desmosine and beta-aminopropionitrile-fumarate

Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-injected control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.

Topics: Amino Acid Oxidoreductases; Aminopropionitrile; Animals; Cricetinae; Desmosine; Emphysema; Female; Isodesmosine; Lung; Lysine; Mesocricetus; Pancreatic Elastase; Protein-Lysine 6-Oxidase