desmethylnaproxen has been researched along with naproxen in 27 studies
| Studies (desmethylnaproxen) | Trials (desmethylnaproxen) | Recent Studies (post-2010) (desmethylnaproxen) | Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) |
|---|---|---|---|---|---|
| 29 | 1 | 8 | 4,551 | 1,057 | 1,429 |
| Protein | Taxonomy | desmethylnaproxen (IC50) | naproxen (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 1.1642 | |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | 1.2 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 4.0203 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 3.8725 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.06 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 0.5867 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 1.26 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 3.36 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 5.8 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 0.06 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Andersen, JV; Hansen, SH | 2 |
| van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, TB | 1 |
| Mengeringhausen, K; Morgan, E; Rudy, JA; Sams, R; Soma, LR; Uboh, CE | 1 |
| de Zeeuw, D; Franssen, EJ; Meijer, DK; Moolenaar, F; van Amsterdam, RG; Visser, J | 1 |
| Pettit, BR; Sandler, M; Walker, PL | 1 |
| Brueren, MM; Guelen, PJ; Janssen, TJ; Lipperts, GJ; Vree, TB | 1 |
| Kiang, CH; Kushinsky, S; Lee, PC | 1 |
| Khalil, SK; Rao, NG; Shimek, JL | 1 |
| Awazu, S; Horie, T; Yokoyama, H | 1 |
| Guelen, PJ; van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, JB; Vree, TB | 1 |
| Guelen, PJ; Van Den Biggelaar-Martea, M; Verwey-Van Wissen, CP; Vree, ML; Vree, TB | 1 |
| Addison, RS; Dickinson, RG; Jaggi, R; King, AR; Suthers, BD | 1 |
| Huang, HH; Liu, L; Sun, L; Zhong, DF | 1 |
| Bowalgaha, K; Elliot, DJ; Knights, KM; Mackenzie, PI; Miners, JO; Swedmark, S | 1 |
| Falany, CN; Ström, P; Swedmark, S | 1 |
| Locuson, CW; Tracy, TS; Wei, L | 1 |
| Hühnerfuss, H; Scheurell, M; Selke, S; Shah, MR | 1 |
| Chow, L; Dasgupta, A; Johnson, M; Langman, LJ | 1 |
| Aracagök, YD; Cihangir, N; Göker, H | 1 |
| Alherz, FA; Almarghalani, DA; Hussein, NA; Kurogi, K; Liu, MC | 1 |
| Campbell, JK; Porter, AW; Wolfson, SJ; Young, LY | 1 |
| Abunnaja, MS; Alatwi, ES; Alherz, FA; Bairam, AF; El Daibani, AA; Gohal, SA; Kurogi, K; Liu, MC; Rasool, MI | 1 |
| Porter, AW; Simon, JE; Villani, TS; Wolfson, SJ; Young, LY | 1 |
| Guzik, U; Wojcieszyńska, D | 1 |
| Calvo, AM; Dionísio, TJ; Faria, FC; Morettin, M; Oliveira, GM; Santos, CF | 1 |
| Calvo, AM; Dionísio, TJ; Faria, FAC; Oliveira, GM; Polanco, NLDH; Santos, CF; Siqueira-Sandrin, VS | 1 |
1 review(s) available for desmethylnaproxen and naproxen
| Article | Year |
|---|---|
Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aquatic Organisms; Bacillus thuringiensis; Bacterial Proteins; Biodegradation, Environmental; Environmental Exposure; Metabolic Networks and Pathways; Naproxen; Water Pollutants, Chemical | 2020 |
1 trial(s) available for desmethylnaproxen and naproxen
| Article | Year |
|---|---|
Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazole.
Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Combinations; Drug Monitoring; Esomeprazole; Female; Gastrointestinal Absorption; Humans; Male; Methanol; Middle Aged; Naproxen; Pain, Procedural; Reproducibility of Results; Saliva; Tablets; Tandem Mass Spectrometry; Young Adult | 2020 |
25 other study(ies) available for desmethylnaproxen and naproxen
| Article | Year |
|---|---|
Simultaneous quantitative determination of naproxen, its metabolite 6-O-desmethylnaproxen and their five conjugates in plasma and urine samples by high-performance liquid chromatography on dynamically modified silica.
Topics: Adult; Animals; Chromatography, High Pressure Liquid; Glucuronates; Humans; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Naproxen; Rabbits; Reference Values; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1992 |
Simultaneous determination of (R)- and (S)-naproxen and (R)- and (S)-6-O-desmethylnaproxen by high-performance liquid chromatography on a Chiral-AGP column.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Naproxen; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Stereoisomerism | 1992 |
Determination of naproxen and its metabolite O-desmethylnaproxen with their acyl glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatography.
Topics: Acylation; Chromatography, High Pressure Liquid; Glucuronates; Humans; Naproxen; Reference Values; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1992 |
Plasma concentration of furosemide versus specific gravity of urine in predicting dose of administration in race horses.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Administration Schedule; Furosemide; Horses; Lung Diseases; Naproxen; Physical Exertion; Reference Standards; Specific Gravity; Urine | 1992 |
Low molecular weight proteins as carriers for renal drug targeting: naproxen-lysozyme.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Cyclooxygenase Inhibitors; Drug Carriers; Guinea Pigs; Kidney; Kidney Cortex; Lysine; Male; Molecular Weight; Muramidase; Naproxen; Protein Binding; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Interference by naproxen in the urinary 5-hydroxyindoleacetic acid assay is due to a metabolite, desmethylnaproxen.
Topics: Adult; Aged; Chromatography, Gas; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Naproxen; Quality Control; Spectrophotometry | 1987 |
The pharmacokinetic profile of naproxen suppository in man.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Naproxen; Suppositories | 1988 |
High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Indicators and Reagents; Naproxen; Spectrophotometry, Ultraviolet | 1986 |
An isocratic high-pressure liquid chromatographic determination of naproxen and desmethylnaproxen in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Naproxen; Spectrometry, Fluorescence | 1982 |
Lipid peroxidation and chemiluminescence during naproxen metabolism in rat liver microsomes.
Topics: Animals; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Cobalt; Electrophoresis, Polyacrylamide Gel; Ferrous Compounds; Histidine; Lipid Peroxidation; Luminescent Measurements; Magnesium Chloride; Male; Microsomes, Liver; Molecular Weight; NADP; Naproxen; Piperonyl Butoxide; Proadifen; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Vitamin E | 1994 |
Pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans.
Topics: Adult; Blood Proteins; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Isomerism; Kidney; Male; Middle Aged; Naproxen | 1993 |
The pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans. Effect of cimetidine.
Topics: Adult; Blood Proteins; Chromatography, High Pressure Liquid; Cimetidine; Female; Glucuronates; Half-Life; Humans; Male; Middle Aged; Naproxen | 1993 |
Conjugation of desmethylnaproxen in the rat--a novel acyl glucuronide-sulfate diconjugate as a major biliary metabolite.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Glucuronides; Male; Naproxen; Rats; Rats, Sprague-Dawley; Sulfates | 2002 |
Microbial transformation of naproxen by Cunninghamella species.
Topics: Biotransformation; Cunninghamella; Cyclooxygenase Inhibitors; Naproxen | 2003 |
S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.
Topics: Glucuronosyltransferase; Humans; In Vitro Techniques; Microsomes, Liver; Naproxen | 2005 |
Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.
Topics: Cytosol; Dose-Response Relationship, Drug; Humans; Isoenzymes; Naproxen; Structure-Activity Relationship; Substrate Specificity; Sulfates; Sulfotransferases | 2005 |
Polymorphic variants of CYP2C9: mechanisms involved in reduced catalytic activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C9; Humans; Hydrogen Peroxide; Kinetics; NADP; Naproxen; Polymorphism, Genetic; Water | 2007 |
Identification and enantioselective gas chromatographic mass-spectrometric separation of O-desmethylnaproxen, the main metabolite of the drug naproxen, as a new environmental contaminant.
Topics: Gas Chromatography-Mass Spectrometry; Geography; Germany; Naproxen; Pakistan; Sewage; Stereoisomerism; Water Pollutants, Chemical | 2010 |
Naproxen metabolites interfere with certain bilirubin assays: elimination of interference by using a Roche bilirubin assay on the Hitachi 917 analyzer.
Topics: Bilirubin; Diagnostic Errors; Diazonium Compounds; Humans; Naproxen; Reagent Kits, Diagnostic | 2010 |
Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspergillus niger; Biodegradation, Environmental; Biotransformation; Carbon-13 Magnetic Resonance Spectroscopy; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Fungal Proteins; Hydroxylation; Mass Spectrometry; Naproxen; Phanerochaete; Proton Magnetic Resonance Spectroscopy; Water Pollutants, Chemical; Water Purification; Yarrowia | 2017 |
A reappraisal of the 6-O-desmethylnaproxen-sulfating activity of the human cytosolic sulfotransferases.
Topics: Caco-2 Cells; Cytosol; Enzyme Assays; Hep G2 Cells; Humans; Kinetics; Naproxen; Sulfates; Sulfotransferases | 2017 |
Naproxen Is Transformed Via Acetogenesis and Syntrophic Acetate Oxidation by a Methanogenic Wastewater Consortium.
Topics: Acetic Acid; Anaerobiosis; Archaea; Bacteria; Biodegradation, Environmental; Demethylation; DNA, Bacterial; Methane; Microbial Consortia; Naproxen; Oxidation-Reduction; Sewage; Time Factors; Vanillic Acid; Wastewater | 2018 |
Effects of the human SULT1A1 polymorphisms on the sulfation of acetaminophen,O-desmethylnaproxen, and tapentadol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Arylsulfotransferase; Cytosol; Escherichia coli; Genotype; Humans; Isoenzymes; Mutagenesis, Site-Directed; Naproxen; Polymorphism, Single Nucleotide; Sulfates; Tapentadol | 2019 |
Pharmaceuticals and Personal Care Products Can Be Transformed by Anaerobic Microbiomes in the Environment and in Waste-Treatment Processes.
Topics: Biodegradation, Environmental; Campylobacteraceae; Cosmetics; Gas Chromatography-Mass Spectrometry; Helicobacteraceae; Microbiota; Naproxen; Pharmaceutical Preparations; RNA, Ribosomal, 16S; Waste Disposal, Fluid; Water Pollutants, Chemical | 2019 |
Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazol-Results.
Topics: Chromatography, Liquid; Esomeprazole; Humans; Naproxen; Saliva; Tandem Mass Spectrometry | 2022 |