Page last updated: 2024-08-22

desmethylmisonidazole and misonidazole

desmethylmisonidazole has been researched along with misonidazole in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	54 (96.43)	18.7374
1990's	2 (3.57)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Stratford, MR	1
Bleehen, NM; Walton, MI; Workman, P	1
Coleman, CN	1
Dische, S	1
Gulyas, S; Varghese, AJ; Whitmore, GF	1
Hodgkiss, RJ	1
Rose, GP; Taylor, JM	1
Gonzalez, DG; Maes, RA; Meering, PG; van Peperzeel, HA	1
Kandaiya, S	1
Smith, RA	1
Ballon, SC; Coleman, CN; Halsey, J; Hirst, VK; Howes, AE; Martinez, A	1
Sinesi, MS; Stone, HB	1
Geard, CR; Rutledge-Freeman, MH; Spunberg, JJ	1
Brown, JM; Hazlehurst, JL; Hirst, DG	1
Brown, JM	1
Adams, GE	1
Lee, FY; Workman, P	1
Hinchliffe, M; McNally, NJ	1
Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH	1
Nelson, JS; VonGerichten, D; Wasserman, TH	1
Dische, S; Saunders, MI; Stratford, MR	1
Brady, LW; Phillips, TL; Wasserman, TH	1
Johnson, RJ; Levin, VA; Phillips, TL; VanRaalte, G; Wasserman, TH	1
Wasserman, TH	1
Siemann, DW	1
Edwards, MS; Gordon, DG; Levin, VA	1
Brown, DM; Coleman, CN; Halsey, J; Hirst, VK	1
Chao, CF; Johnson, RJ; Subjeck, JR; Ting, L	1
Minchinton, AI	1
Baumann, RA; Maes, RA; Meering, PG; Zijp, JJ	1
Hodgkiss, RJ; Jones, NR; Sehmi, DS; Watts, ME; Woodcock, M	1
Bleehen, NM; Gleave, JR; Grant, RM; Hardy, DG; Holmes, AE; Jones, DH; Roberts, JT; Workman, P	1
Bleehen, NM; Jones, DH; Smith, NC; Workman, P	1
Brody, H; Chao, CF; Johnson, RJ; Shen, J; Subjeck, JR	1
Koziol, DR; Raleigh, JA; Saunders, WM; Shum, FY	1
Chao, CF; Johnson, RJ; Subjeck, JR	1
Twentyman, PR; Workman, P	1
Begg, E; O'Shea, K; Wade, D; Williams, K	1
Grdina, DJ; Mian, TA; Theiss, JC	1
Collins, JM; Gianni, L; Greene, RF; Jenkins, JF; Lichter, AS; Myers, CE	1
Breccia, A; Gattavecchia, E; Tonelli, D	1
White, RA; Workman, P	2
Afzal, SM; Curtis, SB; Howard, J; Lyman, JT; Parr, SS; Tenforde, TS	1
Kapp, DS; Rockwell, S	1
Hoerauf, R; McManus, ME; Shoemaker, DD; Strong, JM	1
Beierle, FA; Hubbard, RW	1
Adomat, H; Josephy, PD; Palcic, B; Rootman, J	1
Bennett, MH; Dische, S; Hauck, J; Minchinton, AI; Riley, PJ; Saunders, MI; Stratford, MR	1
Moore, JL; Newman, H; Paterson, IC; Venables, S	1
Maes, RA; Meering, PG	1
Collins, JM; McManus, ME; Monks, A; Strong, JM; White, R	1
Anderson, P; Dische, S; Fowler, JF; Lee, ME; Minchinton, AI; Saunders, MI; Stratford, MR	1
Mulcahy, RT; Siemann, DW; Sutherland, RM	1
Workman, P	1
Chapman, JD; Jaiswal, AK; Joseph, P; Stobbe, CC	1

Reviews

5 review(s) available for desmethylmisonidazole and misonidazole

Article	Year
Pharmacokinetics and subcellular localization of radiosensitizers. BJR supplement, 1992, Volume: 24 Topics: Etanidazole; Humans; Hydrogen-Ion Concentration; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1992
Hypoxic cell radiosensitizers: expectations and progress in drug development. International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:2 Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1984
The potential for radiation sensitizers and radiation protectors combined with radiation therapy in gynecologic cancer. Cancer, 1981, Jul-15, Volume: 48, Issue:2 Suppl Topics: Amifostine; Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Genital Neoplasms, Female; Humans; Misonidazole; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Random Allocation	1981

Trials

6 trial(s) available for desmethylmisonidazole and misonidazole

Article	Year
Hypoxic cell radiosensitizers: expectations and progress in drug development. International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:2 Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1984
Neuropathy of nitroimidazole radiosensitizers: clinical and pathological description. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Etanidazole; Humans; Misonidazole; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents; Sural Nerve	1984
The potential for radiation sensitizers and radiation protectors combined with radiation therapy in gynecologic cancer. Cancer, 1981, Jul-15, Volume: 48, Issue:2 Suppl Topics: Amifostine; Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Genital Neoplasms, Female; Humans; Misonidazole; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Random Allocation	1981
Hypoxic cell radiosensitizers--present and future. International journal of radiation oncology, biology, physics, 1981, Volume: 7, Issue:6 Topics: Animals; Central Nervous System; Clinical Trials as Topic; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1981

Other Studies

49 other study(ies) available for desmethylmisonidazole and misonidazole

Article	Year
Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:3 Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Enzyme Stability; In Vitro Techniques; Male; Methylation; Mice; Microsomes, Liver; Misonidazole; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases, O-Demethylating; Temperature; Time Factors	1989
Reaction of 2-nitroimidazole metabolites with guanine and possible biological consequences. IARC scientific publications, 1986, Issue:70 Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Cricetinae; DNA; DNA Damage; Glyoxal; Guanine; Misonidazole; Oxidation-Reduction	1986
The effect of electron-affinic radiosensitizers on ATP levels in V79 379A Chinese hamster cells. Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3 Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cricetulus; Dinitrophenols; Imidazoles; Metronidazole; Misonidazole; Nitrofurantoin; Nitroimidazoles; Radiation-Sensitizing Agents; Sulfhydryl Compounds	1987
The neurotoxicity of radiosensitizing drugs: a biochemical assessment of desmethylmisonidazole (DMM) in the rat. Toxicology, 1985, Volume: 34, Issue:1 Topics: Animals; beta-Galactosidase; Brain; Cerebellum; Dose-Response Relationship, Drug; Glucuronidase; Male; Medulla Oblongata; Misonidazole; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains	1985
Kinetic aspects of misonidazole and its major metabolite in radiotherapy. Human toxicology, 1985, Volume: 4, Issue:4 Topics: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles	1985
Effect of lipophilicity on the rate of diffusion of sensitizers into cellular targets. Singapore medical journal, 1985, Volume: 26, Issue:1 Topics: Animals; Cell Survival; Cricetinae; Cricetulus; Diffusion; Membrane Lipids; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors	1985
Morphological changes in rat hepatocytes in primary culture induced by Misonidazole, desmethylmisonidazole and Ro 03-8799. Virchows Archiv. B, Cell pathology including molecular pathology, 1984, Volume: 46, Issue:1-2 Topics: Animals; Cell Survival; Cells, Cultured; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats	1984
The current status of drug development of hypoxic cell radiosensitizers and their potential role in gynecologic oncology. Gynecologic oncology, 1984, Volume: 18, Issue:1 Topics: Adult; Aged; Drug Evaluation; Female; Genital Neoplasms, Female; Humans; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Palliative Care; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents	1984
Testing of new hypoxic cell sensitizers in vivo. Radiation research, 1982, Volume: 91, Issue:1 Topics: Animals; Drug Evaluation, Preclinical; Etanidazole; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1982
A comparison of the cytological effects of three hypoxic cell radiosensitizers. International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:7 Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Etanidazole; Lung; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange	1982
Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients. British journal of cancer, 1984, Volume: 49, Issue:1 Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Clinical trials of radiosensitizers: what should we expect? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:3 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Etanidazole; Humans; Kinetics; Lethal Dose 50; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Radiosensitizers: a conference preview. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors	1984
A comparison of the ability of some radiosensitizers undergoing clinical trials to act as chemosensitizers. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Neurotoxicity with desmethylmisonidazole. The British journal of radiology, 1981, Volume: 54, Issue:638 Topics: Female; Humans; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases	1981
Final report on the United States Phase I Clinical Trial of the hypoxic cell radiosensitizer, misonidazole (Ro-07-0582; NSC #261037). Cancer, 1981, Oct-15, Volume: 48, Issue:8 Topics: Adolescent; Adult; Aged; Central Nervous System Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Hearing Loss; Humans; Male; Middle Aged; Misonidazole; Nausea; Nitroimidazoles; Peripheral Nervous System Diseases; Vomiting	1981
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers. British journal of cancer, 1982, Volume: 45, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental	1982
Evaluation of desmethylmisonidazole-induced neurotoxicity in the rat using brainstem auditory evoked potentials. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Anesthesia; Animals; Brain Stem; Evoked Potentials, Auditory; Male; Misonidazole; Nitroimidazoles; Pentobarbital; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Reaction Time	1984
The effect of vitamin B6 on the neurotoxicity and pharmacology of desmethylmisonidazole and misonidazole: clinical and laboratory studies. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Humans; Mice; Mice, Inbred Strains; Misonidazole; Nervous System Diseases; Nitroimidazoles; Pyridoxine; Radiation-Sensitizing Agents	1984
The effect of nitroimidazoles on the oxygen consumption rate and respiratory control ratio of beef heart mitochondria. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Cattle; Dose-Response Relationship, Drug; Female; Misonidazole; Mitochondria, Heart; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Time Factors	1984
Measurements of glutathione and other thiols in cells and tissues: a simplified procedure based on the HPLC separation of monobromobimane derivatives of thiols. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Glutathione; Kidney; Liver; Mercaptoethylamines; Mice; Misonidazole; Muscles; Neoplasms, Experimental; Radiation-Sensitizing Agents; Sulfhydryl Compounds	1984
Determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography with reductive electrochemical detection. Journal of chromatography, 1984, Sep-14, Volume: 310, Issue:1 Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Misonidazole; Nitro Compounds; Nitroimidazoles; Spectrophotometry, Ultraviolet	1984
A rapid-mix study on the effect of lipophilicity of nitroimidazoles on the radiosensitization of mammalian cells in vitro. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 43, Issue:3 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1983
The penetration of misonidazole and desmethylmisonidazole into brain tumours and other central nervous system tissues in man. The British journal of radiology, 1983, Volume: 56, Issue:671 Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Time Factors	1983
The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity. The British journal of radiology, 1983, Volume: 56, Issue:671 Topics: Adult; Aged; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Half-Life; Humans; Kinetics; Microsomes, Liver; Middle Aged; Misonidazole; Nervous System Diseases; Nitroimidazoles; Phenobarbital; Phenytoin	1983
The effect of nitroimidazoles on glucose utilization and lactate accumulation in mouse brain. Radiation research, 1984, Volume: 97, Issue:1 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Glucose; In Vitro Techniques; Kinetics; Lactates; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Structure-function dependence and allopurinol inhibition of radiosensitizer/nitroreductase interaction: approaches to improving therapeutic ratios. Cancer clinical trials, 1980,Spring, Volume: 3, Issue:1 Topics: Allopurinol; Animals; Benzamidines; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Furylfuramide; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Misonidazole; NADPH-Ferrihemoprotein Reductase; Radiation-Sensitizing Agents; Structure-Activity Relationship; Temperature; Xanthine Oxidase	1980
Behavioural and ultrastructural studies of desmethylmisonidazole-induced neurotoxicity in mice. The British journal of radiology, 1983, Volume: 56, Issue:661 Topics: Animals; Behavior, Animal; Brain; Female; Kinetics; Mice; Mice, Inbred C3H; Microscopy, Electron; Misonidazole; Nervous System; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents	1983
An investigation of the possibility of chemosensitization by clinically achievable concentrations of misonidazole. British journal of cancer, 1983, Volume: 47, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Division; Drug Therapy, Combination; Female; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen	1983
Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:3 Topics: Adult; Ascorbic Acid; Drug Interactions; Female; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin; Protein Binding	1983
Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. Cancer research, 1983, Volume: 43, Issue:1 Topics: Adenoma; Animals; Hypoxia; Lung; Lung Neoplasms; Metronidazole; Mice; Mice, Inbred A; Misonidazole; Neoplasms, Radiation-Induced; Radiation-Sensitizing Agents	1983
Pharmacokinetics of the hypoxic radiosensitizers misonidazole and demethylmisonidazole after intraperitoneal administration in humans. Cancer research, 1983, Volume: 43, Issue:2 Topics: Female; Humans; Injections, Intraperitoneal; Kinetics; Misonidazole; Nitroimidazoles; Ovarian Neoplasms; Radiation-Sensitizing Agents	1983
Simultaneous determination of some radiosensitizing and chemotherapeutic drugs in plasma by thin-layer chromatography. Journal of chromatography, 1983, Jun-10, Volume: 275, Issue:1 Topics: Antineoplastic Agents; Chromatography, Thin Layer; Cyclophosphamide; Fluorouracil; Humans; Misonidazole; Radiation-Sensitizing Agents	1983
Effects of the xanthine oxidase inhibitor allopurinol on the renal clearance of nitroimidazoles. Biochemical pharmacology, 1982, Oct-01, Volume: 31, Issue:19 Topics: Allopurinol; Animals; Kidney; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Xanthine Oxidase	1982
Increased enhancement of tumour response to X-rays and high-LET neon ions by desmethylmisonidazole relative to misonidazole. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1982, Volume: 41, Issue:6 Topics: Animals; Dose-Response Relationship, Radiation; Energy Transfer; Misonidazole; Neon; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; X-Rays	1982
Immunosuppression by hypoxic cell radiosensitizers: a phenomenon of potential clinical importance. International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:6 Topics: Animals; Cell Survival; Graft Rejection; Heart; Heart Transplantation; Immunity, Cellular; Immunosuppression Therapy; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Skin Transplantation	1982
Studies on the O-demethylation of misonidazole by rat liver microsomes. Cancer treatment reports, 1982, Volume: 66, Issue:6 Topics: Animals; Kinetics; Male; Microsomes, Liver; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains	1982
Sample preparation and a liquid chromatographic assay for misonidazole and desmethylmisonidazole. Journal of chromatography, 1982, Nov-12, Volume: 232, Issue:2 Topics: Adult; Chromatography, Liquid; Humans; Misonidazole; Nitroimidazoles	1982
Ocular absorption and toxicity of a radiosensitizer and its effect on hypoxic cells. Archives of ophthalmology (Chicago, Ill. : 1960), 1982, Volume: 100, Issue:3 Topics: Animals; Cell Survival; Conjunctiva; Cricetinae; Cricetulus; Eye; Female; In Vitro Techniques; Injections; Injections, Intravenous; Misonidazole; Nitroimidazoles; Oxygen Consumption; Rabbits; Radiation Tolerance; Radiation-Sensitizing Agents; Retinoblastoma	1982
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid. British journal of cancer, 1981, Volume: 43, Issue:3 Topics: Breast Neoplasms; Female; Humans; Misonidazole; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Uterine Cervical Neoplasms	1981
Phenytoin-induced changes in the pharmacokinetics of misonidazole in radiotherapy patients. British journal of cancer, 1981, Volume: 44, Issue:4 Topics: Carcinoma, Squamous Cell; Esophageal Neoplasms; Half-Life; Head and Neck Neoplasms; Humans; Kinetics; Misonidazole; Nitroimidazoles; Phenytoin; Time Factors	1981
Simultaneous determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography. Journal of chromatography, 1981, Oct-09, Volume: 225, Issue:2 Topics: Chromatography, High Pressure Liquid; Humans; Misonidazole; Nitroimidazoles; Radiotherapy; Reference Values	1981
Nonlinear pharmacokinetics of misonidazole and desmethylmisonidazole in the isolated perfused rat liver. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3 Topics: Animals; Dealkylation; Dose-Response Relationship, Drug; Kinetics; Liver; Male; Misonidazole; Models, Biological; Nitroimidazoles; Rats; Rats, Inbred Strains	1981
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs. British journal of cancer, 1980, Volume: 41, Issue:2 Topics: Animals; Biological Availability; Dog Diseases; Dogs; Half-Life; Kinetics; Male; Misonidazole; Neoplasms; Nitroimidazoles	1980
A drug for improved radiosensitization in radiotherapy. British journal of cancer, 1980, Volume: 42, Issue:1 Topics: Half-Life; Humans; Male; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1980
In vivo response of KHT sarcomas to combination chemotherapy with radiosensitizers and BCNU. British journal of cancer, 1981, Volume: 43, Issue:1 Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors	1981
Dose-dependence and related studies on the pharmacokinetics of misonidazole and desmethylmisonidazole in mice. Cancer chemotherapy and pharmacology, 1980, Volume: 5, Issue:1 Topics: Animals; Biological Availability; Body Temperature; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Phenobarbital; Premedication; Sex Factors; Skin Neoplasms	1980
The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles. International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2 Topics: Animals; Biotransformation; Cells, Cultured; Haplorhini; Kidney; Misonidazole; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles	1994