desmethylmianserin has been researched along with mianserin in 13 studies
| Studies (desmethylmianserin) | Trials (desmethylmianserin) | Recent Studies (post-2010) (desmethylmianserin) | Studies (mianserin) | Trials (mianserin) | Recent Studies (post-2010) (mianserin) |
|---|---|---|---|---|---|
| 14 | 1 | 0 | 2,624 | 539 | 488 |
| Protein | Taxonomy | desmethylmianserin (IC50) | mianserin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.0012 | |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | 1.4125 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.163 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 1.078 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 2.066 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.3981 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 1.9 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.32 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0213 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 1.423 | |
| D(2) dopamine receptor | Homo sapiens (human) | 7.0795 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.38 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.026 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0661 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.872 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 1.405 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.543 | |
| D(4) dopamine receptor | Homo sapiens (human) | 3.3113 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.38 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.163 | |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | 1.4125 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.008 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.083 | |
| Endothelin-1 receptor | Homo sapiens (human) | 0.1148 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.3802 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.011 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0043 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.872 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 2.068 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 2.9 | |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | 0.1148 | |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | 0.4074 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0024 | |
| D(3) dopamine receptor | Homo sapiens (human) | 3.8905 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0073 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.19 | |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | 1.4125 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.88 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.085 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 3.5481 | |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | 1.4125 | |
| Transporter | Rattus norvegicus (Norway rat) | 0.022 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushima, Y; Higuchi, H; Hishikawa, Y; Kaneko, S; Otani, K; Sasa, H | 1 |
| de Graaf, JS; Dijcks, FA; Ruigt, GS | 1 |
| Hand, TH; Marek, GJ; Seiden, LS | 1 |
| Leonard, BE; O'Connor, WT | 1 |
| Baettig, D; Baumann, P; Campus-Souche, D; Eap, CB; Monney, C; Powell, K; Taeschner, W | 1 |
| Alm, C; Andreasson, K; Bertilsson, L; Dahl, ML; Elwin, CE; Gyllenpalm, M; Tybring, G | 1 |
| Buist, A; Dennerstein, L; Norman, TR | 1 |
| Fukushima, Y; Kaneko, S; Kondo, T; Otani, K; Sasa, H | 1 |
| Fukushima, Y; Kaneko, S; Mihara, K; Okada, M; Otani, K; Tanaka, O | 1 |
| Bertilsson, L; Fukushima, Y; Kaneko, S; Mihara, K; Otani, K; Tybring, G | 1 |
| Kaneko, S; Mihara, K; Otani, K; Suzuki, A; Svensson, JO; Tybring, G; Yasui, N | 1 |
| Chauhan, B; Guttikar, S; Jadon, N; Padh, H; Rani, S; Zope, A | 1 |
| Lambert, WE; Maudens, KE; Van Peteghem, CH; Wille, SM | 1 |
1 trial(s) available for desmethylmianserin and mianserin
| Article | Year |
|---|---|
Enantioselective determination of mianserin and its desmethyl metabolite in plasma during treatment of depressed Japanese patients.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Depression; Dose-Response Relationship, Drug; Female; Humans; Japan; Male; Mianserin; Middle Aged; Stereoisomerism | 1995 |
12 other study(ies) available for desmethylmianserin and mianserin
| Article | Year |
|---|---|
Subjective side effects of mianserin in relation to plasma concentrations of mianserin and desmethylmianserin.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Psychiatric Status Rating Scales; Sex Factors | 1992 |
Antidepressants affects amine modulation of neurotransmission in the rat hippocampal slice--II. Acute effects.
Topics: Animals; Biogenic Amines; Desipramine; Hippocampus; In Vitro Techniques; Male; Mianserin; Rats; Synaptic Transmission; Time Factors | 1991 |
Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Depression; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Stereoisomerism | 1991 |
The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the 'open field' behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat.
Topics: Animals; Behavior, Animal; Brain; Male; Methoxyhydroxyphenylglycol; Mianserin; Norepinephrine; Olfactory Bulb; Rats; Rats, Inbred Strains | 1987 |
Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Female; Genotype; Humans; Male; Mianserin; Middle Aged; Polymerase Chain Reaction; Stereoisomerism | 1994 |
Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Mianserin; Middle Aged; Mixed Function Oxygenases; Polymorphism, Genetic; Stereoisomerism; Sweden; White People | 1994 |
Mianserin in breast milk.
Topics: Adult; Depression; Female; Humans; Lactation; Mianserin; Milk, Human; Postpartum Period | 1993 |
Steady-state plasma concentrations of mianserin and its major active metabolite, desmethylmianserin.
Topics: Adult; Age Factors; Aged; Chromatography, High Pressure Liquid; Depression; Female; Humans; Male; Mianserin; Middle Aged; Smoking | 1993 |
Prediction of plasma concentrations of mianserin and desmethylmianserin at steady state from those after an initial dose of mianserin.
Topics: Adult; Aged; Animals; Depression; Female; Humans; Male; Mianserin; Middle Aged | 1993 |
Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients.
Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6 Inhibitors; Depression; Enzyme Inhibitors; Female; Homozygote; Humans; Japan; Male; Mianserin; Stereoisomerism; Thioridazine | 1997 |
Analytical method development and validation of mianserin hydrochloride and its metabolite in human plasma by LC-MS.
Topics: Calibration; Chemistry Techniques, Analytical; Chromatography, Liquid; Humans; Mass Spectrometry; Mianserin; Reproducibility of Results | 2005 |
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Mianserin; Microchemistry; Mirtazapine; Piperazines; Reproducibility of Results; Sertraline | 2005 |