desmethylselegiline has been researched along with methamphetamine in 20 studies
| Studies (desmethylselegiline) | Trials (desmethylselegiline) | Recent Studies (post-2010) (desmethylselegiline) | Studies (methamphetamine) | Trials (methamphetamine) | Recent Studies (post-2010) (methamphetamine) |
|---|---|---|---|---|---|
| 42 | 12 | 1 | 10,914 | 409 | 4,888 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmood, I; Mason, WD; Neau, SH | 1 |
| Gaál, J; Lengyel, J; Magyar, K; Szatmári, I; Szebeni, G; Székács, G | 1 |
| Bosc, M; Deffond, D; Dordain, G; Dostert, P; Fiorentini, F; La Croix, R; Persiani, S; Strolin Benedetti, M; Vernay, D | 1 |
| Barrett, JS; De Witt, KE; Ireland, J; Morales, RJ; Rajewski, G; Rohatagi, S; Szego, P | 1 |
| Kikuta, C; Ludwig, G; Mascher, HJ; Millendorfer, A; Schiel, H | 1 |
| Barrett, JS; DeWitt, KE; Morales, RJ; Rohatagi, S | 1 |
| Barrett, JS; DeWitt, KE; Lessard, D; Morales, RJ; Rohatagi, S | 1 |
| Anttila, M; Bertilsson, L; Dahl, ML; Karnani, H; Nyman, L; Pelkonen, O; Scheinin, H; Taavitsainen, P | 1 |
| Fukushima, S; Hasegawa, M; Kimura, K; Maseda, C; Matsubara, K; Uezono, T | 1 |
| Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P | 1 |
| Anttila, M; Backman, JT; Kivistö, KT; Neuvonen, PJ; Nyman, L; Taavitsainen, P; Wang, JS | 1 |
| Anttila, M; Laine, K; Nyman, L; Palovaara, S | 1 |
| Kamata, T; Katagi, M; Miki, A; Nakajima, K; Nishikawa, M; Nishioka, H; Tatsuno, M; Tsuchihashi, H; Tsutsumi, H | 1 |
| Foltz, RL; Moody, DE; Slawson, MH; Taccogno, JL | 1 |
| Ahlner, J; Dizdar, N; Kronstrand, R; Larson, G | 1 |
| Ikeda, N; Inoue, N; Itoh, S; Kudo, K; Nishida, K | 1 |
| Alok, R; Benetton, SA; Fang, C; Lin, CC; Yang, YO; Year, M; Yeh, LT | 1 |
| Lengyel, J; Magyar, K; Szatmáry, I; Szebeni, G | 1 |
| Everhart, T; Harris, DS; Jacob, P; Jones, RT; Lin, E; Mendelson, JE | 1 |
| Chen, L; Duan, G; Shen, B; Shi, Y; Wang, S; Xiang, P; Yan, H; Yu, Y | 1 |
8 trial(s) available for desmethylselegiline and methamphetamine
| Article | Year |
|---|---|
Lack of pharmacokinetic interaction between the selective dopamine agonist cabergoline and the MAO-B inhibitor selegiline.
Topics: Aged; Amphetamine; Amphetamines; Antiparkinson Agents; Cabergoline; Dopamine Agonists; Drug Interactions; Ergolines; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1995 |
Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration.
Topics: Administration, Cutaneous; Amphetamine; Amphetamines; Antiparkinson Agents; Area Under Curve; Humans; Male; Methamphetamine; Models, Biological; Monoamine Oxidase Inhibitors; Pilot Projects; Regression Analysis; Selegiline | 1997 |
Pharmacokinetic evaluation of a selegiline pulsatile oral delivery system.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Area Under Curve; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Delivery Systems; Humans; Intestinal Absorption; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Pilot Projects; Reference Values; Selegiline; Therapeutic Equivalency; Time Factors | 1997 |
CYP2D6 polymorphism is not crucial for the disposition of selegiline.
Topics: Adrenergic Agents; Adult; Amphetamines; Area Under Curve; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Humans; In Vitro Techniques; Male; Methamphetamine; Microsomes, Liver; Monoamine Oxidase Inhibitors; Polymorphism, Genetic; Reference Values; Selegiline | 1998 |
Selegiline pharmacokinetics are unaffected by the CYP3A4 inhibitor itraconazole.
Topics: Adult; Amphetamines; Antifungal Agents; Area Under Curve; Central Nervous System Stimulants; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Itraconazole; Male; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Selegiline; Statistics, Nonparametric | 2001 |
Effect of concomitant hormone replacement therapy containing estradiol and levonorgestrel on the pharmacokinetics of selegiline.
Topics: Administration, Oral; Adult; Amphetamines; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Female; Humans; Levonorgestrel; Methamphetamine; Monoamine Oxidase Inhibitors; Progesterone Congeners; Selegiline | 2002 |
Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication.
Topics: Aged; Aged, 80 and over; Amphetamine; Amphetamines; Antiparkinson Agents; Drug Administration Schedule; Female; Hair; Hair Color; Humans; Male; Melanins; Methamphetamine; Middle Aged; Parkinson Disease; Patient Compliance; Selegiline; Spectrophotometry | 2003 |
A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
Topics: Administration, Cutaneous; Adult; Affect; Amphetamine; Amphetamines; Analysis of Variance; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Homovanillic Acid; Humans; Infusions, Intravenous; Male; Methamphetamine; Methoxyhydroxyphenylglycol; Monitoring, Physiologic; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Prolactin; Selegiline; Statistics, Nonparametric; Substance Withdrawal Syndrome; Young Adult | 2009 |
12 other study(ies) available for desmethylselegiline and methamphetamine
| Article | Year |
|---|---|
An enzymatic assay for the MAO-B inhibitor selegiline in plasma.
Topics: Amphetamine; Amphetamines; Animals; Brain; Humans; Hydroxyquinolines; Male; Methamphetamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Spectrometry, Fluorescence | 1994 |
Gas chromatographic procedure for simultaneous determination of selegiline metabolites, amphetamine, methamphetamine and demethyl-deprenyl in pig plasma.
Topics: Amphetamine; Amphetamines; Animals; Capsules; Central Nervous System Stimulants; Chromatography, Gas; Female; Indicators and Reagents; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Swine; Tablets | 1995 |
Absorption and presystemic metabolism of selegiline hydrochloride at different regions in the gastrointestinal tract in healthy males.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Cross-Over Studies; Duodenum; Gastric Mucosa; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline | 1996 |
Pharmacokinetics and bioequivalence of the main metabolites of selegiline: desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Central Nervous System Stimulants; Half-Life; Humans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Therapeutic Equivalency | 1997 |
Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy.
Topics: Adult; Amphetamine; Amphetamines; Biomarkers; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Selegiline; Stereoisomerism; Substance Abuse Detection; Substance-Related Disorders | 1999 |
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes.
Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline | 2000 |
Urinary excretion of selegiline N-oxide, a new indicator for selegiline administration in man.
Topics: Adrenergic Uptake Inhibitors; Adult; Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Methamphetamine; Models, Chemical; Monoamine Oxidase Inhibitors; Selegiline; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2002 |
Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Topics: Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Freezing; Humans; Mass Spectrometry; Methamphetamine; Monoamine Oxidase Inhibitors; Reproducibility of Results; Selegiline | 2002 |
High-performance liquid chromatographic-mass spectrometric determination of methamphetamine and amphetamine enantiomers, desmethylselegiline and selegiline, in hair samples of long-term methamphetamine abusers or selegiline users.
Topics: Amphetamine; Amphetamines; Antiparkinson Agents; Chromatography, High Pressure Liquid; Hair; Humans; Methamphetamine; Parkinson Disease; Selegiline; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2006 |
P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine.
Topics: Amphetamines; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Monoamine Oxidase Inhibitors; Oxidoreductases, N-Demethylating; Phenotype; Recombinant Proteins; Selegiline; Tandem Mass Spectrometry | 2007 |
Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse.
Topics: Administration, Oral; Amphetamine; Amphetamines; Animals; Antiparkinson Agents; Biological Availability; Biotransformation; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Methamphetamine; Mice; Mice, Inbred Strains; Monoamine Oxidase Inhibitors; Selegiline | 2007 |
Pharmacokinetics of selegiline, R-methamphetamine, R-amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline.
Topics: Administration, Oral; Amphetamine; Amphetamines; Humans; Liquid-Liquid Extraction; Methamphetamine; Monoamine Oxidase Inhibitors; Saliva; Selegiline; Substance Abuse Detection | 2019 |