desmosdumotin-c and flavone

desmosdumotin-c has been researched along with flavone* in 1 studies

Other Studies

1 other study(ies) available for desmosdumotin-c and flavone

Article	Year
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12 The first total synthesis of a unique flavone natural product, desmosdumotin B (1), was accomplished. Furthermore, three novel flavonoids, 6-8, and a novel chalcone, 9, were synthesized. The new compounds were evaluated as in vitro inhibitors of human cancer cell growth. The synthetic 1 showed significant cytotoxic activity against a multi-drug resistant cell line (KB-VIN) with an ED50 value of 2.0 microg/mL compared to >40 microg/mL against the parental KB cell line. Flavone 7 displayed selective activity against 1A9 ovarian carcinoma with an ED50 value of 0.7 microg/mL. Selected 1-analogs and synthetic intermediates were also screened for antitumor-promoting effects as inhibitors of EBV-EA activation. Among them, trihydroxyacetophenone derivatives 11 and 14 showed good activity. Topics: Alkenes; Antigens, Viral; Antineoplastic Agents; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Humans; Ketones; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured	2005

Article

Year

Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.

Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12

The first total synthesis of a unique flavone natural product, desmosdumotin B (1), was accomplished. Furthermore, three novel flavonoids, 6-8, and a novel chalcone, 9, were synthesized. The new compounds were evaluated as in vitro inhibitors of human cancer cell growth. The synthetic 1 showed significant cytotoxic activity against a multi-drug resistant cell line (KB-VIN) with an ED50 value of 2.0 microg/mL compared to >40 microg/mL against the parental KB cell line. Flavone 7 displayed selective activity against 1A9 ovarian carcinoma with an ED50 value of 0.7 microg/mL. Selected 1-analogs and synthetic intermediates were also screened for antitumor-promoting effects as inhibitors of EBV-EA activation. Among them, trihydroxyacetophenone derivatives 11 and 14 showed good activity.

Topics: Alkenes; Antigens, Viral; Antineoplastic Agents; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Humans; Ketones; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured

2005