Page last updated: 2024-09-02

desmethylsertraline and fluoxetine

desmethylsertraline has been researched along with fluoxetine in 7 studies

Compound Research Comparison

Studies
(desmethylsertraline)
Trials
(desmethylsertraline)
Recent Studies (post-2010)
(desmethylsertraline)
Studies
(fluoxetine)
Trials
(fluoxetine)
Recent Studies (post-2010) (fluoxetine)
568910,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomydesmethylsertraline (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dormann, SM; Haefeli, WE; Kerpen, CJ; Ketabi-Kiyanvash, N; Martin-Facklam, M; Weiss, J1
Binkley, SN; Ring, BJ; Roskos, L; Wrighton, SA1
Court, MH; Duan, SX; Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL1
Banks, KE; Brooks, BW; Chambliss, CK; Johnson, RD; Lewis, RJ; Ramirez, A; Stanley, JK1
Lambert, WE; Maudens, KE; Van Peteghem, CH; Wille, SM1
Patel, BN; Sanyal, M; Sharma, N; Shrivastav, PS1
Brose, SA; Golovko, MY; Henry, LK; Krout, D; Rodriquez, M; Thompson, BJ1

Other Studies

7 other study(ies) available for desmethylsertraline and fluoxetine

ArticleYear
Inhibition of P-glycoprotein by newer antidepressants.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection

2003
Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: 1-Naphthylamine; Catalysis; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors; Sertraline

1995
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10

    Topics: Antibodies; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Paroxetine; Piperazines; Sertraline; Triazoles

2000
Determination of select antidepressants in fish from an effluent-dominated stream.
    Environmental toxicology and chemistry, 2005, Volume: 24, Issue:2

    Topics: Animals; Antidepressive Agents; Brain; Fishes; Fluoxetine; Liver; Muscles; Rivers; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors; Water Pollutants, Chemical

2005
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
    Journal of chromatography. A, 2005, Dec-09, Volume: 1098, Issue:1-2

    Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Mianserin; Microchemistry; Mirtazapine; Piperazines; Reproducibility of Results; Sertraline

2005
Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Jan-15, Volume: 877, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Chromatography, Liquid; Drug Stability; Fluoxetine; Humans; Linear Models; Male; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sertraline; Tandem Mass Spectrometry

2009
Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.
    ACS chemical neuroscience, 2017, 05-17, Volume: 8, Issue:5

    Topics: Animals; Citalopram; Fluoxetine; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline; Synaptosomes

2017