Page last updated: 2024-09-02

desmethylsertraline and fluvoxamine

desmethylsertraline has been researched along with fluvoxamine in 2 studies

Compound Research Comparison

Studies (desmethylsertraline)	Trials (desmethylsertraline)	Recent Studies (post-2010) (desmethylsertraline)	Studies (fluvoxamine)	Trials (fluvoxamine)	Recent Studies (post-2010) (fluvoxamine)
56	8	9	2,051	518	434

Protein Interaction Comparison

Protein	Taxonomy	fluvoxamine (IC50)
D	Rattus norvegicus (Norway rat)	0.54
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	0.54
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	0.54
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	0.54
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.0038
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.54
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	0.54
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	3.1
Transporter	Rattus norvegicus (Norway rat)	0.54

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dormann, SM; Haefeli, WE; Kerpen, CJ; Ketabi-Kiyanvash, N; Martin-Facklam, M; Weiss, J	1
Court, MH; Duan, SX; Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL	1

Other Studies

2 other study(ies) available for desmethylsertraline and fluvoxamine

Article	Year
Inhibition of P-glycoprotein by newer antidepressants. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1 Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection	2003
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Antibodies; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Paroxetine; Piperazines; Sertraline; Triazoles	2000

Article

Year

Inhibition of P-glycoprotein by newer antidepressants.

The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection

2003

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10

Topics: Antibodies; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Paroxetine; Piperazines; Sertraline; Triazoles

2000