desmethylsertraline has been researched along with sertraline in 52 studies
| Studies (desmethylsertraline) | Trials (desmethylsertraline) | Recent Studies (post-2010) (desmethylsertraline) | Studies (sertraline) | Trials (sertraline) | Recent Studies (post-2010) (sertraline) |
|---|---|---|---|---|---|
| 56 | 8 | 9 | 3,480 | 1,028 | 1,329 |
| Protein | Taxonomy | desmethylsertraline (IC50) | sertraline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 1.083 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.9848 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 2.7675 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 2.6309 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.8 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.5073 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.2888 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.4 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 1.2882 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 8.3173 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.1814 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 4.477 | |
| D | Rattus norvegicus (Norway rat) | 0.26 | |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | 0.26 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.8783 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.825 | |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | 0.26 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.7409 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 1.083 | |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | 0.26 | |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Homo sapiens (human) | 0.8 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.0016 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.1743 | |
| Melanocortin receptor 5 | Homo sapiens (human) | 4.598 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.655 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 3.3935 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.26 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.2175 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 8.3173 | |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | 8.3173 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.0697 | |
| Transporter | Rattus norvegicus (Norway rat) | 0.26 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (38.46) | 18.2507 |
| 2000's | 22 (42.31) | 29.6817 |
| 2010's | 5 (9.62) | 24.3611 |
| 2020's | 5 (9.62) | 2.80 |
| Authors | Studies |
|---|---|
| Dormann, SM; Haefeli, WE; Kerpen, CJ; Ketabi-Kiyanvash, N; Martin-Facklam, M; Weiss, J | 1 |
| Fischette, CT; Reith, ME; Wiener, HL | 1 |
| Fischette, CT; Reith, ME | 1 |
| Kramer, HK; Reith, ME; Wiener, HL | 1 |
| Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; von Moltke, LL | 1 |
| Audia, JE; Fuller, RW; Hemrick-Luecke, SK; Littlefield, ES | 1 |
| Jenkins, AJ; Levine, B; Smialek, JE | 1 |
| Long, G; Marr, M; Moore, C; Rogowsky, D | 1 |
| Binkley, SN; Ring, BJ; Roskos, L; Wrighton, SA | 1 |
| Clarke, T; Heym, J; Reynolds, L; Rollema, H; Sprouse, J | 1 |
| Ronfeld, RA; Tremaine, LM; Wilner, KD | 1 |
| Foglia, JP; Mammen, OK; Perel, JM; Rudolph, G; Wheeler, SB | 1 |
| Ely, T; Kilts, CD; Landry, JC; Llewellyn, A; Nemeroff, CB; Owens, MJ; Stowe, ZN | 1 |
| Dysken, MW; Hazel, DK; Holden, LA; Vatassery, GT | 1 |
| Blumer, J; Perel, JM; Wisner, KL | 1 |
| Dusci, LJ; Hackett, LP; Ilett, KF; Kristensen, JH; Paech, M; Roberts, MJ; Wojnar-Horton, RE; Yapp, P | 1 |
| Brissie, RM; Davis, GG; Hall, M; Milner, DA; Robinson, CA | 1 |
| He, N; Huang, SL; Liu, ZQ; Shu, Y; Wang, W; Xu, ZH; Zhao, XJ; Zhou, HH; Zhu, B | 1 |
| Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL | 1 |
| Buffum, J; Bui, BC; Chan, WK; Harralson, AF; Lee, AJ | 1 |
| Court, MH; Duan, SX; Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL | 1 |
| Gurbel, PA; O'Connor, CM; Serebruany, VL | 1 |
| Chen, XP; He, N; Liu, ZQ; Shu, Y; Wang, JH; Wang, W; Zhou, HH | 1 |
| Allard, S; Roth-Schechter, BF; Sainati, SM | 1 |
| Anderson, GM; Czarkowski, KA; Epperson, N; Gueorguieva, R; Jatlow, P; Ward-O'Brien, D; Weiss, E | 1 |
| Fraser, AD; Mukherjee, SD; Pollak, PT | 1 |
| Cohen, LS; Hostetter, AL; Nemeroff, CB; Owens, MJ; Ritchie, JC; Sternberg, K; Stowe, ZN | 1 |
| Flynn, DM; Hill, RJ; Knight, DR; Magee, WP; Oleynek, JJ; Smith, AH; Tracey, WR | 1 |
| Aberg-Wistedt, A; Agren, H; Akerblad, AC; Bengtsson, F; Höglund, P; Reis, M | 1 |
| Aberg-Wistedt, A; Agren, H; Akerblad, AC; Bengtsson, F; Reis, M | 1 |
| Banks, KE; Brooks, BW; Chambliss, CK; Johnson, RD; Lewis, RJ; Ramirez, A; Stanley, JK | 1 |
| Cooper, TB; Glassman, AH; Krishnan, KR; Lekht, V; Malinin, AI; O'Connor, CM; Serebruany, VL; Suckow, RF; van Zyl, LT | 1 |
| Lambert, WE; Maudens, KE; Van Peteghem, CH; Wille, SM | 1 |
| Berardi, D; Ferrari, S; Kenndler, E; Mandrioli, R; Raggi, MA; Saracino, MA | 1 |
| Findling, RL; Hanusa, BH; Moses-Kolko, EL; Peindl, KS; Perel, JM; Piontek, CM; Sit, DK; Wisner, KL | 1 |
| Amore, M; Fanali, S; Kenndler, E; Mercolini, L; Musenga, A; Raggi, MA | 1 |
| DeVane, CL; Donovan, JL; Gibson, BB; Markowitz, JS; Wang, JS; Zhu, HJ | 1 |
| Hermann, M; Molden, E; Refsum, H; Rudberg, I | 1 |
| Hori, H; Ikenouchi-Sugita, A; Nakamura, J; Ueda, N; Umene-Nakano, W; Yoshimura, R | 1 |
| Anthony, M; Davis, MF; Fankhauser, M; Freeman, MP; Fried, K; Moreno, F; Nolan, PE; Woosley, RL | 1 |
| Patel, BN; Sanyal, M; Sharma, N; Shrivastav, PS | 1 |
| Bäckvall, JE; Hoben, C; Paetzold, J; Sortais, JB; Thalén, LK; Zhao, D | 1 |
| Akerblad, AC; Ekselius, L; Reis, M; von Knorring, L | 1 |
| Mallett, P; McIntyre, IM | 1 |
| Bourland, JD; Clark, A; Daunais, JB; Johnston, WD; Jones, SR; Kraft, RA; Massey, A; Neely, D; Shively, CA; Uberseder, B; Willard, SL; Williamson, JD | 1 |
| Brose, SA; Golovko, MY; Henry, LK; Krout, D; Rodriquez, M; Thompson, BJ | 1 |
| Dziurkowska, E; Wesolowski, M | 1 |
| Avram, MJ; Caritis, SN; Ciolino, JD; Clark, S; Costantine, MM; George, AL; Mesches, GA; Rasmussen-Torvik, LJ; Stika, CS; Venkataramanan, R; West, HA; Wisner, KL; Zumpf, K | 1 |
| Distefano, GG; Gambaro, A; Picone, M; Volpi Ghirardini, A; Zangrando, R | 1 |
| Ilic, N; Jankovic, SM; Milovanovic, J; Nikolic, VN; Popovic, D; Stoiljkovic, M; Vujovic, M | 1 |
| Hastie, R; Kellermann, T; Phogole, CM | 1 |
| Douda, K; Grabic, R; Grabicová, K; Horký, P; Hubená, P; Randák, T; Slavík, O | 1 |
1 review(s) available for desmethylsertraline and sertraline
| Article | Year |
|---|---|
Sertraline - isolation methods and quantitation in biological material.
Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Saliva; Selective Serotonin Reuptake Inhibitors; Sertraline; Solid Phase Extraction; Urine | 2018 |
8 trial(s) available for desmethylsertraline and sertraline
| Article | Year |
|---|---|
Distribution and excretion of sertraline and N-desmethylsertraline in human milk.
Topics: 1-Naphthylamine; Administration, Oral; Adult; Antidepressive Agents; Area Under Curve; Breast Feeding; Chromatography, High Pressure Liquid; Female; Humans; Infant; Male; Milk, Human; Sertraline; Tissue Distribution | 1998 |
The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study.
Topics: Administration, Oral; Aged; Beverages; Chromatography, High Pressure Liquid; Citrus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression; Female; Food-Drug Interactions; Humans; In Vitro Techniques; Male; Microsomes; Middle Aged; Mixed Function Oxygenases; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 1999 |
Coadministration of short-term zolpidem with sertraline in healthy women.
Topics: Adult; Analysis of Variance; Area Under Curve; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Least-Squares Analysis; Psychomotor Performance; Pyridines; Selective Serotonin Reuptake Inhibitors; Sertraline; Zolpidem | 1999 |
Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression.
Topics: Adolescent; Adult; Aged; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Monitoring; Female; Half-Life; Humans; Male; Middle Aged; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline; Sex Factors | 2004 |
Postpartum depression: a randomized trial of sertraline versus nortriptyline.
Topics: Adaptation, Psychological; Administration, Oral; Adult; Antidepressive Agents, Tricyclic; Capsules; Data Interpretation, Statistical; Depression, Postpartum; Double-Blind Method; Female; Humans; Infant, Newborn; Middle Aged; Nortriptyline; Patient Dropouts; Sertraline; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2006 |
Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients.
Topics: Adult; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Genotype; Humans; Male; Mental Disorders; Metabolic Clearance Rate; Middle Aged; Sertraline; Tandem Mass Spectrometry | 2008 |
Pharmacokinetics of sertraline across pregnancy and postpartum.
Topics: 1-Naphthylamine; Adult; Body Weight; Depressive Disorder, Major; Female; Humans; Longitudinal Studies; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Selective Serotonin Reuptake Inhibitors; Sertraline; Young Adult | 2008 |
Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder, Major; Drug Monitoring; Female; Humans; Male; Medication Adherence; Middle Aged; Primary Health Care; Selective Serotonin Reuptake Inhibitors; Sertraline; Young Adult | 2010 |
43 other study(ies) available for desmethylsertraline and sertraline
| Article | Year |
|---|---|
Inhibition of P-glycoprotein by newer antidepressants.
Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection | 2003 |
Sertraline and cocaine-induced locomotion in mice. I. Acute studies.
Topics: 1-Naphthylamine; Animals; Cocaine; Desipramine; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Serotonin; Serotonin Antagonists; Sertraline; Sex Factors | 1991 |
Sertraline and cocaine-induced locomotion in mice. II. Chronic studies.
Topics: 1-Naphthylamine; Animals; Body Weight; Cocaine; Female; Mice; Mice, Inbred C57BL; Motor Activity; Serotonin Antagonists; Sertraline | 1991 |
Separation and determination of sertraline and its metabolite, desmethylsertraline, in mouse cerebral cortex by reversed-phase high-performance liquid chromatography.
Topics: 1-Naphthylamine; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Serotonin Antagonists; Sertraline | 1990 |
N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.
Topics: 1-Naphthylamine; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Ketoconazole; Kinetics; Liver; Mixed Function Oxygenases; Nortriptyline; Quinidine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1995 |
Comparison of desmethylsertraline with sertraline as a monoamine uptake inhibitor in vivo.
Topics: 1-Naphthylamine; Animals; Dose-Response Relationship, Drug; Epinephrine; Hydroxyindoleacetic Acid; Male; Mice; Norepinephrine; Oxidopamine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1995 |
Distribution of sertraline in postmortem cases.
Topics: 1-Naphthylamine; Adult; Aged; Antidepressive Agents; Chromatography, Gas; Female; Humans; Male; Middle Aged; Retrospective Studies; Sertraline; Tissue Distribution | 1994 |
Determination of sertraline and desmethylsertraline in human serum using copolymeric bonded-phase extraction, liquid chromatography and gas chromatography-mass spectrometry.
Topics: 1-Naphthylamine; Antidepressive Agents; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Sertraline; Spectrophotometry, Ultraviolet | 1994 |
Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.
Topics: 1-Naphthylamine; Catalysis; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors; Sertraline | 1995 |
Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo.
Topics: 1-Naphthylamine; Animals; Dose-Response Relationship, Drug; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors | 1996 |
Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers.
Topics: 1-Naphthylamine; Adult; Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Area Under Curve; Female; Half-Life; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Sertraline; Sex Factors | 1997 |
Sertraline and norsertraline levels in three breastfed infants.
Topics: 1-Naphthylamine; Breast Feeding; Depressive Disorder; Female; Humans; Infant, Newborn; Puerperal Disorders; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Sertraline and desmethylsertraline in human breast milk and nursing infants.
Topics: 1-Naphthylamine; Breast Feeding; Depression, Postpartum; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Lactation; Milk, Human; Pregnancy; Pregnancy Complications; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Analysis of sertraline and desmethylsertraline in human plasma and red blood cells.
Topics: 1-Naphthylamine; Antidepressive Agents; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Sertraline | 1997 |
Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs.
Topics: 1-Naphthylamine; Breast Feeding; Depressive Disorder; Female; Humans; Infant; Infant, Newborn; Lactation; Male; Selective Serotonin Reuptake Inhibitors; Sertraline | 1998 |
Fatal multiple drug intoxication following acute sertraline use.
Topics: Alprazolam; Anti-Anxiety Agents; Antidepressive Agents; Chromatography, High Pressure Liquid; Drug Interactions; Drug Overdose; Fatal Outcome; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Sertraline; Suicide | 1998 |
Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1999 |
Human cytochromes mediating sertraline biotransformation: seeking attribution.
Topics: Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Selective Serotonin Reuptake Inhibitors; Sertraline | 1999 |
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
Topics: Antibodies; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Paroxetine; Piperazines; Sertraline; Triazoles | 2000 |
Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors.
Topics: Coronary Disease; Depression; Flow Cytometry; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Cell Surface; Selective Serotonin Reuptake Inhibitors; Sertraline | 2001 |
Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.
Topics: Administration, Oral; Adult; Antidepressive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; China; Chromatography, Gas; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Male; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Reference Values; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors | 2001 |
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs.
Topics: Blood Platelets; Breast Feeding; Carrier Proteins; Depression, Postpartum; Female; Humans; Infant, Newborn; Membrane Glycoproteins; Membrane Transport Proteins; Milk, Human; Nerve Tissue Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sertraline | 2001 |
Sertraline-induced hypoglycemia.
Topics: Aged; Aged, 80 and over; Blood Glucose; Female; Humans; Hypoglycemia; Selective Serotonin Reuptake Inhibitors; Sertraline | 2001 |
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.
Topics: Breast Feeding; Child Development; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Infant, Newborn; Lactation; Milk, Human; Pregnancy; Selective Serotonin Reuptake Inhibitors; Sertraline | 2003 |
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Humans; Iodine Radioisotopes; Isoxazoles; Myocardial Infarction; Myocardial Reperfusion Injury; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Sertraline; Transfection | 2003 |
Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Drug Monitoring; Female; Humans; Male; Patient Compliance; Periodicity; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors | 2004 |
Determination of select antidepressants in fish from an effluent-dominated stream.
Topics: Animals; Antidepressive Agents; Brain; Fishes; Fluoxetine; Liver; Muscles; Rivers; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors; Water Pollutants, Chemical | 2005 |
Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression.
Topics: Biomarkers; Blood Platelets; Coronary Disease; Coronary Vessels; Endothelium, Vascular; Humans; Selective Serotonin Reuptake Inhibitors; Sertraline | 2005 |
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Mianserin; Microchemistry; Mirtazapine; Piperazines; Reproducibility of Results; Sertraline | 2005 |
HPLC analysis of the second-generation antidepressant sertraline and its main metabolite N-desmethylsertraline in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Sertraline | 2006 |
Determination of sertraline and N-desmethylsertraline in human plasma by CE with LIF detection.
Topics: Electrophoresis, Capillary; Humans; Reproducibility of Results; Sensitivity and Specificity; Sertraline | 2007 |
Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein.
Topics: Adenosine Triphosphatases; Algorithms; Antidepressive Agents; Antidepressive Agents, Second-Generation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Bupropion; Data Interpretation, Statistical; Humans; In Vitro Techniques; Protein Binding; Sertraline | 2008 |
Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline.
Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Risperidone; Sertraline | 2008 |
Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.
Topics: Antidepressive Agents, Second-Generation; Chromatography, Liquid; Drug Stability; Fluoxetine; Humans; Linear Models; Male; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sertraline; Tandem Mass Spectrometry | 2009 |
A chemoenzymatic approach to enantiomerically pure amines using dynamic kinetic resolution: application to the synthesis of norsertraline.
Topics: 1-Naphthylamine; Amines; Biocatalysis; Catalysis; Fungal Proteins; Kinetics; Lipase; Organometallic Compounds; Sertraline; Stereoisomerism; Substrate Specificity | 2009 |
Sertraline concentrations and postmortem redistribution.
Topics: 1-Naphthylamine; Analgesics, Opioid; Antidepressive Agents; Central Nervous System Depressants; Chromatography, Gas; Enzyme-Linked Immunosorbent Assay; Ethanol; Flame Ionization; Forensic Toxicology; Gastrointestinal Contents; Humans; Hypnotics and Sedatives; Liver; Selective Serotonin Reuptake Inhibitors; Sertraline | 2012 |
Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates.
Topics: Administration, Oral; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Depressive Disorder; Female; Hydroxyindoleacetic Acid; Macaca fascicularis; Magnetic Resonance Imaging; Organ Size; Random Allocation; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 2015 |
Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.
Topics: Animals; Citalopram; Fluoxetine; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline; Synaptosomes | 2017 |
Changes in Sertraline Plasma Concentrations Across Pregnancy and Postpartum.
Topics: Cytochrome P-450 CYP2C19; Depressive Disorder, Major; Female; Humans; Postpartum Period; Pregnancy; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline | 2022 |
Neonicotinoids and pharmaceuticals in hair of the Red fox (Vulpes vulpes) from the Cavallino-Treporti peninsula, Italy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Foxes; Hair; Humans; Ibuprofen; Insecticides; Italy; Ketoprofen; Neonicotinoids; Pharmaceutical Preparations; Sertraline | 2023 |
Population Pharmacokinetic Modeling to Inform Sertraline Dosing Optimization in Patients with Depression.
Topics: Adult; Antidepressive Agents; Depression; Depressive Disorder, Major; Female; Humans; Male; Sertraline | 2023 |
A simple and sensitive LC-MS/MS method for the quantitation of sertraline and N-desmethylsertraline in human plasma.
Topics: Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Sertraline; Tandem Mass Spectrometry | 2023 |
Aggression repeatability in stressed fish in response to an environmental concentration of sertraline and lunar cycle as evidenced by brain metabolomics.
Topics: Aggression; Animals; Brain; Cyprinidae; Moon; Sertraline; Water Pollutants, Chemical | 2023 |