vitro.
Topics: Aldosterone; Analysis of Variance; Animals; Animals, Newborn; Calcium; Cells, Cultured; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Fibroblasts; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spironolactone; Tetradecanoylphorbol Acetate; Tritium | 1997 |
Localization of Na,K-ATPase activity in developing rat distal colon: role of corticosteroids.
Topics: 4-Nitrophenylphosphatase; Adrenal Cortex Hormones; Adrenalectomy; Aging; Aldosterone; Animals; Colon; Desoxycorticosterone; Dexamethasone; Glucocorticoids; Hormone Antagonists; Intestinal Mucosa; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Ouabain; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1998 |
Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Collagen; Desoxycorticosterone; Endomyocardial Fibrosis; Fibronectins; Heart; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium, Dietary; Spironolactone; Tetrazoles | 1999 |
Novel effects of deoxycorticosterone on testicular 11beta-hydroxysteroid dehydrogenase activity and plasma testosterone levels in normal and adrenalectomized rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenalectomy; Animals; Carbenoxolone; Desoxycorticosterone; Hydroxysteroid Dehydrogenases; Male; Progesterone; Rats; Rats, Wistar; Reference Values; Spironolactone; Testis; Testosterone | 1999 |
Effects of glucocorticoids and mineralocorticoids on proliferation and maturation of human peripheral blood stem cells.
Topics: Adult; Aldosterone; Cells, Cultured; Colony-Forming Units Assay; Desoxycorticosterone; Erythropoietin; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Interleukin-3; Mifepristone; Mineralocorticoids; Recombinant Proteins; Spironolactone; Triamcinolone Acetonide | 1999 |
The amygdala: site of genomic and nongenomic arousal of aldosterone-induced sodium intake.
Topics: Aldosterone; Amygdala; Animals; Appetite; Arousal; Corticosterone; Desoxycorticosterone; Genome; Hormone Antagonists; Injections; Injections, Intraventricular; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2000 |
Glucocorticoid modulation of dopamine mediated effects on hypothalamic atrial natriuretic factor neurons.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Cells, Cultured; Desoxycorticosterone; Dexamethasone; Dopamine; Down-Regulation; Gene Expression Regulation; Glucocorticoids; Hypothalamus; Mifepristone; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Spironolactone; Transcription, Genetic | 2000 |
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles | 2001 |
Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension.
Topics: Angiotensinogen; Animals; Atrial Natriuretic Factor; Blood Pressure; Brain; Chlorides; Desoxycorticosterone; Diuresis; Hypertension; Injections, Intraventricular; Kidney; Male; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Rats, Wistar; Receptors, Mineralocorticoid; RNA, Messenger; Sodium; Sodium Chloride, Dietary; Spironolactone; Time Factors; Transcription, Genetic | 2002 |
Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla.
Topics: Adrenalectomy; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Desoxycorticosterone; Diabetes Insipidus; Epithelial Cells; Female; Homeostasis; Isoenzymes; Kidney Medulla; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 2002 |
Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Blood Pressure; Carbenoxolone; Cardiomegaly; Coronary Disease; Desoxycorticosterone; Enzyme Inhibitors; Eplerenone; Fibrosis; Heart; Hydroxysteroid Dehydrogenases; Kidney; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Sodium Chloride; Solutions; Spironolactone; Vasculitis | 2003 |
Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.
Topics: Animals; Blood Pressure; Cardiomegaly; Collagen; Desoxycorticosterone; Fibrosis; Guanidines; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones | 2003 |
[Experimental study of the antagonistic actions of a spirolactone (aldactone) and of desoxycorticosterone].
Topics: Desoxycorticosterone; Hostility; Hypertension; Lactones; Spironolactone | 1960 |
Effect of cortisone and spirolactone on potassium excreting action of aldosterone and desoxycorticosterone.
Topics: Aldosterone; Animals; Cortisone; Desoxycorticosterone; Diuretics; Humans; Potassium; Poultry; Spironolactone | 1962 |
THE EFFECTS OF HEMORRHAGE AND HORMONES ON THE PARTITION OF BODY WATER. III. THE EFFECTS OF HEMORRHAGE AND CORTICOSTEROIDS ON FLUID PARTITION IN THE ADRENALECTOMIZED DOG.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Blood Pressure; Blood Volume; Body Fluids; Body Water; Bromine; Capillary Permeability; Desoxycorticosterone; Dogs; Glucocorticoids; Hemorrhage; Hydrocortisone; Radioisotopes; Research; Spironolactone; Splenectomy; Ureteral Obstruction | 1963 |
CONTENT AND UPTAKE OF SODIUM AND POTASSIUM IN BONE. INFLUENCE OF ADRENALECTOMY, ALDOSTERONE, DESOXYCORTICOSTERONE AND SPIRONOLACTONE.
Topics: Adrenalectomy; Aldosterone; Blood Chemical Analysis; Bone and Bones; Desoxycorticosterone; Metabolism; Pharmacology; Potassium; Potassium Isotopes; Rats; Research; Sodium; Sodium Isotopes; Sodium, Dietary; Spironolactone | 1963 |
EXPERIMENTAL STUDIES ON THE RELATIONSHIP BETWEEN ENDOCRINE ORGANS AND HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS. II. EFFECTS OF VARIOUS HORMONES ON BLOOD PRESSURE.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Arginine Vasopressin; Blood Pressure; Body Weight; Cortisone; Desoxycorticosterone; Hormones; Hypertension; Norepinephrine; Progesterone; Rats; Rats, Inbred SHR; Research; Sodium Chloride; Spironolactone; Stilbenes; Testosterone; Thyroid Hormones; Vasopressins | 1963 |
FURTHER NOTES ON THE INTERACTION OF SPIRONOLACTONE AND DEOXYCORTICOSTERONE ACETATE IN DOGS.
Topics: Acetates; Chlorides; Desoxycorticosterone; Desoxycorticosterone Acetate; Dogs; Kidney Function Tests; Kidney Tubules; Pharmacology; Photometry; Potassium; Research; Sodium; Spironolactone; Urine; Water-Electrolyte Balance | 1964 |
THE DIAGNOSTIC IMPLICATION OF RESTRICTION OF SALT INTAKE AND ADMINISTRATION OF VARIOUS DRUGS IN PRIMARY ALDOSTERONISM.
Topics: Aldosterone; Biomedical Research; Cushing Syndrome; Desoxycorticosterone; Diagnosis, Differential; Diet, Sodium-Restricted; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney; Pharmaceutical Preparations; Potassium; Spironolactone; Urine | 1964 |
RELATIONSHIP OF PLASMA ALDADIENE LEVELS AND ANTIMINERALOCORTICOID EFFECTS OF SPIRONOLACTONE IN THE LABORATORY.
Topics: Adrenalectomy; Animals; Blood; Body Fluids; Canrenone; Desoxycorticosterone; Dogs; Natriuresis; Photometry; Plasma; Potassium; Rats; Research; Spironolactone; Urine | 1964 |
MINERALOCORTICOID-BLOCKING PROPERTIES OF A PROGESTERONE-LIKE DERIVATIVE (SC-11835).
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Dogs; Hydrochlorothiazide; Kidney; Metabolism; Mineralocorticoids; Pharmacology; Potassium; Progesterone; Progestins; Rats; Research; Sodium; Spironolactone; Urine | 1964 |
SOME BIOLOGICAL PROPERTIES OF SYNTHETIC 18-HYDROXYTESTOSTERONE.
Topics: Desoxycorticosterone; Diuresis; Hydroxytestosterones; Mineralocorticoid Receptor Antagonists; Pharmacology; Progesterone; Rats; Research; Spironolactone; Testosterone | 1964 |
BIOLOGICAL ACTION OF ALDOSTERONE IN VITRO.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Biological Transport; Bufonidae; Cell Membrane Permeability; Corticosterone; Desoxycorticosterone; Hydrocortisone; In Vitro Techniques; Mucous Membrane; Pharmacology; Research; Sodium; Sodium Isotopes; Spironolactone; Urinary Bladder | 1964 |
ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS.
Topics: Adrenalectomy; Aldosterone; Anuria; Chlorothiazide; Desoxycorticosterone; Diabetes Insipidus; Diazoxide; Diuresis; Diuretics; Dogs; Kidney Function Tests; Organomercury Compounds; Pharmacology; Research; Sodium Chloride; Spironolactone | 1965 |
A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Cardiac Glycosides; Desoxycorticosterone; Digitoxin; Dogs; Heart; Pentobarbital; Pharmacology; Research; Spironolactone; Structure-Activity Relationship | 1965 |
Mineralocorticoids act centrally to regulate blood-borne tumor necrosis factor-alpha in normal rats.
Topics: Animals; Appetite; Desoxycorticosterone; Hypothalamus; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Pituitary Gland; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Tumor Necrosis Factor-alpha | 2003 |
Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats.
Topics: Animals; Biomarkers; Coronary Vessels; Desoxycorticosterone; Eplerenone; Fibrosis; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium Chloride, Dietary; Spironolactone; Vasculitis | 2004 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Finasteride; Mineralocorticoid Receptor Antagonists; Pentylenetetrazole; Rats; Receptors, GABA; Receptors, Mineralocorticoid; Receptors, Progesterone; Seizures; Spironolactone | 2005 |
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.
Topics: Angiotensins; Animals; Blood Pressure; Connective Tissue Growth Factor; Desoxycorticosterone; Fibrosis; Heart; Heart Diseases; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Mutant Strains; Mineralocorticoid Receptor Antagonists; Myocardium; NF-kappa B; Protein Serine-Threonine Kinases; Receptors, Mineralocorticoid; Salts; Spironolactone | 2006 |
Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance.
Topics: Animals; Blood Glucose; Desoxycorticosterone; Female; Immediate-Early Proteins; Male; Mice; Mice, Knockout; Organ Specificity; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Sex Characteristics; Spironolactone | 2006 |
Mineralocorticoid synthesis during the periovulatory interval in macaques.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Cells, Cultured; Chorionic Gonadotropin; Cortodoxone; Cytochrome P-450 CYP11B2; Desoxycorticosterone; Female; Granulosa Cells; Macaca mulatta; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Ovulation; Ovulation Induction; Receptors, Mineralocorticoid; Spironolactone; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase | 2006 |
Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
Topics: Animals; Biomarkers; Blood Pressure; Cardiomegaly; Cardiomyopathies; Coronary Vessels; Desoxycorticosterone; Drug Administration Schedule; Eplerenone; Fibrosis; Hormone Antagonists; Male; Mifepristone; Myocardium; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Signal Transduction; Sodium Chloride; Spironolactone; Vasculitis | 2007 |
Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.
Topics: Animals; Apoptosis; Capillaries; Connective Tissue Growth Factor; Desoxycorticosterone; Endothelium, Vascular; Fibrosis; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone; Thrombospondin 1; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2008 |
Plasma concentrations of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin reflect severity of heart failure in DOCA-salt hypertensive rat.
Topics: Animals; Biomarkers; Blood Pressure; Desoxycorticosterone; Gene Expression Regulation, Enzymologic; Heart Failure; Heart Ventricles; Male; Matrix Metalloproteinase 2; Myocardial Contraction; Osteopontin; Rats; Rats, Sprague-Dawley; Salts; Spironolactone; Tissue Inhibitor of Metalloproteinase-1 | 2008 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Desoxycorticosterone; Heart Ventricles; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Kidney; Losartan; Mice; Mineralocorticoid Receptor Antagonists; Nephrosclerosis; p38 Mitogen-Activated Protein Kinases; Rats; Renin; Reserpine; RNA, Messenger; Spironolactone | 2008 |
Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Diuretics; Dose-Response Relationship, Drug; Glomerulonephritis; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Nephrosclerosis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reserpine; Spironolactone | 2008 |
The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.
Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hypertension; Infusion Pumps, Implantable; Infusions, Subcutaneous; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Spironolactone; Time Factors | 2009 |
Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite.
Topics: Aldosterone; Animals; Appetite; Captopril; Desoxycorticosterone; Drug Interactions; Furosemide; Hyponatremia; Hypothalamic Area, Lateral; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Potassium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin; Renin-Angiotensin System; Reward; Self Stimulation; Sodium; Spironolactone | 2010 |
Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor.
Topics: Aldosterone; Amino Acid Sequence; Animals; Antihypertensive Agents; Cell Line; Desoxycorticosterone; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Molecular Sequence Data; Nimodipine; Receptors, Mineralocorticoid; Sequence Alignment; Sequence Analysis, DNA; Spironolactone; Transcriptional Activation; Zebrafish | 2011 |
Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats.
Topics: Animals; Apoptosis; Blood Pressure; Cell Division; Desoxycorticosterone; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Damage; Guanine; Hypertension, Renal; Kidney; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Nephrectomy; Nephritis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone | 2011 |
Glucocorticoid and mineralocorticoid receptors regulate paracellular permeability in a primary cultured gill epithelium.
Topics: Aldosterone; Animals; Cell Membrane Permeability; Cells, Cultured; Desoxycorticosterone; Dexamethasone; Electric Impedance; Epithelial Cells; Epithelium; Eplerenone; Fish Proteins; Gene Expression Regulation; Gills; Hydrocortisone; Mifepristone; Mineralocorticoid Receptor Antagonists; Oncorhynchus mykiss; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Tight Junctions | 2011 |
Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/salt-induced hypertensive rats.
Topics: Animals; Collagen; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Epithelial-Mesenchymal Transition; Fibrosis; Hypertension; Kidney; Kidney Tubules, Proximal; Male; Matrix Metalloproteinase 2; Nephrectomy; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone | 2011 |
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Apoptosis; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Elastin; Enalapril; Eplerenone; Losartan; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Oxidative Stress; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Time Factors | 2013 |
Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Mineralocorticoids; Phenylephrine; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Staining and Labeling; Vasoconstriction | 2015 |
Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation.
Topics: Biotransformation; Canrenone; Cloning, Molecular; Cortodoxone; Cytochrome P-450 CYP11B2; Desoxycorticosterone; Eplerenone; Escherichia coli; Humans; Kinetics; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Steroid 11-beta-Hydroxylase; Transcriptional Activation | 2016 |
Corticosteroid and progesterone transactivation of mineralocorticoid receptors from Amur sturgeon and tropical gar.
Topics: Aldosterone; Animals; Corticosterone; Cortodoxone; Desoxycorticosterone; Fish Proteins; Fishes; Humans; Hydrocortisone; Phylogeny; Progesterone; Receptors, Mineralocorticoid; Spironolactone; Transcriptional Activation | 2016 |
Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain.
Topics: Aldosterone; Animals; Corticosterone; Cortodoxone; Desoxycorticosterone; Dexamethasone; Eplerenone; Fish Proteins; Fishes; Gene Expression; Hydrocortisone; Kinetics; Progesterone; Protein Domains; Protein Engineering; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Triamcinolone | 2022 |